Thorn-Seshold Lab
@thornsesholdlab.bsky.social
Chemical Biology at TU Dresden. Bringing chromocontrol, redox cascades, and photoswitch-based imaging into biology.
https://tu-dresden.de/chemie/chembio | PI posts.
orcid.org/0000-0003-3981-651X
https://tu-dresden.de/chemie/chembio | PI posts.
orcid.org/0000-0003-3981-651X
Pinned
What can HaloTag do for you?
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
Reposted by Thorn-Seshold Lab
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
October 9, 2025 at 9:01 AM
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
Reposted by Thorn-Seshold Lab
The human UDP-Gal-4-epimerase is important for cellular biosynthesis of UDP-Gal and UDP-GalNAc. Both are important precursors for glycosylation. GALE KO abrogates cellular levels of these metabolites. GALE plays a role in cancer (pubmed.ncbi.nlm.nih.gov/31908526/) - so we decided to drug it!
October 7, 2025 at 6:10 AM
The human UDP-Gal-4-epimerase is important for cellular biosynthesis of UDP-Gal and UDP-GalNAc. Both are important precursors for glycosylation. GALE KO abrogates cellular levels of these metabolites. GALE plays a role in cancer (pubmed.ncbi.nlm.nih.gov/31908526/) - so we decided to drug it!
Reposted by Thorn-Seshold Lab
Video compilation from our #türenauf mit der Maus Tag today! #outreach #chemsky @hhu.de @sophieguti.bsky.social @joguti.bsky.social @markussuta.bsky.social @chemiehhu.bsky.social
October 3, 2025 at 4:45 PM
Video compilation from our #türenauf mit der Maus Tag today! #outreach #chemsky @hhu.de @sophieguti.bsky.social @joguti.bsky.social @markussuta.bsky.social @chemiehhu.bsky.social
What can HaloTag do for you?
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
October 1, 2025 at 2:11 PM
What can HaloTag do for you?
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
Molecular Recording with HaloTag?
H2O2, GSH, Trx, LAP?
→ multiplexable reagents record diverse enzyme activities ratiometrically, without signal loss
@biorxivpreprint.bsky.social
preprint: doi.org/10.1101/2025...
CHalo Crew again programming with HaloTag!
#chembio #fluorescence #wednesday
H2O2, GSH, Trx, LAP?
→ multiplexable reagents record diverse enzyme activities ratiometrically, without signal loss
@biorxivpreprint.bsky.social
preprint: doi.org/10.1101/2025...
CHalo Crew again programming with HaloTag!
#chembio #fluorescence #wednesday
October 1, 2025 at 1:59 PM
Molecular Recording with HaloTag?
H2O2, GSH, Trx, LAP?
→ multiplexable reagents record diverse enzyme activities ratiometrically, without signal loss
@biorxivpreprint.bsky.social
preprint: doi.org/10.1101/2025...
CHalo Crew again programming with HaloTag!
#chembio #fluorescence #wednesday
H2O2, GSH, Trx, LAP?
→ multiplexable reagents record diverse enzyme activities ratiometrically, without signal loss
@biorxivpreprint.bsky.social
preprint: doi.org/10.1101/2025...
CHalo Crew again programming with HaloTag!
#chembio #fluorescence #wednesday
Photocaged HaloTag Ligation with red fluorogenic SiR labels:
→ on-demand HaloTag visualisation and tracking
@biorxivpreprint.bsky.social preprint: doi.org/10.1101/2025...
Congrats Philipp Mauker, Joyce Meiring, & the CHalo Crew for again programming with HaloTag!
#chembio #fluorescence #wednesday
→ on-demand HaloTag visualisation and tracking
@biorxivpreprint.bsky.social preprint: doi.org/10.1101/2025...
Congrats Philipp Mauker, Joyce Meiring, & the CHalo Crew for again programming with HaloTag!
#chembio #fluorescence #wednesday
October 1, 2025 at 1:52 PM
Photocaged HaloTag Ligation with red fluorogenic SiR labels:
→ on-demand HaloTag visualisation and tracking
@biorxivpreprint.bsky.social preprint: doi.org/10.1101/2025...
Congrats Philipp Mauker, Joyce Meiring, & the CHalo Crew for again programming with HaloTag!
