This study used bibliometric analysis to comprehensively map the research landscape of immunomodulatory biomaterials enhancing implant osseointegration between 2005 and 2025. Publications retrieved from the Web of Science Core Collection were analyzed to identify temporal trends, contributing countries, institutions, journals, cocitation networks, and keyword evolution. A total of 419 articles were identified. The annual output and citations increased steadily, with China, the United States, and Australia as major contributors. The terms ‘3D printing’, ‘scaffolds’, and ‘macrophage polarization’ emerged as recent hotspots, reflecting a shift from mechanistic exploration to clinical translation. Compared with prior reviews focusing mainly on mechanisms, this study also analyzed the depth of international collaboration, clinical orientation of journals, and bottlenecks in translational application. The field has evolved from theoretical construction (osteoimmunomodulation theory) to technological innovation (nanoengineering, dynamic response design). Future work should integrate intelligent responsive biomaterials with multiomics validation to accelerate the transition from passive repair to active regulation in bone regeneration.

Over the past four decades, calcium phosphate cements (CPCs) have emerged as promising materials for bone repair due to their biocompatibility, osteoconductivity, and in situ hardening properties. Dev...

Bioprinting continues to expand as a preferred fabrication technology as new biomaterials emerge. These biomaterials must be biocompatible, in addition to exhibiting suitable printing characteristics....

The periosteum serves as a local source of osteoprogenitor cells and vasculature, therefore influencing the key processes of osteogenesis and neovascularization during bone healing. However, it is oft...

Biomaterials and Cell Strategies for Immunoengineering- Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journa...

Bioprinting [in Tissue Engineering and Regenerative Medicine] - Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-re...

Tissue Engineering Part C: Methods

Tissue Engineering Part A

Cancer & Regenerative Medicine- Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in the most promi...

Indigenous health and wellness encompasses physical, mental, emotional, and spiritual well-being, with a focus on “the interconnectedness of these aspects and the importance of community and cultural ...

Tissue Engineering Part A

The tendon–bone interface (TBI) possesses a highly intricate structure, making complete restoration of its native structure postinjury particularly challenging, which often leads to suboptimal healing...

Development of relevant human induced pluripotent stem cell-derived cardiac organoids is essential to recapitulate myocardium physiology and functionality for the assessment of drug-induced toxicity e...

Biomaterials and Cell Strategies for Immunoengineering- Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journa...

Cancer & Regenerative Medicine- Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in the most promi...