Suresh Muthukumaraswamy
@sdmuthu.bsky.social
Researcher at University of Auckland.
Ivory tower inhabitant.
Views are mine.
https://scholar.google.co.uk/citations?user=VU4GTNsAAAAJ&hl=en&oi=ao
Ivory tower inhabitant.
Views are mine.
https://scholar.google.co.uk/citations?user=VU4GTNsAAAAJ&hl=en&oi=ao
Reposted by Suresh Muthukumaraswamy
Great work for psychedelic research to overcome RCT-based epistemic authoritarianism, led by @sdmuthu.bsky.social and @tehseennoorani.bsky.social 👏👏👏.
Thankful for the invite to to collaborate, together with @trpwolff.bsky.social, @mattbagg.bsky.social and others.
osf.io/preprints/ps... 🧪🧠💊
Thankful for the invite to to collaborate, together with @trpwolff.bsky.social, @mattbagg.bsky.social and others.
osf.io/preprints/ps... 🧪🧠💊
February 19, 2025 at 2:21 PM
Great work for psychedelic research to overcome RCT-based epistemic authoritarianism, led by @sdmuthu.bsky.social and @tehseennoorani.bsky.social 👏👏👏.
Thankful for the invite to to collaborate, together with @trpwolff.bsky.social, @mattbagg.bsky.social and others.
osf.io/preprints/ps... 🧪🧠💊
Thankful for the invite to to collaborate, together with @trpwolff.bsky.social, @mattbagg.bsky.social and others.
osf.io/preprints/ps... 🧪🧠💊
Yet another pointless (scientifically speaking) study of psychedelics. With no placebo response the design is clearly a mess. I guess you can juice your stock price but you’ll never see this get published …
and if you don’t publish your participant information sheets then don’t bother ….
and if you don’t publish your participant information sheets then don’t bother ….
Shares in GH Research ( $GHRS ) surged today as the company announced positive results from a Phase 2b study of its inhaled 5-MeO-DMT candidate for treatment-resistant depression.
Here's a summary (image).
And more: psychedelicalpha.com/news/gh-rese...
Here's a summary (image).
And more: psychedelicalpha.com/news/gh-rese...
February 3, 2025 at 8:04 PM
Yet another pointless (scientifically speaking) study of psychedelics. With no placebo response the design is clearly a mess. I guess you can juice your stock price but you’ll never see this get published …
and if you don’t publish your participant information sheets then don’t bother ….
and if you don’t publish your participant information sheets then don’t bother ….
Please god. No more systematic reviews of psychedelics .... (at least for a while 😅)
December 16, 2024 at 8:08 PM
Please god. No more systematic reviews of psychedelics .... (at least for a while 😅)
Fair enough. You’ll note that I wrote that “as a clinical trialist” I wasn’t sorry to see it go. “As a consumer” you are right I am worse off now. We all have many hats we can don ….
December 12, 2024 at 5:23 AM
Fair enough. You’ll note that I wrote that “as a clinical trialist” I wasn’t sorry to see it go. “As a consumer” you are right I am worse off now. We all have many hats we can don ….
I did but nothing changed in my area so I gave up. Also I had deep concern that the loads more regulation it would have introduced is only as useful as the funding that is put into the regulatory system itself… case in point is the the current slashing of the public service.
December 12, 2024 at 4:53 AM
I did but nothing changed in my area so I gave up. Also I had deep concern that the loads more regulation it would have introduced is only as useful as the funding that is put into the regulatory system itself… case in point is the the current slashing of the public service.
This won’t be a popular view on the left but as a clinical trialist I am not sad to see the TPA go.
The current clinical trial system works pretty well actually but the TPA had lots of uncertainty/undefined things in it - definitions that could have been really bad….
The current clinical trial system works pretty well actually but the TPA had lots of uncertainty/undefined things in it - definitions that could have been really bad….
I’m particularly salty about the repeal of the Therapeutic Products Act going through all stages under urgency today.
My relative who sells magic oxygenated water that cures cancer* and protects against COVID* because vaccines are evil^ is delighted, however.
* it doesn’t x2
^ they are not
#nzpol
My relative who sells magic oxygenated water that cures cancer* and protects against COVID* because vaccines are evil^ is delighted, however.
