PolyBio Research Foundation
@polybiorf.bsky.social
501(c)3 transforming how #LongCovid, #ME/CFS & Lyme+ are studied, diagnosed, and treated. Leading the #LongCovid Research Consortium.
Pinned
1/ Introducing PolyBio’s new interactive website module, where you can learn about our #LongCovid Research Consortium projects, technologies, and findings across international institutions:
polybio.org/consortium-p...
polybio.org/consortium-p...
PolyBio and WE&ME supported study identifies two distinct ME/CFS subtypes
🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.
polybio.org/polybio-and-...
🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.
polybio.org/polybio-and-...
May 20, 2025 at 3:27 PM
PolyBio and WE&ME supported study identifies two distinct ME/CFS subtypes
🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.
polybio.org/polybio-and-...
🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.
polybio.org/polybio-and-...
PolyBio’s Spring Symposium is approaching fast—on May 16, watch exciting project updates on clinical trials, tissue pipelines, immune & metabolism findings on infection-associated chronic illnesses.
Sign up now: us02web.zoom.us/webinar/regi...
Sign up now: us02web.zoom.us/webinar/regi...
May 8, 2025 at 12:09 AM
PolyBio’s Spring Symposium is approaching fast—on May 16, watch exciting project updates on clinical trials, tissue pipelines, immune & metabolism findings on infection-associated chronic illnesses.
Sign up now: us02web.zoom.us/webinar/regi...
Sign up now: us02web.zoom.us/webinar/regi...
Post-treatment Lyme Disease patients with chronic pain in the US—consider participating in this decentralized study (completely virtual). It’s run via the CoRE clinic under the direction of Drs. David Putrino and Amy Proal @putrinolab.bsky.social @coresinai.bsky.social
May 2, 2025 at 3:21 PM
Post-treatment Lyme Disease patients with chronic pain in the US—consider participating in this decentralized study (completely virtual). It’s run via the CoRE clinic under the direction of Drs. David Putrino and Amy Proal @putrinolab.bsky.social @coresinai.bsky.social
The PolyBio-supported study on elevated plasma proteins associated with breathlessness in Long COVID was featured in an article in Technology Networks : www.technologynetworks.com/tn/news/long...
May 1, 2025 at 4:48 PM
The PolyBio-supported study on elevated plasma proteins associated with breathlessness in Long COVID was featured in an article in Technology Networks : www.technologynetworks.com/tn/news/long...
Calling all Long Covid, ME/CFS and Post-Treatment Lyme patients in the Boston area! This PolyBio-supported study is now seeking participants.
Participants must be able to attend an in-person visit at Brigham & Women’s hospital in Boston to participate.
Email [email protected] if interested
Participants must be able to attend an in-person visit at Brigham & Women’s hospital in Boston to participate.
Email [email protected] if interested
April 18, 2025 at 6:09 PM
Calling all Long Covid, ME/CFS and Post-Treatment Lyme patients in the Boston area! This PolyBio-supported study is now seeking participants.
Participants must be able to attend an in-person visit at Brigham & Women’s hospital in Boston to participate.
Email [email protected] if interested
Participants must be able to attend an in-person visit at Brigham & Women’s hospital in Boston to participate.
Email [email protected] if interested
We’re truly excited that the PolyBio supported Low-dose Rapamycin trial is now recruiting in the NYC area.
Interested in learning more? Here’s the full study summary: polybio.org/projects/lon...
Interested in learning more? Here’s the full study summary: polybio.org/projects/lon...
April 15, 2025 at 3:16 PM
We’re truly excited that the PolyBio supported Low-dose Rapamycin trial is now recruiting in the NYC area.
Interested in learning more? Here’s the full study summary: polybio.org/projects/lon...
Interested in learning more? Here’s the full study summary: polybio.org/projects/lon...
BREAKING: Development of a spike protein-specific radiolabeled antibody used with PET imaging shows presence of spike in brain & lungs of macaque monkeys 3 months post-COVID; provides new viral reservoir detection opportunity for long COVID: www.nature.com/articles/s41...
Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates - Nature Communications
There are limited approaches to monitor virus spread in vivo. Here, the authors report PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a ra...
www.nature.com
March 28, 2025 at 6:13 PM
BREAKING: Development of a spike protein-specific radiolabeled antibody used with PET imaging shows presence of spike in brain & lungs of macaque monkeys 3 months post-COVID; provides new viral reservoir detection opportunity for long COVID: www.nature.com/articles/s41...
Dr. Rigel Chan is investigating SARS-CoV-2’s impact on the development of #Alzheimers. His work has found that S protein levels in cells aren’t associated with AD, “but exposure to antigens like Spike may alter the conditions such that [patients] become more susceptible to HSV1.”
March 21, 2025 at 7:13 PM
Dr. Rigel Chan is investigating SARS-CoV-2’s impact on the development of #Alzheimers. His work has found that S protein levels in cells aren’t associated with AD, “but exposure to antigens like Spike may alter the conditions such that [patients] become more susceptible to HSV1.”
