Jake Wintermute
@synbio1.bsky.social
Synthetic Biologist - Foundry Theorist
foundrytheory.substack.com
stay humble biodesigners
foundrytheory.substack.com
stay humble biodesigners
Given that GLP-1 drugs were found in gila monster venom it's not totally unrealistic to imagine that one day a breakthrough drug will be discovered in literal snake oil and a biotech startup will be like "ok how do we market this"
November 25, 2025 at 4:42 PM
Given that GLP-1 drugs were found in gila monster venom it's not totally unrealistic to imagine that one day a breakthrough drug will be discovered in literal snake oil and a biotech startup will be like "ok how do we market this"
I dare you to put this in your next talk instead of the slide acknowledging funding sources
November 24, 2025 at 6:52 PM
I dare you to put this in your next talk instead of the slide acknowledging funding sources
"We should keep saying how AI can enable biomedical breakthroughs people seem to like that"
November 24, 2025 at 1:42 AM
"We should keep saying how AI can enable biomedical breakthroughs people seem to like that"
These hotdog looking plants are magic there has to be some kind of cool biotech we can invent from this
November 20, 2025 at 1:09 PM
These hotdog looking plants are magic there has to be some kind of cool biotech we can invent from this
Super interesting article. Particularly the familiar focus on combatting "hesitancy" around modern vaccines.
The tickle-me-elmo marketers weren't trying to combat hesitancy. They were trying to throw gasoline on a craze. Maybe that's what it takes to win.
The tickle-me-elmo marketers weren't trying to combat hesitancy. They were trying to throw gasoline on a craze. Maybe that's what it takes to win.
November 19, 2025 at 6:25 PM
Super interesting article. Particularly the familiar focus on combatting "hesitancy" around modern vaccines.
The tickle-me-elmo marketers weren't trying to combat hesitancy. They were trying to throw gasoline on a craze. Maybe that's what it takes to win.
The tickle-me-elmo marketers weren't trying to combat hesitancy. They were trying to throw gasoline on a craze. Maybe that's what it takes to win.
Is there a real history of grassroots popular demand for the polio vaccine? Like a hula-hoop style consumer craze?
I’d love to read more about it. And I’d love to capture that magic again.
I’d love to read more about it. And I’d love to capture that magic again.
November 19, 2025 at 5:16 PM
Is there a real history of grassroots popular demand for the polio vaccine? Like a hula-hoop style consumer craze?
I’d love to read more about it. And I’d love to capture that magic again.
I’d love to read more about it. And I’d love to capture that magic again.
I wish we lived in a world where consumers jumped for joy when given a chance to purchase the polio vaccine. We don't though.
November 19, 2025 at 3:21 PM
I wish we lived in a world where consumers jumped for joy when given a chance to purchase the polio vaccine. We don't though.
Biotech needs a tickle-me-elmo moment a product so desirable that people will stampede over police barricades to get it
November 19, 2025 at 12:59 PM
Biotech needs a tickle-me-elmo moment a product so desirable that people will stampede over police barricades to get it
Has anyone explored the possibility that Eroom's law and the decline in biotech R&D productivity may be due to the fact that our reagent packaging no longer gives sleek midcentury optimism
November 18, 2025 at 6:34 PM
Has anyone explored the possibility that Eroom's law and the decline in biotech R&D productivity may be due to the fact that our reagent packaging no longer gives sleek midcentury optimism
And then it turns out to be really a new nucleotide and we all win nobel prizes
November 16, 2025 at 6:11 PM
And then it turns out to be really a new nucleotide and we all win nobel prizes
Somebody once sent me a DNA sequence in a Microsoft Word document and something about seeing nucleotides in Times New Roman font really stresses me out
November 16, 2025 at 4:04 PM
Somebody once sent me a DNA sequence in a Microsoft Word document and something about seeing nucleotides in Times New Roman font really stresses me out
There's a lot of bioproduct innovation happening in the world that isn't well connected with academia or the industrial biotech scene like what conferences is this guy attending and how do I get invited
November 15, 2025 at 4:44 PM
There's a lot of bioproduct innovation happening in the world that isn't well connected with academia or the industrial biotech scene like what conferences is this guy attending and how do I get invited
How it feels to add the transformation recovery broth to your microbes after electroporation
November 14, 2025 at 8:22 PM
How it feels to add the transformation recovery broth to your microbes after electroporation
Justice for furbaby
November 14, 2025 at 1:29 PM
Justice for furbaby
Enemies to lovers but make it biology and engineering
November 13, 2025 at 2:07 PM
Enemies to lovers but make it biology and engineering
The application of humanoid robots that I’m the most excited about and one that will definitely work is super dope ass fortune teller machines
November 10, 2025 at 1:50 AM
The application of humanoid robots that I’m the most excited about and one that will definitely work is super dope ass fortune teller machines
Victor frankenstein did nothing wrong
November 9, 2025 at 7:33 PM
Victor frankenstein did nothing wrong
Will AI-generated genomes read like AI slop?
Like you’ll be scrolling GenBank one day and it will be full of microbial genomes with the nucleotide equivalent of
“This lac operon doesn’t just encode LacA and LacY — it expresses LacZ”
Like you’ll be scrolling GenBank one day and it will be full of microbial genomes with the nucleotide equivalent of
“This lac operon doesn’t just encode LacA and LacY — it expresses LacZ”
November 9, 2025 at 4:10 PM
Will AI-generated genomes read like AI slop?
Like you’ll be scrolling GenBank one day and it will be full of microbial genomes with the nucleotide equivalent of
“This lac operon doesn’t just encode LacA and LacY — it expresses LacZ”
Like you’ll be scrolling GenBank one day and it will be full of microbial genomes with the nucleotide equivalent of
“This lac operon doesn’t just encode LacA and LacY — it expresses LacZ”
It may seem obvious but honestly it is worth taking a moment to reflect on how amazing this actually is
November 7, 2025 at 12:03 PM
It may seem obvious but honestly it is worth taking a moment to reflect on how amazing this actually is
If you study cholinesterases in plant tissues you have legendary opportunity to make your work relatable to gen z by showing them this article from 1975 that has PubMed ID # 67
pubmed.ncbi.nlm.nih.gov/67
pubmed.ncbi.nlm.nih.gov/67
November 6, 2025 at 1:38 PM
If you study cholinesterases in plant tissues you have legendary opportunity to make your work relatable to gen z by showing them this article from 1975 that has PubMed ID # 67
pubmed.ncbi.nlm.nih.gov/67
pubmed.ncbi.nlm.nih.gov/67
This is surrealist art
November 5, 2025 at 1:57 AM
This is surrealist art