The Science of Parkinson's
@scienceofpd.bsky.social
Personal account of the Director of Research at Cure Parkinson's - All views my own - Kiwi - Kia kaha - 侘寂 - https://scienceofparkinsons.com/
Ever wondered about the role of USP10 in neurodegenerative conditions?
Yeah, me too
A new review provides a useful overview, with a good section on #Parkinsons
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Yeah, me too
A new review provides a useful overview, with a good section on #Parkinsons
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
November 25, 2025 at 11:05 AM
Ever wondered about the role of USP10 in neurodegenerative conditions?
Yeah, me too
A new review provides a useful overview, with a good section on #Parkinsons
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Yeah, me too
A new review provides a useful overview, with a good section on #Parkinsons
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Combinations - all the cool kids are doing them!
New research presents patient-derived iPSC models of #ALS that identified baricitinib + memantine + riluzole as a promising potential therapeutic combination
www.nature.com/articles/s41...
New research presents patient-derived iPSC models of #ALS that identified baricitinib + memantine + riluzole as a promising potential therapeutic combination
www.nature.com/articles/s41...
November 25, 2025 at 10:50 AM
Combinations - all the cool kids are doing them!
New research presents patient-derived iPSC models of #ALS that identified baricitinib + memantine + riluzole as a promising potential therapeutic combination
www.nature.com/articles/s41...
New research presents patient-derived iPSC models of #ALS that identified baricitinib + memantine + riluzole as a promising potential therapeutic combination
www.nature.com/articles/s41...
Novo Nordisk announce that the EVOKE and EVOKE+ Phase 3 trials of semaglutide in 3808 early-stage #Alzheimers patient did not “translate into a delay of disease progression” even as it “resulted in improvement of AD-related biomarkers”:
www.novonordisk.com/content/nnco...
www.novonordisk.com/content/nnco...
News Details
www.novonordisk.com
November 24, 2025 at 3:03 PM
Novo Nordisk announce that the EVOKE and EVOKE+ Phase 3 trials of semaglutide in 3808 early-stage #Alzheimers patient did not “translate into a delay of disease progression” even as it “resulted in improvement of AD-related biomarkers”:
www.novonordisk.com/content/nnco...
www.novonordisk.com/content/nnco...
Researchers analyzed structural & task-free functional MRI scans from patients across the #Alzheimers -frontotemporal dementia (FTD) spectrum to identify relationships between gray matter atrophy & functional connectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 23, 2025 at 12:03 PM
Researchers analyzed structural & task-free functional MRI scans from patients across the #Alzheimers -frontotemporal dementia (FTD) spectrum to identify relationships between gray matter atrophy & functional connectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
"Acting as a molecular glue, spermine orchestrates in vivo condensation of α-synuclein, influences condensate mobility, & promotes degradation via autophagy, specifically through autophagosome expansion"; Spermine improves #Parkinsons C.elegans model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 23, 2025 at 11:57 AM
"Acting as a molecular glue, spermine orchestrates in vivo condensation of α-synuclein, influences condensate mobility, & promotes degradation via autophagy, specifically through autophagosome expansion"; Spermine improves #Parkinsons C.elegans model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Intermittent hypercapnia (low levels of CO2 in ON-OFF cycles, 3x 10-minute sessions = ~30 min),⬆️the total α-syn, neurofilament light, GFAP, amyloid β1-42, amyloid β1-40, & phosphorylated tau 217 in the plasma of both controls & people with #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 23, 2025 at 11:53 AM
Intermittent hypercapnia (low levels of CO2 in ON-OFF cycles, 3x 10-minute sessions = ~30 min),⬆️the total α-syn, neurofilament light, GFAP, amyloid β1-42, amyloid β1-40, & phosphorylated tau 217 in the plasma of both controls & people with #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Researchers reveal a distinct role for #Parkinsons associated protein DJ-1 in regulating intercellular communication under oxidative stress, highlighting a novel extracellular vesicles-mediated function of DJ-1 that may contribute to PD pathogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 23, 2025 at 11:47 AM
Researchers reveal a distinct role for #Parkinsons associated protein DJ-1 in regulating intercellular communication under oxidative stress, highlighting a novel extracellular vesicles-mediated function of DJ-1 that may contribute to PD pathogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New clinical trial registered: A real-world study of Produodopa (Foslevodopa/Foscarbidopa) from AbbVie has been initiated to assess quality of life outcomes in 100 people with advanced #Parkinsons (the PUCCINI study)
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
ClinicalTrials.gov
clinicaltrials.gov
November 23, 2025 at 11:41 AM
New clinical trial registered: A real-world study of Produodopa (Foslevodopa/Foscarbidopa) from AbbVie has been initiated to assess quality of life outcomes in 100 people with advanced #Parkinsons (the PUCCINI study)
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
A 12-month, multicenter, randomized, open-label phase 2 trial in sub-Saharan Africa investigated Mucuna pruriens monotherapy in 32 untreated #Parkinsons patients. Results show improved quality of life, motor & non-motor symptoms. A cost effective answer?
