The Science of Parkinson's
@scienceofpd.bsky.social
Personal account of the Director of Research at Cure Parkinson's - All views my own - Kiwi - Kia kaha - 侘寂 - https://scienceofparkinsons.com/
Researchers investigated the association between monoamine function & 4 specific non-motor symptoms in early #Parkinsons (using PPMI data) & found novel insights regarding the monoaminergic networks underlying depression, anxiety, & RBD in PD
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
January 31, 2026 at 3:37 PM
Researchers investigated the association between monoamine function & 4 specific non-motor symptoms in early #Parkinsons (using PPMI data) & found novel insights regarding the monoaminergic networks underlying depression, anxiety, & RBD in PD
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New paper mapping cellular vulnerability to #Parkinsons -associated a-synuclein in mice finds"αSyn path. propagates along anatomical pathways, but cell-autonomous factors determine if a neuron exposed to misfolded αSyn will develop Lewy-like path. or not"
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 31, 2026 at 3:33 PM
New paper mapping cellular vulnerability to #Parkinsons -associated a-synuclein in mice finds"αSyn path. propagates along anatomical pathways, but cell-autonomous factors determine if a neuron exposed to misfolded αSyn will develop Lewy-like path. or not"
link.springer.com/article/10.1...
link.springer.com/article/10.1...
New research reveals that partial loss of #Parkinsons -related GBA1 in glia & ATP13A2 in neurons synergistically disrupts lysosomal pH & neuron-glia GlcCer homeostasis, triggering neurodegen. "GBA1 penetrance is influenced by additional genetic modifiers"
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Two lysosomal genes ATP13A2 and GBA1 interact to drive neurodegeneration - Molecular Neurodegeneration
Molecular Neurodegeneration - Parkinson’s disease (PD) is a genetically complex disorder in which combinations of heterozygous risk variants may contribute to pathogenesis. Many PD risk loci...
link.springer.com
January 31, 2026 at 3:28 PM
New research reveals that partial loss of #Parkinsons -related GBA1 in glia & ATP13A2 in neurons synergistically disrupts lysosomal pH & neuron-glia GlcCer homeostasis, triggering neurodegen. "GBA1 penetrance is influenced by additional genetic modifiers"
link.springer.com/article/10.1...
link.springer.com/article/10.1...
A bicentenary tribute to Jean-Martin Charcot (1825–1893), providing an overview of Charcot's place in the context of 21st century movement disorders neurology
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
January 31, 2026 at 3:23 PM
A bicentenary tribute to Jean-Martin Charcot (1825–1893), providing an overview of Charcot's place in the context of 21st century movement disorders neurology
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Whole genome seq of stool samples from 55 cases of #Parkinsons (vs 42 controls) finds 10 functional pathways significantly diff. (all P < 0.0001)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 31, 2026 at 12:06 PM
Whole genome seq of stool samples from 55 cases of #Parkinsons (vs 42 controls) finds 10 functional pathways significantly diff. (all P < 0.0001)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Researchers provide an overview of structure-based selection of a tetracycline derivative for advanced biosensor platforms targeting aggregated α-synuclein in #Parkinsons
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
January 31, 2026 at 11:54 AM
Researchers provide an overview of structure-based selection of a tetracycline derivative for advanced biosensor platforms targeting aggregated α-synuclein in #Parkinsons
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Researchers report that REV-ERB-α & -β (which are circadian clock components & nuclear receptors) regulate astrocyte reactivity state & proteostatic gene expression in a cell-autonomous manner; They also influence #Parkinsons -associated a-synuclein pathology
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
January 31, 2026 at 11:47 AM
Researchers report that REV-ERB-α & -β (which are circadian clock components & nuclear receptors) regulate astrocyte reactivity state & proteostatic gene expression in a cell-autonomous manner; They also influence #Parkinsons -associated a-synuclein pathology
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
A qualitative study explores views & experiences of online exercise groups for people with #Parkinsons; "I don’t ever think it’s going to be first choice. But it is very valuable if for whatever reason that the in-person can’t be done"
onlinelibrary.wiley.com/doi/10.1155/...
onlinelibrary.wiley.com/doi/10.1155/...
January 31, 2026 at 11:43 AM
A qualitative study explores views & experiences of online exercise groups for people with #Parkinsons; "I don’t ever think it’s going to be first choice. But it is very valuable if for whatever reason that the in-person can’t be done"
onlinelibrary.wiley.com/doi/10.1155/...
onlinelibrary.wiley.com/doi/10.1155/...
The results of the DIGI.PARK study have been published, assessing the Empatica E4 wristband on probable REM sleep behavior disorder in people with #Parkinsons; 149 nights recorded continuously in 14 participants
www.frontiersin.org/journals/neu...
www.frontiersin.org/journals/neu...
