The Science of Parkinson's
@scienceofpd.bsky.social
Personal account of the Director of Research at Cure Parkinson's - All views my own - Kiwi - Kia kaha - 侘寂 - https://scienceofparkinsons.com/
Building on the success of Centiloids for #Alzheimers, researchers present the "Centamine scale" holds promise for the harmonized quantification of dopaminergic neuronal imaging markers for #Parkinsons & related synucleinopathies
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
January 29, 2026 at 9:39 PM
Building on the success of Centiloids for #Alzheimers, researchers present the "Centamine scale" holds promise for the harmonized quantification of dopaminergic neuronal imaging markers for #Parkinsons & related synucleinopathies
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Researchers find that targeting mitochondrial morphology is a viable strategy for identifying strategies for treating α-synucleinopathies, highlighting Fis1 as a promising preventive/therapeutic target
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 29, 2026 at 9:32 PM
Researchers find that targeting mitochondrial morphology is a viable strategy for identifying strategies for treating α-synucleinopathies, highlighting Fis1 as a promising preventive/therapeutic target
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New research finds that "synchronisation within the basal ganglia is not a spatially static phenomenon but rather unfolds in space which expands on the current understanding of basal ganglia mechanism"; High-frequency propagation may be a useful marker
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
January 29, 2026 at 9:29 PM
New research finds that "synchronisation within the basal ganglia is not a spatially static phenomenon but rather unfolds in space which expands on the current understanding of basal ganglia mechanism"; High-frequency propagation may be a useful marker
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Cool - can targeting sleep stage-specific neurophysiologies with adaptive Deep Brain Stimulation help ameliorate sleep disruption? Researchers give different stimulation in different sleep stage in people with #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 29, 2026 at 9:25 PM
Cool - can targeting sleep stage-specific neurophysiologies with adaptive Deep Brain Stimulation help ameliorate sleep disruption? Researchers give different stimulation in different sleep stage in people with #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Researchers design small peptidomimetics based on the structure of #Parkinsons -associated α-synuclein aggregates & its chaperone protein αB-Crystallin, & they find that the αB-Crystallin-based compound was able to interfere with αSyn folding & aggregation
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
January 29, 2026 at 9:17 PM
Researchers design small peptidomimetics based on the structure of #Parkinsons -associated α-synuclein aggregates & its chaperone protein αB-Crystallin, & they find that the αB-Crystallin-based compound was able to interfere with αSyn folding & aggregation
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
An article from a few years back, but I just discovered it tonight. Interesting perspective: A neurodegeneration researcher diagnosed with #Parkinsons, who gives future pharmacists a personal account, as well as the observations of a trained scientist
magazine.ucsf.edu/professor-se...
magazine.ucsf.edu/professor-se...
This Professor Sees Brain Disease through a Unique Lens
Every fall, Matt Jacobson relives his Parkinson’s diagnosis so future pharmacists perceive the patient behind the prescription.
magazine.ucsf.edu
January 29, 2026 at 9:09 PM
An article from a few years back, but I just discovered it tonight. Interesting perspective: A neurodegeneration researcher diagnosed with #Parkinsons, who gives future pharmacists a personal account, as well as the observations of a trained scientist
magazine.ucsf.edu/professor-se...
magazine.ucsf.edu/professor-se...
