Science is a shared fabric- each generation weaves its discoveries into the fabric of the next. This week's Nobel honors one vital thread in that tapestry. Here’s to the future our Salk immunologists are stitching together.

#Nobel2025 #Immunology #RegulatoryTcells #SalkScience #ScienceCantWait

🥜 Jamie Blum investigates oral tolerance—the immune system’s calm, noninflammatory response to most foods—opening possibilities for new ways to prevent or treat food allergies.

🤰 Deepshika Ramanan studies how maternal immunity during pregnancy and breastfeeding can shape a baby’s regulatory T cells and influence lifelong disease susceptibility.

🧵 Ye Zheng explores how regulatory T cells develop and function, identifying proteins that could be targeted to boost their protective role in autoimmune diseases.

At the Salk Institute, we’re continuing to unravel the intricate threads of immunity that these scientists first revealed. Our researchers are building on that legacy.

Congratulations to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi on winning the 2025 Nobel Prize in Physiology or Medicine for uncovering regulatory T cells — the immune system’s peacekeepers that protect our bodies from attacking themselves.

A thread:

At Salk, more than half of our research is powered by federal funding. The government might be shut down, but Salk's science continues.

Why? Because cancer doesn't wait. Alzheimer's disease doesn't wait. So science can't wait either.

Donate today: www.salk.edu/support-us/s...

Applications are now open for the Salk SURF — a fully funded, 10-week program that gives undergraduate students access to world-class facilities, mentorship from leading scientists, and a supportive community of peers.

📅 Deadline: December 7, 2025

Apply today: www.salk.edu/about/our-communi...

The federal government has shut down, leaving many questions unanswered.

At Salk, more than half of our research is supported by federal grants. But in times of uncertainty, science can't wait.

Donate to support science now: www.salk.edu/support-us/s...

Listen to Beyond Lab Walls on Apple Podcast: podcasts.apple.com/us/podcast/t...

Listen to Beyond Lab Walls on Spotify: open.spotify.com/episode/0Sg3...

Tune into Salk's podcast, Beyond Lab Walls, and meet Tony Hunter, the famed cancer biologist, who just celebrated 50 years at the Institute.

His persistent curiosity has fueled discovery and lifesaving medications, and continues to shape the future of cancer research.

www.salk.edu/blw-podcast/...

Salk scientists have pinpointed the brain area responsible for distinguishing between painful and non-painful touch. When it malfunctions, it can lead to mechanical allodynia.

This new understanding is a crucial step in designing acute and chronic pain therapeutics.

www.salk.edu/news-release...

Could boosting this molecule slow pancreatic cancer?

Salk and UCSD researchers found that increasing HSAT, an anticoagulant, in pancreatic cancer models slowed cancer progression. Its presence in human blood suggests it may also be a powerful biomarker.

Read more: www.salk.edu/news-release...