Tyler Huycke
@thuycke.bsky.social
Assistant Professor at the University of Michigan
Watching cells do cool things during development🐣🐁🧫🔬
huyckelab.org
Watching cells do cool things during development🐣🐁🧫🔬
huyckelab.org
Reposted by Tyler Huycke
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
November 19, 2025 at 8:23 PM
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
Reposted by Tyler Huycke
I'm thrilled to be able to share this new paper from post-doc Camilla Teng @xsciteng.bsky.social and our collaborators in the Leslie-Clarkson lab @emorygenetics.bsky.social on mechanisms of tissue fusion and cleft lip url: rupress.org/jcb/article/...
Actomyosin contractility and a threshold of cadherin cell adhesion are required during tissue fusion | Journal of Cell Biology | Rockefeller University Press
Teng et al. investigate the cellular basis for tissue fusion during mammalian lip formation. They demonstrate that actomyosin contractility drives fusion,
rupress.org
November 13, 2025 at 6:35 PM
I'm thrilled to be able to share this new paper from post-doc Camilla Teng @xsciteng.bsky.social and our collaborators in the Leslie-Clarkson lab @emorygenetics.bsky.social on mechanisms of tissue fusion and cleft lip url: rupress.org/jcb/article/...
Reposted by Tyler Huycke
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
This is an amazing story and important breakthrough! Awesome stuff from @karalmckinley.bsky.social and @cagricevrim.bsky.social
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
October 16, 2025 at 12:22 AM
This is an amazing story and important breakthrough! Awesome stuff from @karalmckinley.bsky.social and @cagricevrim.bsky.social
Reposted by Tyler Huycke
Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this.
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
A quadratic paradigm describes the relationship between phenotype severity and variation - Nature Communications
Phenotype variation is higher in mutants than wild types. Examining a range of mutant severities, this study unexpectedly found that variation decreases in severe conditions. A quadratic trend best fi...
www.nature.com
October 15, 2025 at 9:24 AM
Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this.
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Reposted by Tyler Huycke
Our faculty job market series continues today on the topic of zoom interviews! Come hear Tyler, Heather, and Duc share their thoughts/advice today at 3pm ET / 12p PT. There will also be time for Q&A.
Registration link in flyer - hope to see you there!
Registration link in flyer - hope to see you there!
October 14, 2025 at 5:34 PM
Our faculty job market series continues today on the topic of zoom interviews! Come hear Tyler, Heather, and Duc share their thoughts/advice today at 3pm ET / 12p PT. There will also be time for Q&A.
Registration link in flyer - hope to see you there!
Registration link in flyer - hope to see you there!
Reposted by Tyler Huycke
Dear VGZT enthusiasts,
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination
VGZT Season 7 - Nomination
Virtual Gastrulation Zoom Talks (VGZT) is an opportunity to share your science with an engaged, international audience of developmental biologists. Running from October 2025 to July 2026, this online ...
www.tinyurl.com
October 6, 2025 at 8:12 AM
Dear VGZT enthusiasts,
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination
Reposted by Tyler Huycke
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 6:21 PM
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
Reposted by Tyler Huycke
We are excited to announce the first Western VGZT of Season 7! 🎉
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
September 25, 2025 at 2:17 PM
We are excited to announce the first Western VGZT of Season 7! 🎉
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
Reposted by Tyler Huycke
Very excited to present my research focussing on the evolutionary differences of epiblast morphogenesis across amniotes next week at the kick-off of @vgzt2021.bsky.social season 7!
A story of 🐁,🧍,🐓 & many 🦎🦎🦎🦎
A story of 🐁,🧍,🐓 & many 🦎🦎🦎🦎
We are excited to announce the first Western VGZT of Season 7! 🎉
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET
Our speakers:
👉 Antonia Weberling (@a-weberling.bsky.social)
👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)
September 25, 2025 at 2:26 PM
Very excited to present my research focussing on the evolutionary differences of epiblast morphogenesis across amniotes next week at the kick-off of @vgzt2021.bsky.social season 7!
A story of 🐁,🧍,🐓 & many 🦎🦎🦎🦎
A story of 🐁,🧍,🐓 & many 🦎🦎🦎🦎
Reposted by Tyler Huycke
I’m thrilled to have our work—“Intestinal secretory differentiation reflects niche-driven phenotypic plasticity of a common signal-responsive terminal cell” (dlvr.it/TK2Fzl) featured in the Preview of this issue of @cp-cellstemcell.bsky.social!
