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Seb Walsh @sebwalsh.bsky.social · 16d

A privilege to represent the population health perspective, alongside Carol Brayne @cph.bsky.social , in this new @thelancet.com Series on #Alzheimer's disease. Expertly led by Giovanni Frisoni

Alzheimer's disease outlook: controversies and future directions www.thelancet.com/journals/lan...

Alzheimer's disease outlook: controversies and future directions

For the first time, reductions in cerebral β-amyloid pathology load and rate of cognitive and functional decline have been achieved in Alzheimer's disease, through pharmacological intervention in rand...

www.thelancet.com

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Seb Walsh @sebwalsh.bsky.social · 26d

Out of 800+ studies on blood-based biomarkers for Alzheimer's, not a single one measured actual changes in patient outcomes.

doi.org/10.1136/bmj-...

Evidence gap in blood biomarkers for Alzheimer’s disease

Willem van Gool and colleagues argue that moves to use blood biomarkers in clinical practice or population screening are inappropriate without evidence on outcomes important to patients and carers T...

doi.org

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Seb Walsh @sebwalsh.bsky.social · 29d

A key (too often ignored) aspect of Alzheimer's research is translation of findings between familial disease, specialist clinics, and general population. In this piece we identify key unanswered research questions and describe a framework for knowledge integration.

www.nature.com/articles/s41...

Key questions for the future of amyloid research in dementia: a framework for integrating complex datasets - Molecular Psychiatry

Molecular Psychiatry - Key questions for the future of amyloid research in dementia: a framework for integrating complex datasets

www.nature.com

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Seb Walsh @sebwalsh.bsky.social · Sep 8

Nice write-up of the RETREAT-FRAIL trial from @nejm.org paper by John Mandrola in the Sensible Medicine substack

www.sensible-med.com/p/evidence-t...

(Paper: www.nejm.org/doi/full/10....)

Evidence, The Elderly and Common Sense

A recent trial presented at the ESC meeting addresses the question of reducing blood pressure meds in the elderly. It’s an important study—for numerous reasons.

www.sensible-med.com

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Seb Walsh @sebwalsh.bsky.social · Sep 2

New paper with Janet Janbek using 🇩🇰 registry data to examine prevalence/co-occurrence of dementia risk factors. 82% of people >65 have multiple risk factors, speaking to the need for upstream public health action. More work soon from this collaboration!

www.sciencedirect.com/science/arti...

Prevalence and co-occurrence of dementia risk factors in Denmark: A nationwide study

The clustering of dementia risk factors is common and has implications for policies targeting risk reduction.To estimate the prevalence of 16 dementia…

www.sciencedirect.com

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Seb Walsh @sebwalsh.bsky.social · Aug 14

We assume that the built environment affects how active we are but solid evidence lacking.

Important paper from 🇺🇸 using📱data to show moving from less walkable neighbourhood to more, or vice versa, has meaningful effect on activity, sustained 3 months after moving

www.nature.com/articles/s41...

Countrywide natural experiment links built environment to physical activity - Nature

By analysing the smartphone data of 2,112,288 participants, in particular observing and comparing the activity of the same individual in two different environments, we find that increases in the walka...

www.nature.com

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Seb Walsh @sebwalsh.bsky.social · Jul 28

Interested? Take a read (it's open access) and get in touch.

Big thanks to co-authors, brought together under the
DEMON Network

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Seb Walsh @sebwalsh.bsky.social · Jul 28

The hope is that this provides a platform for people starting out in the dementia research field to make it easier to incorporate an SDOD lens, by knowing what evidence we do have and where the gaps are

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Seb Walsh @sebwalsh.bsky.social · Jul 28

...all evidence linking social determinants to dementia across 6 domains (education, food environment, housing, SES, physical environment, and social inclusion) identifying where there are reviews/meta-analyses, where there is only primary evidence, and where we have nothing

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Seb Walsh @sebwalsh.bsky.social · Jul 28

What evidence do we have on the Social Determinants of Dementia (SDOD)?

Delighted that this scoping review, a year or so in the making, is now published in @alzdemjournals.bsky.social. Expertly led by Anouk Geraets, we identified...

doi.org/10.1002/alz....

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Seb Walsh @sebwalsh.bsky.social · Jul 25

Making social sciences foundational to academic medicine - putting the 'social' into 'social determinants of health'.

dx.plos.org/10.1371/jour...

Making social sciences foundational to academic medicine

In this Perspective, Sahar Sadjadi and colleagues discuss the imperative for incorporating social sciences into medical research, education and implementation.

dx.plos.org

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Seb Walsh @sebwalsh.bsky.social · Jul 24

Adherence to four dietary indices and the risk of all‐cause and cause‐specific dementia: Findings from the UK Biobank study - Carrasco‐Marín - Diabetes, Obesity and Metabolism - Wiley Online Library dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

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dom-pubs.pericles-prod.literatumonline.com

Seb Walsh @sebwalsh.bsky.social · Jul 15

Dementia and the disappearing subject: a framing analysis of drugs for dementia in UK news media

doi.org/10.1016/j.ss...

Redirecting

doi.org

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Seb Walsh @sebwalsh.bsky.social · Jul 11

Analyses from Sweden suggesting that cognitive reserve is really rooted in early life, with limited opportunity therefore to affect this in adulthood. Supported by findings from the 1946 birth cohort in the UK

doi.org/10.1002/alz....

A lifespan perspective on cognitive reserve and risk for dementia

INTRODUCTION We addressed whether higher education plays a causal role in reducing dementia risk by comparing two indices of cognitive reserve: education and young adult general cognitive ability (G...

doi.org

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Seb Walsh @sebwalsh.bsky.social · Jul 4

Great to work on this with UK colleagues Naaheed Mukadam, Gill Livingston (@uclpsychiatry.bsky.social), and Carol Brayne (@cph.bsky.social). Susanne Roehr, and colleagues from Uni of Auckland

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Seb Walsh @sebwalsh.bsky.social · Jul 4

Issue with PAFs for dementia are that we could never actually achieve risk factor eradication

So, in 🇳🇿 , Etu Ma'u has led modelling of 15-25% reductions in risk factors (still ambitious) and shown meaningful PIFs over time, esp for Maori and Pacific peoples

doi.org/10.1002/alz....