New research "emphasizes the importance of separating aperiodic neural activity from periodic oscillations as a progressive alteration of the aperiodic component represented the most prominent #Parkinsons-related neurophysiological change" (I have no idea)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 29, 2026 at 5:55 PM
New research "emphasizes the importance of separating aperiodic neural activity from periodic oscillations as a progressive alteration of the aperiodic component represented the most prominent #Parkinsons-related neurophysiological change" (I have no idea)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New study finds that moderate alcohol consumption & smoking are associated with a reduced risk of #Parkinsons, with effects that are strongly influenced by sex, genetic susceptibility, & combined exposure
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
January 29, 2026 at 5:51 PM
New study finds that moderate alcohol consumption & smoking are associated with a reduced risk of #Parkinsons, with effects that are strongly influenced by sex, genetic susceptibility, & combined exposure
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New research finds elevated levels of class I HDACs in motor cortex in #Parkinsons patients & bidirectional changes in their regional density in the Lewy body dementias; In PD, [11C]Martinostat uptake was⬆️in precentral gyrus & correlated with H&Y stage
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 29, 2026 at 5:36 PM
New research finds elevated levels of class I HDACs in motor cortex in #Parkinsons patients & bidirectional changes in their regional density in the Lewy body dementias; In PD, [11C]Martinostat uptake was⬆️in precentral gyrus & correlated with H&Y stage
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Researchers present the clinical decision support (CDS) platform for #Parkinsons - a modular & extensible informatics platform for clinicians & researchers with comprehensive functionalities for recording relevant patient information
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 29, 2026 at 5:28 PM
Researchers present the clinical decision support (CDS) platform for #Parkinsons - a modular & extensible informatics platform for clinicians & researchers with comprehensive functionalities for recording relevant patient information
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Researchers report that elevated ceramide levels & biosynthesis genes in #Parkinsons brains; Inhibiting de novo ceramide biosynthesis (via myriocin) decreases α-synuclein aggregation & improves motor & cognitive function in A53T α-synuclein transgenic mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 29, 2026 at 5:24 PM
Researchers report that elevated ceramide levels & biosynthesis genes in #Parkinsons brains; Inhibiting de novo ceramide biosynthesis (via myriocin) decreases α-synuclein aggregation & improves motor & cognitive function in A53T α-synuclein transgenic mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lot of a-syn seeding amplification assay status research today - new imaging report finds positive cases exhibit more dopaminergic deficit, whereas negative cases have more subcortical atrophy across both sporadic & genetic #Parkinsons
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
January 29, 2026 at 11:21 AM
Lot of a-syn seeding amplification assay status research today - new imaging report finds positive cases exhibit more dopaminergic deficit, whereas negative cases have more subcortical atrophy across both sporadic & genetic #Parkinsons
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Ever wondered about the clinical characteristic of a-synuclein seed amplification assay negative cases? Me too. New research looks at 80 cases & finds lower rate of hyposmia at baseline, but otherwise no diff clinically (1/7 got re-diagnosed)
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
January 29, 2026 at 11:05 AM
Ever wondered about the clinical characteristic of a-synuclein seed amplification assay negative cases? Me too. New research looks at 80 cases & finds lower rate of hyposmia at baseline, but otherwise no diff clinically (1/7 got re-diagnosed)
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
A comparison of 4 labs, assessing the performance of the α-Synuclein seed amplification assay for Dementia With Lewy Bodies, "highlights challenges for the reproducibility of α-syn SAA results across different protocols applied by different laboratories"
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
January 29, 2026 at 10:59 AM
A comparison of 4 labs, assessing the performance of the α-Synuclein seed amplification assay for Dementia With Lewy Bodies, "highlights challenges for the reproducibility of α-syn SAA results across different protocols applied by different laboratories"
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
New research reports that #Parkinsons -associated α-synuclein is the major modulator of substantia nigra somatodendritic dopamine release. The researchers find that α-synuclein controls the activity of the L-type calcium ion channels; asyn KO=⬇️plasticity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 29, 2026 at 10:55 AM
New research reports that #Parkinsons -associated α-synuclein is the major modulator of substantia nigra somatodendritic dopamine release. The researchers find that α-synuclein controls the activity of the L-type calcium ion channels; asyn KO=⬇️plasticity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intestinal macrophages modulate synucleinopathy along the gut–brain axis; Muscularis macrophages in PD mouse model contain misfolded α-Syn, adopt a signature reflecting endolysosomal dysfunc. & modulate expansion of T cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 28, 2026 at 11:16 PM
Intestinal macrophages modulate synucleinopathy along the gut–brain axis; Muscularis macrophages in PD mouse model contain misfolded α-Syn, adopt a signature reflecting endolysosomal dysfunc. & modulate expansion of T cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Analysis of serum phosphorylated tau 217 in GBA1 variant carriers with & without #Parkinsons finds no differences between PD groups, but non-manifesting GBA1 variant carriers had higher levels than controls
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
January 28, 2026 at 11:07 PM
Analysis of serum phosphorylated tau 217 in GBA1 variant carriers with & without #Parkinsons finds no differences between PD groups, but non-manifesting GBA1 variant carriers had higher levels than controls
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
New research finds clonal CD8+ T cells populate the leptomeninges; Leptomeningeal immune cells undergo both shared & disease-specific shifts at late stages of neurodegeneration (myeloid changes in #Parkinsons /LBD)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 28, 2026 at 7:44 PM
New research finds clonal CD8+ T cells populate the leptomeninges; Leptomeningeal immune cells undergo both shared & disease-specific shifts at late stages of neurodegeneration (myeloid changes in #Parkinsons /LBD)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
"Nutrition in #Parkinsons - what neurologists need to know" - from some of the best in the business; A treasure trove of useful info & resources for all
pn.bmj.com/content/earl...
pn.bmj.com/content/earl...
