Jake Wintermute
@synbio1.bsky.social
Synthetic Biologist - Foundry Theorist
foundrytheory.substack.com
stay humble biodesigners
foundrytheory.substack.com
stay humble biodesigners
When you work in a yeast lab and you pause a moment to enjoy the aromas of the yeast
January 21, 2026 at 1:51 PM
When you work in a yeast lab and you pause a moment to enjoy the aromas of the yeast
I don't want to be the main character I want to be the quest giver
January 19, 2026 at 11:26 PM
I don't want to be the main character I want to be the quest giver
Mutagen Man, Living Ooze
January 17, 2026 at 9:28 PM
Mutagen Man, Living Ooze
This vintage Abcam fridge magnet does me so right
It’s odd, it’s playful, it’s memorable. But what I like best is the way you can tell if reflects a real human’s sense of humor. It wasn’t designed by committee.
More marketing like this please biotech companies
It’s odd, it’s playful, it’s memorable. But what I like best is the way you can tell if reflects a real human’s sense of humor. It wasn’t designed by committee.
More marketing like this please biotech companies
January 17, 2026 at 2:07 PM
This vintage Abcam fridge magnet does me so right
It’s odd, it’s playful, it’s memorable. But what I like best is the way you can tell if reflects a real human’s sense of humor. It wasn’t designed by committee.
More marketing like this please biotech companies
It’s odd, it’s playful, it’s memorable. But what I like best is the way you can tell if reflects a real human’s sense of humor. It wasn’t designed by committee.
More marketing like this please biotech companies
But there's nothing like the warm sound of an orbital shaker
January 16, 2026 at 9:20 PM
But there's nothing like the warm sound of an orbital shaker
My son's school has scheduled the dungeons and dragons club, the chess club and the programming club all at the same time and I'm just trying to figure out how this could have happened
January 14, 2026 at 1:32 PM
My son's school has scheduled the dungeons and dragons club, the chess club and the programming club all at the same time and I'm just trying to figure out how this could have happened
This is the strongest argument in favor of automated labs
January 12, 2026 at 1:43 PM
This is the strongest argument in favor of automated labs
I've often daydreamed about fantastically large fruits and vegetables, living in a pumpkin house, boats made of watermelons, things of that nature
But maybe I need to re-imagine that future because these large carrots are actually quite unsettling
But maybe I need to re-imagine that future because these large carrots are actually quite unsettling
January 11, 2026 at 4:08 PM
I've often daydreamed about fantastically large fruits and vegetables, living in a pumpkin house, boats made of watermelons, things of that nature
But maybe I need to re-imagine that future because these large carrots are actually quite unsettling
But maybe I need to re-imagine that future because these large carrots are actually quite unsettling
At first I thought this picture was just somebody from woodgang hornyposting so imagine my delight to see bark-dwelling microbes on the cover of science magazine
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 9, 2026 at 1:51 PM
At first I thought this picture was just somebody from woodgang hornyposting so imagine my delight to see bark-dwelling microbes on the cover of science magazine
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Scientists often assume that "the public" has an innate and knee-jerk opposition to GMOs, lab-grown meat or other novel bioproducts
But when you make something people really want it turns out they have a higher weirdness tolerance than you might expect
But when you make something people really want it turns out they have a higher weirdness tolerance than you might expect
January 8, 2026 at 9:23 PM
Scientists often assume that "the public" has an innate and knee-jerk opposition to GMOs, lab-grown meat or other novel bioproducts
But when you make something people really want it turns out they have a higher weirdness tolerance than you might expect
But when you make something people really want it turns out they have a higher weirdness tolerance than you might expect
This is how I feel about attempts to build a virtual cell model
January 8, 2026 at 2:36 PM
This is how I feel about attempts to build a virtual cell model
Writing your lover a note on paper made from your own hair is the kind of high-upside romantic bet you can only make with a bio-based product
January 6, 2026 at 3:17 PM
Writing your lover a note on paper made from your own hair is the kind of high-upside romantic bet you can only make with a bio-based product
Reposted by Jake Wintermute
Proud to announce SimPhyNI, a new tool for bacterial GWAS with higher precision and scalability than existing tools. Try it out and let us know what you think!!
