Rene Sugar
@renesugar.bsky.social
α-Ketoglutarate alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by promoting the expression of CD39 #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
α-Ketoglutarate alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by promoting the expression of CD39
The abnormal activation and differentiation of B cells play an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). Alpha-ketoglutarate (α-KG), a key metabolite in the tricarboxylic acid cycle, has ...
pmc.ncbi.nlm.nih.gov
December 9, 2025 at 7:14 PM
α-Ketoglutarate alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by promoting the expression of CD39 #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit
PMID: 26412325 DOI: 10.1016/j.ccell.2015.08.012
PMID: 26412325 DOI: 10.1016/j.ccell.2015.08.012
December 6, 2025 at 9:37 PM
Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit
PMID: 26412325 DOI: 10.1016/j.ccell.2015.08.012
PMID: 26412325 DOI: 10.1016/j.ccell.2015.08.012
B1, B12, folic acid, copper deficiencies after #SARSCoV2 infection mimicking CIDP; also, new onset celiac #MECFS #LongCovid
youtu.be/ycvOtNOSUsM?...
youtu.be/ycvOtNOSUsM?...
Mayo Clinic FINALLY Finds the cause and treatment plan for my Long-Covid!
YouTube video by TomithyTries
youtu.be
December 6, 2025 at 6:58 PM
B1, B12, folic acid, copper deficiencies after #SARSCoV2 infection mimicking CIDP; also, new onset celiac #MECFS #LongCovid
youtu.be/ycvOtNOSUsM?...
youtu.be/ycvOtNOSUsM?...
Approach to a case of myeloneuropathy #MECFS #LongCovid
PMID: 27293327 PMCID: PMC4888679 DOI: 10.4103/0972-2327.182303
PMID: 27293327 PMCID: PMC4888679 DOI: 10.4103/0972-2327.182303
Approach to a case of myeloneuropathy
Myeloneuropathy is a frequently encountered condition and often poses a diagnostic challenge. A variety of nutritional, toxic, metabolic, infective, inflammatory, and paraneoplastic disorders can present with myeloneuropathy. Deficiencies of vitamin ...
pmc.ncbi.nlm.nih.gov
December 6, 2025 at 6:22 PM
Approach to a case of myeloneuropathy #MECFS #LongCovid
PMID: 27293327 PMCID: PMC4888679 DOI: 10.4103/0972-2327.182303
PMID: 27293327 PMCID: PMC4888679 DOI: 10.4103/0972-2327.182303
Underlying Piezo2 Channelopathy-Induced Neural Switch of #COVID19 Infection #SARSCoV2 #MECFS #LongCovid
pubmed.ncbi.nlm.nih.gov/40801614/
pubmed.ncbi.nlm.nih.gov/40801614/
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection - PubMed
The focal "hot spot" neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology may underpin the systemic findings in COVID-19 inf …
pubmed.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
Underlying Piezo2 Channelopathy-Induced Neural Switch of #COVID19 Infection #SARSCoV2 #MECFS #LongCovid
pubmed.ncbi.nlm.nih.gov/40801614/
pubmed.ncbi.nlm.nih.gov/40801614/
The #SARSCoV2 trigger highlights host interleukin 1 genetics in Epstein-Barr virus reactivation #EBV #MECFS #LongCovid
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The SARS-CoV-2 trigger highlights host interleukin 1 genetics in Epstein-Barr virus reactivation
Studies in large cohorts exposed to the same triggers associated with Epstein-Barr virus (EBV) reactivation and the follow-up of post-acute outcomes m…
www.sciencedirect.com
December 5, 2025 at 4:57 PM
The #SARSCoV2 trigger highlights host interleukin 1 genetics in Epstein-Barr virus reactivation #EBV #MECFS #LongCovid
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Clinical Trial of an Epstein-Barr Virus ( #EBV) Vaccine for Adults Ages 18–55 with Multiple Sclerosis
trials.modernatx.com/study/?id=mR...
clinicaltrials.gov/study/NCT067...
trials.modernatx.com/study/?id=mR...
clinicaltrials.gov/study/NCT067...
Trial Details
Trial Details, Study Participant Requirements, Find a trial site near you, See locations
trials.modernatx.com
December 3, 2025 at 8:26 PM
A Clinical Trial of an Epstein-Barr Virus ( #EBV) Vaccine for Adults Ages 18–55 with Multiple Sclerosis
trials.modernatx.com/study/?id=mR...
clinicaltrials.gov/study/NCT067...
trials.modernatx.com/study/?id=mR...
clinicaltrials.gov/study/NCT067...
Cargo and Biological Properties of Extracellular Vesicles Released from Human Adenovirus Type 4-Infected Lung Epithelial Cells #MECFS #LongCovid
www.mdpi.com/1999-4915/17...
www.mdpi.com/1999-4915/17...
www.mdpi.com
November 29, 2025 at 4:18 PM
Cargo and Biological Properties of Extracellular Vesicles Released from Human Adenovirus Type 4-Infected Lung Epithelial Cells #MECFS #LongCovid
www.mdpi.com/1999-4915/17...
www.mdpi.com/1999-4915/17...
