Stem Cell Reports
@stemcellreports.bsky.social
For scientists. By scientists. The official journal of the @isscr.org | Editor-in-Chief: Janet Rossant, CC, PhD
New #cardiomyocyte research maps temporal alternative splicing regulation during cardiac regulation and uncovers altered splicing events in iPSC-cardiomyocytes, providing insights into the limitations of these models in cardiovascular research. https://ow.ly/kr4550XSzCS
January 13, 2026 at 9:00 PM
New #cardiomyocyte research maps temporal alternative splicing regulation during cardiac regulation and uncovers altered splicing events in iPSC-cardiomyocytes, providing insights into the limitations of these models in cardiovascular research. https://ow.ly/kr4550XSzCS
New research from National Institute of Environmental Health Sciences: Rbm25 governs embryonic stem cell identity and fate through transcriptional regulation of pluripotency and epigenetic programs https://ow.ly/FNNw50XSznN
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
January 13, 2026 at 6:01 PM
New research from National Institute of Environmental Health Sciences: Rbm25 governs embryonic stem cell identity and fate through transcriptional regulation of pluripotency and epigenetic programs https://ow.ly/FNNw50XSznN
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
New research from UC Berkeley and NIH! Evidence for a latent activated stem cell state in which a subset of quiescent olfactory epithelial stem cells are epigenetically primed to support injury-induced regeneration. https://ow.ly/fkpG50XVBmo
The Gairdner Foundation | SickKids Foundation | ISSCR
The Gairdner Foundation | SickKids Foundation | ISSCR
January 13, 2026 at 3:01 PM
New research from UC Berkeley and NIH! Evidence for a latent activated stem cell state in which a subset of quiescent olfactory epithelial stem cells are epigenetically primed to support injury-induced regeneration. https://ow.ly/fkpG50XVBmo
The Gairdner Foundation | SickKids Foundation | ISSCR
The Gairdner Foundation | SickKids Foundation | ISSCR
Comparative lipidomics show that iPSC-derived microglia differentiation methods have a major impact on microglial lipidomes & warrant attention when studying #Alzheimers and neuroinflammatory processes involving lipids. https://ow.ly/aesW50XVB4Y
The Gairdner Foundation | SickKids Foundation | ISSCR
The Gairdner Foundation | SickKids Foundation | ISSCR
January 12, 2026 at 6:02 PM
Comparative lipidomics show that iPSC-derived microglia differentiation methods have a major impact on microglial lipidomes & warrant attention when studying #Alzheimers and neuroinflammatory processes involving lipids. https://ow.ly/aesW50XVB4Y
The Gairdner Foundation | SickKids Foundation | ISSCR
The Gairdner Foundation | SickKids Foundation | ISSCR
Chaperonin proteins CCT5 and CCT7 epigenetically restrict the transition from pluripotency to totipotency in embryonic stem cells, underlining the role of CCT5 and CCT7 in maintaining telomere integrity and regulating pluripotent state dynamics. https://ow.ly/13K950XSzcb
January 9, 2026 at 7:30 PM
Chaperonin proteins CCT5 and CCT7 epigenetically restrict the transition from pluripotency to totipotency in embryonic stem cells, underlining the role of CCT5 and CCT7 in maintaining telomere integrity and regulating pluripotent state dynamics. https://ow.ly/13K950XSzcb
Transitioning from human primordial germ cells to embryonic germ cells. New research applies multi-omic profiling to resolve their pluripotent & epigenetic dynamics, providing new insights into potential mechanisms underlying human germ cell tumorigenesis. https://ow.ly/XhAs50XSz3Y
January 8, 2026 at 2:01 PM
Transitioning from human primordial germ cells to embryonic germ cells. New research applies multi-omic profiling to resolve their pluripotent & epigenetic dynamics, providing new insights into potential mechanisms underlying human germ cell tumorigenesis. https://ow.ly/XhAs50XSz3Y
Hsp70-Bim as a potential therapeutic target for chronic myeloid leukemia (CML) stem cells. Inhibition of Hsp70-Bim blocks mitophagy, leading to differentiation of leukemic stem cells (LSC) and loss of quiescence & LSC self-renewal potential. https://ow.ly/ZHUU50XSyQL
January 7, 2026 at 2:02 PM
Hsp70-Bim as a potential therapeutic target for chronic myeloid leukemia (CML) stem cells. Inhibition of Hsp70-Bim blocks mitophagy, leading to differentiation of leukemic stem cells (LSC) and loss of quiescence & LSC self-renewal potential. https://ow.ly/ZHUU50XSyQL
Elevated Spy1 drives sustained expansion of neural stem cells, increases stemness characteristics, decreases differentiation, and increases susceptibility to oncogenic transformation. #neuralstemcells #braindevelopment https://ow.ly/c7AR50XSyaf
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
January 6, 2026 at 5:01 PM
Elevated Spy1 drives sustained expansion of neural stem cells, increases stemness characteristics, decreases differentiation, and increases susceptibility to oncogenic transformation. #neuralstemcells #braindevelopment https://ow.ly/c7AR50XSyaf