High Precision Binary Trait Association on Phylogenetic Trees https://www.biorxiv.org/content/10.64898/2025.12.24.696407v1
January 5, 2026 at 2:55 PM
Proud to announce SimPhyNI, a new tool for bacterial GWAS with higher precision and scalability than existing tools. Try it out and let us know what you think!!
I wonder if we could replicate this pipeline to get more of the the fitness-style biohacking community interested in fundamental biology and lab-style biohacking
January 2, 2026 at 3:58 PM
I wonder if we could replicate this pipeline to get more of the the fitness-style biohacking community interested in fundamental biology and lab-style biohacking
When you're brainstorming about bioproduct ideas one thing you look for is signs of an unmet market need
December 31, 2025 at 3:48 PM
When you're brainstorming about bioproduct ideas one thing you look for is signs of an unmet market need
We could have GFP cats just sayin
December 29, 2025 at 9:07 PM
We could have GFP cats just sayin
Reposted by Jake Wintermute
Hope it's called WetterHelp
December 29, 2025 at 6:51 PM
Hope it's called WetterHelp
Who’s building BetterHelp for biology grad students where instead of a therapist you get another grad student to complain to about why your Western blots aren’t working
December 29, 2025 at 6:11 PM
Who’s building BetterHelp for biology grad students where instead of a therapist you get another grad student to complain to about why your Western blots aren’t working
Science is an attention economy. “Novelty” is “Virality.” Citations are Likes. Editors are content curators. Prestige journals are the “For You” page.
Yes, scientists prefer fact-based content. But facts need to earn attention before they can drive discoveries or make careers
Yes, scientists prefer fact-based content. But facts need to earn attention before they can drive discoveries or make careers
December 28, 2025 at 4:49 PM
Science is an attention economy. “Novelty” is “Virality.” Citations are Likes. Editors are content curators. Prestige journals are the “For You” page.
Yes, scientists prefer fact-based content. But facts need to earn attention before they can drive discoveries or make careers
Yes, scientists prefer fact-based content. But facts need to earn attention before they can drive discoveries or make careers
Scientists be like “ah the holidays a chance to take a break from the grind” and then read 87 journal articles about the gila monster pancreas
December 27, 2025 at 7:21 PM
Scientists be like “ah the holidays a chance to take a break from the grind” and then read 87 journal articles about the gila monster pancreas
My new startup will genetically engineer bay leafs that actually do something when you add them to a recipe
December 23, 2025 at 7:51 PM
My new startup will genetically engineer bay leafs that actually do something when you add them to a recipe
Is anyone building doordash for that tube of Proteinase K that you need for a time-sensitive experiment but your inconsiderate labmate used it all and didn’t reorder
December 20, 2025 at 7:51 PM
Is anyone building doordash for that tube of Proteinase K that you need for a time-sensitive experiment but your inconsiderate labmate used it all and didn’t reorder
High throughput screens be like
December 19, 2025 at 1:35 PM
High throughput screens be like
It is actually amazing to see in 2025 a political focus group of normal Americans who are 100% happy about something.
Democrat & Republican. Men & Women. White, Black, Latino, Asian.
What are they happy about? Weight loss drugs. Politicians take note.
www.nytimes.com/interactive/...
Democrat & Republican. Men & Women. White, Black, Latino, Asian.
What are they happy about? Weight loss drugs. Politicians take note.
www.nytimes.com/interactive/...
December 18, 2025 at 10:48 PM
It is actually amazing to see in 2025 a political focus group of normal Americans who are 100% happy about something.
Democrat & Republican. Men & Women. White, Black, Latino, Asian.
What are they happy about? Weight loss drugs. Politicians take note.
www.nytimes.com/interactive/...
Democrat & Republican. Men & Women. White, Black, Latino, Asian.
What are they happy about? Weight loss drugs. Politicians take note.
www.nytimes.com/interactive/...