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Snell et al. develop sequencing methodology to identify full-length spike haplotypes and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence, accelerating viral evolution an...

Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...

The Chi-Wang Studentship at Jesus College and the University of Cambridge School of Clinical Medicine. Funding Application deadline: 23:59pm (midnight) UK time on 20th February 2026.

Decision made after outbreaks in 2024, when there were nearly 3,000 cases in England and Wales.

Nearly 100 people have been asked to quarantine in their homes

Heathrow says it has become the biggest airport to drop the limit after rolling out new high-tech scanners.

Human autoantibodies neutralizing type I interferons (IFNs) have emerged as strong, common, and global determinants of a growing number of severe v...

Author summary Interferon-lambdas (IFNλs) are antiviral molecules that help protect the surfaces of our body, such as the gut and lungs, from infection. While IFNλs are best known for being produced d...

Rhinoviruses are the most frequent cause of common colds and also a major cause of respiratory distress in high-risk groups. Using single-cell sequencing of rhinovirus-infected nasal epithelial organo...

ID: 8551. Title: Postdoctoral Research Associate (Molecular Biology of HIV Infection). Application Deadline:

Retroviruses commonly cause neoplasia in many species but have not been described in guinea pigs. While historical evidence exists for the presence of an active retrovirus in domestic guinea pigs ( Cavia porcella), there has been no description of the sequence of these viruses or their role in disease in guinea pigs. This paper uses genome mining of the published domestic and wild ( Cavia aperea) guinea pig genomes for retroviral sequences to identify the gamma and beta-retroviral complement of the Cavia genome, describing eight groups of viruses with evidence of recombination between virus groups. The most intact group, gamma-like retroviruses related to HERV-T (integration estimates of 855,000 to 3.8 million years ago), has five near full length loci that are likely capable of active infection. RNA-Scope In-situ Hybridisation of archived formalin-fixed, paraffin embedded (FFPE) guinea pig lymphoma sections with a probe for one of these loci demonstrated viral RNA expression in lymphoma tissue, strengthening the case for a role of these viruses in the high incidence of leukaemia and lymphoma in this species. ### Competing Interest Statement The authors have declared no competing interest. University of Nottingham, https://ror.org/01ee9ar58

Astroviruses are positive-sense single-stranded RNA viruses that cause significant disease across avian and mammalian hosts, yet their replication mechanisms remain poorly understood. The replication of astrovirus RNA occurs via a double-stranded RNA intermediate that is used as a template for the synthesis of new positive-sense RNA, which is covalently linked to the virus-encoded protein VPg. These viruses also produce a capsid-encoding subgenomic (sg) RNA that is 3′-coterminal with the genomic RNA. The mechanisms by which the astrovirus sgRNA is produced and regulated during infection have not yet been characterized. Using high throughput sequencing of RNA from cells infected with each of five different astrovirus strains, we demonstrate that the presence of a (−)sgRNA is a conserved feature of infection, supporting a premature termination model of subgenomic RNA production. A pronounced pile-up in the mapping positions of the 3ʹ ends of negative-sense RNA reads marks the precise 3ʹ terminus of the (−)sgRNA. We investigate the relative abundance and dynamics of positive and negative RNA species during virus replication and virion packaging, and perform a mutational analysis of conserved residues in the genomic and subgenomic 5ʹ termini. Together, this work elucidates the dynamics of genomic and subgenomic RNA synthesis during astrovirus infection. ### Competing Interest Statement The authors have declared no competing interest. Wellcome Trust, https://ror.org/029chgv08, 220620/Z/20/Z, 220814/Z/20/Z