Lightnews — Scholar-powered news

Sandra McAllister, PhD @sandramcallister.bsky.social · 20d

Loved working with the @theaacr.bsky.social team, Steering Committee, and Dr Lillian Siu on the 15th AACR Cancer Progress Report.

I was honored to present scientific progress and represent the cancer research community, working hard on behalf of all patients, at the press conference in DC.

AACR Journals @aacrjournals.bsky.social · 22d

At the AACR Cancer Progress Report 2025 release, Sandra McAllister touches on her paper in Cancer Discovery, "Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer."

Read the article: buff.ly/fYyGBgI

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Reposted by Sandra McAllister, PhD

AACR Journals @aacrjournals.bsky.social · 22d

At the AACR Cancer Progress Report 2025 release, Sandra McAllister touches on her paper in Cancer Discovery, "Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer."

Read the article: buff.ly/fYyGBgI

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Reposted by Sandra McAllister, PhD

American Association for Cancer Research (AACR) @theaacr.bsky.social · 23d

The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report tomorrow at 12 p.m. ET. Register for free to watch the livestream. buff.ly/zE9wZnZ

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Reposted by Sandra McAllister, PhD

American Association for Cancer Research (AACR) @theaacr.bsky.social · Sep 9

The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report at 12 p.m. ET on Wednesday, September 17, 2025. Register for free to attend in person or watch the livestream. buff.ly/zE9wZnZ

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Sandra McAllister, PhD @sandramcallister.bsky.social · 29d

It’s almost here!!!

Tune in Wed 9/17, 12pm (ET) for the 15th edition of the AACR Cancer Progress Report

The report highlights advances of the past year and celebrates 15 years of transformative research

A powerful testament to how investment in cancer research saves lives.

@theaacr.bsky.social

American Association for Cancer Research (AACR) @theaacr.bsky.social · Sep 9

The American Association for Cancer Research (AACR) will release the 15th edition of the AACR Cancer Progress Report at 12 p.m. ET on Wednesday, September 17, 2025. Register for free to attend in person or watch the livestream. buff.ly/zE9wZnZ

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Reposted by Sandra McAllister, PhD

Nature Reviews Cancer @natrevcancer.nature.com · Aug 19

🚨 REVIEW 🚨

#Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups.

Ageing, immune fitness and cancer - Nature Reviews Cancer

Ageing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.

bit.ly

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Reposted by Sandra McAllister, PhD

Peter van Galen @vangalenlab.bsky.social · Aug 15

Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...

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Sandra McAllister, PhD @sandramcallister.bsky.social · Aug 14

It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.

Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social

So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support

Nature Reviews Cancer @natrevcancer.nature.com · Aug 14

NEW content online!

Ageing, immune fitness and cancer

Nature Reviews Cancer, Published online: 14 August 2025; doi:10.1038/s41568-025-00858-zAgeing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.

www.nature.com

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Reposted by Sandra McAllister, PhD

Nature Reviews Cancer @natrevcancer.nature.com · Jul 11

NEW content online!

Cancer progression through the lens of age-induced metabolic reprogramming

Nature Reviews Cancer, Published online: 11 July 2025; doi:10.1038/s41568-025-00845-4In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.

www.nature.com

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Reposted by Sandra McAllister, PhD

Nature Reviews Cancer @natrevcancer.nature.com · Jul 17

#Review 🚨
Henry & DeGregori @jdegregori.bsky.social‬ discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️

Modelling the ageing dependence of cancer evolutionary trajectories - Nature Reviews Cancer

In this Review, Henry and DeGregori discuss the contributions of the various models and methods used to study the connection between ageing and cancer, highlighting the strengths and limitations of those models and technologies, as well as advocating for the wider adoption of age-appropriate models of cancer to improve our clinical translation of approaches to prevent and treat human cancers.

bit.ly

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Reposted by Sandra McAllister, PhD

Nature Reviews Cancer @natrevcancer.nature.com · Jul 18

#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social‬

Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer

In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.

bit.ly

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Reposted by Sandra McAllister, PhD

Nature Reviews Cancer @natrevcancer.nature.com · Aug 5

NEW content online!

