Therapeutic Advances in Infectious Disease
@tainfdis.bsky.social
🦠🚀 High-impact infectious disease research—Rigorous in review, Global in impact. Gold open access and indexed in PubMed, Scopus, and ESCI.
AI-driven models are showing clear promise in improving HIV/TB detection and management in Nigeria, where immunosuppression drives disproportionate TB risk. Strengthening technical capacity will be essential for translating this potential into practice.
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November 25, 2025 at 2:17 PM
AI-driven models are showing clear promise in improving HIV/TB detection and management in Nigeria, where immunosuppression drives disproportionate TB risk. Strengthening technical capacity will be essential for translating this potential into practice.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Data from 89 patients suggest that follow-up FDG-PET/CT can guide decisions in focal infections but is most informative when bacteremia is gram-positive or clinical status deteriorates. Findings support targeted rather than routine use. 🔍🦠📊 journals.sagepub.com/doi/full/10....
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November 23, 2025 at 8:52 PM
Data from 89 patients suggest that follow-up FDG-PET/CT can guide decisions in focal infections but is most informative when bacteremia is gram-positive or clinical status deteriorates. Findings support targeted rather than routine use. 🔍🦠📊 journals.sagepub.com/doi/full/10....
Recurrent UTIs remain a major burden, and new guidance is steering care toward non-antibiotic prevention—behavioural measures, topical oestrogen, methenamine hippurate, and intravesical HA/CS 💡💊💧
Read this review for more 📘✨
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Read this review for more 📘✨
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November 19, 2025 at 4:10 PM
Recurrent UTIs remain a major burden, and new guidance is steering care toward non-antibiotic prevention—behavioural measures, topical oestrogen, methenamine hippurate, and intravesical HA/CS 💡💊💧
Read this review for more 📘✨
journals.sagepub.com/doi/full/10....
Read this review for more 📘✨
journals.sagepub.com/doi/full/10....
Antibiotics disrupt gut/airway microbiomes across ages 🦠, amplifying both targeted and background resistance genes 🧬. Recovery remains especially poor in children 👶
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November 15, 2025 at 2:41 PM
Antibiotics disrupt gut/airway microbiomes across ages 🦠, amplifying both targeted and background resistance genes 🧬. Recovery remains especially poor in children 👶
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journals.sagepub.com/doi/full/10....
A multistep UTI-focused stewardship initiative reduced unnecessary treatment of asymptomatic presentations by 12% & improved adherence to UTI management guidelines.
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Impact of a multistep urinary tract infection-focused disease state stewardship initiative on the treatment of asymptomatic urinary presentations: a retrospective cohort study - Christian Tyler Pitcoc...
Background: Asymptomatic bacteriuria (ASB) is often overtreated, risking patient harm through unnecessary antimicrobial use and fostering antimicrobial resistan...
journals.sagepub.com
November 11, 2025 at 9:07 PM
A multistep UTI-focused stewardship initiative reduced unnecessary treatment of asymptomatic presentations by 12% & improved adherence to UTI management guidelines.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Novel entomo-virological tools, such as honey-baited traps preserving mosquito-expectorated RNA, are reshaping arbovirus monitoring. Integrating these with genomic surveillance can bridge field ecology and molecular epidemiology. 🔬🦟https://journals.sagepub.com/doi/full/10.1177/20499361251391261
November 2, 2025 at 5:05 PM
Novel entomo-virological tools, such as honey-baited traps preserving mosquito-expectorated RNA, are reshaping arbovirus monitoring. Integrating these with genomic surveillance can bridge field ecology and molecular epidemiology. 🔬🦟https://journals.sagepub.com/doi/full/10.1177/20499361251391261
P. aeruginosa is the archetype of adaptive resistance—porins close, pumps activate, enzymes evolve. New β-lactam/β-lactamase inhibitor combos and cefiderocol offer treatment options.
