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Reposted by Simon Haas

Nature Methods @natmethods.nature.com · Aug 7

Interact-omics is a high-throughput cytometry-based framework for cellular interaction mapping. @simonhaas.bsky.social

www.nature.com/articles/s41...

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Reposted by Simon Haas

Viktoria Flore @viktoriaflore.bsky.social · Aug 7

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

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Reposted by Simon Haas

MDC-BIMSB @mdc-bimsb.bsky.social · Aug 7

Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...

#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology

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Simon Haas @simonhaas.bsky.social · Aug 7

Huge shout-out to the incredible first authors Dominik Vonficht, Lea Jopp-Saile, Schayan Yousefian, Viktoria Flore & all other collaborators, esp. Daniel Hübschmann!
Grateful to @bihatcharite.bsky.social, @mdc-berlin.bsky.social, @qmul.bsky.social HI-STEM, @dkfz.bsky.social
@erc.europa.eu
(4/4)

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Simon Haas @simonhaas.bsky.social · Aug 7

We demonstrated its applicability to:
• Track CAR-T & bispecific Ab dynamics
• Predict immunotherapy responses
• Map organ-wide immune cell networks post-viral infection
• Uncover pathogenic interactions in human disease phenotypes
(3/4)

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Simon Haas @simonhaas.bsky.social · Aug 7

Inspired by conceptual work from @idoamitlab.bsky.social & others, we developed a cytometry-based approach to simultaneously profile all immune cell types and their physical interactions.
✅ Millions of cells and interactions
✅ Minutes to analyze
✅ Low cost
✅ No reporters required
(2/4).

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Simon Haas @simonhaas.bsky.social · Aug 7

Excited to share our latest paper @natmethods.nature.com
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...

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Reposted by Simon Haas

Itai Yanai @itaiyanai.bsky.social · Feb 27

"Innovations in Single Cell Omics" Berlin 5.12-13.
Organizers:
@stefaniegrosswendt.bsky.social
@simonhaas.bsky.social
@leifludwig.bsky.social
Ashley Sanders
@larsplus.bsky.social
@elimereu.bsky.social
@alejofraticelli.bsky.social

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Reposted by Simon Haas

Max Delbrück Center @mdc-berlin.bsky.social · Feb 24

A group of Berlin researchers and international colleagues have found differences in heart inflammation caused by COVID-19, vaccination, and heart disease. The results pave the way for more personalized therapies, they report in "Nature Cardiovascular Research.”
➡️ www.mdc-berlin.de/news/press/n... ⬅️

Microscopic image of heart cells glowing green and blue, with the caption "Not all heart inflammation is the same" written in white letters across the bottom of the graphic.

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Reposted by Simon Haas

Max Delbrück Center @mdc-berlin.bsky.social · Feb 11

Zooming in on how multiple myeloma starts to spread in the body: Single-cell analyses and spatial omics allowed international researchers, including the @simonhaas.bsky.social lab at the #mdcBerlin, to see a co-evolution of blood cancer and immune cells. #ScienceImmunology

More details 👇

When blood cancer starts to spread

When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response in the region changes, researchers from Berlin and Heidelberg report in “Sci...

www.mdc-berlin.de

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Reposted by Simon Haas

Sheela Abraham @haemev.bsky.social · Feb 8

Super intriguing findings

Simon Haas @simonhaas.bsky.social · Feb 8

Ever wondered what drives hematopoietic stem cell (HSC) heterogeneity? In this preprint, our collaborative team uncovered that differences in HSC reconstitution kinetics play a key role in shaping stem cell heterogeneity and lineage biases. doi.org/10.1101/2025... (1/2)

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...

doi.org

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Simon Haas @simonhaas.bsky.social · Feb 8

Great opportunity to learn more about the most recent possiblities on single-cell lineage tracing!!! Attend a workshop led by one of the key experts in the field @leifludwig.bsky.social
Join us at the ISCO2025 conference!

