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spcembl.bsky.social
SPC Facility & Garcia-Alai Lab
@spcembl.bsky.social
410 followers 190 following 32 posts
Sample Preparation & Characterisation Facility at EMBL Hamburg: Integrative Structural Biology, Microbiology & Biotechnology.
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spcembl.bsky.social
New preprint out!📃

This work uncovers how the clathrin adaptors Ent5 & Sla2
undergo LLPS, revealing distinct structural drivers that shape endocytic and trafficking dynamics.

@lucasdefelipe.bsky.social @katharinchen.bsky.social @embl.org @cssbhamburg.bsky.social

👉 www.biorxiv.org/content/10.1...
Clathrin adaptors drive phase separation in endocytosis and trafficking
Liquid-liquid phase separation (LLPS) underlies the formation of biomolecular condensates that organize cellular processes, including endocytosis and membrane trafficking. Although LLPS has been impli...
www.biorxiv.org
November 21, 2025 at 10:13 AM
spcembl.bsky.social
New paper from our postdoc @fedevignale.bsky.social, et.al!

Studying microbialites in Argentina 🇦🇷, they show how extreme, early Earth-like conditions shape microbes, minerals & biosignatures- insights for Earth’s past and life beyond 🌎 🧬.

👉 www.nature.com/articles/s43...

@embl.org @ebi.embl.org
September 17, 2025 at 11:36 AM
spcembl.bsky.social
We’re looking for a GL!

Join us at EMBL Hamburg! 🧫🦠🧬

The position will be based at CSSB @cssbhamburg.bsky.social , an interdisciplinary research centre focused on infection biology, and will be integrated into EMBL's research programme. @embl.org

Find out more and apply here: lnkd.in/dJU9pee7
September 15, 2025 at 4:20 PM
Reposted by SPC Facility & Garcia-Alai Lab
embl.org
At EMBL Grenoble, lead an independent research group using bold, original approaches to integrate complementary structural biology methods with emerging nano X-ray imaging technologies, bridging scales and modalities to unravel molecular mechanisms.

embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
August 8, 2025 at 7:17 AM
spcembl.bsky.social
Check it out the latest open position to join EMBL in Heidelberg!
@embl.org
embl.org EMBL @embl.org · Aug 7
We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠

Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels.

Take a look at these four open positions 👇
September 15, 2025 at 3:59 PM
spcembl.bsky.social
Congrats to the Grünewald, Topf groups & et. al @cssbhamburg.bsky.social on their Nature paper! 📃 🍾

Trapping and resolving the elusive prefusion form of HSV gB - neutralizing HSV-1 & HSV-2 with a single nanobody is no small feat!🦙

Glad that our SPC facility have contributed to this [email protected]
September 8, 2025 at 1:57 PM
Reposted by SPC Facility & Garcia-Alai Lab
cssbhamburg.bsky.social
Excited to be part of the Instruct Centre Germany!

@jankosinski.bsky.social @landaulabcssb.bsky.social @topf-lab.bsky.social @carobarisch.bsky.social @bosse-lab.bsky.social @spcembl.bsky.social
instruct-eric.bsky.social Instruct-ERIC @instruct-eric.bsky.social · Aug 7
We are delighted to announce that Instruct has added a Centre in Germany, and expanded its existing Centre in Spain with new facilities, services, and technologies!

See the list below - all new services will be available for funded access soon!
Watch this space!
instruct-eric.org/news/new-ger...
New German Centre and Expanded Spanish Centre Approved
Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.
instruct-eric.org
August 27, 2025 at 8:02 AM
spcembl.bsky.social
Exciting to be with part of my group at the 15th European Biophysics Congress (EBSA) in beautiful Rome, Italy 🇮🇹

If you are around, join my talk today about tools for the analysis of biophysical data 💡🧩

Check our posters for open discussion and networking !📃🖇️

@embl.org
@cssbhamburg.bsky.social
July 1, 2025 at 12:14 PM
spcembl.bsky.social
KinGenie, an online tool for the analysis of kinetics data, has been introduced on the 4th MOSBRI Scientific Conference in Paris, France 🇫🇷

A great addition to our eSPC web server💡🚀

Reach out to us for further input!

@osvalb.bsky.social
@mosbri.bsky.social
@embl.org
@cssbhamburg.bsky.social
June 11, 2025 at 3:37 PM
spcembl.bsky.social
4th MOSBRI Scientific Conference starts today 📍in beautiful Paris, France 🇫🇷

Excited to see familiar and new faces from our TNA site, network and continue collaborating on research infrastructures projects in molecular biophysics 🧬🧫 🤝

@mosbri.bsky.social @embl.org @cssbhamburg.bsky.social
June 10, 2025 at 12:19 PM
Reposted by SPC Facility & Garcia-Alai Lab
cssbhamburg.bsky.social
Happy to co-host a workshop on lipid nanoparticles together with @embl.org Hamburg this week. The workshop is a part of the @eugloh.bsky.social ‘Entrepreneurship meets Health Innovation at Large-Scale Facilities’ conference.

@landaulabcssb.bsky.social @spcembl.bsky.social
June 6, 2025 at 8:31 AM
spcembl.bsky.social
Our latest research is out 📄 !

This study provides an interaction map of Sla2 & the regulatory proteins Sla1 & Pan1, predicted by AI modeling & confirmed by molecular biophysics.