* it doesn’t x2
^ they are not
#nzpol
December 12, 2024 at 4:42 AM
This won’t be a popular view on the left but as a clinical trialist I am not sad to see the TPA go.
The current clinical trial system works pretty well actually but the TPA had lots of uncertainty/undefined things in it - definitions that could have been really bad….
The current clinical trial system works pretty well actually but the TPA had lots of uncertainty/undefined things in it - definitions that could have been really bad….
I’m extremely curious to see more details on this one …
December 12, 2024 at 12:26 AM
I’m extremely curious to see more details on this one …
Always exciting to receive the investigational product for a new clinical trial. First time I’ve had one go through a ceremonial blessing process (karakia and waiata) though … (see below for details).
Seen Māori protests/haka on social media?
Seen panels complaining of indigenous exclusion in psychedelic science?
Check out our new pre-print:
“Tū Wairua: Development of an Indigenous Rongoā Māori Approach to Healing with Psilocybin Containing Mushrooms”
osf.io/preprints/ps...
Seen panels complaining of indigenous exclusion in psychedelic science?
Check out our new pre-print:
“Tū Wairua: Development of an Indigenous Rongoā Māori Approach to Healing with Psilocybin Containing Mushrooms”
osf.io/preprints/ps...
OSF
osf.io
December 12, 2024 at 12:24 AM
Always exciting to receive the investigational product for a new clinical trial. First time I’ve had one go through a ceremonial blessing process (karakia and waiata) though … (see below for details).
We’ve done this is humans. Paper in submission …
Good morning #ACNP2024! Had enough neuroscience yet? Time to learn a little cardiology (as performed by neuroscientist. @Devineffinger.Bsky.social). Specifically, does chronic microdosing of LSD pose a cardiovascular risk by chronically activating 5HT2B receptors? Find out at poster W234 today!!
December 12, 2024 at 12:20 AM
We’ve done this is humans. Paper in submission …
Reposted by Suresh Muthukumaraswamy
Interesting new study on "personality" change due to psilocybin administration. Lots in here, but just focusing on one element, they found that psilocybin in the lab reduced neuroticism, but not any other aspect of the Big 5. www.sciencedirect.com/science/arti... #psychedelicscience
An investigation of acute Physiological and Psychological Moderators of Psychedelic-induced Personality Change among Healthy Volunteers
This study investigated the effects of a single high-dose of psilocybin on personality traits in psychedelic-naïve healthy volunteers. These data orig…
www.sciencedirect.com
December 5, 2024 at 2:54 PM
Interesting new study on "personality" change due to psilocybin administration. Lots in here, but just focusing on one element, they found that psilocybin in the lab reduced neuroticism, but not any other aspect of the Big 5. www.sciencedirect.com/science/arti... #psychedelicscience
There is that. The administrative overhead of doing lab /compliance paperwork across 20 sites would be a pain in the balls. I barely have the patience to do it for a single site 😂.
December 5, 2024 at 6:13 PM
There is that. The administrative overhead of doing lab /compliance paperwork across 20 sites would be a pain in the balls. I barely have the patience to do it for a single site 😂.
Yeh this struck me as weird as well and I think is intentional and perhaps reflects a negativity bias.
Also hallucinogen is a bit of a weird one. More often than not they are “Pseudo-hallucinogens” as it’s much rarer for the person to actually believe the “hallucinations” are actually real …
Also hallucinogen is a bit of a weird one. More often than not they are “Pseudo-hallucinogens” as it’s much rarer for the person to actually believe the “hallucinations” are actually real …
December 5, 2024 at 6:10 PM
Yeh this struck me as weird as well and I think is intentional and perhaps reflects a negativity bias.
Also hallucinogen is a bit of a weird one. More often than not they are “Pseudo-hallucinogens” as it’s much rarer for the person to actually believe the “hallucinations” are actually real …
Also hallucinogen is a bit of a weird one. More often than not they are “Pseudo-hallucinogens” as it’s much rarer for the person to actually believe the “hallucinations” are actually real …
Difficult to believe it was costs. I know stuff is expensive in the States but a blood panel here (CNC/LFT/Renal/Thyroid) costs me less than the equivalent of $100 US pp. Scales (DEQ) etc basically free.
