SBGrid Consortium
LightNews LightNews
banner
sbgrid.bsky.social
SBGrid Consortium
@sbgrid.bsky.social
1.5K followers 190 following 450 posts
Harvard-based consortium curating structural biology (CryoEM Crystallography NMR Tomography) software, hosting educational webinars, supporting reproducibility, validation, reprocessing of data, & access to scientific resources sbgrid.org / biogrids.org
Posts Replies Media Videos
sbgrid.bsky.social
SBGrid's eLife paper received a citation in December from Elizabeth Campbell from @rockefeller.edu in @natmicrobiol.nature.com: Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas.

Read more here: buff.ly/6yvUxRw

#SBGrid
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas - Nature Microbiology
Targeting two distinct steps of the transcription process yields synergistic antibiotics that kill non-replicating Mycobacterium tuberculosis and reduce drug resistance.
buff.ly
January 16, 2026 at 5:03 PM
sbgrid.bsky.social
New Title Alert: cryomaskR- is a desktop application that provides WYSIWYG mask generation for cryo-electron microscopy data analysis.

Learn more here: buff.ly/MC0uNqR

#SBGrid #SBGridSoftware #StructuralBiology
CryomaskR - Matthew Byrne
WYSIWYG CRYO-EM MASK GENERATION
buff.ly
January 14, 2026 at 5:05 PM
sbgrid.bsky.social
Our January software webinar will feature Sliz Lab postdoc Alice-Roza Eruera on Building CryoET Training Workflows Using the SBGrid Ecosystem. Be sure to join us on January 13th!

Register here: buff.ly/wwNF6Zh

#SBGrid #StructuralBiology #Webinars
Webinars
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
buff.ly
January 12, 2026 at 5:04 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Rick Page from Miami University Ohio in Biochemical and Biophysical Research Communications: Functional and structural analyses of UbcH5 mutants with enhanced binding to the E3 ubiquitin ligase CHIP.

Read more here: buff.ly/y6AVbkb

#SBGrid
Functional and structural analyses of UbcH5 mutants with enhanced binding to the E3 ubiquitin ligase CHIP
The E3 ubiquitin ligase CHIP ubiquitinates substrates in chaperone-dependent or -independent manners. Structural studies, particularly by cryo-electro…
buff.ly
January 9, 2026 at 5:31 PM
sbgrid.bsky.social
New Title Alert: meteor- a tool for computing crystallographic difference maps that specializes in robust identification of weak signals from minor populations such as bound ligands or time-resolved experimental changes.

Learn more here: buff.ly/bgJYF9N

#SBGrid #SBGridSoftware #StructuralBiology
GitHub - rs-station/meteor: bringing you the best difference maps
bringing you the best difference maps. Contribute to rs-station/meteor development by creating an account on GitHub.
github.com
January 9, 2026 at 5:03 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from @palencialab.bsky.social from @ugrenoblealpes.bsky.social in @natcomms.nature.com Hierarchical folding-upon-binding of an intrinsically disordered protein.

Read more here: buff.ly/EYrkdWw

#SBGrid #Stayconnected
January 6, 2026 at 6:39 PM
sbgrid.bsky.social
Technical Notes: This month's software push includes updates to BioEmu, BoltzGen, ChimeraX, DOCK, Google Cloud SDK, HADDOCK3, NAMD, OpenFold, ORCA, pytom-match-pick, pyTME, SamTOOLS, Schrödinger 2025-3 and 2025-4, and Topaz.

More information here: buff.ly/lgtNHCd

#SBGrid #SBGridSoftware
SBGrid Consortium - Software Updates
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
buff.ly
January 6, 2026 at 5:02 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November [email protected] from @harvardmed.bsky.social [email protected] : Structures of human organellar SPFH protein complexes.

Read more here: buff.ly/lbuE0ZR

#SBGrid #ScienceMatters
Structures of human organellar SPFH protein complexes - Nature Communications
SPFH proteins oligomerize with distinct stoichiometries in all kingdoms of life. Here, Gao et al. determine cryo-EM structures to elucidate the compositions of the ER-resident Erlin and the…
buff.ly
December 31, 2025 at 5:02 PM
sbgrid.bsky.social
New Member Alert: Cesar Santiago from @cnb-csic.bsky.social in Spain joined SBGrid in November. Welcome!
December 30, 2025 at 5:04 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from @cijilim.bsky.social from University of Wisconsin-Madison in @science.org : Human RPA is an essential telomerase processivity factor for maintaining telomeres.

Read more here: buff.ly/83Fx3qA

#SBGrid #Stayconnected
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical…
buff.ly
December 25, 2025 at 5:03 PM
sbgrid.bsky.social
New Title Alert: Protein-Hunter- a tool for exploiting structure hallucination within diffusion for protein design. A fast, fine-tuning-free framework for de novo protein design.

Learn more here: buff.ly/DrCDsKH

#SBGrid #StructuralBiology #SBGridSoftware
GitHub - yehlincho/Protein-Hunter
Contribute to yehlincho/Protein-Hunter development by creating an account on GitHub.
buff.ly
December 24, 2025 at 5:05 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Andrew Kruse from @harvardmed.bsky.social in @pnas.org : Conformational regulation of two essential activators of bacterial cell elongation.

Read more here: buff.ly/fKVkrjw

#SBGrid #ScienceMatters
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly…
buff.ly
December 23, 2025 at 5:05 PM
sbgrid.bsky.social
New Member Alert: Wayne Patrick from @vicuniwgtn.bsky.social joined SBGrid in November. Welcome!
December 22, 2025 at 5:04 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Jean-Philippe Julien from
@sickkidsto.bsky.social in Journal of Virology.

