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Samantha Klasfeld #opentowork

@sklasfeld.bsky.social

47 followers 140 following 12 posts

Bioinformatics postdoctoral research fellow

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Samantha Klasfeld #opentowork @sklasfeld.bsky.social · May 29

Excited to share my work is published in HGG Advances! 🧬🖥️
Thankful to my mentors at Pfizer for the incredible opportunity.
TL;DR We explore the interplay between rare pathogenic variants and common genetic modifiers of cardiomyopathy and provide an assessment of variant effect predictions.

Human Genetics and Genomics Advances @hggadvances.bsky.social · May 27

📣New from @sklasfeld.bsky.social & co!
📄Common genetic modifiers influence #cardiomyopathy susceptibility among the carriers of rare pathogenic variants
👉https://tinyurl.com/2rsbzphf

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Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Sep 4

🧬 💻 In my first blog post with Boston Women in Bioinformatics, I unpack how meaningful inclusion in genetics research not only addresses ethical imperatives but also unlocks more robust scientific insights.

🔗 boston-wib.org/blog/deepdiv...

#InclusiveResearch #EquityInScience #DiversityInSTEM

The Genomics Diversity Crisis: Why DEI Isn't Just About Workplace Culture

When 86% of genomic data comes from European ancestry, treatments built on this data will inevitably fail marginalized communities.

boston-wib.org

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Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Aug 22

💻 🧬 New survey for job seekers AND hiring teams in biotech/bioinformatics/data science. ~10 min, anonymous, results shared with community. Please take it AND share with your network! tinyurl.com/biotechjobma...

State of the Biotech Job Market: A Survey on Employment Experiences in Biotechnology, Bioinformatics, and Data Science

This survey aims to understand the current employment landscape and job search experiences of professionals in biotechnology, bioinformatics, and data science fields. We're collecting data on various ...

tinyurl.com

Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Aug 20

💻🧬 Are you a computational biologist? Working in an adjacent field? Please respond to this survey to support community-driven research and programming.

Conducted by Boston Women in Bioinformatics (BWIB), all responses are anonymous. [~5 min]

Google Form:
tinyurl.com/mm424zdw

a cat wearing a pair of glasses with the words talk data to me above it

ALT: a cat wearing a pair of glasses with the words talk data to me above it

media.tenor.com

Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Jun 24

🧬💻 "It was the best of times, it was the worst of times" - Eric Green, Former Director of the National Human Genome Research Institute, quoting Mark Twain #FoG #FoGBoston #FoG2025 #FestivalOfGenomics #FesivalOfGenomicsBoston

Reposted by Samantha Klasfeld #opentowork

American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · May 29

Exploring the interplay of rare pathogenic variants and common genetic modifiers of cardiomyopathy, @hggadvances.bsky.social's latest study carefully assesses the benefits provided by variant effect predictions: www.cell.com/hgg-advances... @sklasfeld.bsky.social #ASHG #HumanGenetics

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Samantha Klasfeld #opentowork @sklasfeld.bsky.social · May 29

Human Genetics and Genomics Advances @hggadvances.bsky.social · May 27

📣New from @sklasfeld.bsky.social & co!
📄Common genetic modifiers influence #cardiomyopathy susceptibility among the carriers of rare pathogenic variants
👉https://tinyurl.com/2rsbzphf

1 4

Samantha Klasfeld #opentowork @sklasfeld.bsky.social · May 28

🧬🖥️ Super cool work! This blog post introduces the idea that our sociopolitical ecosystem can cause inherit biases in statistical methods, and the paper reviews existing and future approaches to improve our practices.

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Reposted by Samantha Klasfeld #opentowork

E. Rosalie @erosalie.infoepi.com · Mar 13

A French University is funding a Safe Place For Science program meant to recruit scientists who cannot continue their work in the US. www.univ-amu.fr/fr/public/a...

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Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Mar 7

Taylor swift or Tailor Swiftiles? emze.csail.mit.edu/tailors #wids2025 #widscambridge #womenindatascience #efficientcomputing

Tailors

emze.csail.mit.edu

Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Jan 7

🧬 I'm delighted to share the preprint to my postdoc project where we used predicted rare pathogenic variants to improve our understanding of the interplay between common genetic modifiers and rare pathogenic mutations in cardiomyopathy risk. www.medrxiv.org/content/10.1...
#Genetics #Bioinformatics

www.medrxiv.org

Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Jan 3

🧬 New DNA language model using evolutionary conservation provides exciting results and an intriguing discussion on where specific models may outperform due to certain conditions.

Yun S. Song @yun-s-song.bsky.social · Jan 2

Happy New Year! Our GPN-MSA paper is finally published, under a slightly different title from the preprint. Please check it out and share it with your colleagues:

doi.org/10.1038/s415...

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A DNA language model based on multispecies alignment predicts the effects of genome-wide variants - Nature Biotechnology

A language model predicts the effects of genetic variants in the human genome.

doi.org

Reposted by Samantha Klasfeld #opentowork

Kexin Huang @kexinhuang.bsky.social · Dec 9

🧬 Thrilled to share Knowledge Graph GWAS (KGWAS), the largest AI model that integrates >10 millions of multi-modal and multi-scale functional genomics data to improve GWAS power by 100% while discovering novel disease-critical variants, genes, cells, and networks!

1/15🧵

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Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Dec 12

Thank you @ericfauman.bsky.social for sharing this intriguing paper!

Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Dec 12

For many quantitative phenotypes with selective pressure at their high and low ends (the "tails"), the association between PRS and the trait is diminished at these extremes due to high-impact rare variant alleles not included in the PRS.
www.biorxiv.org/content/10.1...

Striking Departures from Polygenic Architecture in the Tails of Complex Traits

Understanding the genetic architecture of human traits is of key biological, medical and evolutionary importance[[1][1]]. Despite much progress, little is known about how genetic architecture varies a...

www.biorxiv.org

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Samantha Klasfeld #opentowork @sklasfeld.bsky.social · Nov 30

What a beautiful bedtime story for baby geneticists 😊