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
New research using ex vivo vibrissae explant and skin #organoids identifies IGF1R as a potential regulator of Merkel cell formation, which likely exerts its effects through the AKT pathway #skinorganoid https://ow.ly/zsgS50XS7sg
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
January 5, 2026 at 9:45 PM
New research using ex vivo vibrissae explant and skin #organoids identifies IGF1R as a potential regulator of Merkel cell formation, which likely exerts its effects through the AKT pathway #skinorganoid https://ow.ly/zsgS50XS7sg
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
New review on hematopoietic #organoids summarizes recent progress in HO construction, explores their potential applications, & discusses opportunities & challenges in modeling human hematopoiesis & diseases in vitro. https://ow.ly/Ku0z50XS7fX
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
January 5, 2026 at 6:58 PM
New review on hematopoietic #organoids summarizes recent progress in HO construction, explores their potential applications, & discusses opportunities & challenges in modeling human hematopoiesis & diseases in vitro. https://ow.ly/Ku0z50XS7fX
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Anne Grapin-Botton, Stem Cell Reports Associate Editor, is attending the Organoids from stem cells to diseases modeling in Paris, France in January 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!
January 5, 2026 at 4:00 PM
Anne Grapin-Botton, Stem Cell Reports Associate Editor, is attending the Organoids from stem cells to diseases modeling in Paris, France in January 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!
Genetic screening of lncRNAs in human embryonic stem cells reveals novel regulators of pluripotency and provides insights into lcRNA-mediated regulation of hESC growth and differentiation. #OCT4 #VRTN https://ow.ly/H0t150XMxxO
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
December 31, 2025 at 1:35 PM
Genetic screening of lncRNAs in human embryonic stem cells reveals novel regulators of pluripotency and provides insights into lcRNA-mediated regulation of hESC growth and differentiation. #OCT4 #VRTN https://ow.ly/H0t150XMxxO
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
New in vitro model provides a highly tractable system to study human pluripotent & early developmental transition. High resolution multi-scale profiling of embryonic germ cell-like cell derivation reveals pluripotent state transitions in humans https://ow.ly/hssJ50XMx1s
Human Technopole | ISSCR
Human Technopole | ISSCR
December 30, 2025 at 3:25 PM
New in vitro model provides a highly tractable system to study human pluripotent & early developmental transition. High resolution multi-scale profiling of embryonic germ cell-like cell derivation reveals pluripotent state transitions in humans https://ow.ly/hssJ50XMx1s
Human Technopole | ISSCR
Human Technopole | ISSCR
Human CRX regulates #photoreceptor cell development via bidirectional transcriptional control in retinal #organoids, providing critical insights into the role of human CRX in retinal development and implications for retinal degenerative diseases. https://ow.ly/BRZr50XMwQz
ISSCR
ISSCR
December 29, 2025 at 8:00 PM
Human CRX regulates #photoreceptor cell development via bidirectional transcriptional control in retinal #organoids, providing critical insights into the role of human CRX in retinal development and implications for retinal degenerative diseases. https://ow.ly/BRZr50XMwQz
ISSCR
ISSCR
Explore the 10 most downloaded papers of 2025! Together, these highly read articles reflect the extraordinary scientific range of the field and underscore the journal’s role as a trusted platform for impactful stem cell science. https://www.isscr.org/isscr-news/04ry219odbnptyf0we3sikaw0311hh
December 23, 2025 at 9:09 PM
Explore the 10 most downloaded papers of 2025! Together, these highly read articles reflect the extraordinary scientific range of the field and underscore the journal’s role as a trusted platform for impactful stem cell science. https://www.isscr.org/isscr-news/04ry219odbnptyf0we3sikaw0311hh
New study provides the alternative splicing landscape during muscle stem cell activation & demonstrates that a single-gene splicing change can significantly influence satellite cell activation & essential pathways such as #Notch signaling. https://ow.ly/8uJP50XMwJU ISSCR
December 23, 2025 at 3:20 PM
New study provides the alternative splicing landscape during muscle stem cell activation & demonstrates that a single-gene splicing change can significantly influence satellite cell activation & essential pathways such as #Notch signaling. https://ow.ly/8uJP50XMwJU ISSCR
New #organoid study published in Stem Cell Reports highlights the role of #autophagy in lacrimal glands along with potential therapeutic interventions for dry eye disease. https://ow.ly/9kxK50XMwiT
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
December 22, 2025 at 8:01 PM
