PhageExe
@phagexe.bsky.social
Promoting the University of Exeter's world leading research in translational phage biology
Reposted by PhageExe
How do macrophages influence the evolution of phage resistance?
We show that macrophages reduce the efficacy of a bacteriophage cocktail 🦠, resulting in greater bacteria population densities which, in-turn, facilitate greater rates of phage resistance.
Pre-print 👇
www.biorxiv.org/content/10.1...
We show that macrophages reduce the efficacy of a bacteriophage cocktail 🦠, resulting in greater bacteria population densities which, in-turn, facilitate greater rates of phage resistance.
Pre-print 👇
www.biorxiv.org/content/10.1...
Antagonism between bacteriophages and macrophages decreases efficacy of a bacteriophage cocktail and increases bacteriophage resistance
Phage therapy, the use of viruses that infect bacteria (bacteriophages), is a promising complement to antibiotics during the antimicrobial resistance crisis, but treatment success is very variable. Ev...
www.biorxiv.org
July 10, 2025 at 9:39 AM
How do macrophages influence the evolution of phage resistance?
We show that macrophages reduce the efficacy of a bacteriophage cocktail 🦠, resulting in greater bacteria population densities which, in-turn, facilitate greater rates of phage resistance.
Pre-print 👇
www.biorxiv.org/content/10.1...
We show that macrophages reduce the efficacy of a bacteriophage cocktail 🦠, resulting in greater bacteria population densities which, in-turn, facilitate greater rates of phage resistance.
Pre-print 👇
www.biorxiv.org/content/10.1...
Reposted by PhageExe
At long last, the MHRA have released their much promised guidance document for phage therapeutics in the UK: assets.publishing.service.gov.uk/media/683ed3...
Early impression is it's either as hard as it was to access phage therapeutics, or they've closed the door on the one route we did have.
Early impression is it's either as hard as it was to access phage therapeutics, or they've closed the door on the one route we did have.
assets.publishing.service.gov.uk
June 4, 2025 at 7:44 PM
At long last, the MHRA have released their much promised guidance document for phage therapeutics in the UK: assets.publishing.service.gov.uk/media/683ed3...
Early impression is it's either as hard as it was to access phage therapeutics, or they've closed the door on the one route we did have.
Early impression is it's either as hard as it was to access phage therapeutics, or they've closed the door on the one route we did have.
If you want to improve promiscuity and yield of Pseudomonas aeruginosa for production of phages, start by taking out its restriction modification system: www.biorxiv.org/content/10.1...
Eliminating the type I restriction endonuclease from Pseudomonas aeruginosa PAO1 for optimised phage isolation
Phage therapy is a promising treatment for multidrug-resistant bacterial infections. Due to their high host specificity, phages must be matched to the target clinical strains. Efficiently identifying ...
www.biorxiv.org
May 31, 2025 at 9:13 AM
If you want to improve promiscuity and yield of Pseudomonas aeruginosa for production of phages, start by taking out its restriction modification system: www.biorxiv.org/content/10.1...
Remy Chait's super-cool paper on phage lasers is now up on Biorxiv. A beautiful collaboration between modelling and experimental work, driven by passionate curiosity about unusual features Remy observed on some spot assays.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Stable coexistence and transport of lytic phage infections with migrating bacterial hosts
Bacteriophages (phages), viruses that exclusively infect bacterial hosts, are the most abundant living entities across diverse environments, coexisting with their bacterial hosts at densities exceedin...
www.biorxiv.org
April 29, 2025 at 1:22 PM
Remy Chait's super-cool paper on phage lasers is now up on Biorxiv. A beautiful collaboration between modelling and experimental work, driven by passionate curiosity about unusual features Remy observed on some spot assays.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Using CRISPRi to non-invasively manipulate and probe the lifecycle and infectivity of T7. Very cool work from @bergmillerlab.bsky.social . T7 is a tough cookie to control! www.frontiersin.org/journals/mic...
Frontiers | Programming CRISPRi to control the lifecycle of bacteriophage T7
www.frontiersin.org
March 7, 2025 at 9:49 AM
Using CRISPRi to non-invasively manipulate and probe the lifecycle and infectivity of T7. Very cool work from @bergmillerlab.bsky.social . T7 is a tough cookie to control! www.frontiersin.org/journals/mic...
Reposted by PhageExe
Amazing few days with collaborators at Mowi and PhD student @mrliambh.bsky.social understanding where phage therapeutics could have the greatest impact in salmon farming in Scotland.
March 5, 2025 at 5:58 PM
Amazing few days with collaborators at Mowi and PhD student @mrliambh.bsky.social understanding where phage therapeutics could have the greatest impact in salmon farming in Scotland.
Reposted by PhageExe
Hello new phage phollowers!
I am shamelessly self-promoting mine and Angus Buckling's relatively new review "Critically evaluating the relative importance of phage in shaping microbial community composition"
www.cell.com/trends/micro...
I am shamelessly self-promoting mine and Angus Buckling's relatively new review "Critically evaluating the relative importance of phage in shaping microbial community composition"
www.cell.com/trends/micro...
Critically evaluating the relative importance of phage in shaping microbial community composition
The ubiquity of bacteriophages (phages) and the major evolutionary and ecological
impacts they can have on their microbial hosts has resulted in phages often cited
as key drivers shaping microbial com...
www.cell.com
November 15, 2024 at 3:52 PM
Hello new phage phollowers!
I am shamelessly self-promoting mine and Angus Buckling's relatively new review "Critically evaluating the relative importance of phage in shaping microbial community composition"
www.cell.com/trends/micro...
I am shamelessly self-promoting mine and Angus Buckling's relatively new review "Critically evaluating the relative importance of phage in shaping microbial community composition"
www.cell.com/trends/micro...
Reposted by PhageExe
On a day where the National Audit Office reported that the government was not doing enough to combat the threat of untreatable bacterial infections (www.theguardian.com/society/2025...), we met with legislators to highlight the power of phage therapy to provide new treatments to patients.
February 27, 2025 at 9:14 AM
On a day where the National Audit Office reported that the government was not doing enough to combat the threat of untreatable bacterial infections (www.theguardian.com/society/2025...), we met with legislators to highlight the power of phage therapy to provide new treatments to patients.
Reposted by PhageExe
December 12, 2024 at 11:02 AM