#chembio #fluorescence #wednesday
→ on-demand HaloTag visualisation and tracking
@biorxivpreprint.bsky.social preprint: doi.org/10.1101/2025...
Congrats Philipp Mauker, Joyce Meiring, & the CHalo Crew for again programming with HaloTag!
#chembio #fluorescence #wednesday
Chemically Induced Dimerisation, modular & on-demand:
=> Fast, stepwise reagents for HaloTag-to-SNAP-tag heterodimerisation without a hook effect
Now preprinted: doi.org/10.1101/2025...
Congratulations to Philipp Mauker & the CHalo Crew for programming with HaloTag!
#chembio #fluorescence #friday
=> Fast, stepwise reagents for HaloTag-to-SNAP-tag heterodimerisation without a hook effect
Now preprinted: doi.org/10.1101/2025...
Congratulations to Philipp Mauker & the CHalo Crew for programming with HaloTag!
#chembio #fluorescence #friday
October 1, 2025 at 1:45 PM
Chemically Induced Dimerisation, modular & on-demand:
=> Fast, stepwise reagents for HaloTag-to-SNAP-tag heterodimerisation without a hook effect
Now preprinted: doi.org/10.1101/2025...
Congratulations to Philipp Mauker & the CHalo Crew for programming with HaloTag!
#chembio #fluorescence #friday
=> Fast, stepwise reagents for HaloTag-to-SNAP-tag heterodimerisation without a hook effect
Now preprinted: doi.org/10.1101/2025...
Congratulations to Philipp Mauker & the CHalo Crew for programming with HaloTag!
#chembio #fluorescence #friday
Reposted by Thorn-Seshold Lab
We boosted tumour-selective delivery of nano-formulated chemotherapeutics by transiently shaking up tumour blood vessels. The catch? You only get one shot at this ☝️ This #BMBF funded work, driven by a predominantly female team @lmumuenchen.bsky.social is available on the @biorxivpreprint.bsky.social
The delivery of nano-formulated drugs to solid tumours is selectively increased by co-application of the vascular disrupting agent CA4P https://www.biorxiv.org/content/10.1101/2025.08.10.669501v1
August 12, 2025 at 10:47 PM
We boosted tumour-selective delivery of nano-formulated chemotherapeutics by transiently shaking up tumour blood vessels. The catch? You only get one shot at this ☝️ This #BMBF funded work, driven by a predominantly female team @lmumuenchen.bsky.social is available on the @biorxivpreprint.bsky.social
Reposted by Thorn-Seshold Lab
🔍 Chemie studieren - eine Formel für die Zukunft!
Ihr kennt jemanden, der überlegt Chemie zu studieren, aber sich nicht sicher ist? Ein Chemiestudium bietet spannende Möglichkeiten. Auf www.chemie-studieren.de finden sich alle Infos rund um Studiengänge, Ausbildungen und Berufe in der Chemie.
Ihr kennt jemanden, der überlegt Chemie zu studieren, aber sich nicht sicher ist? Ein Chemiestudium bietet spannende Möglichkeiten. Auf www.chemie-studieren.de finden sich alle Infos rund um Studiengänge, Ausbildungen und Berufe in der Chemie.
February 13, 2025 at 8:12 AM
🔍 Chemie studieren - eine Formel für die Zukunft!
Ihr kennt jemanden, der überlegt Chemie zu studieren, aber sich nicht sicher ist? Ein Chemiestudium bietet spannende Möglichkeiten. Auf www.chemie-studieren.de finden sich alle Infos rund um Studiengänge, Ausbildungen und Berufe in der Chemie.
Ihr kennt jemanden, der überlegt Chemie zu studieren, aber sich nicht sicher ist? Ein Chemiestudium bietet spannende Möglichkeiten. Auf www.chemie-studieren.de finden sich alle Infos rund um Studiengänge, Ausbildungen und Berufe in der Chemie.
Reposted by Thorn-Seshold Lab
Join our GBM Redox Meeting 2025 in Saarbrücken! We put together an exciting program covering diverse aspects of Redox Regulation in Life.
Check out the Programm and register until Feb 28!
redox-gbm-meeting-2025.uni-koeln.de
#redox #redoxbiology #gbm
@gbmev.bsky.social
Check out the Programm and register until Feb 28!
redox-gbm-meeting-2025.uni-koeln.de
#redox #redoxbiology #gbm
@gbmev.bsky.social
February 13, 2025 at 4:15 PM
Join our GBM Redox Meeting 2025 in Saarbrücken! We put together an exciting program covering diverse aspects of Redox Regulation in Life.