January 31, 2026 at 11:37 AM
The results of the DIGI.PARK study have been published, assessing the Empatica E4 wristband on probable REM sleep behavior disorder in people with #Parkinsons; 149 nights recorded continuously in 14 participants
www.frontiersin.org/journals/neu...
www.frontiersin.org/journals/neu...
“The more you learn, the more you can influence”
Researchers present a pilot study exploring the potential of learning circles for strengthening self-care & citizen science in #Parkinsons
Results: Resources, agency, & context; Promising format
www.frontiersin.org/journals/pub...
Researchers present a pilot study exploring the potential of learning circles for strengthening self-care & citizen science in #Parkinsons
Results: Resources, agency, & context; Promising format
www.frontiersin.org/journals/pub...
January 31, 2026 at 11:26 AM
“The more you learn, the more you can influence”
Researchers present a pilot study exploring the potential of learning circles for strengthening self-care & citizen science in #Parkinsons
Results: Resources, agency, & context; Promising format
www.frontiersin.org/journals/pub...
Researchers present a pilot study exploring the potential of learning circles for strengthening self-care & citizen science in #Parkinsons
Results: Resources, agency, & context; Promising format
www.frontiersin.org/journals/pub...
New review explores the interplay of genomics, transcriptomics, proteomics, & lipidomics in GBA1-associated #Parkinsons; "It is a systemic disease characterized by a core failure of the lysosomal-lipid-protein homeostasis network"
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 31, 2026 at 11:21 AM
New review explores the interplay of genomics, transcriptomics, proteomics, & lipidomics in GBA1-associated #Parkinsons; "It is a systemic disease characterized by a core failure of the lysosomal-lipid-protein homeostasis network"
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Large cohort study finds plasma pTau217 (but not GFAP or NfL) levels accurately reflect the presence of #Alzheimer neuropathological change in the brain even in individuals with a primary neuropathologic diagnosis of a non-AD dementia
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias | Neurology
Background and ObjectivesAlzheimer disease (AD) and its related disorders (ADRDs) are characterized by a high
frequency of copathologies. We aimed to determine the specificity of plasma pTau217,
glial...
www.neurology.org
January 30, 2026 at 5:19 PM
Large cohort study finds plasma pTau217 (but not GFAP or NfL) levels accurately reflect the presence of #Alzheimer neuropathological change in the brain even in individuals with a primary neuropathologic diagnosis of a non-AD dementia
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Researchers report induction of #Parkinsons α-synuclein pathology in the rodent brain stimulates energy metabolism; Aberrant ROCK2 & SPP1 signaling reflect progressive tissue damage; CREBBP expression could be a marker of advanced α-synuclein pathology
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
January 30, 2026 at 5:15 PM
Researchers report induction of #Parkinsons α-synuclein pathology in the rodent brain stimulates energy metabolism; Aberrant ROCK2 & SPP1 signaling reflect progressive tissue damage; CREBBP expression could be a marker of advanced α-synuclein pathology
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
New research finds oral NAD-augmentation with nicotinamide riboside or nicotinamide mononucleotide requires ∼2 weeks to reach steady-state, & the extent of NAD augmentation is independent of sex & #Parkinsons status
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
January 30, 2026 at 5:09 PM
New research finds oral NAD-augmentation with nicotinamide riboside or nicotinamide mononucleotide requires ∼2 weeks to reach steady-state, & the extent of NAD augmentation is independent of sex & #Parkinsons status
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
ABLi Therapeutics announces their c-Abl inhibitor Risvodetinib will be one of the agents on the Michael J Fox Foundation's "Path to Prevention" platform trial (expected to launch in the coming months) assessing safety & efficacy in pre- #Parkinsons cohorts
www.ablitherapeutics.com/news/detail/...
www.ablitherapeutics.com/news/detail/...
ABLi Therapeutics, Inc. | Innovative Treatments for Neurodegenerative Diseases
Developing disease-modifying therapies for Parkinson's and related neurodegenerative diseases through targeting Abelson Tyrosine Kinases.
www.ablitherapeutics.com
January 30, 2026 at 5:03 PM
ABLi Therapeutics announces their c-Abl inhibitor Risvodetinib will be one of the agents on the Michael J Fox Foundation's "Path to Prevention" platform trial (expected to launch in the coming months) assessing safety & efficacy in pre- #Parkinsons cohorts
www.ablitherapeutics.com/news/detail/...
www.ablitherapeutics.com/news/detail/...
Analysing urinary proteomes from 1215 individuals across 3 cohorts & integrating whole-genome sequencing from >500 participants, researchers find 177 urinary proteins associated with pathogenic LRRK2, enriched for lyso, immune, & membrane-trafficking paths
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 30, 2026 at 11:38 AM
Analysing urinary proteomes from 1215 individuals across 3 cohorts & integrating whole-genome sequencing from >500 participants, researchers find 177 urinary proteins associated with pathogenic LRRK2, enriched for lyso, immune, & membrane-trafficking paths
link.springer.com/article/10.1...
link.springer.com/article/10.1...