Autonomic dysfunction in vitamin B12 deficiency: A heart rate variability study #MECFS #LongCovid
www.sciencedirect.com/science/arti...
"It was concluded that B12 deficiency may cause autonomic dysfunction."
www.sciencedirect.com/science/arti...
"It was concluded that B12 deficiency may cause autonomic dysfunction."
Autonomic dysfunction in vitamin B12 deficiency: A heart rate variability study
This study was arranged to examine whether vitamin B12 deficiency may cause autonomic dysfunction. Time-domain and long-term frequency-domain heart ra…
www.sciencedirect.com
November 28, 2025 at 5:28 PM
Autonomic dysfunction in vitamin B12 deficiency: A heart rate variability study #MECFS #LongCovid
www.sciencedirect.com/science/arti...
"It was concluded that B12 deficiency may cause autonomic dysfunction."
www.sciencedirect.com/science/arti...
"It was concluded that B12 deficiency may cause autonomic dysfunction."
Calprotectin, a new biomarker for diagnosis of acute respiratory infections #MECFS #LongCovid
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Calprotectin, a new biomarker for diagnosis of acute respiratory infections - Scientific Reports
Scientific Reports - Calprotectin, a new biomarker for diagnosis of acute respiratory infections
www.nature.com
November 28, 2025 at 5:08 PM
Calprotectin, a new biomarker for diagnosis of acute respiratory infections #MECFS #LongCovid
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Riboflavin as a promising antimicrobial agent? A multi-perspective review #SARSCoV2 #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Riboflavin as a promising antimicrobial agent? A multi-perspective review
Riboflavin demonstrates antioxidant and photosensitizing properties. Riboflavin is able to induce ROS and modulate immune response. Riboflavin possesses potent antimicrobial activity when used alone or combined with other anti-infectives. The ...
pmc.ncbi.nlm.nih.gov
November 27, 2025 at 6:48 PM
Riboflavin as a promising antimicrobial agent? A multi-perspective review #SARSCoV2 #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
NE3107 ( #bezisterim) in Adults With Neurological Symptoms of #LongCOVID (ADDRESS-LC)
clinicaltrials.gov/study/NCT068...
clinicaltrials.gov/study/NCT068...
ClinicalTrials.gov
clinicaltrials.gov
November 26, 2025 at 7:29 PM
NE3107 ( #bezisterim) in Adults With Neurological Symptoms of #LongCOVID (ADDRESS-LC)
clinicaltrials.gov/study/NCT068...
clinicaltrials.gov/study/NCT068...
Monogenic disorders of the IRF transcription factors #IEI #MECFS #LongCovid
rupress.org/jem/article/...
rupress.org/jem/article/...
November 26, 2025 at 4:26 PM
Monogenic disorders of the IRF transcription factors #IEI #MECFS #LongCovid
rupress.org/jem/article/...
rupress.org/jem/article/...
November 20, 2025 at 6:40 PM
Signs of Lyme disease that appear on your skin #MECFS #LongCovid
www.aad.org/public/disea...
"When you see signs of changing skin and symptoms: These tend to occur months or years after you are bitten by a tick."
www.aad.org/public/disea...
"When you see signs of changing skin and symptoms: These tend to occur months or years after you are bitten by a tick."
Signs of Lyme disease that appear on your skin
Learn how dermatologists identify the signs of Lyme disease on your skin.
www.aad.org
November 20, 2025 at 1:10 AM
Signs of Lyme disease that appear on your skin #MECFS #LongCovid
www.aad.org/public/disea...
"When you see signs of changing skin and symptoms: These tend to occur months or years after you are bitten by a tick."
www.aad.org/public/disea...
"When you see signs of changing skin and symptoms: These tend to occur months or years after you are bitten by a tick."
Reposted by Rene Sugar
Just heard about this huge (49 state) long covid trial using tirzepetide (aka zepbound) one of the newer glp meds. It’s run by researchers at scripps, funded by the eric & wendy schmidt foundation. It looks like it is still enrolling, fully remote participation:
longcovid.scripps.edu/locitt-t/?ut...
longcovid.scripps.edu/locitt-t/?ut...
LoCITT-T - Long COVID Treatment Trial
The Long COVID Treatment Trial-Tirzepatide (LoCITT-T) is investigating the efficacy of repurposing this drug to treat Long COVID.
longcovid.scripps.edu
November 16, 2025 at 4:40 AM
Just heard about this huge (49 state) long covid trial using tirzepetide (aka zepbound) one of the newer glp meds. It’s run by researchers at scripps, funded by the eric & wendy schmidt foundation. It looks like it is still enrolling, fully remote participation:
longcovid.scripps.edu/locitt-t/?ut...
longcovid.scripps.edu/locitt-t/?ut...
