Lightnews — Scholar-powered news

Synlett Journal

@synlettjournal.bsky.social

330 followers 470 following 120 posts

An international, peer-reviewed #Account and #Letter journal from Thieme reporting research results and current trends in #chemicalsynthesis. 🔗 https://www.thieme.de/de/synlett/journal-information-55964.htm

www.thieme.de

Posts Media Videos Starter Packs

Pinned

Synlett Journal @synlettjournal.bsky.social · Jul 15

Are you an innovator in #ChemicalSynthesis? Find your audience with SYNLETT!

Why SYNLETT:

👥 Rapid Select Crowd Review
🤝 Support for Early Career Researchers
💡 Diverse Editorial Board
...and more!

Submit today: buff.ly/2q3gEkL

Synlett Journal @synlettjournal.bsky.social · 3h

Vicinal tetrasubstituted carbons remain a tough synthetic challenge🔬 Sohtome & Sodeoka (RIKEN) unveil a catalytic aerobic #carbooxygenation strategy that balances uphill & downhill energy profiles, enabling efficient construction of these demanding motifs⚡

👉 buff.ly/eBuOgso

Synlett Journal @synlettjournal.bsky.social · 2d

#Cyclopentenones made simple🌟 Haberhauer & co-workers report a metal-free route via halogen-stabilized #carbanion + #thiolate cyclization🚀 Broad functional group tolerance & pharma relevance make this a powerful tool🔬

👉 buff.ly/WQhB4xs

Synlett Journal @synlettjournal.bsky.social · 4d

Protecting-group-free #glycosylations are reshaping #glycoscience 🧪 From Ca²⁺-mediated regioselective reactions to #Mitsunobu + photoredox strategies, new methods enable direct, selective glycoside synthesis with high efficiency in our Account by Dey & Jayaraman⚡

👉 buff.ly/HRUIAyu

Synlett Journal @synlettjournal.bsky.social · 7d

#Benzimidazole breakthroughs in our Account by Sun & Pawar✨ Rh/Pd-catalyzed C–H activation + N–H DG enables diverse C–C, C–N, C–O & C–F bond formations using diazo, alkynes, maleimides & more🚀
#CHActivation

👉 buff.ly/T57Emm1

Synlett Journal @synlettjournal.bsky.social · 9d

💡New photocatalytic route to deuterated #oxazoloisoindolinones ! Using D₂O as a cost-effective source, this method by Songjie Yu & co-workers delivers high deuterium incorporation⚡
#DrugDiscovery #deuterium

👉 buff.ly/RMCpnwZ

Synlett Journal @synlettjournal.bsky.social · 11d

⚗️From silica & zeolites to MOFs, nanotubes & graphene – advanced templates are powering stable, efficient nanocatalysts⚡Driving sustainable organic transformations & industrial applications by Purohit, Rawat & Rawat🚀
#nanocatalysis

👉 buff.ly/VeKf9Hw

Synlett Journal @synlettjournal.bsky.social · 14d

Josep Cornella & co-workers @cornellab.bsky.social unveil one-step heteroatom exchange🚀 A Ni(0)-catalyzed route converts #isoxazoles & #oxadiazoles into #pyrazoles & 1,2,4-triazoles🧪 A blueprint for rapid #azole scaffold exploration without de novo synthesis🌟
#nickel

👉 buff.ly/BabxqGG

1 4

Synlett Journal @synlettjournal.bsky.social · 16d

Fuxing Yang & Lei Gong developed a dual-catalyst strategy combining photoinduced HAT + chiral #copper #catalysis ✨ Enables regiodivergent, enantioselective C(sp³)–H functionalization of N-aryl #glycines 🎯

👉 buff.ly/eXW6lVz

Synlett Journal @synlettjournal.bsky.social · 18d

Dive into the fascinating world of eco-friendly photocyclization 🌱 Valerii Shirinian & co-workers report a novel, transition metal-free synthesis of oxa[5]helicenes, remarkably stable under UV & visible light💡
#photochemistry #photocyclization #helicenes

👉 buff.ly/2BLUMt4

Synlett Journal @synlettjournal.bsky.social · 20d

How is AI reshaping peer review? 🧠

At Synlett Journal, #PeerReviewWeek2025 is a chance to reflect on the opportunities AI offers, such as efficiency and support, while addressing questions of bias, transparency, and the role of human judgment.

#AI #PeerReview #Thieme

Sustainability & Circularity NOW @suscircnow.bsky.social · 22d

🤖 Peer Review Week 2025: Rethinking Peer Review in the AI Era.🤖

Let’s discuss how #AI can boost efficiency & integrity while keeping human judgment central. Share your thoughts!

📌 Learn more: peerreviewweek.net/theme.php
Peer Review Guidelines: www.thieme.com/en-us/guidel...

#SCNOW

Reposted by Synlett Journal

TeichertLab @TUC @teichertlab.bsky.social · 21d

We have just published a short overview article explaining the concepts copper catalysys with bifunctional ligands published recently. @synlettjournal.bsky.social.

It's a short read, check it out here: www.thieme-connect.com/products/ejo...

