PLMcCarthyBuffalo
@plmbuffalo.bsky.social
Translational Hematology Oncology Investigator, Roswell Park Comprehensive Cancer Center, Buffalo, NY
Guardians of the tumor microenvironment: the neutrophil saga url: ashpublications.org/blood/articl...
Guardians of the tumor microenvironment: the neutrophil saga
In this issue of Blood, Rivera et al1 demonstrate that aberrant mature neutrophil populations are capable of promoting myeloma by inhibiting T-cell prolife
ashpublications.org
November 21, 2025 at 11:55 PM
Guardians of the tumor microenvironment: the neutrophil saga url: ashpublications.org/blood/articl...
Redirecting
doi.org
November 21, 2025 at 1:04 PM
Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy: Cell www.cell.com/cell/fulltex...
Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy
MiTEs are myeloid-targeted immunocytokine prodrugs that block TREM2+ tumor-associated
macrophages while activating cytotoxic lymphocytes via TME-specific IL-2 activity,
eliciting strong anti-tumor eff...
www.cell.com
November 21, 2025 at 12:48 PM
Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy: Cell www.cell.com/cell/fulltex...
ashpublications.org/blood/articl...
Now officially in print
Now officially in print
Deciphering neutrophil dynamics in the focal lesion tumor microenvironment to overcome immunosuppression in multiple myeloma
Key PointsThree distinct neutrophil subsets were identified, with immunosuppressive CD10+TREM1+CXCR2+ neutrophils dominating the TME.CXCR2 blockade suppres
ashpublications.org
November 19, 2025 at 4:18 PM
ashpublications.org/blood/articl...
Now officially in print
Now officially in print
Miriam Merad’s 20-year quest to understand one cell is starting to rewrite the rules of cancer immunotherapy www.statnews.com/2025/10/28/m... via @statnews.com
Miriam Merad’s 20-year quest to understand one cell is starting to rewrite the rules of cancer immunotherapy
Miriam Merad’s 20-year quest to understand one cell is starting to rewrite the rules of cancer immunotherapy.
www.statnews.com
November 14, 2025 at 12:22 PM
Miriam Merad’s 20-year quest to understand one cell is starting to rewrite the rules of cancer immunotherapy www.statnews.com/2025/10/28/m... via @statnews.com
Reposted by PLMcCarthyBuffalo
Today the U.S. Supreme Court denied review of a case that sought to challenge marriage equality. It’s a major relief for so many in the LGBTQ community, who have seen relentless attacks on their dignity and equality in recent years.
Why Marriage Matters
www.whymarriagematters.org
November 10, 2025 at 2:57 PM
Today the U.S. Supreme Court denied review of a case that sought to challenge marriage equality. It’s a major relief for so many in the LGBTQ community, who have seen relentless attacks on their dignity and equality in recent years.
Reposted by PLMcCarthyBuffalo
CART in MCL: risk and reward? buff.ly/dcvXKdH #hemesky
CART in MCL: risk and reward?
Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has revolutionized the management of several lymphoma subtypes, including mantle cell lymphoma (MC
buff.ly
November 10, 2025 at 3:04 PM
CART in MCL: risk and reward? buff.ly/dcvXKdH #hemesky
Reposted by PLMcCarthyBuffalo
Embarrassment of riches: which donor for allo-transplant? buff.ly/FoaCxcR #hemesky
Embarrassment of riches: which donor for allo-transplant?
For patients with acute myeloid leukemia (AML) in their first complete remission, the prospect of an allogeneic transplantation comes with the task of graf
buff.ly
November 10, 2025 at 7:02 PM
Embarrassment of riches: which donor for allo-transplant? buff.ly/FoaCxcR #hemesky
Reposted by PLMcCarthyBuffalo
The respective INMBs are $497 100 and £235 600, respectively, for the United States and the United Kingdom. buff.ly/gd0OapY #hemesky
November 5, 2025 at 5:03 PM
The respective INMBs are $497 100 and £235 600, respectively, for the United States and the United Kingdom. buff.ly/gd0OapY #hemesky
Reposted by PLMcCarthyBuffalo
MAC was no more effective than RIC in eradicating FLT3-ITD MRD. buff.ly/shyvtjc #hemesky
November 5, 2025 at 3:04 PM
MAC was no more effective than RIC in eradicating FLT3-ITD MRD. buff.ly/shyvtjc #hemesky
Reposted by PLMcCarthyBuffalo
ctDNA levels correlated with PET-CT–based TMTV and may enable earlier relapse detection than imaging alone. buff.ly/vy0A6qH #hemesky
November 4, 2025 at 2:04 PM
ctDNA levels correlated with PET-CT–based TMTV and may enable earlier relapse detection than imaging alone. buff.ly/vy0A6qH #hemesky
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine | Science Immunology www.science.org/doi/10.1126/...
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.
www.science.org
November 2, 2025 at 12:01 AM
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine | Science Immunology www.science.org/doi/10.1126/...
www.nytimes.com/2025/10/27/s...
This is sad.
This is sad.
Vaccine Skepticism Comes for Pet Owners, Too
www.nytimes.com
November 1, 2025 at 12:19 AM
www.nytimes.com/2025/10/27/s...
This is sad.
This is sad.
Reprogramming RIPK3-induced cell death in malignant B cells promotes immune-mediated tumor control | Science Advances www.science.org/doi/10.1126/...
Reprogramming RIPK3-induced cell death in malignant B cells promotes immune-mediated tumor control
A cell death reprogramming therapy that promotes robust necroptosis leads to immune-mediated clearance of malignant B cells.
www.science.org
October 31, 2025 at 12:16 PM
Reprogramming RIPK3-induced cell death in malignant B cells promotes immune-mediated tumor control | Science Advances www.science.org/doi/10.1126/...
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases | Science Translational Medicine www.science.org/doi/10.1126/...
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases
Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.
www.science.org
October 25, 2025 at 12:34 AM
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases | Science Translational Medicine www.science.org/doi/10.1126/...
Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris | Science Translational Medicine www.science.org/doi/10.1126/...
Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris
Functionally stable regulatory T cells converted in vitro from pathogenic T cells can confer antigen-specific immunosuppression in pemphigus vulgaris.
www.science.org
October 25, 2025 at 12:33 AM
Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris | Science Translational Medicine www.science.org/doi/10.1126/...
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization | Science Immunology www.science.org/doi/10.1126/...
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.
www.science.org
October 24, 2025 at 8:14 PM
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization | Science Immunology www.science.org/doi/10.1126/...
New recipe improves creation of cells that could fight most autoimmune diseases | Science | AAAS www.science.org/content/arti...
New recipe improves creation of cells that could fight most autoimmune diseases
Nobel laureate makes regulatory T cells that last longer in the body, boosting clinical hopes
www.science.org
October 24, 2025 at 12:52 PM
New recipe improves creation of cells that could fight most autoimmune diseases | Science | AAAS www.science.org/content/arti...
