React4Kids
@r4knetwork.bsky.social
80 followers
190 following
7 posts
French national network for basic and translational research in pediatric oncology - Understand to treat #Medsky #Oncosky
Posts
Media
Videos
Starter Packs
Reposted by React4Kids
Reposted by React4Kids
React4Kids
@r4knetwork.bsky.social
· Mar 31
Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors - Nature Medicine
Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling w...
www.nature.com
React4Kids
@r4knetwork.bsky.social
· Mar 24
Progressive chromatin rewiring by ETO2::GLIS2 revealed in a human iPSC model of pediatric leukemia initiation
Key Points. Precise engineering of the ETO2::GLIS2 fusion in iPSC reproduces leukemogenesis in a developmentally-relevant human cell contextThe temporal or
ashpublications.org
React4Kids
@r4knetwork.bsky.social
· Mar 17
Researchers @uthealthsa.bsky.social just published an interesting study in @neuroonc.bsky.social showing that radio-resistance in pediatric BRAFV600E gliomas is associated with an up-regulation in MAPK & PI3K/mTOR signaling, which can be therapeutically exploited.
academic.oup.com/neuro-oncolo...
academic.oup.com/neuro-oncolo...
Dual Inhibition of MAPK and TORC1 Signaling Retards Development of Radiation Resistance in Pediatric BRAFV600E Glioma Models
AbstractBackground. MAPK pathway inhibitors (MAPKi) have shown significant efficacy in treating childhood BRAF-activated brain tumors. For tumors harboring
academic.oup.com
React4Kids
@r4knetwork.bsky.social
· Mar 10
High-resolution proteomic analysis of medulloblastoma clinical samples identifies therapy resistant subgroups and MYC immunohistochemistry as a powerful outcome predictor
AbstractBackground. While international consensus and the 2021 WHO classification recognize multiple molecular medulloblastoma subgroups, these are difficu
academic.oup.com
Reposted by React4Kids