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orgbiomolchem.rsc.org
Organic & Biomolecular Chemistry
@orgbiomolchem.rsc.org
510 followers 220 following 320 posts
Rapid publication of organic synthesis, physical organic, chemical biology and supramolecular chemistry research.

Published by @rsc.org 🌐 Website: rsc.li/orgbiomolchem
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orgbiomolchem.rsc.org
Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 8d
📢We are delighted to announce our #OpenCall for papers to our Electrosynthesis themed collection #chemsky #electrochem

Guest Editors: Alastair Lennox, @lundbergchemlab.bsky.social, Lei Wang & Zhong-Wei Hou

Deadline: 30th June 2026

Find more about the collection🔽
www.rsc.org/publishing/j...
orgbiomolchem.rsc.org
Read this paper by Reuben Peters, Justin Siegel, Dean Tantillo & co. @iastateresearch.bsky.social & @ucdavis.bsky.social on mechanistic molecular modeling of the ent-copalyl diphosphate synthase from Arabidopsis thaliana #orgchem #compchem

Find in full here🔽
Basic importance: mechanistic molecular modeling of the ent-copalyl diphosphate synthase from Arabidopsis thaliana (AtCPS)
Terpene synthases/cyclases catalyze the formation of complex polycyclic natural products via mechanisms proceeding through carbocation intermediates. Their active sites are generally lined with…
pubs.rsc.org
February 10, 2026 at 3:22 PM
orgbiomolchem.rsc.org
🔓Don't miss this #OpenAccess research in our latest issue from Olga García Mancheño, Monika Schönhoff & co. @uni-muenster.de describing new supramolecular light-switchable triazole-hosts for photoresponsive anion binding #orgchem #supramolecular

Check it out in full👇
Supramolecular light-switchable triazole-hosts for photoresponsive anion binding
A series of photoreversible anion binding hosts is developed, combining either an azobenzene or an arylazopyrazole as a central photoswitch unit and tetrakis-triazoles as anion binding motifs. By…
pubs.rsc.org
February 9, 2026 at 12:30 PM
orgbiomolchem.rsc.org
Check out this paper by Wei-Cheng Yuan, Yong You et al. from Chengdu University in our latest issue reporting a photoredox-catalyzed Giese reaction for the synthesis of γ-nitro alcohols #orgchem

Read their full report on our website🔽
Photoredox-catalyzed Giese reaction for the synthesis of γ-nitro alcohols
The direct synthesis of γ-nitro alcohols, valuable precursors to 1,3-amino alcohols, from simple starting materials remains a challenge. Herein, we disclose a photoredox-catalyzed Giese reaction…
pubs.rsc.org
February 8, 2026 at 9:48 AM
orgbiomolchem.rsc.org
🔓Take a look at #OpenAccess research by Atsushi Yoshimori, Kazuhiro Abe, Satoshi Yokoshima et al. on the design, synthesis & structural analysis of a gastric proton pump inhibitor with a diaza-tricyclic skeleton #orgchem

📍Hokkaido University, @en.nagoya-u.ac.jp
Design, synthesis, and structural analysis of an inhibitor of the gastric proton pump with a diaza-tricyclic skeleton
The development of potent K+-competitive acid blockers (P-CABs) as inhibitors of acid gastric secretion attracts much research attention. In this study, the structure-guided design and…
pubs.rsc.org
February 7, 2026 at 9:48 AM
orgbiomolchem.rsc.org
🔓Don't miss this #OpenAccess paper in our latest issue from Shiqing Xu & co. @tamu.bsky.social reporting the discovery of a potent main protease inhibitor by regioselective multicomponent synthesis of α-boryl ureas #orgchem

Check it out in full on our website🔽
pubs.rsc.org/en/content/a...
Regioselective multicomponent synthesis of α-boryl ureas: discovery of a potent main protease inhibitor
The development of efficient synthetic methods for α-boryl ureas is of significant interest due to their potential as drug-like scaffolds in medicinal chemistry. Herein, we present a multicomponent st...
pubs.rsc.org
February 5, 2026 at 3:55 PM
orgbiomolchem.rsc.org
📢Our latest issue is now online!

