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Science X / Phys.org
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Science X provides daily science news on research developments, technological breakthroughs and the latest science innovations.
Phys. org: https://phys.org/
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Defective variants of the ASTN1 gene have been linked to a broad spectrum of neurodevelopmental disorders in children, providing new diagnostic insights for previously undiagnosed cases. doi.org/hbn58p
From bench to bedside—research in mice leads to answers for undiagnosed human neurodevelopmental conditions
Nearly 30 years ago, researchers began studying the gene Astn1, which encodes the cell adhesion protein astrotactin 1 in mice, and its role in brain development.
medicalxpress.com
February 10, 2026 at 10:20 PM
A 45-year climate model ensemble using water isotopes offers improved accuracy in tracing global water movement and enhances understanding of weather patterns linked to climate change. doi.org/hbn58n
Where did that raindrop come from? Climate model ensemble captures worldwide water isotopes over 45 years
Water is made of hydrogen and oxygen, and sometimes these atoms are slightly heavier than usual. These heavier forms are called isotopes.
phys.org
February 10, 2026 at 10:20 PM
Detection of virus-specific T cells in blood may help predict which PML patients are more likely to benefit from immune checkpoint inhibitor therapy and experience improved outcomes. doi.org/hbn58m
Virus-specific T cells may predict immunotherapy success for a rare brain infection
Progressive multifocal leukoencephalopathy (PML) is a rare but serious brain infection. It gradually destroys brain tissue and often leads to death within a few weeks.
medicalxpress.com
February 10, 2026 at 10:16 PM
Early clinical trial data suggest that adding high-dose niacin to standard glioblastoma treatment may improve progression-free survival, though careful monitoring for toxicity is essential. doi.org/hbn58k
Investigating the use of a common vitamin to treat the aggressive brain cancer glioblastoma
Edward (Ed) Waldner had no idea why he didn't feel well, but he knew he didn't feel like himself. At 55 years of age, he felt exhausted all the time.
medicalxpress.com
February 10, 2026 at 10:13 PM
Naming systems worldwide balance the need to identify individuals with cognitive limits, leading to diverse first names in the West and fixed, low-information first names in East Asia. doi.org/hbn58j
What's in a name? Information structure parallels discovered across cultures—with repercussions for Asian names
First names in Western countries today are more diverse than they were before early modern states evolved. This difference started to emerge in the 17th century in response to a change that took place in the naming system in large parts of Europe and the English-speaking world.
phys.org
February 10, 2026 at 10:10 PM
Acoustic communication has played a significant role in the evolution of boxfishes, highlighting how sound production can drive evolutionary changes in fish beyond visual signals.
Acoustic communication—an overlooked driver in boxfish evolution
A new international study reveals the unexpected importance of acoustic communication in the evolution of boxfishes. This discovery offers new perspectives on the role of acoustic communication in the evolutionary history of numerous fish groups.
phys.org
February 10, 2026 at 10:06 PM
Polarized-light imaging of unstained skin biopsies can distinguish between classical and hypermobile Ehlers–Danlos syndromes by detecting differences in collagen structure.
Polarized-light imaging shows potential for distinguishing Ehlers–Danlos subtypes
Ehlers–Danlos syndromes (EDS) are inherited conditions that affect the body's connective tissue, which provides strength and support to the skin, joints, and blood vessels.
medicalxpress.com
February 10, 2026 at 10:00 PM
Epigenetic changes driven by the KLF5 gene promote growth and spread in metastatic pancreatic cancer cells, highlighting potential new targets for therapy beyond genetic mutations. doi.org/hbn58h
Growth of spreading pancreatic cancer is fueled by 'underappreciated' epigenetic changes, shows study
In a lab-grown cell study focused on potential new treatment targets for halting the spread of most pancreatic cancers, Johns Hopkins Medicine scientists report they have found that a gene called KLF5 (Krueppel-like factor 5) fuels the growth of such spreading tumors, not by acquiring abnormal changes in the cancer cells' DNA code itself, but by altering chemical changes and organization of DNA, or epigenetics, that turns genes on and off.
