Organic Chemistry Portal
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Lithium perchlorate efficiently catalyzes the Biginelli three-component condensation reaction of aldehydes, β-keto esters and urea in refluxing acetonitrile
Lithium perchlorate efficiently catalyzes the Biginelli three-component condensation reaction of aldehydes, β-keto esters and urea in refluxing acetonitrile
November 25, 2025 at 11:21 AM
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Lithium perchlorate efficiently catalyzes the Biginelli three-component condensation reaction of aldehydes, β-keto esters and urea in refluxing acetonitrile
Lithium perchlorate efficiently catalyzes the Biginelli three-component condensation reaction of aldehydes, β-keto esters and urea in refluxing acetonitrile
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A trifluoroacetic acid-promoted amino-Claisen rearrangement provides highly functionalized indoles.
A trifluoroacetic acid-promoted amino-Claisen rearrangement provides highly functionalized indoles.
November 25, 2025 at 11:19 AM
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A trifluoroacetic acid-promoted amino-Claisen rearrangement provides highly functionalized indoles.
A trifluoroacetic acid-promoted amino-Claisen rearrangement provides highly functionalized indoles.
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A Cu-catalyzed propargylic amination of amines with propargylic cyclic carbonates provides chiral acyclic α-quaternary α-amino ketones.
A Cu-catalyzed propargylic amination of amines with propargylic cyclic carbonates provides chiral acyclic α-quaternary α-amino ketones.
November 25, 2025 at 11:16 AM
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A Cu-catalyzed propargylic amination of amines with propargylic cyclic carbonates provides chiral acyclic α-quaternary α-amino ketones.
A Cu-catalyzed propargylic amination of amines with propargylic cyclic carbonates provides chiral acyclic α-quaternary α-amino ketones.
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A cross-coupling reaction of homoallyl alcohols with aldehydes in the presence of Amberlyst-15 yields 4-hydroxy-2,6-disubstituted tetrahydropyrans
A cross-coupling reaction of homoallyl alcohols with aldehydes in the presence of Amberlyst-15 yields 4-hydroxy-2,6-disubstituted tetrahydropyrans
November 25, 2025 at 11:13 AM
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A cross-coupling reaction of homoallyl alcohols with aldehydes in the presence of Amberlyst-15 yields 4-hydroxy-2,6-disubstituted tetrahydropyrans
A cross-coupling reaction of homoallyl alcohols with aldehydes in the presence of Amberlyst-15 yields 4-hydroxy-2,6-disubstituted tetrahydropyrans
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A simple and mild direct chloride/fluoride exchange for the synthesis of sulfonyl fluorides
A simple and mild direct chloride/fluoride exchange for the synthesis of sulfonyl fluorides
November 25, 2025 at 11:11 AM
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A simple and mild direct chloride/fluoride exchange for the synthesis of sulfonyl fluorides
A simple and mild direct chloride/fluoride exchange for the synthesis of sulfonyl fluorides
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A transition-metal-free α-cyanation of easy accessible N-fluorotosylsulfonamides
A transition-metal-free α-cyanation of easy accessible N-fluorotosylsulfonamides
November 25, 2025 at 11:08 AM
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A transition-metal-free α-cyanation of easy accessible N-fluorotosylsulfonamides
A transition-metal-free α-cyanation of easy accessible N-fluorotosylsulfonamides
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Cerium chloride efficiently catalyses the ring opening of epoxides with aromatic amines to generate β-amino alcohols.
Cerium chloride efficiently catalyses the ring opening of epoxides with aromatic amines to generate β-amino alcohols.
November 24, 2025 at 11:43 AM
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Cerium chloride efficiently catalyses the ring opening of epoxides with aromatic amines to generate β-amino alcohols.
Cerium chloride efficiently catalyses the ring opening of epoxides with aromatic amines to generate β-amino alcohols.
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An N-heterocyclic carbene catalyzes a radical-mediated sulfonyl methylation of readily available aldehydes to provide α-sulfonyl ketones.
An N-heterocyclic carbene catalyzes a radical-mediated sulfonyl methylation of readily available aldehydes to provide α-sulfonyl ketones.
November 24, 2025 at 11:40 AM
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An N-heterocyclic carbene catalyzes a radical-mediated sulfonyl methylation of readily available aldehydes to provide α-sulfonyl ketones.
An N-heterocyclic carbene catalyzes a radical-mediated sulfonyl methylation of readily available aldehydes to provide α-sulfonyl ketones.
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The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes
The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes
November 24, 2025 at 11:37 AM
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The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes
The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes
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Oxidation of anthranilamides, salicylamides and some β-substituted amides with iodobenzene diacetate in methanolic potassium hydroxide
Oxidation of anthranilamides, salicylamides and some β-substituted amides with iodobenzene diacetate in methanolic potassium hydroxide
November 24, 2025 at 11:34 AM
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Oxidation of anthranilamides, salicylamides and some β-substituted amides with iodobenzene diacetate in methanolic potassium hydroxide
Oxidation of anthranilamides, salicylamides and some β-substituted amides with iodobenzene diacetate in methanolic potassium hydroxide
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Mechanochemically activated magnesium(0) metal is a highly active mediator for the direct C-4-H alkylation of pyridines with alkyl halides.
Mechanochemically activated magnesium(0) metal is a highly active mediator for the direct C-4-H alkylation of pyridines with alkyl halides.
November 24, 2025 at 11:31 AM
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Mechanochemically activated magnesium(0) metal is a highly active mediator for the direct C-4-H alkylation of pyridines with alkyl halides.