🔓Check out the #OpenAccess review behind the cover by Basab Bijayi Dhar & co. from Shiv Nadar University looking at C(sp3)–H halogenation using first-row transition metal catalysts under homogeneous conditions #orgchem

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February 4, 2026 at 4:47 PM
orgbiomolchem.rsc.org
🔓Be sure to read in our latest issue research by Alexander Ciupa @liverpooluni.bsky.social discovering novel fluorescent sensors using high-throughput DoE synthesis of chalcones and pyrazolines #orgchem #sensors

Find the full report here🔽
High-throughput DoE synthesis of chalcones and pyrazolines for fluorescent sensing
Pyrazolines are attractive scaffolds for fluorescent sensors due to their unique photophysical properties and the ease of their synthesis from chalcone precursors. While both chalcones and…
pubs.rsc.org
February 3, 2026 at 12:48 PM
orgbiomolchem.rsc.org
📢We are delighted to announce our #OpenCall for papers to our Electrosynthesis themed collection #chemsky #electrochem

Guest Editors: Alastair Lennox, @lundbergchemlab.bsky.social, Lei Wang & Zhong-Wei Hou

Deadline: 30th June 2026

Find more about the collection🔽
www.rsc.org/publishing/j...
February 2, 2026 at 2:01 PM
orgbiomolchem.rsc.org
🔓Don't miss this #OpenAccess paper by Spyridon Mourtas & co. at the University of Patras reporting the use of homoserinyl γ-aldehyde–containing peptides in solid-phase reductive amination #orgchem #peptides

Check it out on our website👇
Use of homoserinyl γ-aldehyde–containing peptides in solid-phase reductive amination
Reduced peptide bonds of the methyleneamino Ψ[CH2–NH] type are widely recognized as peptide bond isosteres with significant value in drug discovery and development. Solid-Phase Synthesis (SPS)…
pubs.rsc.org
February 2, 2026 at 11:01 AM
orgbiomolchem.rsc.org
Check out research in our latest issue by Weichao Xue, Xueli Zheng & co. from Sichuan University using electrochemical cross-electrophile coupling of unactivated tertiary alkyl bromides with benzyl chloride to access quaternary stereocenters #orgchem

Read in full here🔽
Electrochemical cross-electrophile coupling of unactivated tertiary alkyl bromides with benzyl chloride to access quaternary stereocenters
Constructing quaternary carbon centers represents a significant yet challenging task in synthetic and medicinal chemistry. Herein, we report an efficient electrochemical nickel-catalyzed reductive…
pubs.rsc.org
February 1, 2026 at 9:48 AM
orgbiomolchem.rsc.org
Take a look at this review by Mrittika Mohar, Tanmay Das & Alakananda Hajra covering the recent advances in the synthesis and applications of oxaborole derivatives in our latest issue #orgchem

📍Visva-Bharati University
Recent advances in the synthesis and applications of oxaborole derivatives
Oxaboroles, five-membered boron-containing heterocycles, have emerged as an increasingly versatile framework in drug discovery and molecular design. Their significance stems from the unique Lewis…
pubs.rsc.org
January 31, 2026 at 9:45 AM
orgbiomolchem.rsc.org
🔓Read this #OpenAccess paper in our latest issue by Eric A. Nicol & Adrian L. Schwan @uofguelph.bsky.social describing a computational investigation of the thermal elimination chemistry of β-borylated sulfoxides #orgchem #compchem

Find their full report below👇
A computational investigation of the thermal elimination chemistry of β-borylated sulfoxides. Sulfenic acid vs. boryl sulfenate elimination
Electronic structure calculations were performed to assess how a β-boryl substituent modulates barriers for the classical Ei elimination of sulfoxides. Four main boron substituents were investigated:…
pubs.rsc.org
January 30, 2026 at 3:01 PM
orgbiomolchem.rsc.org
🔓Don't miss this #OpenAccess paper by Camilla Loro, Raffaella Bucci from the University of Milan in our latest issue building parallel β-hairpins using electrochemical synthesis of a new isoxazoline scaffold #orgchem

