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Organic Chemistry Frontiers

@orgchemfront.rsc.org

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An international high impact journal for cutting-edge research from all disciplines of organic chemistry. Published by @rsc.org 🌐 Website: rsc.li/orgchemfront

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Organic Chemistry Frontiers @orgchemfront.rsc.org · 1h

👉 𝐑𝐡𝐨𝐝𝐢𝐮𝐦-𝐜𝐚𝐭𝐚𝐥𝐲𝐳𝐞𝐝 𝐜𝐲𝐜𝐥𝐨𝐚𝐝𝐝𝐢𝐭𝐢𝐨𝐧 𝐨𝐟 𝐛𝐢𝐜𝐲𝐜𝐥𝐨[𝟏.𝟏.𝟎]𝐛𝐮𝐭𝐚𝐧𝐞𝐬 𝐰𝐢𝐭𝐡 𝐍,𝐍′-𝐜𝐲𝐜𝐥𝐢𝐜 𝐚𝐳𝐨𝐦𝐞𝐭𝐡𝐢𝐧𝐞 𝐢𝐦𝐢𝐧𝐞𝐬 by Zijun Zhou 𝘦𝘵 𝘢𝘭.

Rhodium-catalyzed cycloaddition yields azabicyclo[3.1.1]heptanes (up to 98%, 27 examples) with broad scope; enantioselective version achieves 91% ee.

🔗 doi.org/10.1039/D5QO01147G

Rhodium-catalyzed cycloaddition of bicyclo[1.1.0]butanes with N,N′-cyclic azomethine imines: en route to fused diaza-3D scaffolds

The construction of aza-3D frameworks has emerged as a pivotal strategy in drug discovery, owing to their ability to mimic heteroarene bioisosteres. In this study, we introduce a novel strategy that e...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 1d

👉Don't miss the outside back cover article of issue 20:

𝐒𝐢𝐭𝐞 𝐬𝐞𝐥𝐞𝐜𝐭𝐢𝐯𝐞 𝐇𝐞𝐜𝐤 𝐚𝐫𝐲𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐍-𝐯𝐢𝐧𝐲𝐥-𝟕-𝐚𝐳𝐚𝐢𝐧𝐝𝐨𝐥𝐞 𝐞𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐞𝐝 𝐛𝐲 𝐍-𝐨𝐱𝐢𝐝𝐞 𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐨𝐧: 𝐬𝐜𝐨𝐩𝐞 𝐚𝐧𝐝 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐬𝐭𝐮𝐝𝐢𝐞𝐬

by Parthasarathi Das 𝘦𝘵 𝘢𝘭.
🔗 doi.org/10.1039/D5QO00976F

Organic Chemistry Frontiers @orgchemfront.rsc.org · 1d

📢 Issue 20 of OCF is now available! Read the outside front cover article

𝐁𝐲𝐩𝐚𝐬𝐬𝐢𝐧𝐠 𝐭𝐡𝐞 𝐚𝐛𝐧𝐨𝐫𝐦𝐚𝐥 𝐂𝐡𝐢𝐜𝐡𝐢𝐛𝐚𝐛𝐢𝐧 𝐫𝐞𝐚𝐜𝐭𝐢𝐨𝐧 𝐝𝐞𝐚𝐝-𝐞𝐧𝐝 𝐩𝐫𝐨𝐯𝐢𝐝𝐞𝐬 𝐚 𝐛𝐢𝐨𝐦𝐢𝐦𝐞𝐭𝐢𝐜 𝐚𝐜𝐜𝐞𝐬𝐬 𝐭𝐨 𝐩𝐫𝐞-𝐡𝐚𝐨𝐮𝐚𝐦𝐢𝐧𝐞

by Mehdi A. Beniddir, Erwan Poupon 𝘦𝘵 𝘢𝘭.
🔗 doi.org/10.1039/D5QO01111F

Organic Chemistry Frontiers @orgchemfront.rsc.org · 1d

👉𝐂𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲 𝐍𝐨𝐛𝐞𝐥 𝐏𝐫𝐢𝐳𝐞 𝐂𝐨𝐥𝐥𝐞𝐜𝐭𝐢𝐨𝐧 𝟐𝟎𝟐𝟓

🎉A RSC cross-journal collection celebrating the 2025 Nobel Prize in Chemistry, highlighting the work of Susumu Kitagawa, Richard Robson, and Omar M. Yaghi on metal–organic frameworks (MOFs) is now online！

pubs.rsc.org/en/journals/...

