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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · 6d

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs

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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · 6d

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a PEPR-funded project! (2.5y)

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs

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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · 25d

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social @rechercheulille.bsky.social @inserm.fr

Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · 25d

The Plague & Yersinia pestis team @pasteurlille.bsky.social , led by F Sebbane, shared their latest research at the Yersinia 15th Symposium in Ulaanbaatar! A Baillez presented his thesis work, A Dewitte and @sebbontempsgallo.bsky.social showcased their recent findings.
@rolandelliagus.bsky.social

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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · 26d

First day of the 15th International #Yersinia symposium in Ulaanbaatar, Mongolia

Reposted by Sébastien Bontemps-Gallo, Ph.D.

Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · Sep 2

🎓 Funded PhD position available in the team of M. Pichavant & P. Gosset! Send your CV and a brief note on why you’re excited about this opportunity.

@cnrs-hautsdefrance.bsky.social @pasteurlille.bsky.social @univlille.bsky.social @inserm.fr @chulille.bsky.social

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · Aug 22

⚠️ Cas de peste détecté aux USA : peut-on encore mourir de cette maladie ? Le 19 août 2025 un cas a été confirmé en Californie

Dans un article @ouest-france.fr Dr Sebbane, Chef d'équipe @inserm.fr fait le point.

@pasteurlille.bsky.social @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social

Cas de peste détecté aux États-Unis : peut-on encore mourir de cette maladie ? | Ouest-France

[Ouest-France] Un cas de peste a été détecté en Californie, aux États-Unis, mardi 19 août. Pourrait-on voir réapparaître la bactérie responsable de la maladie en France, où la dernière infection connu...

sante.ouest-france.fr

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

STAR Protocols @cp-starprotocols.bsky.social · Aug 5

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel #protocol #starprotocols #cellpress

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel

Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adaptation and infection processes. Here, we present a protocol for the semi-quantitative assessment of the phosphorylation level of the transcriptional regulator CpxR during the infection process using Phos-tag gel. We describe steps for Dickeya dadantii infection of chicory leaves, followed by bacterial extraction, rapid acidic cell lysis, and subseque...

dlvr.it

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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · Aug 5

Just out in Nature Genetics @natureportfolio.nature.com !

Wu et al. analyzed 242 Yersinia pestis genomes, uncovering IS-driven rearrangements, which enhanced #phylogenetic resolution and resolved the third #pandemic’s polytomy, revealing adaptive changes in #virulence and #stress response.

Insights into Yersinia pestis evolution through rearrangement analysis of 242 complete genomes - Nature Genetics

Analysis of synteny blocks and genomic rearrangement patterns of 178 newly sequenced and 64 publicly available complete genomes of Yersinia pestis highlights the impact of key variations on genes invo...

www.nature.com

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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · Aug 2

This work was funded by the @cnrs.fr through MITI and the @agencerecherche.bsky.social

@pasteurlille.bsky.social @univlille.bsky.social @fst-ulille.bsky.social @inserm.fr @chulille.bsky.social

Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · Aug 2

New pub in STAR Protocols @cp-starprotocols.bsky.social to detect the phosphorylation level of response regulators of two-component systems during host infection using a Phos-tag approach.

By @ugsf-lille.bsky.social @ciilofficiel.bsky.social
@univlille.bsky.social @cnrs-hautsdefrance.bsky.social

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel

Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adapta…

www.sciencedirect.com

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Jul 30

[Resources]

#AlphaFold protein and PPI prediction databases

1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org

2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...

3️⃣ Human interactome prodata.swmed.edu/humanPPI

4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

Géraldine Laloux @lalouxlab.bsky.social · Jul 29

Bacterial cell wall & periplasm paradigm shift - important read #MicroSky

www.nature.com/articles/s41...

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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · Jul 21

#Climate extremes may reduce #Lymedisease risk?

Broughton et al. show Borrelia burgdorferi prevalence in Ixodes pacificus ticks declines under climate stress—challenging long-held assumptions about vector-borne disease and global warming.

#VectorBiology

Climate differentially impacts ticks infected and uninfected with Borrelia burgdorferi

Climate parameters show negative correlations with B. burgdorferi infection prevalence but low impact on uninfected tick density.

www.science.org

Reposted by Sébastien Bontemps-Gallo, Ph.D.

Mathieu Gissot @gissotlab.bsky.social · Jul 16

We will soon hire a postdoctoral fellow. Please contact me for more details.

Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · Jul 16

A project coordinated by Mathieu Gissot @gissotlab.bsky.social in collaboration with David Dauvillée @chlamyd0.bsky.social - @ugsf-lille.bsky.social , PSBToxo, has been selected by the #ANR
More info below👇

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social @pasteurlille.bsky.social @inserm.fr

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

Audrey Linkenheld @audreylinkenheld.bsky.social · Jul 9

#VSS
Merci @thiebaultceline.bsky.social de faire vivre la coalition féministe entre associations et parlementaires pour une loi cadre intégrale.