Check it out in full on our website🔽
Sustainable electrochemical synthesis of a new isoxazoline scaffold as turn inducer to build parallel β-hairpins
New diastereoisomeric isoxazoline scaffolds bearing two amino-alkyl chains were synthesized using a 1,3-dipolar cycloaddition reaction, with the aim to prepare N-to-N parallel β-hairpins. Two…
pubs.rsc.org
January 29, 2026 at 12:27 PM
orgbiomolchem.rsc.org
📢Our latest issue is now online!

🔓Check out the #OpenAccess review behind the cover by Michal Szostak, Chinnappan Sivasankar & co. at Rutgers University & Pondicherry University covering the synthesis, carbene generation and reactivity of diazo compounds #orgchem

pubs.rsc.org/en/content/a...
January 28, 2026 at 3:06 PM
orgbiomolchem.rsc.org
🔓Read a #OpenAccess paper in our latest issue by @prof-ian-fairlamb.bsky.social, @unsworthchem.bsky.social & co. @york.ac.uk reporting innovations to the ‘Clip-Cycle’ approach for functionalised pyrrolidines, pyrrolizidines and indolizidines #orgchem

Find it in full🔽
‘Clip-Cycle’ approaches to functionalised pyrrolidines, pyrrolizidines and indolizidines
The ‘Clip-Cycle’ approach is a versatile and modular synthetic method for the synthesis of aza-heterocycles via sequential cross metathesis and aza-Michael reactions. In this manuscript, a series of…
pubs.rsc.org
January 27, 2026 at 12:30 PM
orgbiomolchem.rsc.org
🔓Don't miss this #OpenAccess paper in our latest issue by Stephen G. Withers & co. from @science.ubc.ca synthesising carbagalactosyl 1,2-aziridines and -epoxides as glycosidase inhibitors #orgchem

Check it out in full here👇
Synthesis and evaluation of carbagalactosyl 1,2-aziridines and -epoxides as glycosidase inhibitors
The natural product cyclophellitol is a cyclitol epoxide that mimics a β-glucoside and functions as a mechanism-based inhibitor for retaining β-glucosidases by forming a stable covalent intermediate…
pubs.rsc.org
January 26, 2026 at 3:02 PM
orgbiomolchem.rsc.org
Check out this paper from Junhong Li, Xuanxuan Chen, Xin Wu & co. at Xiamen University in our latest issue using a simple bis-squaramide with charge-enhanced acidity for anion recognition in water #orgchem #supramolecular

Read their full report below🔽
Anion recognition in water by a simple bis-squaramide with charge-enhanced acidity
Synthetic anion receptors that function in water are typically elaborately designed macrocycles and cages, as a high level of pre-organisation is required to overcome the free energy cost from anion…
pubs.rsc.org
January 25, 2026 at 9:30 AM
orgbiomolchem.rsc.org
Take a look in our latest issue at research from Ja Young Cho, Taejung Kim & co. reporting the synthesis-enabled conformational assignment of natural N-acyl l-phenylalanine derivatives from freshwater sponge–associated Micromonospora sp. MS-62 #natprod #orgchem

📍KIST
Synthesis-enabled conformational assignment of natural N-acyl L-phenylalanine derivatives from freshwater sponge–associated Micromonospora sp. MS-62
This study demonstrates a concise four-step total synthesis of N-acyl-l-phenylalanine derivatives (P1–P5) from Micromonospora sp. MS-62 enabling definitive assignment of the S configuration at C-1′…
pubs.rsc.org
January 24, 2026 at 10:00 AM
orgbiomolchem.rsc.org
🔓Be sure to read this #OpenAccess paper by Keisuke Tomohara, Hisanori Nambu, Takeru Nose et al. at Kyoto Pharmaceutical University describing N-to-C peptide elongation by ammonia-Ugi reaction for self-assembling elastin-like short peptides #orgchem