Metal-Organic Frameworks: Celebrating the 2025 Nobel Prize in Chemistry Home

Organic Chemistry Frontiers @orgchemfront.rsc.org · 14d

We have published a outside back over article, read

𝐄𝐥𝐞𝐜𝐭𝐫𝐨𝐩𝐡𝐢𝐥𝐢𝐜 𝐢𝐧𝐬𝐞𝐫𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐫𝐢𝐧𝐠 𝐠𝐫𝐨𝐰𝐭𝐡 𝐢𝐧 𝟏,𝟐,𝟓-𝐚𝐳𝐚𝐝𝐢𝐛𝐨𝐫𝐨𝐥𝐢𝐝𝐢𝐧𝐞𝐬: 𝐭𝐡𝐞𝐨𝐫𝐞𝐭𝐢𝐜𝐚𝐥 𝐞𝐯𝐢𝐝𝐞𝐧𝐜𝐞 𝐟𝐨𝐫 𝐛𝐨𝐫𝐨𝐧-𝐝𝐫𝐢𝐯𝐞𝐧 𝐞𝐱𝐩𝐚𝐧𝐬𝐢𝐨𝐧

by J. Oscar C. Jiménez-Halla 𝘦𝘵 𝘢𝘭.
🔗 doi.org/10.1039/D5QO...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 14d

Don't miss the inside front cover article of issue 19

𝐂𝐨𝐨𝐩𝐞𝐫𝐚𝐭𝐢𝐯𝐞 𝐍-𝐡𝐞𝐭𝐞𝐫𝐨𝐜𝐲𝐜𝐥𝐢𝐜 𝐜𝐚𝐫𝐛𝐞𝐧𝐞/𝐩𝐡𝐨𝐭𝐨𝐜𝐚𝐭𝐚𝐥𝐲𝐬𝐢𝐬: 𝐯𝐢𝐬𝐢𝐛𝐥𝐞-𝐥𝐢𝐠𝐡𝐭-𝐩𝐫𝐨𝐦𝐨𝐭𝐞𝐝 𝐭𝐚𝐧𝐝𝐞𝐦 α-𝐬𝐩³ 𝐂–𝐇 𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐫𝐞𝐝𝐮𝐜𝐭𝐢𝐯𝐞 𝐍-𝐚𝐥𝐤𝐲𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐞𝐭𝐫𝐚𝐡𝐲𝐝𝐫𝐨𝐢𝐬𝐨𝐪𝐮𝐢𝐧𝐨𝐥𝐢𝐧𝐞

by C. Uma Maheswari 𝘦𝘵 𝘢𝘭.
🔗 doi.org/10.1039/D5QO...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 14d

📢 Issue 19 of Organic Chemistry Frontiers is available! In this issue read the outside front cover article:

𝐓𝐮𝐧𝐚𝐛𝐥𝐞 𝐭𝐡𝐢𝐨𝐟𝐮𝐦𝐚𝐫𝐚𝐭𝐞 𝐬𝐭𝐞𝐫𝐞𝐨𝐬𝐞𝐥𝐞𝐜𝐭𝐢𝐯𝐞 𝐜𝐲𝐜𝐥𝐨𝐚𝐝𝐝𝐢𝐭𝐢𝐨𝐧𝐬 𝐯𝐢𝐚 𝐚𝐦𝐢𝐧𝐨𝐦𝐞𝐟𝐥𝐨𝐪𝐮𝐢𝐧𝐞 𝐜𝐚𝐭𝐚𝐥𝐲𝐬𝐢𝐬

by Rafał Szabla, Rafał Kowalczyk 𝘦𝘵 𝘢𝘭.
🔗 doi.org/10.1039/D5QO...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 14d

Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity by Xuebin Huang et al. ⚗️ Mild, atom-economical route to selective 3,4-Markovnikov products. doi.org/10.1039/D5QO...
#Catalysis #Organoselenium #Regioselectivity

Organic Chemistry Frontiers @orgchemfront.rsc.org · 15d

🧪 Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes
by Xiao-Hui Yang et al. — Rh catalysis gives 3,4-Markovnikov products with high regioselectivity.
doi.org/10.1039/D5QO...

#Organoselenium #RhodiumCatalysis #Regioselectivity

Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 17d

Bypassing the abnormal Chichibabin reaction dead-end provides a biomimetic access to pre-haouamine by Mehdi A. Beniddir et al. 🔹 Biomimetic strategy avoids Chichibabin dead-end, enabling concise synthesis of pre-haouamine. 🌊
doi.org/10.1039/D5QO...
#OrganicSynthesis #BiomimeticChemistry #Alkaloids

Bypassing the abnormal Chichibabin reaction dead-end provides a biomimetic access to pre-haouamine

Haouamines are highly constrained marine alkaloids possessing a unique in nature skeleton. The high degree of complexity of such alkaloids raises questions about their chemical assembly. This is addre...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 17d

Harnessing the synergistic power of light and electricity: an emerging frontier in catalytic heterocycle synthesis by Huang et al. ⚡🌞 Photoelectrocatalysis enables novel pathways for heterocycle formation. 🔗 doi.org/10.1039/D5QO...

