Stem Cell Reports
@stemcellreports.bsky.social
For scientists. By scientists. The official journal of the @isscr.org | Editor-in-Chief: Janet Rossant, CC, PhD
In this episode of The Stem Cell Report Podcast, guests discuss their investigation on the effect of diverse culture conditions on the cell type composition, gene expression profiles, & maturation status of human PSC-derived intestinal epithelial cells. tinyurl.com/3s4pkj34
November 26, 2025 at 2:54 PM
In this episode of The Stem Cell Report Podcast, guests discuss their investigation on the effect of diverse culture conditions on the cell type composition, gene expression profiles, & maturation status of human PSC-derived intestinal epithelial cells. tinyurl.com/3s4pkj34
New study finds inducible Cars2 mutation in mice causes mitochondrial dysfunction and anemia and Cars2-mutant megakaryocyte-erythroid progenitors (MEPs) generate less erythroblasts, revealing mitochondria as key “navigators” for MEP lineage commitment. https://ow.ly/Xn6U50Xve7I
ISSCR
ISSCR
November 26, 2025 at 1:35 PM
New study finds inducible Cars2 mutation in mice causes mitochondrial dysfunction and anemia and Cars2-mutant megakaryocyte-erythroid progenitors (MEPs) generate less erythroblasts, revealing mitochondria as key “navigators” for MEP lineage commitment. https://ow.ly/Xn6U50Xve7I
ISSCR
ISSCR
New research from NYU Grossman School of Medicine: Stem cell-based approach to identify important regulatory transcription factors in various pathways during mammalian cell differentiation. #development #spinalcord https://ow.ly/i55H50Xve5V
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 25, 2025 at 3:35 PM
New research from NYU Grossman School of Medicine: Stem cell-based approach to identify important regulatory transcription factors in various pathways during mammalian cell differentiation. #development #spinalcord https://ow.ly/i55H50Xve5V
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
New #organoid research models RPGRIP1-inherited retinal disease; connecting cilium, stress response, and #proteostasis abnormalities to inform variant and therapy assessment. #ciliopathies #AAVtherapy #photoreceptors https://ow.ly/xTwl50Xva6s
University of Sydney (USYD) | ISSCR
University of Sydney (USYD) | ISSCR
November 24, 2025 at 4:01 PM
New #organoid research models RPGRIP1-inherited retinal disease; connecting cilium, stress response, and #proteostasis abnormalities to inform variant and therapy assessment. #ciliopathies #AAVtherapy #photoreceptors https://ow.ly/xTwl50Xva6s
University of Sydney (USYD) | ISSCR
University of Sydney (USYD) | ISSCR
Reposted by Stem Cell Reports
Hi All, @stemcellreports.bsky.social, is the official meeting journal of #ISSCR2026. It communicates basic discoveries in stem cell research, plus translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbk6l8kbi
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 21, 2025 at 3:06 PM
Hi All, @stemcellreports.bsky.social, is the official meeting journal of #ISSCR2026. It communicates basic discoveries in stem cell research, plus translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbk6l8kbi
Meet Early Career Editor Harsha Devalla at the Assembloids and Complex Cell-Cell Interactions meeting in New York, USA, 8-11 December 2025. Connect with Dr. Devalla to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 24, 2025 at 1:00 PM
Meet Early Career Editor Harsha Devalla at the Assembloids and Complex Cell-Cell Interactions meeting in New York, USA, 8-11 December 2025. Connect with Dr. Devalla to discuss whether your research is a fit for publishing in Stem Cell Reports!
Community and bioethicists’ perspectives on iPSC research with biobanked samples collected using broad consent; support for broad consent, commercial, more benefit sharing, ongoing community engagement, and oversight. https://ow.ly/qApR50Xv90Y
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 21, 2025 at 7:05 PM
Community and bioethicists’ perspectives on iPSC research with biobanked samples collected using broad consent; support for broad consent, commercial, more benefit sharing, ongoing community engagement, and oversight. https://ow.ly/qApR50Xv90Y
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Meet Early Career Editor Bruno Di Stefano (Bruno Di Stefano) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 21, 2025 at 3:00 PM
Meet Early Career Editor Bruno Di Stefano (Bruno Di Stefano) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!
