🧬 PRSs in practice (4/5): Lower-risk PRS results — false reassurance, or false assumption?

A common concern is that lower-risk PRS results cause false reassurance. But evidence & theory do not support this.

Read my paper with @mikeinouye.bsky.social here👉 rdcu.be/eNeKN

#Genomics #PolygenicScores

🧬 PRSs in practice (3/5): Higher-risk results = behaviour change?

A common concern is that higher-risk polygenic risk scores (PRSs) don’t motivate lifestyle behaviour change.

My @nathumbehav.nature.com paper with @mikeinouye.bsky.social addresses this 👉 rdcu.be/eNeKN

#Genomics #BehaviourChange

🧬 PRSs in practice (2/5): Do higher-risk polygenic risk score (PRS) results really cause distress?

Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited.

👉 rdcu.be/eNeKN

#Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety

🧬 I’ve started a series on polygenic risk scores (PRSs) in healthcare practice, from my new paper with @mikeinouye.bsky.social in @nathumbehav.nature.com.

Yesterday’s post was on public understanding.

Tomorrow: do higher-risk PRS results cause distress?

👉 rdcu.be/eNeKN

#Genomics #PolygenicScores

🧬 PRSs in practice (1/5): Public understanding — are we underestimating the public?

A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