medicalxpress.com
February 10, 2026 at 10:00 PM
Chronic inflammation alters macrophages, trapping them in hybrid states that sustain inflammation but hinder tissue repair, providing new insight into immune dysfunction in various diseases. doi.org/hbn58g
How chronic inflammation traps white blood cells in hybrid states and blocks healing
Researchers at the University of North Carolina at Chapel Hill have uncovered how chronic inflammation disrupts the immune system's ability to heal the body, offering new insight into diseases associated with inflammation such as cancer, diabetes, heart disease, and neurological disorders.
medicalxpress.com
February 10, 2026 at 9:58 PM
A new dataset reconstructs the U.S. Code from 1926 to 2023, highlighting how federal law has expanded, reorganized, and become more interconnected over the past century. doi.org/hbn58f
New dataset reveals how US law has grown more complex over the past century
A century ago, the section of U.S. federal law governing public health and welfare was relatively small and loosely connected to the rest of the legal system.
phys.org
February 10, 2026 at 9:54 PM
Targeted partial reprogramming of memory-related neurons in mice restores learning and memory performance, suggesting potential strategies for addressing age-related cognitive decline. doi.org/hbn58d
Rejuvenating neurons restores learning and memory in mice
Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible. But the brain is not static; neurons continually adjust the strength of their connections, a property called "synaptic plasticity," and this flexibility is the basis of memory and learning.
medicalxpress.com
February 10, 2026 at 9:54 PM
An mRNA-based therapy instructing skin cells to produce telomerase reverse transcriptase shows potential to reduce radiation-induced DNA damage during cancer treatment. doi.org/hbn58c
mRNA therapy could protect patients from radiation-induced skin damage caused by cancer treatment
Radiation therapy is highly effective at killing cancer cells, but it often harms healthy skin around the treatment area, a common side effect experienced by up to 95% of cancer patients undergoing treatment.
medicalxpress.com
February 10, 2026 at 9:51 PM
Neural crest cells use electrical activity and contractile forces, regulated by endothelin 3, to migrate through embryonic tissues, with disruptions linked to conditions such as Hirschsprung disease.
Neural crest cells: Miniature electric muscles that colonize embryonic organs
Neural crest cells are a population of stem cells that invade the embryo in early development. They play a big role in what you look like: the pigments of your eyes, of your skin, and the bone structure of your face are all neural crests.
phys.org
February 10, 2026 at 9:40 PM
During food shortages, stress hormones shift the immune system into an energy-saving mode, prioritizing rapid-response cells and preserving long-term immunity while conserving glucose. doi.org/hbn58b
How food shortages reprogram the immune system's response to infection
When food is scarce, stress hormones direct the immune system to operate in "low power" mode to preserve immune function while conserving energy, according to researchers at Weill Cornell Medicine.
medicalxpress.com
February 10, 2026 at 9:40 PM
Adult survivors of childhood cancer, especially those treated with certain chemotherapies or cranial radiation, face an increased long-term risk of developing meningiomas. Lifelong monitoring is recommended. doi.org/hbn579
Adult survivors of childhood cancer may be at higher risk for meningiomas
Certain chemotherapies are associated with an increased long-term risk of subsequent tumors in survivors of childhood cancer, according to a study led by researchers at UT Southwestern Medical Center.
medicalxpress.com
February 10, 2026 at 9:38 PM
A reimagined nickel-iron battery design demonstrates rapid recharging and long cycle life, offering potential for efficient, durable energy storage in applications like solar power and backup systems. doi.org/hbn578
A forgotten battery design from Thomas Edison—how scientists helped reimagine it
A little-known fact: In the year 1900, electric cars outnumbered gas-powered ones on the American road. The lead-acid auto battery of the time, courtesy of Thomas Edison, was expensive and had a range of only about 30 miles.
