🌍 Baking for a better world — one cookie at a time!
On June 25, from 9–11:30h at Parc Científic de Barcelona, we’re selling organ-themed cakes & cookies to raise funds for the DTI Foundation.

Donation & transplantation save lives💚

🚀New research published in @naturecomms.bsky.social!
👉'Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer', with @paulanietog.bsky.social and @hoheyn.bsky.social from CNAG

📎 www.nature.com/articles/s41...

📢New paper out in Oncogene!

➡️'Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes', with the collaboration of @paulanietog.bsky.social, Ginevra Caratù and @hoheyn.bsky.social (CNAG)

📎 www.nature.com/articles/s41...

I'm thrilled to finally share the publication of this collaborative paper in @naturecomms.bsky.social ! Excited to contribute to the immuno-oncology field and can’t wait to see where this takes us! Check it out here: nature.com/articles/s41...
#SingleCell @cnag-eu.bsky.social @hoheyn.bsky.social

Excited to share a paper I recently collaborated on, now published in Oncogene! 🧬 It was great working on this with an amazing team. Check it out here: www.nature.com/articles/s41...
#melanocyte #oncology #research #collaboration
@cnag-eu.bsky.social
@vhio.bsky.social

🏆Exciting news! Our colleague Gerard Dauner has won the
VHIO Computational Oncology Master Thesis Award

His research, supervised by @paulanietog.bsky.social and
@hoheyn.bsky.social, explores immune dynamics in colorectal and endometrial cancer metastases

#CancerResearch #CNAG @vhio.bsky.social

Big thanks to @paulanietog.bsky.social , @piazeiner.bsky.social , @hoheyn.bsky.social & the team for this collaboration! 🚀 Our study shows how CSF liquid biopsy mirrors CNS tumor immunity using single-cell & spatial transcriptomics. Insights into T cell responses, myeloid dominance & biomarkers!

Excited to collaborate with @hoheyn.bsky.social, @jcnietos.bsky.social, @paulanietog.bsky.social & team on leptomeningeal metastatic disease - a key challenge in #NeuroOncology. Our study reveals unique immune responses in CSF, highlighting CSF liquid biopsy’s potential to guide CNS tumor therapies.

Nice way to begin my journey in the blue platform 🤓

📖 Want the full story? Check out our preprint for more on how immune profiling of CSF is changing our understanding of CNS diseases:

t.co/DbDFmnKe8x

🧠 This study highlights CSF as a window into brain immune activity and tumor biology. Single-cell technologies paired with liquid biopsies pave the way for non-invasive diagnostics and precision oncology 🚀💥

🛠 This has relevant clinical implications:
💪 CSF profiling can guide personalized therapies: i.e. identify active immune responses and monitor therapy resistance
💪 It brings us a step closer to using CSF for tailored cancer treatments

🧫 The Myeloid landscapes of CNS lymphomas and inflammatory diseases presented infiltrating macrophages whereas glioblastomas and brain metastases have more resident-like macrophages and showed relevant metabolic reprogramming (e.g., lactate production).

🔄 Regarding T cell dynamics, CD8 T cells showed high clonal expansion and activity in CNS lymphomas whereas exhausted and regulatory T cell phenotypes dominated in glioblastomas and brain metastases, hinting at immune evasion 😶‍🌫️

We found distinct immune profiles in the CSF:
1. Robust T cell activation & clonal expansion in CNS lymphoma
2. Myeloid-dominated CSF, w/ fewer T cells in glioblastomas & brain metastases
3. Lymphoid cell dominance reflecting active immune responses in CNS inflammatory disorders

💡 Our goal was to establish CSF as a minimally invasive "liquid biopsy" that mirrors brain immune responses.
Therefore enabling:
- Immune response tracking
- Monitoring tumor progression
- Identifying therapy resistance
- Unlocking new biomarkers

This work has been a huge effort where we applied:
✅ Single-cell RNA sequencing
✅ Single cell and deep TCR sequencing
✅ Cell-free DNA sequencing
✅ Spatial transcriptomics
of cerebrospinal fluid and matched blood and brain tissue pieces of patients suffering from CNS diseases.

📢 SUPER EXCITED to share our latest preprint:
Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid

Incredible work and collaboration from @jcnietos.bsky.social @piazeiner.bsky.social @hoheyn.bsky.social and others.
biorxiv.org/content/10.110…