New article explores 4,481 YouTube videos about stem cells to map how medical knowledge is shared online, revealing a complex discourse dominated by celebrity influencers in the promotion and discussion of putative stem cell treatments. https://ow.ly/iNUG50Xv8Ay
November 20, 2025 at 10:04 PM
New article explores 4,481 YouTube videos about stem cells to map how medical knowledge is shared online, revealing a complex discourse dominated by celebrity influencers in the promotion and discussion of putative stem cell treatments. https://ow.ly/iNUG50Xv8Ay
New paper from Center for iPS Cell Research and Application (CiRA)! Aging reduces KAT7/HBO1 activity, impairing immortalized megakaryocyte progenitor cell line (imMKCL)-based platelet production by promoting immune-like properties via the cGAS-STING pathway. #cellcycle https://ow.ly/J80850XrNh1
November 20, 2025 at 8:00 PM
New paper from Center for iPS Cell Research and Application (CiRA)! Aging reduces KAT7/HBO1 activity, impairing immortalized megakaryocyte progenitor cell line (imMKCL)-based platelet production by promoting immune-like properties via the cGAS-STING pathway. #cellcycle https://ow.ly/J80850XrNh1
Reposted by Stem Cell Reports
Totally psyched that our paper is out in @stemcellreports.bsky.social!
For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue?
We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head.
Spoiler: the chip wins.
🧵&🔗👇
For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue?
We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head.
Spoiler: the chip wins.
🧵&🔗👇
November 19, 2025 at 10:13 PM
Totally psyched that our paper is out in @stemcellreports.bsky.social!
For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue?
We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head.
Spoiler: the chip wins.
🧵&🔗👇
For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue?
We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head.
Spoiler: the chip wins.
🧵&🔗👇
Online now! #Autophagy is dispensable in germline stem cells but is required in the cap cells for maintaining the #Drosophila ovarian niche. Atg5-mediated autophagy preserves cap cell viability and BMP signaling during #aging. https://ow.ly/Zhum50XrN46
ISSCR
ISSCR
November 19, 2025 at 3:01 PM
Online now! #Autophagy is dispensable in germline stem cells but is required in the cap cells for maintaining the #Drosophila ovarian niche. Atg5-mediated autophagy preserves cap cell viability and BMP signaling during #aging. https://ow.ly/Zhum50XrN46
ISSCR
ISSCR
New research from UT Southwestern Medical Center: Analysis of 1,996,260 sequenced cells across benchmarking datasets reveals shared regulatory networks linking disease-associated enhancers and genes with downstream targets during cardiomyocyte differentiation. https://ow.ly/czPo50XrMAL
ISSCR
ISSCR
November 18, 2025 at 8:05 PM
New research from UT Southwestern Medical Center: Analysis of 1,996,260 sequenced cells across benchmarking datasets reveals shared regulatory networks linking disease-associated enhancers and genes with downstream targets during cardiomyocyte differentiation. https://ow.ly/czPo50XrMAL
ISSCR
ISSCR
Hear from Stem Cell Reports Associate Editor Martin Pera, PhD, as he shares expert guidance on preparing and submitting your manuscript. ISSCR
👉 https://youtu.be/xH5OMEvYw2Y
👉 https://youtu.be/xH5OMEvYw2Y
Stem Cell Reports Submission Tips
Stem Cell Reports is an open access forum communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell...