New #organoid study published in Stem Cell Reports highlights the role of #autophagy in lacrimal glands along with potential therapeutic interventions for dry eye disease. https://ow.ly/9kxK50XMwiT
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
Online now! A comprehensive overview of pluripotent stem cell lines for clinical use.166 clinical hPSC lines available for licensing and distribution, including 11 used in clinical trials, with information on consent, regulation, and characterization. https://ow.ly/tQ2j50XMw30
ISSCR
ISSCR
December 19, 2025 at 8:10 PM
Online now! A comprehensive overview of pluripotent stem cell lines for clinical use.166 clinical hPSC lines available for licensing and distribution, including 11 used in clinical trials, with information on consent, regulation, and characterization. https://ow.ly/tQ2j50XMw30
ISSCR
ISSCR
New airway #clubcell research! Metabolic-immune crosstalk underlying #asthma pathogenesis and identify mitochondrial pyruvate metabolism as a therapeutic target to limit epithelial remodeling and type 2 inflammation. https://ow.ly/s5tS50XMvME
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
December 19, 2025 at 2:44 PM
New airway #clubcell research! Metabolic-immune crosstalk underlying #asthma pathogenesis and identify mitochondrial pyruvate metabolism as a therapeutic target to limit epithelial remodeling and type 2 inflammation. https://ow.ly/s5tS50XMvME
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Anne Grapin-Botton, Stem Cell Reports Associate Editor, is attending the Organoids from Stem Cells to Disease Modeling in Paris, France in January 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!
December 16, 2025 at 2:00 PM
Anne Grapin-Botton, Stem Cell Reports Associate Editor, is attending the Organoids from Stem Cells to Disease Modeling in Paris, France in January 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!
Reposted by Stem Cell Reports
Delighted to share our publication in @stemcellreports.bsky.social on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by Hemant and @barorunumi.bsky.social. 🔗 www.cell.com/stem-cell-re...
@isscr.org
🧵
@isscr.org
🧵
The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages
In this article, Gayen and colleagues demonstrate that m6A RNA methylation is dispensable
for the maintenance of X chromosome inactivation; however, it partly contributes to
the maintenance of X to au...
www.cell.com
December 13, 2025 at 4:55 AM
Delighted to share our publication in @stemcellreports.bsky.social on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by Hemant and @barorunumi.bsky.social. 🔗 www.cell.com/stem-cell-re...
@isscr.org
🧵
@isscr.org
🧵
Reposted by Stem Cell Reports
Excited to share my first-ever publication, now out in @stemcellreports.bsky.social !! Heartiest congratulations to
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Delighted to share our publication in @stemcellreports.bsky.social on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by Hemant and @barorunumi.bsky.social. 🔗 www.cell.com/stem-cell-re...
@isscr.org
🧵
@isscr.org
🧵
The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages
In this article, Gayen and colleagues demonstrate that m6A RNA methylation is dispensable
for the maintenance of X chromosome inactivation; however, it partly contributes to
the maintenance of X to au...
www.cell.com
December 15, 2025 at 6:56 AM
Excited to share my first-ever publication, now out in @stemcellreports.bsky.social !! Heartiest congratulations to
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Do not miss the latest episode of The Stem Cell Report Podcast - Guests discuss their research on cultural conditions effects on PSC-derived intestinal epithelial cells. Listen to the episode: tinyurl.com/3s4pkj34 @jorammooiweer.bsky.social @isscr.org
December 11, 2025 at 9:20 PM
Do not miss the latest episode of The Stem Cell Report Podcast - Guests discuss their research on cultural conditions effects on PSC-derived intestinal epithelial cells. Listen to the episode: tinyurl.com/3s4pkj34 @jorammooiweer.bsky.social @isscr.org
New research provides significant insight into the role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages. https://ow.ly/76jn50XHyLs
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
December 11, 2025 at 6:11 PM
New research provides significant insight into the role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages. https://ow.ly/76jn50XHyLs
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
New study uses cross-modal integration of #metabolomics and cardiac functionality to capture dynamic metabotoxic effects of #doxorubicin in engineered heart tissues. #heartonchip #cardiotoxicity https://ow.ly/HfsS50XC6NI
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
December 8, 2025 at 7:10 PM
New study uses cross-modal integration of #metabolomics and cardiac functionality to capture dynamic metabotoxic effects of #doxorubicin in engineered heart tissues. #heartonchip #cardiotoxicity https://ow.ly/HfsS50XC6NI
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press