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October 30, 2025 at 1:19 PM
P. aeruginosa is the archetype of adaptive resistance—porins close, pumps activate, enzymes evolve. New β-lactam/β-lactamase inhibitor combos and cefiderocol offer treatment options.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
📈 Retrospective time-series study (2014–2019, Mysuru, India):
Rising temperature, humidity, and monsoon rainfall were linked to increased Salmonella bacteraemia.
Findings suggest climate–infection interplay with implications for AMR trends.
journals.sagepub.com/doi/full/10....
Rising temperature, humidity, and monsoon rainfall were linked to increased Salmonella bacteraemia.
Findings suggest climate–infection interplay with implications for AMR trends.
journals.sagepub.com/doi/full/10....
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
October 28, 2025 at 1:10 PM
📈 Retrospective time-series study (2014–2019, Mysuru, India):
Rising temperature, humidity, and monsoon rainfall were linked to increased Salmonella bacteraemia.
Findings suggest climate–infection interplay with implications for AMR trends.
journals.sagepub.com/doi/full/10....
Rising temperature, humidity, and monsoon rainfall were linked to increased Salmonella bacteraemia.
Findings suggest climate–infection interplay with implications for AMR trends.
journals.sagepub.com/doi/full/10....
Meta-analysis (7 studies, n=1685): Cefazolin vs. ASPs for MSSA endocarditis — similar efficacy, lower 30-day mortality (OR 0.49, 95% CI 0.29–0.83), and fewer adverse events. Supports cefazolin as a viable alternative
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Comparative effectiveness of cefazolin versus antistaphylococcal penicillins in methicillin-susceptible Staphylococcus aureus infective endocarditis: a systematic review of observational studies - Lau...
Background: Methicillin-susceptible Staphylococcus aureus (MSSA) is a leading cause of infective endocarditis (IE), associated with high morbidity and mortality...
journals.sagepub.com
October 28, 2025 at 1:08 PM
Meta-analysis (7 studies, n=1685): Cefazolin vs. ASPs for MSSA endocarditis — similar efficacy, lower 30-day mortality (OR 0.49, 95% CI 0.29–0.83), and fewer adverse events. Supports cefazolin as a viable alternative
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🚨study from Bolivia: A novel PCR platform—Orange G3 TBC—shows comparable accuracy to GeneXpert Ultra for TB diagnosis (sensitivity = 90%, specificity = 97%). Its biosafe, low-resource–friendly design could expand TB testing access in endemic settings.
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Diagnostic accuracy of the novel and biosafe molecular assay Orange G3 TBC compared to GeneXpert for tuberculosis diagnosis in resource-limited settings - Juan Carlos Garberi, Gabriel Estryk, Richard ...
Background: Tuberculosis (TB) remains a global public health priority, with 10.5 million new cases and 1.5 million deaths reported in 2023. Current diagnostic m...
journals.sagepub.com
October 22, 2025 at 12:47 PM
🚨study from Bolivia: A novel PCR platform—Orange G3 TBC—shows comparable accuracy to GeneXpert Ultra for TB diagnosis (sensitivity = 90%, specificity = 97%). Its biosafe, low-resource–friendly design could expand TB testing access in endemic settings.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Excited to see everyone at #IDWeek2025! Catch the @TAInfDis team sharing insights across these great sessions.
October 20, 2025 at 10:54 AM
Excited to see everyone at #IDWeek2025! Catch the @TAInfDis team sharing insights across these great sessions.
A systematic review (2003–2023) shows live attenuated (LAIV) and inactivated (IIV) influenza vaccines protect children/adolescents equally well (~50% VE). Post-2017 LAIV strain updates restored H1N1 protection and improved efficacy vs influenza B.
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Sage Journals: Discover world-class research
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October 18, 2025 at 2:32 PM
A systematic review (2003–2023) shows live attenuated (LAIV) and inactivated (IIV) influenza vaccines protect children/adolescents equally well (~50% VE). Post-2017 LAIV strain updates restored H1N1 protection and improved efficacy vs influenza B.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
In a survey of 128 HIV care workers, negative attitudes toward people who use drugs were strongly linked to lower acceptance of harm reduction practices. Acceptance varied by site, race, and experience—pointing to structural and training gaps.
