Rikesh Rajani
@rikeshrajani.bsky.social
Group Leader at the BHF-UK DRI Centre for Vascular Dementia Research at The University of Edinburgh | Visiting Researcher at UCL | Neuroscientist/dementia researcher | Living with #LongCovid | He/him
Pinned
Rikesh Rajani
@rikeshrajani.bsky.social
· Sep 24
Research Fellow
We are looking for an enthusiastic postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
The Rajani Lab is hiring again! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate vascular-oligodendrocyte interactions in dementia.
Apply here 👇
bit.ly/4nm8csZ
Apply here 👇
bit.ly/4nm8csZ
Reposted by Rikesh Rajani
Meet Dr @rikeshrajani.bsky.social , Group Leader at the BHF - UK DRI Centre for Vascular Dementia Research (CVDR)👋
Dr Rajani has dedicated his career to understanding white matter damage across multiple forms of dementia.
Learn more about Dr Rajani's work 👉 tinyurl.com/3bwez8r6
Dr Rajani has dedicated his career to understanding white matter damage across multiple forms of dementia.
Learn more about Dr Rajani's work 👉 tinyurl.com/3bwez8r6
October 14, 2025 at 3:54 PM
Meet Dr @rikeshrajani.bsky.social , Group Leader at the BHF - UK DRI Centre for Vascular Dementia Research (CVDR)👋
Dr Rajani has dedicated his career to understanding white matter damage across multiple forms of dementia.
Learn more about Dr Rajani's work 👉 tinyurl.com/3bwez8r6
Dr Rajani has dedicated his career to understanding white matter damage across multiple forms of dementia.
Learn more about Dr Rajani's work 👉 tinyurl.com/3bwez8r6
Reposted by Rikesh Rajani
🎉 This week, we’re proud to officially launch the BHF-UK DRI Centre for Vascular Dementia Research, in partnership with the British Heart Foundation.
The centre will explore how changes in vascular health contribute to dementia - paving the way for new treatments👉 buff.ly/5ZEjQx8
The centre will explore how changes in vascular health contribute to dementia - paving the way for new treatments👉 buff.ly/5ZEjQx8
October 13, 2025 at 8:30 AM
🎉 This week, we’re proud to officially launch the BHF-UK DRI Centre for Vascular Dementia Research, in partnership with the British Heart Foundation.
The centre will explore how changes in vascular health contribute to dementia - paving the way for new treatments👉 buff.ly/5ZEjQx8
The centre will explore how changes in vascular health contribute to dementia - paving the way for new treatments👉 buff.ly/5ZEjQx8
Reposted by Rikesh Rajani
📢 Job Alert 📢: Research Fellow in new national BHF-UK DRI Centre for Vascular Dementia Research. You will use in vitro and ex vivo techniques to investigate the relationship between endothelial cells, oligodendrocytes and neurons in the context of Alzheimer’s and vascular dementias.
edin.ac/4nrMrIm
edin.ac/4nrMrIm
September 25, 2025 at 12:14 PM
📢 Job Alert 📢: Research Fellow in new national BHF-UK DRI Centre for Vascular Dementia Research. You will use in vitro and ex vivo techniques to investigate the relationship between endothelial cells, oligodendrocytes and neurons in the context of Alzheimer’s and vascular dementias.
edin.ac/4nrMrIm
edin.ac/4nrMrIm
The Rajani Lab is hiring again! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate vascular-oligodendrocyte interactions in dementia.
Apply here 👇
bit.ly/4nm8csZ
Apply here 👇
bit.ly/4nm8csZ
Research Fellow
We are looking for an enthusiastic postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
September 24, 2025 at 3:35 PM
The Rajani Lab is hiring again! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate vascular-oligodendrocyte interactions in dementia.
Apply here 👇
bit.ly/4nm8csZ
Apply here 👇
bit.ly/4nm8csZ
Just over a week left to apply for this position in our lab!
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Research Fellow
We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
August 5, 2025 at 11:29 AM
Just over a week left to apply for this position in our lab!
Reposted by Rikesh Rajani
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Research Fellow
We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
July 10, 2025 at 11:08 AM
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Reposted by Rikesh Rajani
📢JOB ALERT📢 @rikeshrajani.bsky.social is looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
edin.ac/3GGUwZn
edin.ac/3GGUwZn
Research Fellow
We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
edin.ac
July 11, 2025 at 1:05 PM
📢JOB ALERT📢 @rikeshrajani.bsky.social is looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
edin.ac/3GGUwZn
edin.ac/3GGUwZn
Reposted by Rikesh Rajani
Amazing opportunity postdocs
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Research Fellow
We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
July 11, 2025 at 11:21 AM
Amazing opportunity postdocs
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Research Fellow
We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
bit.ly
July 10, 2025 at 11:08 AM
The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.
Apply here 👇
bit.ly/44AFJHx
Apply here 👇
bit.ly/44AFJHx
Reposted by Rikesh Rajani
NEW FROM ME -
Britain is abandoning international medical consensus on disability.
Every other developed nation recognizes cumulative impairment as genuine severity.
We're about to become an anomaly—and the logic of 4+ suggests it was deliberate.
tinyurl.com/mwwb5xv4
Britain is abandoning international medical consensus on disability.