To play Paneth or goblet: Shapeshifting secretory cells read the room
The intestinal secretory lineage is thought to comprise four distinct cell types derived
from one Atoh1+ progenitor, but the mechanisms that distinguish Paneth and goblet
cells are unclear. Bhattachar...
www.cell.com
June 7, 2025 at 1:33 AM
I’m thrilled to have our work—“Intestinal secretory differentiation reflects niche-driven phenotypic plasticity of a common signal-responsive terminal cell” (dlvr.it/TK2Fzl) featured in the Preview of this issue of @cp-cellstemcell.bsky.social!
Reposted by Tyler Huycke
Wanna grow organoids to understand human retinal development as a research assistant?
Wanna help run the lab as a lab manager?
The Johnston lab is hiring a research assistant/lab manager.
If you are interested, please apply (also please share!):
jobs.jhu.edu/job/Baltimor...
Wanna help run the lab as a lab manager?
The Johnston lab is hiring a research assistant/lab manager.
If you are interested, please apply (also please share!):
jobs.jhu.edu/job/Baltimor...
Research Technologist
Research Technologist
jobs.jhu.edu
April 22, 2025 at 2:06 PM
Wanna grow organoids to understand human retinal development as a research assistant?
Wanna help run the lab as a lab manager?
The Johnston lab is hiring a research assistant/lab manager.
If you are interested, please apply (also please share!):
jobs.jhu.edu/job/Baltimor...
Wanna help run the lab as a lab manager?
The Johnston lab is hiring a research assistant/lab manager.
If you are interested, please apply (also please share!):
jobs.jhu.edu/job/Baltimor...
Reposted by Tyler Huycke
🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)
April 6, 2025 at 10:24 PM
🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)
Reposted by Tyler Huycke
Congratulations to Camilla Teng, for winning the "Platform presentation SDB prize" for post-docs at the Northwest SDB meeting, which sounds like it was a fantastic meeting! Camilla will be on the faculty job market soon, so look out for her! @socdevbio.bsky.social @ctbatucsf.bsky.social
March 28, 2025 at 4:32 PM
Congratulations to Camilla Teng, for winning the "Platform presentation SDB prize" for post-docs at the Northwest SDB meeting, which sounds like it was a fantastic meeting! Camilla will be on the faculty job market soon, so look out for her! @socdevbio.bsky.social @ctbatucsf.bsky.social
Reposted by Tyler Huycke
Come check out my talk, where I'll be giving (or attempting) a lesson on *actin* your age
Mark your calendars for our western/evening 🌙 session seminar next week!
We’ll have a 🐁 double feature with:
Kate Cavanaugh @katecavanaugh.bsky.social and
Vera Van der Weijden @vvdw.bsky.social
🗓️ Thursday, March 20th at
⏰ 10:30 PDT (!) / 13:30 EDT (!) / 17:30 UTC / 17:30 GMT / 18:30 CET
We’ll have a 🐁 double feature with:
Kate Cavanaugh @katecavanaugh.bsky.social and
Vera Van der Weijden @vvdw.bsky.social
🗓️ Thursday, March 20th at
⏰ 10:30 PDT (!) / 13:30 EDT (!) / 17:30 UTC / 17:30 GMT / 18:30 CET
March 14, 2025 at 11:50 PM
Come check out my talk, where I'll be giving (or attempting) a lesson on *actin* your age
Reposted by Tyler Huycke
Mark your calendars for our western/evening 🌙 session seminar next week!
We’ll have a 🐁 double feature with:
Kate Cavanaugh @katecavanaugh.bsky.social and
Vera Van der Weijden @vvdw.bsky.social
🗓️ Thursday, March 20th at
⏰ 10:30 PDT (!) / 13:30 EDT (!) / 17:30 UTC / 17:30 GMT / 18:30 CET
We’ll have a 🐁 double feature with:
Kate Cavanaugh @katecavanaugh.bsky.social and
Vera Van der Weijden @vvdw.bsky.social
🗓️ Thursday, March 20th at
⏰ 10:30 PDT (!) / 13:30 EDT (!) / 17:30 UTC / 17:30 GMT / 18:30 CET
March 14, 2025 at 11:21 PM
Mark your calendars for our western/evening 🌙 session seminar next week!