December 5, 2024 at 6:01 PM
Difficult to believe it was costs. I know stuff is expensive in the States but a blood panel here (CNC/LFT/Renal/Thyroid) costs me less than the equivalent of $100 US pp. Scales (DEQ) etc basically free.
Following in the footsteps of lanicemine (AZD6765) and memantine (and PCN-101) as it were ….
December 4, 2024 at 7:18 PM
Following in the footsteps of lanicemine (AZD6765) and memantine (and PCN-101) as it were ….
Can you elaborate? 🙏
December 4, 2024 at 5:44 PM
Can you elaborate? 🙏
Reposted by Suresh Muthukumaraswamy
My full comments on the cuts to the Marsden Fund of the @royalsocietynz.bsky.social are now up here:
Govt cuts humanities and social science funding - Expert Reaction
Humanities and social science funding has been cut from the Marsden Fund, the main fund for 'blue-skies' research in Aotearoa New Zealand.
The areas that have been cut include research in subjects lik...
www.sciencemediacentre.co.nz
December 4, 2024 at 4:24 AM
My full comments on the cuts to the Marsden Fund of the @royalsocietynz.bsky.social are now up here:
Complexity in MEG/EEG. My prediction is that a good number of results are not actually showing changes in brain “complexity” but reflect spectral power changes - failing to use surrogate data properly.
Some bright PhD/PostDoc should do this. Will make a great paper. I’m too time poor else I would…
Some bright PhD/PostDoc should do this. Will make a great paper. I’m too time poor else I would…
December 3, 2024 at 5:12 PM
Complexity in MEG/EEG. My prediction is that a good number of results are not actually showing changes in brain “complexity” but reflect spectral power changes - failing to use surrogate data properly.
Some bright PhD/PostDoc should do this. Will make a great paper. I’m too time poor else I would…
Some bright PhD/PostDoc should do this. Will make a great paper. I’m too time poor else I would…
I’m not a sociologist but was introduced to this fabulous paper - Becker (1953) “Becoming a marihuana user”.
Sometimes the archives of academia are amazing!
www.jstor.org/stable/2771989
Sometimes the archives of academia are amazing!
www.jstor.org/stable/2771989
Becoming a Marihuana User on JSTOR
Howard S. Becker, Becoming a Marihuana User, American Journal of Sociology, Vol. 59, No. 3 (Nov., 1953), pp. 235-242
www.jstor.org
December 3, 2024 at 8:17 AM
I’m not a sociologist but was introduced to this fabulous paper - Becker (1953) “Becoming a marihuana user”.
Sometimes the archives of academia are amazing!
www.jstor.org/stable/2771989
Sometimes the archives of academia are amazing!
www.jstor.org/stable/2771989
Yes that is interesting. A lot to think about there.
November 30, 2024 at 9:33 AM
Yes that is interesting. A lot to think about there.
Honestly I’m still grappling/learning about this type of research. I’m just interested to find out more and muse.
November 30, 2024 at 9:32 AM
Honestly I’m still grappling/learning about this type of research. I’m just interested to find out more and muse.
I would be concerned that since the trials can’t be blinded that the estimands can’t uniquely identify treatment effects from placebo/expectancy effects.
The same theoretical issue applies to psychopharmacology and psychotherapy trials but the latter seems to get a pass. I don’t understand why.
The same theoretical issue applies to psychopharmacology and psychotherapy trials but the latter seems to get a pass. I don’t understand why.
November 30, 2024 at 8:25 AM
I would be concerned that since the trials can’t be blinded that the estimands can’t uniquely identify treatment effects from placebo/expectancy effects.
The same theoretical issue applies to psychopharmacology and psychotherapy trials but the latter seems to get a pass. I don’t understand why.
The same theoretical issue applies to psychopharmacology and psychotherapy trials but the latter seems to get a pass. I don’t understand why.
Awesome thanks -- will read :D
November 30, 2024 at 6:02 AM
Awesome thanks -- will read :D
Ok fair. I'm curious Do people ever try to do the equivalent of a dose/exposure response study as we do in pharmacology ? For example, in this case you could time limit App time in this case.....
November 30, 2024 at 5:55 AM
Ok fair. I'm curious Do people ever try to do the equivalent of a dose/exposure response study as we do in pharmacology ? For example, in this case you could time limit App time in this case.....