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
November 22, 2025 at 11:08 PM
A 12-month, multicenter, randomized, open-label phase 2 trial in sub-Saharan Africa investigated Mucuna pruriens monotherapy in 32 untreated #Parkinsons patients. Results show improved quality of life, motor & non-motor symptoms. A cost effective answer?
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
I love the name of this study: BUTTER
This was an open-label target engagement study of dietary tributyrin (500 mg taken orally 3x daily) in 14 people with #Parkinsons for 30 days; Interesting results, novel [11C]butyrate PET ligand used
www.neurotherapeuticsjournal.org/article/S187...
This was an open-label target engagement study of dietary tributyrin (500 mg taken orally 3x daily) in 14 people with #Parkinsons for 30 days; Interesting results, novel [11C]butyrate PET ligand used
www.neurotherapeuticsjournal.org/article/S187...
November 22, 2025 at 11:02 PM
I love the name of this study: BUTTER
This was an open-label target engagement study of dietary tributyrin (500 mg taken orally 3x daily) in 14 people with #Parkinsons for 30 days; Interesting results, novel [11C]butyrate PET ligand used
www.neurotherapeuticsjournal.org/article/S187...
This was an open-label target engagement study of dietary tributyrin (500 mg taken orally 3x daily) in 14 people with #Parkinsons for 30 days; Interesting results, novel [11C]butyrate PET ligand used
www.neurotherapeuticsjournal.org/article/S187...
For those who missed the Autumn Research Update meeting from @cureparkinsons.org.uk, the video recordings of the presentations are now available online - the event focused on platform trials for #Parkinsons & our updated Research Strategy
cureparkinsons.org.uk/2025/10/autu...
cureparkinsons.org.uk/2025/10/autu...
Autumn Research Update Meeting 2025: watch again - Cure Parkinson's
Our 2025 Autumn Research Update Meeting took place at The Royal Society of Medicine (RSM), Wimpole Street, London, on Monday 10 November, where we invited
cureparkinsons.org.uk
November 21, 2025 at 10:12 AM
For those who missed the Autumn Research Update meeting from @cureparkinsons.org.uk, the video recordings of the presentations are now available online - the event focused on platform trials for #Parkinsons & our updated Research Strategy
cureparkinsons.org.uk/2025/10/autu...
cureparkinsons.org.uk/2025/10/autu...
Downregulation of Macrophage migration inhibitory factor (MIF) attenuates neuroinflammation - via TLR4/MyD88/TRAF6/NF-κB pathway - resulting in neuroprotection of dopaminergic neurons in a model of #Parkinsons (MPTP mouse)
www.nature.com/articles/s42...
www.nature.com/articles/s42...
November 21, 2025 at 10:09 AM
Downregulation of Macrophage migration inhibitory factor (MIF) attenuates neuroinflammation - via TLR4/MyD88/TRAF6/NF-κB pathway - resulting in neuroprotection of dopaminergic neurons in a model of #Parkinsons (MPTP mouse)
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Researchers conduct a brain imaging-based metabolic time series comparison, & reveal hypometabolism in bilateral clusters in the substantia nigra in #Parkinsons patients (vs controls)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 21, 2025 at 10:03 AM
Researchers conduct a brain imaging-based metabolic time series comparison, & reveal hypometabolism in bilateral clusters in the substantia nigra in #Parkinsons patients (vs controls)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new multi-ethnic Asian #Parkinsons cohort study provides epidemiology & clinical insights, particularly around the distribution of LRRK2 Asian variants - suggesting they influence onset age, familial occurrence, non-motor features, & disease course
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 21, 2025 at 9:56 AM
A new multi-ethnic Asian #Parkinsons cohort study provides epidemiology & clinical insights, particularly around the distribution of LRRK2 Asian variants - suggesting they influence onset age, familial occurrence, non-motor features, & disease course
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New study using semi-structured interviews & focus groups "highlights the complex relationship between public understanding, perceptions, & the quality of life for individuals with PD, as viewed through the lens of #Parkinsons disease nurse specialists"
bmcgeriatr.biomedcentral.com/articles/10....
bmcgeriatr.biomedcentral.com/articles/10....
‘Breaking the stigma’: a qualitative study on how public perceptions affect individuals with Parkinson’s disease – a nurse specialist perspective - BMC Geriatrics
Background Parkinson’s disease (PD) is a chronic neurological disorder that affects around 24,000 people in Ireland. Despite being relatively common, awareness and understanding of the condition remai...
bmcgeriatr.biomedcentral.com
November 21, 2025 at 9:51 AM
New study using semi-structured interviews & focus groups "highlights the complex relationship between public understanding, perceptions, & the quality of life for individuals with PD, as viewed through the lens of #Parkinsons disease nurse specialists"
bmcgeriatr.biomedcentral.com/articles/10....
bmcgeriatr.biomedcentral.com/articles/10....