A double-blinded, randomised feasibility trial finds spinal cord stimulation therapy was well-tolerated for gait impairment in #Parkinsons, but it did not significantly improve Postural Instability and Gait Disorder (PIGD) score at 6 months
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 30, 2026 at 11:34 AM
A double-blinded, randomised feasibility trial finds spinal cord stimulation therapy was well-tolerated for gait impairment in #Parkinsons, but it did not significantly improve Postural Instability and Gait Disorder (PIGD) score at 6 months
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcriptome analyses reveal a demyelination-related features in multiple system atrophy (MSA) oligodendrocytes; Elevated TLR2 expression in MSA oligodendrocytes inversely correlates with MBP expression, & this correlation is absent in #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 30, 2026 at 9:30 AM
Transcriptome analyses reveal a demyelination-related features in multiple system atrophy (MSA) oligodendrocytes; Elevated TLR2 expression in MSA oligodendrocytes inversely correlates with MBP expression, & this correlation is absent in #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Building on the success of Centiloids for #Alzheimers, researchers present the "Centamine scale" holds promise for the harmonized quantification of dopaminergic neuronal imaging markers for #Parkinsons & related synucleinopathies
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
January 29, 2026 at 9:39 PM
Building on the success of Centiloids for #Alzheimers, researchers present the "Centamine scale" holds promise for the harmonized quantification of dopaminergic neuronal imaging markers for #Parkinsons & related synucleinopathies
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Researchers find that targeting mitochondrial morphology is a viable strategy for identifying strategies for treating α-synucleinopathies, highlighting Fis1 as a promising preventive/therapeutic target
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 29, 2026 at 9:32 PM
Researchers find that targeting mitochondrial morphology is a viable strategy for identifying strategies for treating α-synucleinopathies, highlighting Fis1 as a promising preventive/therapeutic target
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New research finds that "synchronisation within the basal ganglia is not a spatially static phenomenon but rather unfolds in space which expands on the current understanding of basal ganglia mechanism"; High-frequency propagation may be a useful marker
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
January 29, 2026 at 9:29 PM
New research finds that "synchronisation within the basal ganglia is not a spatially static phenomenon but rather unfolds in space which expands on the current understanding of basal ganglia mechanism"; High-frequency propagation may be a useful marker
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Cool - can targeting sleep stage-specific neurophysiologies with adaptive Deep Brain Stimulation help ameliorate sleep disruption? Researchers give different stimulation in different sleep stage in people with #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 29, 2026 at 9:25 PM
Cool - can targeting sleep stage-specific neurophysiologies with adaptive Deep Brain Stimulation help ameliorate sleep disruption? Researchers give different stimulation in different sleep stage in people with #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Researchers design small peptidomimetics based on the structure of #Parkinsons -associated α-synuclein aggregates & its chaperone protein αB-Crystallin, & they find that the αB-Crystallin-based compound was able to interfere with αSyn folding & aggregation
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
January 29, 2026 at 9:17 PM
Researchers design small peptidomimetics based on the structure of #Parkinsons -associated α-synuclein aggregates & its chaperone protein αB-Crystallin, & they find that the αB-Crystallin-based compound was able to interfere with αSyn folding & aggregation
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
An article from a few years back, but I just discovered it tonight. Interesting perspective: A neurodegeneration researcher diagnosed with #Parkinsons, who gives future pharmacists a personal account, as well as the observations of a trained scientist
magazine.ucsf.edu/professor-se...
magazine.ucsf.edu/professor-se...
This Professor Sees Brain Disease through a Unique Lens
Every fall, Matt Jacobson relives his Parkinson’s diagnosis so future pharmacists perceive the patient behind the prescription.
magazine.ucsf.edu
January 29, 2026 at 9:09 PM
An article from a few years back, but I just discovered it tonight. Interesting perspective: A neurodegeneration researcher diagnosed with #Parkinsons, who gives future pharmacists a personal account, as well as the observations of a trained scientist
magazine.ucsf.edu/professor-se...
magazine.ucsf.edu/professor-se...
New research "emphasizes the importance of separating aperiodic neural activity from periodic oscillations as a progressive alteration of the aperiodic component represented the most prominent #Parkinsons-related neurophysiological change" (I have no idea)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 29, 2026 at 5:55 PM
New research "emphasizes the importance of separating aperiodic neural activity from periodic oscillations as a progressive alteration of the aperiodic component represented the most prominent #Parkinsons-related neurophysiological change" (I have no idea)
www.nature.com/articles/s41...
www.nature.com/articles/s41...