@lucasdefelipe.bsky.social @meytallandau.bsky.social
@emilgustavsson.bsky.social
@embl.org
@cssbhamburg.bsky.social
May 12, 2025 at 8:15 AM
spcembl.bsky.social
🔊 Thrilled to share our latest work, just published in NAR! 📃

We present ChiraKit, open-source tool to process raw CD data and perform advanced analysis!

Access via our eSPC web-server!

➡️ spc.embl-hamburg.de
@osvalb.bsky.social @lucasdefelipe.bsky.social @embl.org @cssbhamburg.bsky.social
April 28, 2025 at 9:24 AM
Reposted by SPC Facility & Garcia-Alai Lab
cczekster.bsky.social
Just want to say thanks to @spcembl.bsky.social for developing ChiraKit and allowing quick and informative analysis of CD data - more here www.biorxiv.org/content/10.1...
best news of the day today as we were stuck with beautiful but hard to analyze data 🙂 #scienceisawesome
ChiraKit, an online tool for the analysis of circular dichroism spectroscopy data
Circular dichroism (CD) spectroscopy is an established biophysical technique to study chiral molecules. CD allows investigating conformational changes under varying experimental conditions and has bee...
www.biorxiv.org
April 24, 2025 at 2:17 PM
Reposted by SPC Facility & Garcia-Alai Lab
biophysicalsoc.bsky.social
We're hosting an Ask Me Anything about Biophysics on Bluesky today with BPS Ambassador Alumnus Gonzalo de Prat Gay! Tweet your questions with #BiophysicsAMA and tune in at 11am USA Eastern time.
March 28, 2025 at 2:29 PM
Reposted by SPC Facility & Garcia-Alai Lab
emilgustavsson.bsky.social
🚨The registration for the Functional #Amyloid Meeting is finally open, check it out on landau-cssb.de

🧪🧬🧶
March 26, 2025 at 3:51 PM
spcembl.bsky.social
Congratulations to George who had his PhD defense today! 🥂🍾🥳🎉 @uni-hamburg.de @embl.org @cssbhamburg.bsky.social
March 21, 2025 at 5:29 PM
Reposted by SPC Facility & Garcia-Alai Lab
cssbhamburg.bsky.social
Happy International Women's Day! #IWD2025

We encourage everyone to #AccelerateAction and support #DEI.

@carobarisch.bsky.social @landaulabcssb.bsky.social @topf-lab.bsky.social @mariarosenthal.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social
March 7, 2025 at 10:03 AM
spcembl.bsky.social
🚨 New preprint alert 🚨!

👉🏼 @fedevignale.bsky.social

🏔️ Our latest study explores seasonal biogeochemical variations in a modern microbialite reef at Laguna Pozo Bravo 🇦🇷 - a site with conditions reminiscent of early Earth 🌍🦠

📖 Read here : doi.org/10.1101/2025...

@embl.org @cssbhamburg.bsky.social
February 24, 2025 at 9:36 AM
spcembl.bsky.social
If you’re attending the BPS 2025, don’t miss the poster of our ARISE fellow @osvalb.bsky.social

He’s presenting eSPC, online data analysis platform on biophysics ! 🔎

Date : 18/02/25
Time : 13:45
Session: “Protein stability folding & chaperones”
Poster : B38

@embl.org @cssbhamburg.bsky.social
February 17, 2025 at 10:02 AM
Reposted by SPC Facility & Garcia-Alai Lab
osvalb.bsky.social
Looking forward to making new connections at #BPS2025👨 Meet me at poster B38 on Tuesday 18 Feb 13:45. Session "protein stability folding and chaperones"
espc poster details BPS conference banner
February 14, 2025 at 2:41 PM
spcembl.bsky.social
Today,on #InternationalDayOfWomenAndGirlsInScience, we celebrate the contributions of women in structural biology & biophysics!

As an international team of women scientists 🇦🇷 🇷🇺 🇩🇪 🇻🇪 , we’re proud to push the boundaries of discovery 🧬🦠

#WomenInSTEM #ScienceForAll

@embl.org @cssbhamburg.bsky.social
February 11, 2025 at 10:31 AM
Reposted by SPC Facility & Garcia-Alai Lab
embl.org
Scientists at University of Buenos Aires, EMBL Hamburg, and others mapped yerba mate’s genome, providing surprising facts about its biochemistry and evolution of caffeine biosynthesis. 🧉🧬🧪

Find out more: www.embl.org/news/science...

@spcembl.bsky.social
A cup of yerba mate on a wooden surface and some dried yerba mate next to it.
February 3, 2025 at 8:46 AM
spcembl.bsky.social
Exciting work on the Yerba mate (Ilex paraguariensis) genome providing new insights into convergent evolution of caffeine biosynthesis 🧬🧉

Amazing work from our postdoc Federico Vignale and our STO @lucasdefelipe.bsky.social

@embl.org @cssbhamburg.bsky.social

🔗 elifesciences.org/articles/104759
February 3, 2025 at 10:05 AM
Reposted by SPC Facility & Garcia-Alai Lab
osvalb.bsky.social
After many months of gathering user feedback and improving our software, we think it's time to share it with the community. Enjoy our latest tool 🥳 , and stay tuned for the next one 😉
spcembl.bsky.social SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · Jan 31
🔊 Our latest biophysical tool for circular dichroism analysis, ChiraKit, is out 🔍

To read more about it, visit www.biorxiv.org/content/10.1...

ChiraKit can be accessed at spc.embl-hamburg.de

@osvalb.bsky.social @lucasdefelipe.bsky.social @embl.org @cssbhamburg.bsky.social
@mosbri.bsky.social
January 31, 2025 at 10:35 AM