New paper from @malutansey.bsky.social et al reports that #Parkinsons -linked LRRK2 & GBA1 variants converge on peripheral blood immune cell dysregulation; LRRK2 inhibitors & GCase activators modulate ex vivo response to bacterial exposure
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
November 21, 2025 at 9:42 AM
New paper from @malutansey.bsky.social et al reports that #Parkinsons -linked LRRK2 & GBA1 variants converge on peripheral blood immune cell dysregulation; LRRK2 inhibitors & GCase activators modulate ex vivo response to bacterial exposure
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New paper presents previously uncharacterized genomic dynamics in 18 cells from three human brains utilizing single cell long-read whole genome sequencing, highlighting CNS specific activity of transposable elements
www.nature.com/articles/s42...
www.nature.com/articles/s42...
November 21, 2025 at 9:31 AM
New paper presents previously uncharacterized genomic dynamics in 18 cells from three human brains utilizing single cell long-read whole genome sequencing, highlighting CNS specific activity of transposable elements
www.nature.com/articles/s42...
www.nature.com/articles/s42...
New research points to a convergent mechanism of PINK1–Parkin activation by mitochondrial damage: Loss of mitochondrial membrane potential stalls PINK1 import during its transfer from translocase of the outer membrane (TOM) to the inner membrane (TIM23)
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 21, 2025 at 9:23 AM
New research points to a convergent mechanism of PINK1–Parkin activation by mitochondrial damage: Loss of mitochondrial membrane potential stalls PINK1 import during its transfer from translocase of the outer membrane (TOM) to the inner membrane (TIM23)
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Researchers report low dose GLP-1R agonist treatment for 30 weeks in♂️mice at 11 months of age (mid-life) results in body-wide multi-omic age-counteracting effects & improved certain physical functions; Effects were specific to aged mice, not young adults
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 21, 2025 at 9:13 AM
Researchers report low dose GLP-1R agonist treatment for 30 weeks in♂️mice at 11 months of age (mid-life) results in body-wide multi-omic age-counteracting effects & improved certain physical functions; Effects were specific to aged mice, not young adults
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A new review "places α-synuclein at the nexus of mechanistic synergy between #Parkinsons & depression, & incorporates secondary analyses of genomic & transcriptomic datasets to identify convergent genes & pathways"; Potential biomarker?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 20, 2025 at 11:51 PM
A new review "places α-synuclein at the nexus of mechanistic synergy between #Parkinsons & depression, & incorporates secondary analyses of genomic & transcriptomic datasets to identify convergent genes & pathways"; Potential biomarker?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New research reports that synphilin-1 modulates alpha synuclein assembly, release & uptake - highlighting the importance of Sph1 & other aSyn-interacting proteins in synucleinopathies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 20, 2025 at 11:48 PM
New research reports that synphilin-1 modulates alpha synuclein assembly, release & uptake - highlighting the importance of Sph1 & other aSyn-interacting proteins in synucleinopathies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New preclinical data provides support for chimeric antigen receptor (CAR)-engineered astrocytes in the context of #Parkinsons; Therapeutic potential demonstrated in A53T PD transgenic mice
translationalneurodegeneration.biomedcentral.com/articles/10....
translationalneurodegeneration.biomedcentral.com/articles/10....
November 20, 2025 at 11:43 PM
New preclinical data provides support for chimeric antigen receptor (CAR)-engineered astrocytes in the context of #Parkinsons; Therapeutic potential demonstrated in A53T PD transgenic mice
translationalneurodegeneration.biomedcentral.com/articles/10....
translationalneurodegeneration.biomedcentral.com/articles/10....
New research suggest that the nucleus basalis of Meynert white matter pathways could serve as non-invasive biomarkers indicating risk for clinical conversion & cortical pathology in iRBD & #Parkinsons, both baseline & longitudinal cognitive function
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
November 20, 2025 at 11:36 PM
New research suggest that the nucleus basalis of Meynert white matter pathways could serve as non-invasive biomarkers indicating risk for clinical conversion & cortical pathology in iRBD & #Parkinsons, both baseline & longitudinal cognitive function
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Researchers present preclinical data for a novel non-antibiotic tetracycline derivative called DDOX (4-dedimethylamino 12a-deoxydoxycycline) in models of #Parkinsons; The agent suppresses microglial and astrocytic reactivity & is neuroprotective
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The Small Molecule DDOX Confers Neuroprotection and Alleviates Motor Deficits in a Preclinical Rat Model of Parkinson’s Disease - Neurotoxicity Research
Tetracycline-derived compounds with anti-inflammatory properties have demonstrated neuroprotective potential in preclinical models of Parkinson’s disease. In this study, we investigated the efficacy o...
link.springer.com
November 20, 2025 at 11:32 PM
Researchers present preclinical data for a novel non-antibiotic tetracycline derivative called DDOX (4-dedimethylamino 12a-deoxydoxycycline) in models of #Parkinsons; The agent suppresses microglial and astrocytic reactivity & is neuroprotective
link.springer.com/article/10.1...
link.springer.com/article/10.1...