Mechanochemically activated magnesium(0) metal is a highly active mediator for the direct C-4-H alkylation of pyridines with alkyl halides.
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Trifluoromethyl thianthrenium triflate is a conveniently accessible trifluoromethylating reagent
Trifluoromethyl thianthrenium triflate is a conveniently accessible trifluoromethylating reagent
November 24, 2025 at 11:29 AM
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Trifluoromethyl thianthrenium triflate is a conveniently accessible trifluoromethylating reagent
Trifluoromethyl thianthrenium triflate is a conveniently accessible trifluoromethylating reagent
www.organic-chemistry.org/Highlights/2...
Douglass features Carbon-Carbon Bond Formation: The Renata Synthesis of Lycoposerramine W
Douglass features Carbon-Carbon Bond Formation: The Renata Synthesis of Lycoposerramine W
November 23, 2025 at 5:40 PM
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Douglass features Carbon-Carbon Bond Formation: The Renata Synthesis of Lycoposerramine W
Douglass features Carbon-Carbon Bond Formation: The Renata Synthesis of Lycoposerramine W
Molecule of the week: Lycoposerramine W
Lycopodium alkaloids are attractive synthetic targets due to their diverse and unusual skeletal features. While numerous synthetic approaches have been reported, outstanding synthetic challenges remain.
More Info: www.organic-chemistry.org/Highlights/2...
Lycopodium alkaloids are attractive synthetic targets due to their diverse and unusual skeletal features. While numerous synthetic approaches have been reported, outstanding synthetic challenges remain.
More Info: www.organic-chemistry.org/Highlights/2...
November 23, 2025 at 5:30 PM
Molecule of the week: Lycoposerramine W
Lycopodium alkaloids are attractive synthetic targets due to their diverse and unusual skeletal features. While numerous synthetic approaches have been reported, outstanding synthetic challenges remain.
More Info: www.organic-chemistry.org/Highlights/2...
Lycopodium alkaloids are attractive synthetic targets due to their diverse and unusual skeletal features. While numerous synthetic approaches have been reported, outstanding synthetic challenges remain.
More Info: www.organic-chemistry.org/Highlights/2...
www.organic-chemistry.org/abstracts/li...
Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF
Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF
November 21, 2025 at 12:58 PM
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Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF
Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF
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An unprecedented metal-free reaction of o-aminobenzamides with CO2 provides N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones
An unprecedented metal-free reaction of o-aminobenzamides with CO2 provides N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones
November 21, 2025 at 12:56 PM
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An unprecedented metal-free reaction of o-aminobenzamides with CO2 provides N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones
An unprecedented metal-free reaction of o-aminobenzamides with CO2 provides N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones
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A Rh/Cu co-catalytic system enables an asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source
A Rh/Cu co-catalytic system enables an asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source
November 21, 2025 at 12:54 PM
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A Rh/Cu co-catalytic system enables an asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source
A Rh/Cu co-catalytic system enables an asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source
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A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates
A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates
November 21, 2025 at 12:51 PM
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A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates
A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates
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A practical and efficient photoinduced decarboxylative/dehydrogenative coupling of α-fluoroacrylic acids with phosphine oxides
A practical and efficient photoinduced decarboxylative/dehydrogenative coupling of α-fluoroacrylic acids with phosphine oxides
November 21, 2025 at 12:48 PM
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A practical and efficient photoinduced decarboxylative/dehydrogenative coupling of α-fluoroacrylic acids with phosphine oxides
A practical and efficient photoinduced decarboxylative/dehydrogenative coupling of α-fluoroacrylic acids with phosphine oxides
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Manganese mediates a direct functionalization of Hantzsch esters with readily accessible alkyl iodides
Manganese mediates a direct functionalization of Hantzsch esters with readily accessible alkyl iodides
November 21, 2025 at 12:00 PM
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Manganese mediates a direct functionalization of Hantzsch esters with readily accessible alkyl iodides
Manganese mediates a direct functionalization of Hantzsch esters with readily accessible alkyl iodides
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A Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides and cyanamides
A Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides and cyanamides
November 21, 2025 at 11:58 AM
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A Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides and cyanamides
A Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides and cyanamides
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A convenient Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols
A convenient Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols
November 21, 2025 at 11:55 AM
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A convenient Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols
A convenient Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols
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A chloroaluminate ionic liquid can be used as a solvent as well as a catalyst for the The Fischer indole synthesis.
A chloroaluminate ionic liquid can be used as a solvent as well as a catalyst for the The Fischer indole synthesis.
November 21, 2025 at 11:53 AM
www.organic-chemistry.org/abstracts/li...
A chloroaluminate ionic liquid can be used as a solvent as well as a catalyst for the The Fischer indole synthesis.
A chloroaluminate ionic liquid can be used as a solvent as well as a catalyst for the The Fischer indole synthesis.
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November 21, 2025 at 11:33 AM
Fair fees will soon allow to cover more chemistry, to feature more details and to invest in better, faster, more reliable servers... even at remote locations. Please check out our offer here: www.organic-chemistry.org/info/plus/
We have just published a vacancy for a Process Chemist at Vertex in San Diego, CA: www.organic-chemistry.org/jobs/offers/... - please check and share!
November 20, 2025 at 5:59 PM
We have just published a vacancy for a Process Chemist at Vertex in San Diego, CA: www.organic-chemistry.org/jobs/offers/... - please check and share!