Check out the Programm and register until Feb 28!
redox-gbm-meeting-2025.uni-koeln.de
#redox #redoxbiology #gbm
@gbmev.bsky.social
Check out the Programm and register until Feb 28!
redox-gbm-meeting-2025.uni-koeln.de
#redox #redoxbiology #gbm
@gbmev.bsky.social
For ion-specific photocurrents across membranes: just let ionophores intermingle with photolipids.
A fully modular approach with easy access to large currents.
Stoked that this years-long sleuthing effort led by Peter Pohl is finally out! doi.org/10.1101/2025...
#photopharma #ChemBio #lipidtime
A fully modular approach with easy access to large currents.
Stoked that this years-long sleuthing effort led by Peter Pohl is finally out! doi.org/10.1101/2025...
#photopharma #ChemBio #lipidtime
January 26, 2025 at 6:33 PM
For ion-specific photocurrents across membranes: just let ionophores intermingle with photolipids.
A fully modular approach with easy access to large currents.
Stoked that this years-long sleuthing effort led by Peter Pohl is finally out! doi.org/10.1101/2025...
#photopharma #ChemBio #lipidtime
A fully modular approach with easy access to large currents.
Stoked that this years-long sleuthing effort led by Peter Pohl is finally out! doi.org/10.1101/2025...
#photopharma #ChemBio #lipidtime
Reposted by Thorn-Seshold Lab
The Young Scientist Award of @gdchbiochem.bsky.social of @gdch.bsky.social is open for nominations. If you know an excellent candidate, who defended their PhD or had a publication in 2024 in the field of biochemistry (or related), consider nominating them. #chemsky #ChemBio en.gdch.de/network-s...
January 20, 2025 at 3:00 PM
The Young Scientist Award of @gdchbiochem.bsky.social of @gdch.bsky.social is open for nominations. If you know an excellent candidate, who defended their PhD or had a publication in 2024 in the field of biochemistry (or related), consider nominating them. #chemsky #ChemBio en.gdch.de/network-s...
Congrats to our new Doctor Markus!
@m-markus.bsky.social pioneered chromocontrol by ideal efficacy photoswitching (doi.org/10.1101/2024...), TRPC5 photopharma (doi.org/10.1002/anie...), & switch-based photoacoustic imaging (doi.org/10.1002/anie... & doi.org/10.26434/che...) : a tour de force summa!
@m-markus.bsky.social pioneered chromocontrol by ideal efficacy photoswitching (doi.org/10.1101/2024...), TRPC5 photopharma (doi.org/10.1002/anie...), & switch-based photoacoustic imaging (doi.org/10.1002/anie... & doi.org/10.26434/che...) : a tour de force summa!
January 8, 2025 at 12:39 AM
Congrats to our new Doctor Markus!
@m-markus.bsky.social pioneered chromocontrol by ideal efficacy photoswitching (doi.org/10.1101/2024...), TRPC5 photopharma (doi.org/10.1002/anie...), & switch-based photoacoustic imaging (doi.org/10.1002/anie... & doi.org/10.26434/che...) : a tour de force summa!
@m-markus.bsky.social pioneered chromocontrol by ideal efficacy photoswitching (doi.org/10.1101/2024...), TRPC5 photopharma (doi.org/10.1002/anie...), & switch-based photoacoustic imaging (doi.org/10.1002/anie... & doi.org/10.26434/che...) : a tour de force summa!
Reposted by Thorn-Seshold Lab
Gregorio Weber is a giant in our field, and I am deeply honored to receive this award in his name. I want to acknowledge all my collaborators over the years—especially @dyerfulchymist.bsky.social—and the place that made everything possible: @hhmijanelia.bsky.social
December 5, 2024 at 12:16 PM
Gregorio Weber is a giant in our field, and I am deeply honored to receive this award in his name. I want to acknowledge all my collaborators over the years—especially @dyerfulchymist.bsky.social—and the place that made everything possible: @hhmijanelia.bsky.social
Reposted by Thorn-Seshold Lab
Ein Jahr kostenfreie Mitgliedschaft bei der GBM bei Registrierung bis Ende März 2025! Become a member of the GBM now and the 1st year is for free!