Dr. Zian Tseng has been studying sudden cardiac deaths since 2011–and is now using those data to compare to SCDs post-COVID. “A post-2020 person who recovered from COVID… died suddenly from their acute myocardial infarction. We found SARS-CoV-2 Spike RNA in their brain [tissue].”
March 18, 2025 at 8:45 PM
Dr. Zian Tseng has been studying sudden cardiac deaths since 2011–and is now using those data to compare to SCDs post-COVID. “A post-2020 person who recovered from COVID… died suddenly from their acute myocardial infarction. We found SARS-CoV-2 Spike RNA in their brain [tissue].”
Dr. David Price is investigating the role of lung dysfunction in Long Covid: “We’re sampling bronchoalveolar lavage fluid and transbronchial biopsies… what we plan to do is metagenomics, metatranscriptomics & RNA seq… to get some idea of the pathogenesis of LC at the site of initial infection.”
March 11, 2025 at 7:41 PM
Dr. David Price is investigating the role of lung dysfunction in Long Covid: “We’re sampling bronchoalveolar lavage fluid and transbronchial biopsies… what we plan to do is metagenomics, metatranscriptomics & RNA seq… to get some idea of the pathogenesis of LC at the site of initial infection.”
Dr. Petter Brodin is leading a project investigating the genetic determinants of Long Covid. “We’re currently looking for genetic variants that could explain why [Long Covid patients] have what we think is impaired antiviral immunity, leading to viral persistence.”
March 8, 2025 at 12:20 AM
Dr. Petter Brodin is leading a project investigating the genetic determinants of Long Covid. “We’re currently looking for genetic variants that could explain why [Long Covid patients] have what we think is impaired antiviral immunity, leading to viral persistence.”
Dr. Akiko Iwasaki, who has led work on the role of human endogenous retroviruses (HERVs) in chronic diseases i.e. lupus, is now investigating the role of HERVs in Long Covid.
March 5, 2025 at 6:31 PM
Dr. Akiko Iwasaki, who has led work on the role of human endogenous retroviruses (HERVs) in chronic diseases i.e. lupus, is now investigating the role of HERVs in Long Covid.
“We’re trialing a low dose of Rapamycin once a week… which may have an immune-supporting effect,” Dr. Proal explained last week via the CoRE clinic. There are a couple studies that show this low dose could improve signalling of interferons… used to control viral infections.”
February 26, 2025 at 5:06 PM
“We’re trialing a low dose of Rapamycin once a week… which may have an immune-supporting effect,” Dr. Proal explained last week via the CoRE clinic. There are a couple studies that show this low dose could improve signalling of interferons… used to control viral infections.”
Dr. Amy Proal, Scientific Director of the CoRE Clinic at Mount Sinai, discusses viral persistence as a driver of ME/CFS with Dr.s Raven Baxter & David Putrino: “[research] finds the RNA backbone & protein of enteroviruses in ME/CFS gut tissue.” @coresinai.bsky.social
February 18, 2025 at 10:57 PM
Dr. Amy Proal, Scientific Director of the CoRE Clinic at Mount Sinai, discusses viral persistence as a driver of ME/CFS with Dr.s Raven Baxter & David Putrino: “[research] finds the RNA backbone & protein of enteroviruses in ME/CFS gut tissue.” @coresinai.bsky.social
PolyBio president Dr. Amy Proal outlines the direction that research must take to address long COVID in her new op-ed for @latimes.com: “The urgency of long COVID is a call to arms for government and private funders to help bring medications and protocols to the people who need them.”
Opinion: Long COVID is solvable, but we need more clinical trials
Some people may remain ill after COVID infection because the virus still lurks in their bodies. The looming question now is: Who will pay for drug development and trials?
www.latimes.com
February 16, 2025 at 6:02 PM
PolyBio president Dr. Amy Proal outlines the direction that research must take to address long COVID in her new op-ed for @latimes.com: “The urgency of long COVID is a call to arms for government and private funders to help bring medications and protocols to the people who need them.”
Dr. Ed Breitschwerdt is investigating the proportion of Long Covid, ME & EDS patients with Borrelia, Babesia and Bartonella in their blood using a highly accurate ddPCR assay. “We’ve seen every combination of infection, from only 1 organism to co-infection with all 3.”
February 14, 2025 at 5:22 PM
Dr. Ed Breitschwerdt is investigating the proportion of Long Covid, ME & EDS patients with Borrelia, Babesia and Bartonella in their blood using a highly accurate ddPCR assay. “We’ve seen every combination of infection, from only 1 organism to co-infection with all 3.”
Reposted by PolyBio Research Foundation
Post-COVID-19 condition (also known as long COVID) is a debilitating disease state following SARS-CoV-2 infection.
In @thelancetinfdis.bsky.social, authors outline major considerations for clinical trials targeting SARS-CoV-2 persistence in long COVID: tinyurl.com/bdfyn74m
In @thelancetinfdis.bsky.social, authors outline major considerations for clinical trials targeting SARS-CoV-2 persistence in long COVID: tinyurl.com/bdfyn74m
February 13, 2025 at 12:43 PM
Post-COVID-19 condition (also known as long COVID) is a debilitating disease state following SARS-CoV-2 infection.