We’ll have a 🐁 double feature with:
Kate Cavanaugh @katecavanaugh.bsky.social and
Vera Van der Weijden @vvdw.bsky.social
🗓️ Thursday, March 20th at
⏰ 10:30 PDT (!) / 13:30 EDT (!) / 17:30 UTC / 17:30 GMT / 18:30 CET
We’ll have a 🐁 double feature with:
Kate Cavanaugh @katecavanaugh.bsky.social and
Vera Van der Weijden @vvdw.bsky.social
🗓️ Thursday, March 20th at
⏰ 10:30 PDT (!) / 13:30 EDT (!) / 17:30 UTC / 17:30 GMT / 18:30 CET
Reposted by Tyler Huycke
🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
A computational pipeline for spatial mechano-transcriptomics - Nature Methods
The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.
www.nature.com
March 17, 2025 at 12:53 PM
🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
Reposted by Tyler Huycke
born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze
March 10, 2025 at 4:32 PM
born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze
An exciting example of how mechanical forces pattern ECM to drive morphogenesis. Love the movies and synergy between experiment and model!
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
March 10, 2025 at 11:26 AM
An exciting example of how mechanical forces pattern ECM to drive morphogenesis. Love the movies and synergy between experiment and model!
Reposted by Tyler Huycke
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
March 10, 2025 at 2:43 AM
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
Such a cool study by @drkatiegoodwin.bsky.social - a nice distraction from everything else going on!
Thrilled to share my postdoc work now available on biorxiv!
See below for the thread, including tons of live imaging, mechanobiology, and some surprising findings about the nucleus and DNA damage during cell migration in the embryo!
See below for the thread, including tons of live imaging, mechanobiology, and some surprising findings about the nucleus and DNA damage during cell migration in the embryo!
Primordial germ cells experience increasing physical confinement and DNA damage during migration in the mouse embryo https://www.biorxiv.org/content/10.1101/2025.03.03.641275v1
March 8, 2025 at 1:30 AM
Such a cool study by @drkatiegoodwin.bsky.social - a nice distraction from everything else going on!
Reposted by Tyler Huycke
#Postdocs! Going on academic job market? Apply for SDB GetHIRED! Take stock of what you want, know your options, prepare an outstanding job packet, organize your research & chalk talks, perfect your interview. Deadline: March 21 sdbonline.org/gethired
February 26, 2025 at 9:50 PM
#Postdocs! Going on academic job market? Apply for SDB GetHIRED! Take stock of what you want, know your options, prepare an outstanding job packet, organize your research & chalk talks, perfect your interview. Deadline: March 21 sdbonline.org/gethired
Reposted by Tyler Huycke
Join us tomorrow for the last session for this cycle!
What happens during second visits and how to negotiate your offer?
We will discuss with @lydiagrmai.bsky.social @thuycke.bsky.social Anna Maurer and Ben Vincent
Please notice there is a slight time change at
2 PM EST/ 11 AM PST
What happens during second visits and how to negotiate your offer?
We will discuss with @lydiagrmai.bsky.social @thuycke.bsky.social Anna Maurer and Ben Vincent
Please notice there is a slight time change at
2 PM EST/ 11 AM PST
February 5, 2025 at 8:37 PM
Join us tomorrow for the last session for this cycle!
What happens during second visits and how to negotiate your offer?
We will discuss with @lydiagrmai.bsky.social @thuycke.bsky.social Anna Maurer and Ben Vincent
Please notice there is a slight time change at
2 PM EST/ 11 AM PST
What happens during second visits and how to negotiate your offer?
We will discuss with @lydiagrmai.bsky.social @thuycke.bsky.social Anna Maurer and Ben Vincent
Please notice there is a slight time change at
2 PM EST/ 11 AM PST
Super excited to announce my new lab at the University of Michigan opening Jan 2025! 🎉We’ll study how cells work together to shape the GI tract, with ties to regeneration & disease.
Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org
#DevBio #CellBio #Hiring
Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org
#DevBio #CellBio #Hiring
December 13, 2024 at 5:09 PM
Super excited to announce my new lab at the University of Michigan opening Jan 2025! 🎉We’ll study how cells work together to shape the GI tract, with ties to regeneration & disease.
Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org
#DevBio #CellBio #Hiring
Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org
#DevBio #CellBio #Hiring
Happening tomorrow! 👇
Next week, we’re back with two unique development talks: mouse gastruloids 🐭 with Kristina Stapornwongkul and turtles 🐢 with Agáta Horáčková & Barbora Straková. Mark your calendar—you won’t want to miss this!
🗓️ Dec 5, 12:30 EST / 18:30 CET / 17:30 UTC 🕥
🗓️ Dec 5, 12:30 EST / 18:30 CET / 17:30 UTC 🕥
December 5, 2024 at 12:29 AM
Happening tomorrow! 👇