#Photoelectrocatalysis #OrganicSynthesis #Heterocycles

Harnessing the synergistic power of light and electricity: an emerging frontier in catalytic heterocycle synthesis

The strategic integration of photochemistry and electrochemistry in organic synthesis has opened new avenues for catalytic heterocycle synthesis. This highlight provides a comprehensive overview of ph...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 21d

🔥Hot article:

Diastereoselective and enantioselective construction of 1,4-nonadjacent alkyne-tethered products through CuI-promoted deprotonation and addition of terminal alkynes by Ying-Chun Chen et al. ⚗️

doi.org/10.1039/D5QO...
#AsymmetricCatalysis #OrganicChemistry #Alkyne

Organic Chemistry Frontiers @orgchemfront.rsc.org · 23d

🔔Open Access:
Structurally divergent reactivity of 2,2-disubstituted azetidines

by Alan C. Spivey et al.

🧪 Conditions tune azetidines to N-acylation or ring expansion → diverse heterocycles for drug discovery.

🔗 doi.org/10.1039/D5QO...
#Azetidines #Heterocycles #DrugDiscovery

Structurally divergent reactivity of 2,2-disubstituted azetidines – mechanistic insights and stereochemical implications of amide coupling and ring expansion to 5,6-dihydro-4H-1,3-oxazines

Azetidines have gained traction in drug discovery for their ability to introduce conformational constraint and modulate physiochemical properties. Strategies that enable their selective functionalizat...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 24d

🔥Recent advances in C(sp³)–H functionalization via molecular electrocatalysis ⚡🔬 by Peng Xiong et al.

Review highlights transition-metal & metal-free systems, mechanisms & photoelectrocatalysis.

doi.org/10.1039/D5QO...
#OrganicChemistry #Electrocatalysis #SustainableSynthesis

Recent advances in C(sp3)–H functionalization via molecular electrocatalysis

Selective functionalization of inert C(sp3)–H bonds remains a central challenge in modern organic synthesis. Molecular electrocatalysis provides a sustainable platform for C(sp3)–H activation by enabl...

Reposted by Organic Chemistry Frontiers

Royal Society of Chemistry @rsc.org · 27d

Share your latest research at the Organic chemistry poster symposium 2025.

Poster abstract submissions close soon – this is your last chance as an early career researcher to gain experience and get feedback at an event dedicated to you.

Submit your abstract today: https://rsc.li/41IZufF
#ChemSky

Organic poster symposium - submit your abstract by 29 September

Organic Chemistry Frontiers @orgchemfront.rsc.org · 25d

Electrophilic insertion and ring growth in 1,2,5-azadiborolidines: theoretical evidence for boron-driven expansion
by Albert Poater et al.

CO insertion enables new boracycles ⚗️

doi.org/10.1039/D5QO...

#BoronChemistry #RingExpansion #ComputationalChemistry

Electrophilic insertion and ring growth in 1,2,5-azadiborolidines: theoretical evidence for boron-driven expansion

This study computationally investigates the reactivity of 1,2,5-azadiborolidine derivatives toward carbon monoxide (CO), extending ring-expansion mechanisms from borole chemistry. Establishing structu...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 28d

AgOTf-promoted transetherification of p-methoxybenzyl ethers with allyl and benzyl bromides

by Wanshu Wang et al.

⚗️ AgOTf enables C–O/C–Br bond metathesis to access unsymmetrical ethers with broad functional group tolerance.

🔗 doi.org/10.1039/D5QO...

#OrganicChemistry #Catalysis #Synthesis

AgOTf-promoted transetherification of p-methoxybenzyl ethers with allyl and benzyl bromides

Conventional transetherification involves activation of the ether C–O bond, enabling either C–O/O–H bond metathesis with alcohols or C–O/C–O metathesis with other ethers. Here, we report an alternativ...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 28d

Back cover of Issue 18 showcases research from Basab Bijayi Dhar 𝘦𝘵 𝘢𝘭.

Oxidative copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines

#Free_to_read
🔗 doi.org/10.1039/D5QO...

Organic Chemistry Frontiers @orgchemfront.rsc.org · 28d

🔔Issue 18 is available! Please read the cover article:

Exploring the intricacies of inverse hydride shuttle catalysis in azabicyclic scaffold construction with contiguous stereocenters by Vidya Avasare 𝘦𝘵 𝘢𝘭.