Les travaux avancent !
Pour les concrétiser il faudra évidemment aussi des moyens #PLF2026

@socialistesan.bsky.social @socialistes-senat.bsky.social

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

Yoann Santin @ysantin.bsky.social · Jul 7

You thought all OMPs were trimeric? 🧐 Not in our predator B. bacteriovorus! 🦠
Excited to have contributed to this great collab with the Lovering lab on this intriguing protein. @lalouxlab.bsky.social
👉 Paper here!
www.nature.com/articles/s41...

#BacterialPredation #Bdellovibrio #StructuralBiology

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications

This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...

www.nature.com

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · Jul 7

A new study delivers the most comprehensive phylogenomic analysis of Spirochaetes to date, revealing their deep evolutionary roots and shedding light on the loss of spiral morphology and host adaptation.
✍️ @microbiomol.bsky.social and coll. @pasteur.fr
📖 shorturl.at/UxAWu
#MicroSky

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

Brian Stevenson Ph.D. spirochete lab @bstevensonlab.bsky.social · Mar 14

Recently interviewed by Mark Martin for his “Matters Microbial” podcast!

m.youtube.com/watch?si=O6w...

Matters Microbial #31: Spirochetes do things...differently

Today, Dr. Brian Stevenson of the University of Kentucky College of Medicine joins the #QualityQuorum to discuss a twisty twirling form of life, spirochetes,...

m.youtube.com

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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · Jul 3

At long last, the genome of Xenopsylla cheopis — the infamous Oriental rat flea and historic vector of plague — has been sequenced and published!

A genomic treasure trove for vector biologists, evolutionary entomologists, and plague researchers alike.

#Genomics #Entomology #VectorBiology #NIH

An insight into the draft genome of the Oriental rat flea, Xenopsylla cheopis, together with its Wolbachia endosymbiont - BMC Genomics

Background The Oriental rat flea, Xenopsylla cheopis, is a main vector of plague caused by the bacterium Yersinia pestis. Transcriptomic analysis of this insect and the interaction between Yersinia an...

bmcgenomics.biomedcentral.com

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

Arnaud Machelart @arnaudmachelart.bsky.social · Jul 2

🚨 New review from our group!
PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases.
@ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social

www.sciencedirect.com/science/arti...

Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers

Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dC…

www.sciencedirect.com

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

Pierre Lê-Bury @pierrelebury.bsky.social · Jul 1

1/8 - New in @natcomms.nature.com !
☣️ Meet Yersinia enterocolitica (Ye) — a lesser-known but still dangerous cousin of Yersinia pestis.
We uncover how this invasive pathogen can survive and adapt for 14 years inside a human host under constant antibiotic pressure 👇
www.nature.com/articles/s41...

In-host evolution of Yersinia enterocolitica during a chronic human infection - Nature Communications

This study documents the evolution of antibiotic resistance and major growth defects in Yersinia enterocolitica in a patient over 14 years, revealing genetic changes that shed light on bacterial adapt...

www.nature.com

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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · Jul 1

Special thanks to Dr @brandonrobin.bsky.social !

The project was carried out at @ciilofficiel.bsky.social ( @cnrs-hautsdefrance.bsky.social @inserm.fr @pasteurlille.bsky.social @univlille.bsky.social ) with financial support from @agencerecherche.bsky.social and @erc.europa.eu

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Sébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · Jul 1

📢 Our latest article is out!
We present a cost-effective in-house #RNASeq workflow using @nanoporetech.com direct cDNA, perfect for high-risk pathogens.
Applied to #Yersinia pestis, transcriptomic profiling (21 °C/flea vs 37 °C/host) reveals novel operons & sulfur metabolism upregulation.

Exploring temperature-dependent transcriptomic adaptations in Yersinia pestis using direct cDNA sequencing by Oxford Nanopore Technologies - Scientific Reports

Scientific Reports - Exploring temperature-dependent transcriptomic adaptations in Yersinia pestis using direct cDNA sequencing by Oxford Nanopore Technologies

doi.org

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Reposted by Sébastien Bontemps-Gallo, Ph.D.

Institut Pasteur de Lille @pasteurlille.bsky.social · Jun 12

🔬 Maladie de #Lyme : à l'Institut Pasteur de Lille (@ciilofficiel.bsky.social) le Dr Bontemps-Gallo décrypte Borrelia burgdorferi, rôle des tiques, défis du diagnostic et impact de l’environnement. 🔎 Un regard captivant sur une zoonose discrète mais complexe ➡️ bit.ly/4kNtQF9

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