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Attitudes of HIV healthcare Provider Attitudes Towards PWH who use Drugs and acceptance of harm reduction strategies: a cross-sectional study - Rabab F. M. Ahmed, Robert W. S. Coulter, M. Reuel Friedm...
Background: Negative attitudes toward people who use drugs (PWUD) can hinder their engagement in healthcare and contribute to poor clinical outcomes. While harm...
journals.sagepub.com
October 15, 2025 at 1:02 PM
In a survey of 128 HIV care workers, negative attitudes toward people who use drugs were strongly linked to lower acceptance of harm reduction practices. Acceptance varied by site, race, and experience—pointing to structural and training gaps.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Dolutegravir/lamivudine improved quality of life, treatment acceptability, and symptom burden in PLWH over 6 months (French multicenter study, n=260). Gains appeared by month 1 and persisted. Monitoring discontinuations—especially among women—remains key.
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Sage Journals: Discover world-class research
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October 15, 2025 at 12:59 PM
Dolutegravir/lamivudine improved quality of life, treatment acceptability, and symptom burden in PLWH over 6 months (French multicenter study, n=260). Gains appeared by month 1 and persisted. Monitoring discontinuations—especially among women—remains key.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Systematic review/meta-analysis (2013–2024, n=23,319): In febrile neutropenia after chemotherapy, bloodstream infections were 59% Gram-negative, 39.7% Gram-positive, and 2.5% fungal.
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October 10, 2025 at 12:41 PM
Systematic review/meta-analysis (2013–2024, n=23,319): In febrile neutropenia after chemotherapy, bloodstream infections were 59% Gram-negative, 39.7% Gram-positive, and 2.5% fungal.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
The Clade IIb #mpox 🌍 outbreak exposed major gaps in evidence for antivirals 💊, vaccine equity 💉, and surveillance. This review maps the path toward targeted, evidence-based treatments and prevention✨
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October 7, 2025 at 1:13 PM
The Clade IIb #mpox 🌍 outbreak exposed major gaps in evidence for antivirals 💊, vaccine equity 💉, and surveillance. This review maps the path toward targeted, evidence-based treatments and prevention✨
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
ED study in Japan: Relaxation of COVID-19 IPC practices led to a surge in virus-related exacerbations of COPD (7.7%→52.5%) & asthma (39.7%→66.7%). Reinforcing viral prevention is key in chronic airway disease care.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Sage Journals: Discover world-class research
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October 2, 2025 at 2:36 PM
ED study in Japan: Relaxation of COVID-19 IPC practices led to a surge in virus-related exacerbations of COPD (7.7%→52.5%) & asthma (39.7%→66.7%). Reinforcing viral prevention is key in chronic airway disease care.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
📊 HIV from injection drug use is climbing (2016–2022).
PrEP uptake in PWID remains critically low.
Call to action: integrate ID + addiction care, expand low-barrier services, implement LA-PrEP, and fight stigma through policy + education.
journals.sagepub.com/doi/full/10....
PrEP uptake in PWID remains critically low.
Call to action: integrate ID + addiction care, expand low-barrier services, implement LA-PrEP, and fight stigma through policy + education.
journals.sagepub.com/doi/full/10....
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
October 2, 2025 at 2:34 PM
📊 HIV from injection drug use is climbing (2016–2022).
PrEP uptake in PWID remains critically low.
Call to action: integrate ID + addiction care, expand low-barrier services, implement LA-PrEP, and fight stigma through policy + education.
journals.sagepub.com/doi/full/10....
PrEP uptake in PWID remains critically low.
Call to action: integrate ID + addiction care, expand low-barrier services, implement LA-PrEP, and fight stigma through policy + education.
journals.sagepub.com/doi/full/10....
Hospital clinician training transformed care for PWUD w/ severe infections. Post-training: 95% applied harm reduction (vs 55%), 69% discussed safer use (vs 38%).