Neuropsychiatric Manifestations of Thyroid Diseases #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Neuropsychiatric Manifestations of Thyroid Diseases
Thyroid disorders are known to cause neuropsychiatric manifestations. Various neuropsychiatric manifestations are depression, dementia, mania, and autoimmune Hashimoto encephalopathy. Numerous investigations carried out in the previous 50-60 years ...
pmc.ncbi.nlm.nih.gov
November 15, 2025 at 9:18 PM
Neuropsychiatric Manifestations of Thyroid Diseases #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health #MECFS #LongCovid
www.frontiersin.org/journals/nut...
www.frontiersin.org/journals/nut...
November 15, 2025 at 8:28 PM
Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health #MECFS #LongCovid
www.frontiersin.org/journals/nut...
www.frontiersin.org/journals/nut...
Some People With Schizophrenia May Simply Have a Vitamin Deficiency #NAPRT1
scitechdaily.com/some-people-...
scitechdaily.com/some-people-...
Some People With Schizophrenia May Simply Have a Vitamin Deficiency
A new hypothesis may hold the key to solving four medical mysteries associated with the chronic brain disorder. Four unsolved mysteries around schizophrenia have long plagued the medical community, bu...
scitechdaily.com
November 13, 2025 at 7:07 PM
Some People With Schizophrenia May Simply Have a Vitamin Deficiency #NAPRT1
scitechdaily.com/some-people-...
scitechdaily.com/some-people-...
Association between hypothyroidism and small intestinal bacterial overgrowth #SIBO #MECFS #LongCovid
pubmed.ncbi.nlm.nih.gov/17698907/
pubmed.ncbi.nlm.nih.gov/17698907/
Association between hypothyroidism and small intestinal bacterial overgrowth - PubMed
The history of overt hypothyroidism is associated with bacterial overgrowth development. Excess bacteria could influence clinical gastrointestinal manifestations. Bacterial overgrowth decontamination is associated with improved gastrointestinal symptoms. However, fermenting carbohydrate luminal bact …
pubmed.ncbi.nlm.nih.gov
November 13, 2025 at 6:05 PM
Association between hypothyroidism and small intestinal bacterial overgrowth #SIBO #MECFS #LongCovid
pubmed.ncbi.nlm.nih.gov/17698907/
pubmed.ncbi.nlm.nih.gov/17698907/
Reposted by Rene Sugar
Sydney Gesualdi was diagnosed with craniocervical instability, a rare condition that mostly affects women. After nine neurosurgeon referrals, she still can’t get surgery. She tells @namshine.bsky.social her story on an upcoming episode of (MIS)Treated. podcasts.apple.com/ca/podcast/m...
October 24, 2025 at 3:09 PM
Sydney Gesualdi was diagnosed with craniocervical instability, a rare condition that mostly affects women. After nine neurosurgeon referrals, she still can’t get surgery. She tells @namshine.bsky.social her story on an upcoming episode of (MIS)Treated. podcasts.apple.com/ca/podcast/m...
Reposted by Rene Sugar
She couldn't get diagnosed in Ontario & went to the US & was diagnosed with Craniocervical Instability, a condition that impacts mostly women. She suspects she also has Ehlers-Danlos Syndrome. Her family doctor referred her to 9 neurosurgeons and her consultations have been denied. Upcoming episode.
Sydney Gesualdi was diagnosed with craniocervical instability, a rare condition that mostly affects women. After nine neurosurgeon referrals, she still can’t get surgery. She tells @namshine.bsky.social her story on an upcoming episode of (MIS)Treated. podcasts.apple.com/ca/podcast/m...
October 24, 2025 at 3:27 PM
She couldn't get diagnosed in Ontario & went to the US & was diagnosed with Craniocervical Instability, a condition that impacts mostly women. She suspects she also has Ehlers-Danlos Syndrome. Her family doctor referred her to 9 neurosurgeons and her consultations have been denied. Upcoming episode.
Atlanto‐odontoid pyogenic arthritis revealing a Jugular Vein Thrombosis
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Atlanto‐odontoid pyogenic arthritis revealing a Jugular Vein Thrombosis
Pyogenic arthritis of the atlantoaxial joint is scarce. It can lead to several complications, such as spinal cord compression and cerebral vein thrombosis. A 51‐year‐old man presented with a twenty‐day history of inflammatory neck pain. Physical ...
pmc.ncbi.nlm.nih.gov
October 25, 2025 at 11:35 AM
Atlanto‐odontoid pyogenic arthritis revealing a Jugular Vein Thrombosis
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Matrix Metalloproteinases in Neuropathic Pain and Migraine: Friends, Enemies, and Therapeutic Targets #MMP2 #MMP9 #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Matrix Metalloproteinases in Neuropathic Pain and Migraine: Friends, Enemies, and Therapeutic Targets
Matrix metalloproteinases (MMPs) constitute a family of zinc-dependent endopeptidases that mediate extracellular matrix turnover and associated processes, such as cell survival, growth, and differentiation. This paper discusses important functions ...
pmc.ncbi.nlm.nih.gov
October 23, 2025 at 4:10 PM
Matrix Metalloproteinases in Neuropathic Pain and Migraine: Friends, Enemies, and Therapeutic Targets #MMP2 #MMP9 #MECFS #LongCovid
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...