Read more here: buff.ly/08Bai02

#SBGrid #ScienceMatters
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions | Journal of Virology
Bats and pangolins are natural reservoirs of betacoronaviruses (β-CoVs) and continue to pose a significant risk for future outbreaks through zoonotic transmissions. This highlights the need for…
buff.ly
December 19, 2025 at 5:06 PM
sbgrid.bsky.social
New Title Alert: CryoSiam- a self-supervised deep learning framework that works on dense and subtomogram levels.

Learn more here: buff.ly/xt1uGJt

#SBGrid #SBGridSoftware
CryoSiam Documentation
Welcome to the official documentation for the CryoSiam method. This guide will help to use this tool effectively.
buff.ly
December 18, 2025 at 5:05 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Seth Darst at @rockefelleruniv.bsky.social in @nature.com Communications: Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase.

Read more here: buff.ly/VXkYTjT

#SBGrid #ScienceMatters
Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase - Nature Communications
Promoter escape is a key step in bacterial transcription and a target of the antibiotic rifampicin. Here, the authors use cryo-EM to explore this step, finding seven structural intermediates of M.…
buff.ly
December 17, 2025 at 5:04 PM
sbgrid.bsky.social
New Title Alert: CryoLithe- a supervised machine learning method to directly reconstruct the tomogram from aligned cryo-ET tilt series. The methods is trained on real measurements using FBP+cryo-CARE+IsoNet reconstructions as the reference.

Learn more here: buff.ly/3jxoax3

#SBGrid #Software
GitHub - swing-research/CryoLithe
Contribute to swing-research/CryoLithe development by creating an account on GitHub.
github.com
December 16, 2025 at 5:04 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from Titus Boggon from Yale University in Protein and Peptide Letters: Nickel Binding to the c-Src SH3 Domain Facilitates Crystallization.

Read more here: buff.ly/diXPL4b

#SBGrid #ScienceMatters
Nickel Binding to the c-Src SH3 Domain Facilitates Crystallization
Introduction: Numerous X-ray crystal structures of the c-Src SH3 domain have provided a large sampling of atomic-level information for this important signaling domain. Multiple crystal forms have…
buff.ly
December 15, 2025 at 5:04 PM
sbgrid.bsky.social
New Title Alert: CryoCAT- an open source, GPL-3.0+ licensed library providing contextual analysis tools for cryo electron tomography and subtomogram averaging.

Learn more here: buff.ly/ug59jUR

#SBGrid #SBGridSoftware #StructuralBiology
cryoCAT: Contextual Analysis Tools for cryo electron tomography — cryoCAT 0.2.2 documentation
Site Navigation
buff.ly
December 12, 2025 at 5:02 PM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in November from @demet-arac.bsky.social from the University of Chicago in @pnas.org : The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling.

Read more here: buff.ly/PPDb9qD

#SBGrid #ScienceMatters
The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling | PNAS
Adhesion G protein–coupled receptors (aGPCRs) transduce extracellular adhesion events into cytoplasmic signaling pathways. ADGRG6/GPR126 is an aGPC...
buff.ly
December 11, 2025 at 5:03 PM
sbgrid.bsky.social
New Title Alert: CryoAtom- is a software that automatically constructs full-atom 3D structural models of proteins based on cryo-EM density maps and sequence information.

Learn more here: buff.ly/gjVyH1m

#SBGrid #SBGridSoftware #StructuralBiology
GitHub - YangLab-SDU/CryoAtom: From cryo-EM density map to atomic structure
From cryo-EM density map to atomic structure. Contribute to YangLab-SDU/CryoAtom development by creating an account on GitHub.
buff.ly
December 10, 2025 at 5:05 PM
sbgrid.bsky.social
Technical Notes: This month's software push includes updates to BCFTools, BioXTAS RAW 2, CCPEM-Pipeliner, CNIO relion_tools, COOT, Doppio, OpenEye, RDKit, Scipion, and Surface-morphometrics.

More here: buff.ly/SS4Qn0w

#SBGrid #SBGridSoftware
SBGrid Consortium - Software Updates
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
buff.ly
December 9, 2025 at 5:04 PM
sbgrid.bsky.social
Mark your calendars for January 13th when our own Alice-Roza Eruera will give a primer on Building CryoET Training Workflows Using the SBGrid Ecosystem.

Register here: buff.ly/AaZQlJL

#SBGrid #Structuralbiology #Webinars
Webinars
The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…
buff.ly
December 8, 2025 at 5:05 PM
sbgrid.bsky.social
Mapping bacteriophages: a publication highlight from @keandreyam.bsky.social featuring a new article from the lab of Mihnea Bostina at the @universityofotago.bsky.social & colleagues.

Read more here: buff.ly/Wgfu3bt

#SBGrid #cryoem
Mapping bacteriophages
SBGrid member Mihnea Bostina helps to uncover the first high-resolution, head-to-tail structural map of a Felixounavirus bacteriophage.
buff.ly
December 5, 2025 at 5:04 PM
sbgrid.bsky.social
Melanie Ohi from @umich.edu is the focus of our November member tale. Ohi stuck with cryoEM, despite warnings that becoming a "blobologist" would limit her options.

Read more here: buff.ly/nPzs4rm

#SBGridTales #Stayconnected
Reshaping membranes
Melanie Ohi from the University of Michigan studies membrane proteins that work together as complex molecular machines.
buff.ly
December 4, 2025 at 5:04 PM