November 28, 2024 at 10:02 AM
Ein Jahr kostenfreie Mitgliedschaft bei der GBM bei Registrierung bis Ende März 2025! Become a member of the GBM now and the 1st year is for free!
Reposted by Thorn-Seshold Lab
The RSC Chemical Biology and Bioorganic Group is now on Bluesky and delighted to be here! We're really looking forward to keeping you all updated with the latest events and news from our community, across the UK and internationally. Spread the word to those you know, and give us a follow! #chembio
November 27, 2024 at 3:13 PM
The RSC Chemical Biology and Bioorganic Group is now on Bluesky and delighted to be here! We're really looking forward to keeping you all updated with the latest events and news from our community, across the UK and internationally. Spread the word to those you know, and give us a follow! #chembio
Reposted by Thorn-Seshold Lab
You don´t find your people? Check blueskystarterpack.com and search for your community! #organicchemistry #Chemicalbiology #MedChem #naturalproductchemistry
Bluesky Starter Packs
Discover and organize your Bluesky experience with curated starter packs. Find and follow amazing accounts based on your interests.
blueskystarterpack.com
November 27, 2024 at 5:05 AM
You don´t find your people? Check blueskystarterpack.com and search for your community! #organicchemistry #Chemicalbiology #MedChem #naturalproductchemistry
Reposted by Thorn-Seshold Lab
Misogeny and sexism is not always easy to recognise, but it's systematic and it paves the way for inequality, hate and violence. Took me painfully long to become angry enough about this. Feminism, and make it intersectional, is good for EVERYONE. #StopViolenceAgainstWomen #TagGegenGewaltAnFrauen
It’s the International Day to End Violence against Women and Girls!
1 in 3 girls and women around the world experience physical and/or sexual violence by:
A husband
A boyfriend
An intimate partner
A lover
A parent
A relative
A colleague
A boss
A stranger
bit.ly/3gy8pfq
#NoExcuse
1 in 3 girls and women around the world experience physical and/or sexual violence by:
A husband
A boyfriend
An intimate partner
A lover
A parent
A relative
A colleague
A boss
A stranger
bit.ly/3gy8pfq
#NoExcuse
November 25, 2024 at 5:08 PM
Misogeny and sexism is not always easy to recognise, but it's systematic and it paves the way for inequality, hate and violence. Took me painfully long to become angry enough about this. Feminism, and make it intersectional, is good for EVERYONE. #StopViolenceAgainstWomen #TagGegenGewaltAnFrauen
Reposted by Thorn-Seshold Lab
@thornsesholdlab.bsky.social set up a feed, that will show all posts with #ChemBio. If you are interested in the feed, click this link, click "Pin to Home" and it will be added as feed to your home screen:
bsky.app/profile/did...
I will use this hashtag in all relevant posts.
bsky.app/profile/did...
I will use this hashtag in all relevant posts.
November 25, 2024 at 4:00 PM
@thornsesholdlab.bsky.social set up a feed, that will show all posts with #ChemBio. If you are interested in the feed, click this link, click "Pin to Home" and it will be added as feed to your home screen:
bsky.app/profile/did...
I will use this hashtag in all relevant posts.
bsky.app/profile/did...
I will use this hashtag in all relevant posts.
Reposted by Thorn-Seshold Lab
Thanks Stephan!
Feed is ordered like this:
(1) prioritises recent posts hashtagged #ChemBio or #ChemicalBiology (not case sensitive)
(2) then other recent posts with "chembio", "chemical biology" etc (not as hashes)
(3) then the "best 5%HN" of recent #ChemSky, #realtimechem, #FluorescenceFriday etc
Feed is ordered like this:
(1) prioritises recent posts hashtagged #ChemBio or #ChemicalBiology (not case sensitive)
(2) then other recent posts with "chembio", "chemical biology" etc (not as hashes)
(3) then the "best 5%HN" of recent #ChemSky, #realtimechem, #FluorescenceFriday etc
bsky.app
November 25, 2024 at 4:52 PM
Thanks Stephan!