#CHEMnitz
#copper
#NHCs

1 3 6

Synlett Journal @synlettjournal.bsky.social · 21d

Ni-catalyzed regioselective #hydroalkenylation of alkynes with #aziridines paves the way to valuable homoallylic amines✨ In this Letter by Ruben Martin & co-workers no stoichiometric organometallics required, just mild conditions and broad substrate scope🌿
#nickel

👉 buff.ly/AjXXA7D

Synlett Journal @synlettjournal.bsky.social · 23d

In our #Synpacts by Qiqige Qiqige & Zhaobin Wang, #chromium #catalysis transforms gem-dihaloalkanes into chiral #cyclopropanes with high stereo-control & up to 3 contiguous stereocenters.

👉 buff.ly/m4MwnXW

Synlett Journal @synlettjournal.bsky.social · 25d

#Thiosemicarbazones (TSCs) stand out for their structural diversity, bioactivity, & ion-sensing potential🧪 In our Account by Tahmeena Khan & co-workers, tweaking molecular weight, benzene rings, and functional groups can boost #ADME & bioactivity scores.

👉 buff.ly/tPHyu2Q

Synlett Journal @synlettjournal.bsky.social · 28d

Discover a dual Ni/#organophotoredox catalytic system by Lei Shi & co-workers for stereoselective #allylation of aldehydes with vinyl cyclic carbonates💡 delivering 1,3-diols with tertiary stereocenters in high yield & dr (>20:1) at room temp! 🌟
#catalysis

👉 buff.ly/1eGcns5

Synlett Journal @synlettjournal.bsky.social · Sep 10

How do you design #cyclooctynes that work in both #bioorthogonal and surface chemistry?🧠 Discover new functionalized cyclooctynes with high chemoselectivity, transannular compatibility & applications on Si(001) surfaces in our Account by Koert & co-workers🧪

Read more👉 buff.ly/b4S1znx

Synlett Journal @synlettjournal.bsky.social · Sep 8

A protecting group-free, 4-step total synthesis of (±)-β-eudesmol in 25% yield by Pulukuri & co-workers!🚀 Highlights include a Cu-catalyzed Michael–aldol cascade and a one-step Fe(III)-mediated radical cyclization–oxidation to build the eudesmane core🧪
#TotalSynthesis

👉 buff.ly/c7upFCj

Synlett Journal @synlettjournal.bsky.social · Sep 5

🌟From Cluster Hydrogen Atom Transfer Reactions🌟

Gong & co-workers report a decatungstate-mediated double #HAT for regioselective #hydroacylation of N-sulfonylimine esters 💡 Exclusive C–N bond formation gives diverse N-sulfonyl N-carbonyl amides
#photocatalysis

👉 buff.ly/wSo72lo

Synlett Journal @synlettjournal.bsky.social · Sep 3

🌟From Cluster Hydrogen Atom Transfer Reactions🌟

An #iron bromide/blue light system enables #cumene photooxidation to CHP via #HAT with bromine radicals💡Followed by Hock rearrangement, this offers a selective & mild route to #phenol production with broad scope

👉 buff.ly/us2Gb5u

Synlett Journal @synlettjournal.bsky.social · Sep 1

🌟From Cluster Hydrogen Atom Transfer Reactions🌟

S. Hong & co-workers report phosphine-mediated 1,2-HAT of amidyl #radicals via FLP activation – no photocatalyst needed!💡This enables selective C4-alkylation of #pyridines with broad scope⚡

👉 buff.ly/htGLoAw

Synlett Journal @synlettjournal.bsky.social · Aug 29

🌟From Cluster Hydrogen Atom Transfer Reactions🌟

By merging palladium and tetrabutylammonium decatungstate as a HAT photocatalyst, Wang & co-workers achieved acyl C–H #alkenylation of aldehydes with alkenyl triflates, enabling multi-substituted cyclic alkenes💡

👉 buff.ly/qW9DGmA

Synlett Journal @synlettjournal.bsky.social · Aug 28

🌟From Cluster Hydrogen Atom Transfer Reactions🌟

García Mancheño, Ohmatsu, Ooi & co-workers report a sustainable catalytic system for acceptorless #dehydrogenation. Hydrocarbons undergo smooth CAD using a zwitterionic acridinium amidate + cobaloxime🌱
#photocatalysis

👉 buff.ly/D3xFmv0

Synlett Journal @synlettjournal.bsky.social · Aug 27

🌟From Cluster Hydrogen Atom Transfer Reactions🌟

Kokotos & co-workers present a green, metal-free approach🌱 for selective C–H activation: #hydroacylation of alkenes using NBI #photocatalysis under blue LEDs💡
#organocatalysis

Read more👉 buff.ly/c5NKx3e

Synlett Journal @synlettjournal.bsky.social · Aug 25

🌟From Cluster Hydrogen Atom Transfer Reactions🌟

Explore how #cumyloxyl radicals unlock new insights into C–H bond reactivity. A kinetic, product & DFT study by Liu, Houk, Bietti & co-workers reveals how 1,3-diaxial #StrainRelease shapes HAT selectivity in #cyclohexanes 🧪

👉 buff.ly/psJGxcr

Synlett Journal @synlettjournal.bsky.social · Aug 22

🚨 Special Issue Alert❗
Explore the latest #HAT Reactions research in SYNLETT! Cutting-edge radical chemistry and innovative transformations await⚡

🔜 Next weeks we’ll spotlight all letters from this cluster. Stay tuned!

Read it here👉 buff.ly/KfAghrR