Leif S. Ludwig @leifludwig.bsky.social · Jan 31

Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference!

www.isco-conference.eu

www.mdc-berlin.de/news/events/...

Mitochondrial single cell-multi-omics for lineage tracing and genetics

www.mdc-berlin.de

Reposted by Simon Haas

Mike Spencer Chapman @mikespencerchapman.bsky.social · Jan 15

So pleased to have the paper out, available here: www.nature.com/articles/s41586-024-08423-8
For me this was discovery science as I had always hoped it would be. A lot of fun, and some proper detective work with plenty of twists & turns on the way. Brief thread below

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Reposted by Simon Haas

MDC-BIMSB @mdc-bimsb.bsky.social · Jan 27

Join us to connect with the vibrant #singlecell community.
📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin!
🗓️ 12-13 May 2025
🎤 fantastic Keynote and Confirmed Speakers
🫵🏿 Many slots for talks: submit your abstract
🔗http://isco-conference.eu

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Simon Haas @simonhaas.bsky.social · Feb 8

Curious about the latest innovations in single-cell omics? 🔬✨
Join us at the next ISCO conference for groundbreaking insights, exciting speakers, and plenty of fun! Don't miss it!
🗓️ 12-13 May 2025
🔗http://isco-conference.eu

Leif S. Ludwig @leifludwig.bsky.social · Jan 31

Join us to connect with the vibrant #singlecell community.
📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin!
🗓️ 12-13 May 2025
🎤 Fantastic Keynote and Invited Speakers
🫵🏿 Many slots for talks: submit your abstract
🔗http://isco-conference.eu
Please spread the word!

Reposted by Simon Haas

Leif S. Ludwig @leifludwig.bsky.social · Jan 31

Join us to connect with the vibrant #singlecell community.
📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin!
🗓️ 12-13 May 2025
🎤 Fantastic Keynote and Invited Speakers
🫵🏿 Many slots for talks: submit your abstract
🔗http://isco-conference.eu
Please spread the word!

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Reposted by Simon Haas

Leif S. Ludwig @leifludwig.bsky.social · Jan 31

Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference!

www.isco-conference.eu

www.mdc-berlin.de/news/events/...

Mitochondrial single cell-multi-omics for lineage tracing and genetics

www.mdc-berlin.de

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Simon Haas @simonhaas.bsky.social · Feb 8

Great teamwork with co-lead Niels Weinhold (@HDMyeloma) and a fantastic effort led by Raphael Lutz, Alexandra Poos, Llorenç Solé Boldo, Lukas John, and many others. Grateful for such an incredible team! 👏 #TeamScience 2/2

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Simon Haas @simonhaas.bsky.social · Feb 8

How does multiple myeloma progress? In our latest Science Immunology cover story, we reveal how myeloma cells breaking through bone trigger dangerous diversity. This arises from bidirectional interactions with the immune system, fueling disease evolution. scim.ag/4hMrLHs 1/2

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Simon Haas @simonhaas.bsky.social · Feb 8

Be sure to check out the fantastic tweetorial by @milsommick.bsky.social on our collaborative work uncovering the sources of hematopoeitic stem cell heterogeneity 🔥

Mick Milsom @milsommick.bsky.social · Feb 5

New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...

doi.org

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Simon Haas @simonhaas.bsky.social · Feb 8

Great team work with @milsommick.bsky.social Hübschmann lab, Hofer lab and many others, spearheaded by @estherrodriguezc.bsky.social, Florian Grünschläger and Tamar Nizharadze 👏 #TeamScience (2/2).

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Simon Haas @simonhaas.bsky.social · Feb 8

Ever wondered what drives hematopoietic stem cell (HSC) heterogeneity? In this preprint, our collaborative team uncovered that differences in HSC reconstitution kinetics play a key role in shaping stem cell heterogeneity and lineage biases. doi.org/10.1101/2025... (1/2)

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...

doi.org

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