Author | Lightnews

Raza Hoda MD

@razahoda.bsky.social

34 followers 15 following 6 posts

Staff Pathologist at Cleveland Clinic & Assistant Professor of #Pathology Cleveland Clinic Lerner College of Medicine. Ask your healthcare provider if these tweets are right for you.

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Raza Hoda MD @razahoda.bsky.social · Dec 20

Neoadjuvant Chemotherapy in Breast Cancer:

The NSABP B-18 trial (1998) by Fisher et al. demonstrated that preoperative chemotherapy could shrink tumors, leading to more lumpectomies. #BreastCancer #Oncology #PathSky #MedSky #breastpath

pubmed.ncbi.nlm.nih.gov/9704717/

Effect of preoperative chemotherapy on the outcome of women with operable breast cancer - PubMed

Preoperative chemotherapy is as effective as postoperative chemotherapy, permits more lumpectomies, is appropriate for the treatment of certain patients with stages I and II disease, and can be used t...

pubmed.ncbi.nlm.nih.gov

Raza Hoda MD @razahoda.bsky.social · Dec 19

Gene Expression Profiling Leading to Molecular Subtypes of Breast Cancer:

Perou et al. (2000) published in Nature gave us the Luminal A/B, HER2-enriched, and Basal-like classifications.

#MolecularBiology #BreastCancer #BreastPathology #PathSky #BreastOncology

pubmed.ncbi.nlm.nih.gov/10963602/

Molecular portraits of human breast tumours - PubMed

Human breast tumours are diverse in their natural history and in their responsiveness to treatments. Variation in transcriptional programs accounts for much of the biological diversity of human cells ...

pubmed.ncbi.nlm.nih.gov

Raza Hoda MD @razahoda.bsky.social · Dec 18

The Tamoxifen Trial.

Fisher et al. (1989) in the New England Journal of Medicine showed us the power of hormone therapy in ER+ breast cancer—a landmark study that revolutionized breast cancer treatment protocols.

pubmed.ncbi.nlm.nih.gov/2644532/

#BreastCancer #BreastOncology #Pathology #PathSky

A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors - PubMed

We conducted a randomized, double-blind, placebo-controlled trial of postoperative therapy with tamoxifen (10 mg twice a day) in 2644 patients with breast cancer, histologically negative axillary node...

pubmed.ncbi.nlm.nih.gov

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Raza Hoda MD @razahoda.bsky.social · Dec 17

Understanding HER2 in Breast Cancer:

Slamon et al.'s 1987 study on HER2/neu amplification paved the way for targeted therapies like Herceptin. #HER2Positive #BreastCancer

pubmed.ncbi.nlm.nih.gov/3798106/

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene - PubMed

The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to, but distinct from, the epidermal growth factor receptor. This gene has been shown to be amplified in human breas...

pubmed.ncbi.nlm.nih.gov

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Raza Hoda MD @razahoda.bsky.social · Dec 16

Estrogen Receptor in Breast Carcinoma.

Remmele & Stegner's 1987 study revolutionized how we diagnose and treat breast carcinoma by identifying ER by immunohistochemistry. #BreastCancer #BreastPath

pubmed.ncbi.nlm.nih.gov/3303008/

[Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue] - PubMed

[Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue]

pubmed.ncbi.nlm.nih.gov

Raza Hoda MD @razahoda.bsky.social · Dec 15

I’ll try something new on Bluesky and post small summaries of landmark papers in breast cancer.

Discovering the BRCA1 Gene: A Game-Changer in Breast Cancer Genetics.

Miki et al. (1994) opened new avenues for understanding hereditary breast cancer. #BreastCancer

pubmed.ncbi.nlm.nih.gov/7545954/

pubmed.ncbi.nlm.nih.gov