#Free_to_read
🔗https://doi.org/10.1039/D5QO00627A

Organic Chemistry Frontiers @orgchemfront.rsc.org · Sep 9

Oxidative copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines
by Basab Bijayi Dhar et al.

A Cu-catalyzed method using H₂O₂ enables efficient β-amino ketone synthesis from allyl alcohols and anilines in high yield ⚗️🌱✨

👉 doi.org/10.1039/D5QO...
#CopperCatalysis ⚛️

Oxidative copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines

A copper-catalyzed method has been developed for synthesizing β-amino ketones using allyl alcohols and substituted anilines in 2-methyl-THF at 60 °C. This reaction employs hydrogen peroxide (H2O2) as ...

Organic Chemistry Frontiers @orgchemfront.rsc.org · Sep 8

Utilisation of CO₂ in the simultaneous installation of the C–C and C═C bonds of α,β-unsaturated carboxylic acids
Peter A. Byrne et al.
🌱 Phosphonium carboxylate ylides enable a direct Wittig-type route with high selectivity.
doi.org/10.1039/D5QO...

#CO2Utilisation ♻️ #OrganicChemistry ⚗️ #Synthesis

Utilisation of CO2 in the simultaneous installation of the C–C and CC bonds of α,β-unsaturated carboxylic acids

Development of methods for the conversion of CO2 (a major waste product) into value-added chemicals has become an area of great interest. Herein we report the development of a new retrosynthetic doubl...

Organic Chemistry Frontiers @orgchemfront.rsc.org · Sep 5

🌀 New in Org. Chem. Front. by Dominique Armspach* & Dario Pasini*: Binaphthol-bridged α-/β-cyclodextrins with “chiral mismatch” act as reversible pH-controlled chiroptical switches & selective ReO₄⁻ sensors in water 🌊🔬

🔗 doi.org/10.1039/D5QO...

#Chirality #Sensors #Cyclodextrins

Manipulating stereo-communication in binaphthol-bridged α- and β-cyclodextrins to develop β-selective chiroptical pH switching and anion sensing in water

Molecular structures comprising naturally-occurring, stereodefined cyclodextrins and binaphthyls as bridging units have been realized, designed in such a way that the stereocommunication mode between ...

Organic Chemistry Frontiers @orgchemfront.rsc.org · Sep 4

🔥 Photocatalytic ketone synthesis: recent advances in radical-based approaches from carboxylic acids and derivatives

by Shengbiao Yang, Xiaochen Wang et al.

🔗 doi.org/10.1039/D5QO...
#OrganicChemistry #Photocatalysis #SyntheticMethods

Photocatalytic ketone synthesis: recent advances in radical-based approaches from carboxylic acids and derivatives

Ketones are widely recognized as privileged structural motifs in organic synthesis due to their unique dual reactivity profile, serving as versatile electrophiles in numerous carbon–carbon and carbon–...

Organic Chemistry Frontiers @orgchemfront.rsc.org · Sep 2

📖 Palladium/photoredox catalysis for decarboxylative radical C(sp³)–C(sp³) cross-coupling reaction of γ-methylidene-δ-valerolactones with alkyl carboxylic acids

Wen Si , Jian Lv et al.

🔗 doi.org/10.1039/D5QO...
#OrganicChemistry #Catalysis #DrugDiscovery ⚗️💡

Palladium/photoredox catalysis for a decarboxylative radical C(sp3)–C(sp3) cross-coupling reaction of γ-methylidene-δ-valerolactones with alkyl carboxylic acids

Developing applicable methods to forge linkages between sp3- and sp3-hybridized carbons is of great significance in drug discovery. Here, a radical decarboxylative C(sp3)–C(sp3) cross-coupling of γ-me...

Organic Chemistry Frontiers @orgchemfront.rsc.org · Sep 1

Divergent synthesis of two polycyclic frameworks containing tricyclic bridgehead carbon centers

by Manuel A. Fernández-Rodríguez & Patricia García-García et al.

🔗 doi.org/10.1039/D5QO...

#OrganicSynthesis #GoldCatalysis #PolycyclicCompounds #DrugDiscovery #MechanisticChemistry

Divergent synthesis of two polycyclic frameworks containing tricyclic bridgehead carbon centers by gold-catalyzed cycloisomerization of o-cyclopropylidenemethyl-o′-alkynylbiaryls

Compounds containing tricyclic bridgehead carbon centers are privileged structures in drug discovery. In this work, two different polycyclic scaffolds containing this substructure have been accessed b...