Feed is ordered like this:
(1) prioritises recent posts hashtagged #ChemBio or #ChemicalBiology (not case sensitive)
(2) then other recent posts with "chembio", "chemical biology" etc (not as hashes)
(3) then the "best 5%HN" of recent #ChemSky, #realtimechem, #FluorescenceFriday etc
Feed is ordered like this:
(1) prioritises recent posts hashtagged #ChemBio or #ChemicalBiology (not case sensitive)
(2) then other recent posts with "chembio", "chemical biology" etc (not as hashes)
(3) then the "best 5%HN" of recent #ChemSky, #realtimechem, #FluorescenceFriday etc
This is cool, D2O (in place of H2O) as analgesic via TRPV1 permeation modulation
November 25, 2024 at 2:44 AM
Reposted by Thorn-Seshold Lab
This is cool, D2O (in place of H2O) as analgesic via TRPV1 permeation modulation
November 25, 2024 at 1:35 AM
This is cool, D2O (in place of H2O) as analgesic via TRPV1 permeation modulation
📯📯NEW Chemical Biology Feed bsky.app/profile/did:...
📯List: >200 chemical biologists (probes, OC, PC, imaging): bsky.app/profile/did:...
📯Women in ChemBio Pack: bsky.app/starter-pack...
📯General #ChemBio Pack: bsky.app/starter-pack...
📯 #Photopharma: bsky.app/profile/trac...
#chemsky 🧪 🔬
📯List: >200 chemical biologists (probes, OC, PC, imaging): bsky.app/profile/did:...
📯Women in ChemBio Pack: bsky.app/starter-pack...
📯General #ChemBio Pack: bsky.app/starter-pack...
📯 #Photopharma: bsky.app/profile/trac...
#chemsky 🧪 🔬
November 25, 2024 at 12:49 AM
📯📯NEW Chemical Biology Feed bsky.app/profile/did:...
📯List: >200 chemical biologists (probes, OC, PC, imaging): bsky.app/profile/did:...
📯Women in ChemBio Pack: bsky.app/starter-pack...
📯General #ChemBio Pack: bsky.app/starter-pack...
📯 #Photopharma: bsky.app/profile/trac...
#chemsky 🧪 🔬
📯List: >200 chemical biologists (probes, OC, PC, imaging): bsky.app/profile/did:...
📯Women in ChemBio Pack: bsky.app/starter-pack...
📯General #ChemBio Pack: bsky.app/starter-pack...
📯 #Photopharma: bsky.app/profile/trac...
#chemsky 🧪 🔬
A reminder for new folks. BlueSky does not have an algorithm to raise posts of interest. It is incumbent upon you to do so via reposting. Liking things only provides feedback to the poster but does not promote the post. The signal to noise ratio is taking a brief beating, so great to help curate.
November 24, 2024 at 7:16 PM
📯Chemical Biology Starter Pack ＃2: Probes Aficionadas👩🔬 go.bsky.app/DEjVGEn
as generalist ChemBio Pack ＃1
go.bsky.app/KLrTWoj is full
🚩Feed reposting #ChemBio: bsky.app/profile/trac...
🚩 #Photoswitch: bsky.app/profile/trac...
🚩 #FluorescenceFriday:
bsky.app/profile/trac...
#chemsky #realtimechem
as generalist ChemBio Pack ＃1
go.bsky.app/KLrTWoj is full
🚩Feed reposting #ChemBio: bsky.app/profile/trac...
🚩 #Photoswitch: bsky.app/profile/trac...
🚩 #FluorescenceFriday:
bsky.app/profile/trac...
#chemsky #realtimechem
November 23, 2024 at 11:50 PM
📯Chemical Biology Starter Pack ＃2: Probes Aficionadas👩🔬 go.bsky.app/DEjVGEn
as generalist ChemBio Pack ＃1
go.bsky.app/KLrTWoj is full
🚩Feed reposting #ChemBio: bsky.app/profile/trac...
🚩 #Photoswitch: bsky.app/profile/trac...
🚩 #FluorescenceFriday:
bsky.app/profile/trac...
#chemsky #realtimechem
as generalist ChemBio Pack ＃1
go.bsky.app/KLrTWoj is full
🚩Feed reposting #ChemBio: bsky.app/profile/trac...
🚩 #Photoswitch: bsky.app/profile/trac...
🚩 #FluorescenceFriday:
bsky.app/profile/trac...
#chemsky #realtimechem