In @thelancetinfdis.bsky.social, authors outline major considerations for clinical trials targeting SARS-CoV-2 persistence in long COVID: tinyurl.com/bdfyn74m
In @thelancetinfdis.bsky.social, authors outline major considerations for clinical trials targeting SARS-CoV-2 persistence in long COVID: tinyurl.com/bdfyn74m
1/ Cutting-edge Recommendations Provide Treatment Path for Millions of Long COVID Patients
In a new report, global experts outline key considerations to address persistent SARS-CoV-2; provide a
roadmap to test critical new long COVID therapies
polybio.org/cutting-edge...
In a new report, global experts outline key considerations to address persistent SARS-CoV-2; provide a
roadmap to test critical new long COVID therapies
polybio.org/cutting-edge...
Cutting-edge Recommendations Provide Treatment Path for Millions of Long COVID Patients - PolyBio Research Foundation
In a new report, global experts outline key considerations to address persistent SARS-CoV-2; provide a roadmap to test critical new long...
polybio.org
February 11, 2025 at 2:27 PM
1/ Cutting-edge Recommendations Provide Treatment Path for Millions of Long COVID Patients
In a new report, global experts outline key considerations to address persistent SARS-CoV-2; provide a
roadmap to test critical new long COVID therapies
polybio.org/cutting-edge...
In a new report, global experts outline key considerations to address persistent SARS-CoV-2; provide a
roadmap to test critical new long COVID therapies
polybio.org/cutting-edge...
Children with Long Covid who received Larazotide for GI symptoms reported a fast & sustained recovery following treatment vs. controls.
February 7, 2025 at 5:23 PM
Children with Long Covid who received Larazotide for GI symptoms reported a fast & sustained recovery following treatment vs. controls.
Dr. Brent Harris & colleagues at NIH are forming a rapid autopsy program to assess SARS-CoV-2’s effects on body tissues, focusing on the brain. “NIH will focus on detection of RNA, proteins & replication-competent virus… using RNA scope [we’ve] found a wide persistence of SCV2.”
February 7, 2025 at 5:14 PM
Dr. Brent Harris & colleagues at NIH are forming a rapid autopsy program to assess SARS-CoV-2’s effects on body tissues, focusing on the brain. “NIH will focus on detection of RNA, proteins & replication-competent virus… using RNA scope [we’ve] found a wide persistence of SCV2.”
In a recent RCT of Larazotide for GI symptoms in Long Covid, “the clearance in the Larazotide group of the Spike clearance was much faster,” Dr. Fasano says. “About 30% of placebo group tested positive for spike, while eventually none of them had Spike in Larazotide group.”
January 31, 2025 at 8:02 PM
In a recent RCT of Larazotide for GI symptoms in Long Covid, “the clearance in the Larazotide group of the Spike clearance was much faster,” Dr. Fasano says. “About 30% of placebo group tested positive for spike, while eventually none of them had Spike in Larazotide group.”
PolyBio's Drs. Proal & VanElzakker today in front of a poster at the Harvard/MIT Martinos Center featuring sections from their 2021 paper on #LongCovid disease mechanisms.
January 29, 2025 at 4:44 PM
PolyBio's Drs. Proal & VanElzakker today in front of a poster at the Harvard/MIT Martinos Center featuring sections from their 2021 paper on #LongCovid disease mechanisms.
Dr. Giannarelli is analyzing cardiac tissue of heart attack patients post-mortem to study SARS-CoV-2’s impact on cardiovascular disease. “NRP-1 is expressed more in foam cells in atherosclerosis… when we silence the expression of NRP-1 in macrophages & foam cells, cellular SCV2 infection decreased.”
January 27, 2025 at 11:40 PM
Dr. Giannarelli is analyzing cardiac tissue of heart attack patients post-mortem to study SARS-CoV-2’s impact on cardiovascular disease. “NRP-1 is expressed more in foam cells in atherosclerosis… when we silence the expression of NRP-1 in macrophages & foam cells, cellular SCV2 infection decreased.”
“At least 2/3 of individuals with Long COVID contained [SARS-CoV-2] infected megakaryocytes,” says Dr. Morgane Bomsel. “This suggests that megakaryocytes form reservoirs in LC patients—which may produce platelets sheltering infectious SCV2.”
January 23, 2025 at 8:15 PM
“At least 2/3 of individuals with Long COVID contained [SARS-CoV-2] infected megakaryocytes,” says Dr. Morgane Bomsel. “This suggests that megakaryocytes form reservoirs in LC patients—which may produce platelets sheltering infectious SCV2.”
“We’re building a rigorous cohort of people with chronic conditions, starting off with ME,” said Dr. Steve Deeks, collaborator on the LIINC team. “We want to build on what’s already been done to identify pathways of interest—focusing first on pathogen persistence.”
January 20, 2025 at 8:16 PM
“We’re building a rigorous cohort of people with chronic conditions, starting off with ME,” said Dr. Steve Deeks, collaborator on the LIINC team. “We want to build on what’s already been done to identify pathways of interest—focusing first on pathogen persistence.”