youtu.be
November 18, 2025 at 3:00 PM
Hear from Stem Cell Reports Associate Editor Martin Pera, PhD, as he shares expert guidance on preparing and submitting your manuscript. ISSCR
👉 https://youtu.be/xH5OMEvYw2Y
👉 https://youtu.be/xH5OMEvYw2Y
Reposted by Stem Cell Reports
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbe646iod
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 18, 2025 at 1:29 AM
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbe646iod
Reposted by Stem Cell Reports
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbzaorikl
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 18, 2025 at 1:33 AM
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbzaorikl
Reposted by Stem Cell Reports
@stemcellreports.bsky.social, Stem Cell Reports, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research & clinical research. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbaici36t
@isscr.org
@isscr.org
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 17, 2025 at 4:45 PM
@stemcellreports.bsky.social, Stem Cell Reports, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research & clinical research. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbaici36t
@isscr.org
@isscr.org
Reposted by Stem Cell Reports
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbvzmjckk
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 17, 2025 at 4:53 PM
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbvzmjckk
Reposted by Stem Cell Reports
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbdpyyw3k
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 17, 2025 at 5:04 PM
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbdpyyw3k
Reposted by Stem Cell Reports
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxb9jxi7fs
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 17, 2025 at 4:14 PM
@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxb9jxi7fs
Online now! First derivation of nuclear transfer embryonic stem cells (ntESCs) from cloned blastocysts generated by somatic cell nuclear transfer in the #marmoset; ntESCs show normal karyotypes & #pluripotency. https://ow.ly/Xkus50XrM7Z
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 17, 2025 at 4:05 PM
Online now! First derivation of nuclear transfer embryonic stem cells (ntESCs) from cloned blastocysts generated by somatic cell nuclear transfer in the #marmoset; ntESCs show normal karyotypes & #pluripotency. https://ow.ly/Xkus50XrM7Z
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
New organ-on-chip research! Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells. #iPSC #organonchip #organoid https://ow.ly/hBIX50XrKs2
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 14, 2025 at 3:07 PM
New organ-on-chip research! Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells. #iPSC #organonchip #organoid https://ow.ly/hBIX50XrKs2
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Exploring advances & challenges in modeling Charcot-Marie-Tooth type 2A (#CMT2A) using iPSC-based models, focusing on pathogenetic insights, elucidating disease mechanisms, & developing innovative testing platforms & therapeutic strategies. https://ow.ly/B1pf50XrgNF
ISSCR
ISSCR
November 13, 2025 at 6:12 PM
Exploring advances & challenges in modeling Charcot-Marie-Tooth type 2A (#CMT2A) using iPSC-based models, focusing on pathogenetic insights, elucidating disease mechanisms, & developing innovative testing platforms & therapeutic strategies. https://ow.ly/B1pf50XrgNF
ISSCR
ISSCR
A novel paradigm for single-cell annotation in stem cell research. Explores different approaches, implementation challenge in stem cell-derived models, and offers recommendations and a vision for the future. #hPSC #singlecell #cellulargenomics #AI #cellannotation https://ow.ly/jwl050Xo5Fq
ISSCR
ISSCR
November 12, 2025 at 9:45 PM
A novel paradigm for single-cell annotation in stem cell research. Explores different approaches, implementation challenge in stem cell-derived models, and offers recommendations and a vision for the future. #hPSC #singlecell #cellulargenomics #AI #cellannotation https://ow.ly/jwl050Xo5Fq
ISSCR
ISSCR
Loss-of-function analysis of the #Oct4 distal (DE) and proximal enhancers (PE) shows that Oct4 PE and DE are required for primed and naive pluripotency, respectively. Powerful genetic tools to dissect Oct4’s role in #pluripotency & early development. https://ow.ly/JShz50Xo5nz
ISSCR
ISSCR
November 11, 2025 at 5:35 PM
Loss-of-function analysis of the #Oct4 distal (DE) and proximal enhancers (PE) shows that Oct4 PE and DE are required for primed and naive pluripotency, respectively. Powerful genetic tools to dissect Oct4’s role in #pluripotency & early development. https://ow.ly/JShz50Xo5nz
ISSCR
ISSCR