January 28, 2026 at 7:29 PM
"Nutrition in #Parkinsons - what neurologists need to know" - from some of the best in the business; A treasure trove of useful info & resources for all
pn.bmj.com/content/earl...
pn.bmj.com/content/earl...
"Recent initiatives, such as the Global #Parkinsons Genetics Program (GP2) represent an important step toward global inclusivity by integrating cohorts from Africa, Asia, & Latin America" - New opinion on why genomic diversity matters in PD research
www.frontiersin.org/journals/gen...
www.frontiersin.org/journals/gen...
January 28, 2026 at 7:22 PM
"Recent initiatives, such as the Global #Parkinsons Genetics Program (GP2) represent an important step toward global inclusivity by integrating cohorts from Africa, Asia, & Latin America" - New opinion on why genomic diversity matters in PD research
www.frontiersin.org/journals/gen...
www.frontiersin.org/journals/gen...
New research evaluates the neuroprotective potential of a novel peptide osmotin-derived 9-amino-acid (Os_9aa, C-T-Q-G-P-C-G-P-T) in α-syn & neurotoxin (MPTP)-induced models of #Parkinsons; Multifaceted protection
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 27, 2026 at 11:23 AM
New research evaluates the neuroprotective potential of a novel peptide osmotin-derived 9-amino-acid (Os_9aa, C-T-Q-G-P-C-G-P-T) in α-syn & neurotoxin (MPTP)-induced models of #Parkinsons; Multifaceted protection
link.springer.com/article/10.1...
link.springer.com/article/10.1...
"Successes & failures in our journey to find more efficacious therapies to alleviate #Parkinsons represent incomparable learning opportunities, all of which will one day benefit patients suffering from the disease" - challenges of experimental pharmacology
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
January 27, 2026 at 11:13 AM
"Successes & failures in our journey to find more efficacious therapies to alleviate #Parkinsons represent incomparable learning opportunities, all of which will one day benefit patients suffering from the disease" - challenges of experimental pharmacology
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Researchers at Nod Thera present the ester prodrug NLRP3 inflammasome inhibitor NT-0796; Highly brain penetrant, after crossing the blood brain barrier, NT-0796 is metabolized predominantly by CES1 in brain parenchyma into its active metabolite NDT-19795
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
January 27, 2026 at 11:08 AM
Researchers at Nod Thera present the ester prodrug NLRP3 inflammasome inhibitor NT-0796; Highly brain penetrant, after crossing the blood brain barrier, NT-0796 is metabolized predominantly by CES1 in brain parenchyma into its active metabolite NDT-19795
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Researchers report that the C-domain of the cerebral dopamine neurotrophic factor (CDNF) "is responsible for its cardioprotective activity by binding to the KDEL receptor relocated to the plasma membrane under endoplasmic reticulum stress conditions"
www.jmcc-online.com/article/S002...
www.jmcc-online.com/article/S002...
January 27, 2026 at 11:04 AM
Researchers report that the C-domain of the cerebral dopamine neurotrophic factor (CDNF) "is responsible for its cardioprotective activity by binding to the KDEL receptor relocated to the plasma membrane under endoplasmic reticulum stress conditions"
www.jmcc-online.com/article/S002...
www.jmcc-online.com/article/S002...
New review explores the gut microbiota & #Parkinsons - pathogenesis & potential therapeutic strategies from a gut-brain axis perspective; "Future PD therapeutic approaches should adopt a precision med framework, supported by robust fundamental research"
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
January 27, 2026 at 11:03 AM
New review explores the gut microbiota & #Parkinsons - pathogenesis & potential therapeutic strategies from a gut-brain axis perspective; "Future PD therapeutic approaches should adopt a precision med framework, supported by robust fundamental research"
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...