techxplore.com
February 10, 2026 at 9:31 PM
3D-printed brain models that closely mimic real tissue properties are advancing medical training and research, offering new opportunities for personalized treatment planning and device testing. doi.org/hbn577
3D-printed brain models could improve medical research and training
University of Missouri researchers are developing new ways to better simulate the complex nature of human brain tissue.
medicalxpress.com
February 10, 2026 at 9:30 PM
An oral combination of cabozantinib and temozolomide may help slow disease progression in advanced leiomyosarcoma, with most patients showing progression-free survival at 12 weeks. doi.org/hbn576
Combination treatment may slow disease progression in advanced sarcoma
An oral combination treatment may prevent the progression of advanced leiomyosarcoma, one of the most common subtypes of soft tissue sarcoma, according to a recent study published in The Lancet Oncology.
medicalxpress.com
February 10, 2026 at 9:28 PM
Analysis of high-redshift galaxies observed with JWST suggests some may be nearly as old as the universe at that epoch, presenting a significant challenge to current cosmological models.
Old galaxies in a young universe?
The standard cosmological model (present-day version of "Big Bang," called Lambda-CDM) gives an age of the universe close to 13.8 billion years and much younger when we explore the universe at high-redshift.
phys.org
February 10, 2026 at 9:20 PM
New insights into GaN transistor design enable higher threshold voltages and reduced leakage, supporting safer and more reliable power devices for electric vehicles and data centers. doi.org/hbn575
Redefining GaN power devices for adoption in EVs and data centers
Researchers at the Indian Institute of Science (IISc) have uncovered fundamental insights into designing gallium nitride (GaN) power transistors, making them safer and easier to utilize in high-value electronics such as electric vehicles and data centers.
techxplore.com
February 10, 2026 at 9:20 PM
Distinct molecular subtypes of mismatch repair deficient high-grade gliomas have been identified, enabling more precise immunotherapy approaches and informing future targeted treatment strategies. doi.org/hbn574
Discovery of unique brain tumor subtypes offers hope for targeted glioma therapies
Researchers have uncovered the mechanisms behind three unique subtypes of mismatch repair deficient high-grade gliomas.
medicalxpress.com
February 10, 2026 at 9:20 PM
The severity of sickle cell disease may be driven by a small population of highly stiff red blood cells, which disrupt blood flow and contribute to varying symptoms among patients. doi.org/hbn573
'Stiff' cells provide new explanation for differing symptoms in sickle cell patients
A new breakthrough study led by researchers at the University of Minnesota Twin Cities could explain why patients with the same genetic sickle cell mutation experience different levels of pain, organ damage, and response to treatment.
medicalxpress.com
February 10, 2026 at 9:19 PM
Inherited mutations in the VSIG10L gene have been linked to increased risk of Barrett's esophagus, providing new opportunities for early screening and prevention of esophageal cancer. doi.org/hbn572
Genetic link to Barrett's esophagus discovered, offering new hope for esophageal cancer patients
Case Western Reserve University researchers have made a significant breakthrough in understanding Barrett's esophagus, a precancerous condition that dramatically increases the risk of developing esophageal adenocarcinoma, one of the fastest-spreading and deadliest forms of cancer.
medicalxpress.com
February 10, 2026 at 9:18 PM
A deep learning model now accurately detects bacterial contamination in food within three hours by distinguishing bacteria from microscopic food debris, streamlining food safety testing. doi.org/hbn57x
Deep learning detects foodborne bacteria within three hours by eliminating debris misclassifications
Researchers have significantly enhanced an artificial intelligence tool used to rapidly detect bacterial contamination in food by eliminating misclassifications of food debris that looks like bacteria.
phys.org
February 10, 2026 at 9:17 PM
A compact device integrates nanomaterials and thermoelectric technology to convert sunlight and waste heat into hydrogen at 28% efficiency, while also purifying polluted water. doi.org/hbn57w
Compact device turns sunlight and waste heat into hydrogen at 28% efficiency
Hydrogen is widely regarded as one of the cleanest fuels for the future, producing only water when used. However, generating hydrogen efficiently and sustainably remains a major challenge.
techxplore.com
February 10, 2026 at 9:12 PM