Find it in full here👇
N-to-C peptide elongation by ammonia-Ugi reaction: synthesis of potent self-assembling elastin-like short peptides
The ammonia-Ugi reaction employing ammonium carboxylates of N-protected amino acids (or peptides), ketones, and α-isocyano esters enabled N-to-C peptide elongation, together with in situ construction…
pubs.rsc.org
January 23, 2026 at 9:48 AM
orgbiomolchem.rsc.org
🔓Don't miss this #OpenAccess review in our latest issue by Niamh Lehane & Patrick J. Guiry from @ucddublin.bsky.social looking at the recent advances in Pd-catalysed decarboxylative asymmetric allylic alkylation #orgchem

Check it out in full on our website🔽
Recent advances in Pd-catalysed decarboxylative asymmetric allylic alkylation
This comprehensive review on the Pd-catalysed decarboxylative asymmetric allylic alkylation details the development of this important transformation from its origins to more recent advances. Selected…
pubs.rsc.org
January 22, 2026 at 2:45 PM
orgbiomolchem.rsc.org
📢Our latest issue is now online!

🔓Check out the #OpenAccess paper behind the cover by Hari Prasad Kokatla & co. from NIT Warangal using a metal- and hydride-free approach for the chemoselective reduction of α-keto aldehydes by rongalite in water #orgchem

pubs.rsc.org/en/content/a...
January 21, 2026 at 12:30 PM
orgbiomolchem.rsc.org
Be sure to read in our latest issue this paper by Charles H. Chen & co. at @astra-zeneca.bsky.social enabling effective mRNA delivery to the lungs via new oxabispidine-derived ionizable lipid nanoparticles #medchem #orgchem

Find it in full on our website🔽
Oxabispidine-derived ionizable lipids for effective mRNA delivery to the lungs using lipid nanoparticles
Lipid nanoparticles have been proven effective for mRNA delivery to the liver and in a vaccine context. There is general interest in identifying new ionizable lipids to enable safe and efficient mRNA…
pubs.rsc.org
January 20, 2026 at 3:02 PM
orgbiomolchem.rsc.org
🔓Don't miss this #OpenAccess paper by Bidraha Bagh et al. from NISER Bhubaneswar using a cobalt-catalyzed hydrosilylation approach for the reductive deoxygenation of tertiary alcohols #orgchem

Check it out below👇
Reductive deoxygenation of tertiary alcohols: a cobalt-catalyzed hydrosilylation approach
Dehydrogenation of tertiary alcohols is both highly challenging and of notable importance in synthetic chemistry. We report a readily available Co2(CO)8 catalyzed hydrosilylation protocol for the…
pubs.rsc.org
January 19, 2026 at 10:00 AM
orgbiomolchem.rsc.org
Check out research from Ryohei Yamakado & co. at Yamagata University in our latest issue showing how X-shaped π-conjugated fluorophores enable cooperative ion-pair recognition with multicolour emission #orgchem

Read their full report here🔽
X-shaped π-conjugated fluorophores enable cooperative ion-pair recognition with multicolour emission
An X-shaped π-conjugated molecule (X1) incorporating orthogonal cation- and anion-recognition sites, azacrown ethers and dimesitylborane units, respectively, was synthesised and compared with two…
pubs.rsc.org
January 18, 2026 at 9:48 AM
orgbiomolchem.rsc.org
🔓Take a look in our latest issue at this #OpenAccess paper by Anna Mkrtchyan, Andrei Malkov, Ashot Saghyan et al. reporting the synthesis of enantiomerically enriched β-N-amino (S)-α-alanine analogs #orgchem

📍Yerevan State University, @lborouniversity.bsky.social
Synthesis of enantiomerically enriched β-N-amino (S)-α-alanine analogs via sequential reactions on a chiral Ni(II) complex
A concise synthetic route to enantiomerically enriched β-N-substituted (S)-α-diaminopropanoic acids is reported. An acetylene group was introduced into the alanine side chain by nucleophilic Michael…
pubs.rsc.org
January 17, 2026 at 12:30 PM