Stromal senescence contributes to age-related increases in cancer

Nature Reviews Cancer, Published online: 04 August 2025; doi:10.1038/s41568-025-00840-9Ageing influences cancer risk through cellular and environmental changes, including the induction of cellular senescence. In this Review, Ye, Melam and Stewart highlight the role of senescent stromal cells in cancer and the therapeutic implications of this.

www.nature.com

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Reposted by Sandra McAllister, PhD

Ruth Franklin @ruthfranklinlab.bsky.social · Jul 11

🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage

Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...

www.science.org

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Sandra McAllister, PhD @sandramcallister.bsky.social · Jul 11

Great work, Franklin team!!

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Sandra McAllister, PhD @sandramcallister.bsky.social · Jun 16

Congrats Judith!!👏👏

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Reposted by Sandra McAllister, PhD

Dana-Farber’s Breast Oncology Center @dfcibreastonc.bsky.social · May 20

The purpose of the #ASPRIA trial is to determine if a combination of two drugs, #Atezolizumab and #SacituzumabGovitecan, can be used to prevent recurrence in #TripleNegativeBreastCancer.
For more information call 877-338-7425 or visit:
www.dana-farber.org/clinical-tri...
#BreastCancer #TNBC

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Sandra McAllister, PhD @sandramcallister.bsky.social · May 20

Congrats to Huntsman Cancer Institute!! (and to Alana 😊)

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Sandra McAllister, PhD @sandramcallister.bsky.social · May 9

👏👏

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Sandra McAllister, PhD @sandramcallister.bsky.social · May 7

👏👏congrats!! Nice work👏👏

Reposted by Sandra McAllister, PhD

Dana-Farber’s Breast Oncology Center @dfcibreastonc.bsky.social · May 7

Join Dana-Farber’s Young and Strong and Young Adult Programs for a free, family-friendly workshop on May 31 at the Yawkey Center.

For parents with #BreastCancer: Get guidance on talking to your kids, managing home life, and caring for yourself.
youngandstrong.dana-farber.org/upcoming-eve...

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Sandra McAllister, PhD @sandramcallister.bsky.social · May 7

👏👏👏🙏🏻🙏🏻🙏🏻

American Association for Cancer Research (AACR) @theaacr.bsky.social · May 6

Today, the American Association for Cancer Research (AACR) called on Congress to reject the Administration's nearly 40% cut to the NIH budget and allocate a bipartisan funding increase to $51.3 billion for the agency to accelerate progress for patients. www.aacr.org/about-the-aa...

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Reposted by Sandra McAllister, PhD

American Association for Cancer Research (AACR) @theaacr.bsky.social · May 6

Today, the American Association for Cancer Research (AACR) called on Congress to reject the Administration's nearly 40% cut to the NIH budget and allocate a bipartisan funding increase to $51.3 billion for the agency to accelerate progress for patients. www.aacr.org/about-the-aa...

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Reposted by Sandra McAllister, PhD

American Association for Cancer Research (AACR) @theaacr.bsky.social · Apr 28

Day 4 of #AACR25 features the Annual Business Meeting of Members, at which Lillian Siu will begin her term as AACR President. In addition, join us this morning for the plenary session on Innovative Technologies Driving Advances in Cancer Research.

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Reposted by Sandra McAllister, PhD

Jeffrey Townsend @jeffreytownsend.bsky.social · Apr 26

@jdegregori.bsky.social illuminates how aging and smoking alter tumor adaptive landscapes at #AACR25.

James Degregori at a lectern presenting a slide about somatic genetic variants.

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Sandra McAllister, PhD @sandramcallister.bsky.social · Apr 26

Sorry to miss it. Making my way to Chicago now !

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