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
A descriptive survey evaluating the implementation and outcomes of a training session highlighting concepts in antimicrobial management and harm reduction for hospital-based clinicians treating person...
Background: People who use drugs (PWUD) are at increased risk for severe infections and face many barriers when completing conventional, typically parenteral an...
journals.sagepub.com
September 23, 2025 at 1:42 PM
Hospital clinician training transformed care for PWUD w/ severe infections. Post-training: 95% applied harm reduction (vs 55%), 69% discussed safer use (vs 38%).
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
East Jerusalem hospital study (2019–2023): CRE in 20.6% of Enterobacterales isolates; blaNDM dominated (82%), blaOXA-48 (13%). Prevalence rising, Klebsiella most common. journals.sagepub.com/doi/full/10....
Prevalence, molecular carbapenemase detection, and antibiotic resistance of carbapenem-resistant Enterobacterales in a tertiary care hospital in East Jerusalem (2019–2023): a retrospective study - Lil...
Background: Carbapenem-resistant Enterobacterales (CRE) are a significant public health threat affecting human health globally. Unfortunately, the incidence of ...
journals.sagepub.com
September 15, 2025 at 3:25 PM
East Jerusalem hospital study (2019–2023): CRE in 20.6% of Enterobacterales isolates; blaNDM dominated (82%), blaOXA-48 (13%). Prevalence rising, Klebsiella most common. journals.sagepub.com/doi/full/10....
Despite free HIV care & PrEP in Peru, HIV incidence among youth remains high (13% at age 18; 25% in trans youth <18). Restricting PrEP to 18+ misses a critical window. Peru must expand PrEP to 15–17-year-olds.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
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September 12, 2025 at 11:24 AM
Despite free HIV care & PrEP in Peru, HIV incidence among youth remains high (13% at age 18; 25% in trans youth <18). Restricting PrEP to 18+ misses a critical window. Peru must expand PrEP to 15–17-year-olds.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
In CNS neuroimmunological disease, anti-CD20/S1PRM therapies blunt humoral responses even after 4th SARS-CoV-2 vaccine dose or breakthrough infection. Encouragingly, no evidence of intermediate-term neuroinflammation or neural injury post-COVID-19
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Sage Journals: Discover world-class research
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September 10, 2025 at 1:23 PM
In CNS neuroimmunological disease, anti-CD20/S1PRM therapies blunt humoral responses even after 4th SARS-CoV-2 vaccine dose or breakthrough infection. Encouragingly, no evidence of intermediate-term neuroinflammation or neural injury post-COVID-19
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Rare case: concurrent Mycobacterium avium & M. kansasii infection in a patient w/ MDS & germline GATA2, on cobimetinib. Suggests profound susceptibility to NTM & therapeutic challenges in this setting.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
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September 7, 2025 at 5:20 AM
Rare case: concurrent Mycobacterium avium & M. kansasii infection in a patient w/ MDS & germline GATA2, on cobimetinib. Suggests profound susceptibility to NTM & therapeutic challenges in this setting.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Real-world fascioliasis data (174 pts, TriNetX 2021–24): common comorbidities, GI symptoms, biliary complications in ~10%, 90-day mortality <6%. Triclabendazole reported in just 6%—access or reporting gap? Prospective studies needed
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Sage Journals: Discover world-class research
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September 7, 2025 at 5:16 AM
Real-world fascioliasis data (174 pts, TriNetX 2021–24): common comorbidities, GI symptoms, biliary complications in ~10%, 90-day mortality <6%. Triclabendazole reported in just 6%—access or reporting gap? Prospective studies needed
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
UTIs drive huge antimicrobial use worldwide. This editorial highlights innovations—PCR, AMR surveillance, PROMs—to guide sustainable, patient-centred therapy.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
journals.sagepub.com
September 4, 2025 at 7:13 AM
UTIs drive huge antimicrobial use worldwide. This editorial highlights innovations—PCR, AMR surveillance, PROMs—to guide sustainable, patient-centred therapy.
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....