The Woo Lab
@thewoolab.bsky.social
Official Account for Christina Woo’s Lab at Harvard CCB| chembio, protein mods, chemoproteomics, TPD | Student-run account | posts by Christina signed CMW
we hope you enjoyed this paper as much as we do! 😉😘
if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD
if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD
Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...
January 22, 2026 at 7:45 PM
we hope you enjoyed this paper as much as we do! 😉😘
if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD
if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD
Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...
January 21, 2026 at 4:29 PM
Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...
He’s gonna be gonna be golden! ⭐️ While we’re sad that our beloved postdoc, Dr. Zhenguang Zhao, is leaving, we’re excited for his next steps as he becomes Prof. Zhao at China Pharmaceutical University! 🤩✨🌟
January 20, 2026 at 11:34 PM
He’s gonna be gonna be golden! ⭐️ While we’re sad that our beloved postdoc, Dr. Zhenguang Zhao, is leaving, we’re excited for his next steps as he becomes Prof. Zhao at China Pharmaceutical University! 🤩✨🌟
wow! Thanks for the shoutout 🥹 Hopefully our papers in the coming year will continue to impress 😉
stay tuned!!
stay tuned!!
Cereblon is one of the most used E3 ligases for degraders. After showing that C-terminal cyclic imids on proteins are ligands for cereblon, the @thewoolab.bsky.social showed that PCMT1 can install them on asparagines via SAM-dependent methyl ester formation. (5/12)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates - Nature Chemical Biology
The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in m...
www.nature.com
January 4, 2026 at 6:54 AM
wow! Thanks for the shoutout 🥹 Hopefully our papers in the coming year will continue to impress 😉
stay tuned!!
stay tuned!!
Reposted by The Woo Lab
Last paper post of the year!
Amazing @natchembio.nature.com paper by @thewoolab.bsky.social. PCMT1 installs cyclic imides at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
Amazing @natchembio.nature.com paper by @thewoolab.bsky.social. PCMT1 installs cyclic imides at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates - Nature Chemical Biology
The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in m...
www.nature.com
December 31, 2025 at 11:19 AM
Last paper post of the year!
Amazing @natchembio.nature.com paper by @thewoolab.bsky.social. PCMT1 installs cyclic imides at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
Amazing @natchembio.nature.com paper by @thewoolab.bsky.social. PCMT1 installs cyclic imides at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
We’re popping the champagne prior to New Year’s because our work on how PCMT1 enzymatically forms the CRBN degron is officially out in Nature ChemBio🥂!! Congrats to Zhenguang, Wenqing, Ethan, Shiyun, and all the authors! 🎉💜🍾
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates - Nature Chemical Biology
The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in m...
www.nature.com
December 30, 2025 at 10:27 PM
We’re popping the champagne prior to New Year’s because our work on how PCMT1 enzymatically forms the CRBN degron is officially out in Nature ChemBio🥂!! Congrats to Zhenguang, Wenqing, Ethan, Shiyun, and all the authors! 🎉💜🍾
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Let us take you to the land of sweets with our latest work in
@CellChemBiol ! Excited to share this proximity-induced target O-GlcNAc approach, where we uncover transcriptional effects of O-GlcNAc. Congrats to Alison and Dan! 🟦🍭🍬🎵❄️https://sciencedirect.com/science/article/pii/S2451945625003538
@CellChemBiol ! Excited to share this proximity-induced target O-GlcNAc approach, where we uncover transcriptional effects of O-GlcNAc. Congrats to Alison and Dan! 🟦🍭🍬🎵❄️https://sciencedirect.com/science/article/pii/S2451945625003538
December 8, 2025 at 8:47 PM
Let us take you to the land of sweets with our latest work in
@CellChemBiol ! Excited to share this proximity-induced target O-GlcNAc approach, where we uncover transcriptional effects of O-GlcNAc. Congrats to Alison and Dan! 🟦🍭🍬🎵❄️https://sciencedirect.com/science/article/pii/S2451945625003538
@CellChemBiol ! Excited to share this proximity-induced target O-GlcNAc approach, where we uncover transcriptional effects of O-GlcNAc. Congrats to Alison and Dan! 🟦🍭🍬🎵❄️https://sciencedirect.com/science/article/pii/S2451945625003538
After some ~technical difficulties~ the Woo Lab is officially (back) on BlueSky!! Apologies for ignoring all the love for the past month 😅 Excited to share some exciting science on this platform 😉✨💜
November 5, 2025 at 11:25 PM
After some ~technical difficulties~ the Woo Lab is officially (back) on BlueSky!! Apologies for ignoring all the love for the past month 😅 Excited to share some exciting science on this platform 😉✨💜