Pathogenic Missense Mutations in Intrinsically Disordered Regions Reveal Functional and Clinical Signals https://www.biorxiv.org/content/10.1101/2025.05.01.651640v1

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Excited to share our latest preprint! We reveal how intrinsically disordered protein regions (IDRs) harbor critical pathogenic mutations, often overlooked in clinical genomics. 🧬
www.biorxiv.org/content/10.1...

#Genomics #Bioinformatics #AlphaMissense #IDPs #SLiMs #Dlab #IDP2Biomed #IDPfun2

I'm excited to share that our latest manuscript accepted and published in JMB.
We created AIUPred-binding which use energy embedding and AlphaMissense scores to accurately predict functional binding regions in IDRs.
sciencedirect.com/science/arti...

#IDP2Biomed, #Dosztanyilab, @gerdos.bsky.social

I'm excited to share our preprint, created in collaboration with the @teamgogl.bsky.social , where we at @idp2biomed.bsky.social (Dosztányi lab) performed the bioinformatics analysis for the manuscript.

Welcome to the IDP2Biomed project! The “Bringing Intrinsically Disordered Proteins to Biomedical Applications” Twinning Program has been launched on 01/10/2024 with the aim of strengthening scientific excellence and innovation capacity at the interface of biology and chemistry at the ELTE.

🎉 Thrilled to announce that our paper is now accepted in Bioinformatics! 📄🧬✨ A collaborative project enhancing diagnostic accuracy for SARS-CoV-2, Mpox, and more. 🌐🔬 Check it out: viralprimer.elte.hu

Manuscript:
academic.oup.com/bioinformati...

#DosztanyiLAB #Bioinformatics #SARS-CoV-2 #Webserver

🚀 Excited to announce our latest paper just published! Discover new insights into protein disorder and prediction methods in computational biology. Read more here: www.sciencedirect.com/science/arti... #DosztanyiLAB #Bioinformatics #IDPs #ProteinResearch