Every other developed nation recognizes cumulative impairment as genuine severity.
We're about to become an anomaly—and the logic of 4+ suggests it was deliberate.
tinyurl.com/mwwb5xv4
Who Will Count as Disabled Tomorrow?
The dangerous redefinition of welfare disguised as Labour's compassionate reform.
tinyurl.com
June 29, 2025 at 2:29 PM
NEW FROM ME -
Britain is abandoning international medical consensus on disability.
Every other developed nation recognizes cumulative impairment as genuine severity.
We're about to become an anomaly—and the logic of 4+ suggests it was deliberate.
tinyurl.com/mwwb5xv4
Britain is abandoning international medical consensus on disability.
Every other developed nation recognizes cumulative impairment as genuine severity.
We're about to become an anomaly—and the logic of 4+ suggests it was deliberate.
tinyurl.com/mwwb5xv4
Reposted by Rikesh Rajani
Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.
Apply here👇
shorturl.at/LpCAq
Apply here👇
shorturl.at/LpCAq
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
shorturl.at
May 16, 2025 at 8:48 AM
Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.
Apply here👇
shorturl.at/LpCAq
Apply here👇
shorturl.at/LpCAq
More great work from the Busche Lab that I’m glad to have played a part in. Now out in @cp-neuron.bsky.social, we show that the earliest neuronal dysfunction in Alzheimer’s models is seen in parvalbumin interneurons in deep cortical layers.
Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2.
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo
Papanikolaou et al. show that deep-layer cortical neurons exhibit abnormally prolonged
Ca2+ transients early in Alzheimer’s mouse models. This is linked to suppressed activity
and altered tuning of fa...
www.cell.com
May 9, 2025 at 12:28 PM
More great work from the Busche Lab that I’m glad to have played a part in. Now out in @cp-neuron.bsky.social, we show that the earliest neuronal dysfunction in Alzheimer’s models is seen in parvalbumin interneurons in deep cortical layers.
Delighted to have played a part in this work, now out in @cellpress.bsky.social, where we show how soluble high molecular weight tau from Alzheimer’s brain suppresses burst firing in hippocampal neurons.
Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
In mouse models, tau impairs neuronal complex spike bursting and associated network
processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight
tau species drive these ...
www.cell.com
April 29, 2025 at 2:17 PM
Delighted to have played a part in this work, now out in @cellpress.bsky.social, where we show how soluble high molecular weight tau from Alzheimer’s brain suppresses burst firing in hippocampal neurons.
Reposted by Rikesh Rajani
New research led by @marcaurelbusche.bsky.social has found that tau specifically disrupts a certain type of electrical activity in the hippocampus in Alzheimer's🧠
The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6
The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6
April 28, 2025 at 4:08 PM
New research led by @marcaurelbusche.bsky.social has found that tau specifically disrupts a certain type of electrical activity in the hippocampus in Alzheimer's🧠
The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6
The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6
Excited to share that I'll soon be moving back to Edinburgh to start my own lab, as part of the BHF-UK DRI Centre for Vascular Dementia Research!
The Rajani Lab will be recruiting soon, so keep your eyes peeled.
The Rajani Lab will be recruiting soon, so keep your eyes peeled.
Delighted to announce @rikeshrajani.bsky.social as the first Group Leader to join our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏
The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉 buff.ly/4hIGaVM
The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉 buff.ly/4hIGaVM
February 19, 2025 at 5:17 PM
Excited to share that I'll soon be moving back to Edinburgh to start my own lab, as part of the BHF-UK DRI Centre for Vascular Dementia Research!
The Rajani Lab will be recruiting soon, so keep your eyes peeled.
The Rajani Lab will be recruiting soon, so keep your eyes peeled.
Reposted by Rikesh Rajani
Delighted to announce @rikeshrajani.bsky.social as the first Group Leader to join our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏
The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉 buff.ly/4hIGaVM
The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉 buff.ly/4hIGaVM
February 19, 2025 at 4:47 PM
Delighted to announce @rikeshrajani.bsky.social as the first Group Leader to join our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏
The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉 buff.ly/4hIGaVM
The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉 buff.ly/4hIGaVM
Reposted by Rikesh Rajani
Link to British dementia work with @selinawray.bsky.social : link.springer.com/article/10.1...
Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...
Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia - Acta Neuropathologica
Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-ter...
link.springer.com
January 9, 2025 at 1:39 PM
Link to British dementia work with @selinawray.bsky.social : link.springer.com/article/10.1...
Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...
Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...
Reposted by Rikesh Rajani
My colleague @neuroschnell.bsky.social chose this study of the surprising role played by oligodendrocyte (rather than neuronal) amyloid in Alzheimer's: journals.plos.org/plosbiology/...
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease
Neurons are thought to be the primary source of pathogenic amyloid beta (Aβ) in Alzheimer’s disease. This study identifies oligodendrocytes as significant contributors to Aβ production and shows that ...
journals.plos.org
January 3, 2025 at 1:28 PM
My colleague @neuroschnell.bsky.social chose this study of the surprising role played by oligodendrocyte (rather than neuronal) amyloid in Alzheimer's: journals.plos.org/plosbiology/...