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Todd Lencz

@toddlencz.bsky.social

940 followers 640 following 27 posts

Genetics, Psychiatry, Polygenic Risk Scores, Embryo Screening... https://feinstein.northwell.edu/institutes-researchers/our-researchers/todd-lencz-phd

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Todd Lencz @toddlencz.bsky.social · Nov 25

NOW HIRING
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...

https://acnp.org/wp-content/uploads/2021/09/Postdoc_listing-_Lencz_polygenic.pdf…

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Todd Lencz @toddlencz.bsky.social · Sep 10

Please see our new work, led by @shaicarmi.bsky.social - in addition to a free online risk calculator, we demonstrate (for the first time), the degree to which real-world live birth rates attenuate the potential risk reduction in polygenic embryo screening (PES)

Shai Carmi @shaicarmi.bsky.social · Sep 10

Excited to present our new tool "PEStimate", an online app for predicting risk reductions after Polygenic Embryo Screening (PES).

Find the app here:
polygenicembryo.shinyapps.io/pestimate/

Preprint:
www.medrxiv.org/content/10.1...

PEStimate: Predicting offspring disease risk after Polygenic Embryo Screening

Motivation: Polygenic embryo screening (PES) is a new technology in reproductive medicine, whereby human in-vitro fertilization embryos are screened for their genetic risk of complex, polygenic diseas...

www.medrxiv.org

Todd Lencz @toddlencz.bsky.social · Aug 22

Given that we are unlikely to scale much beyond this enormous dataset anytime soon, this appears to be quite a negative result…

Reposted by Todd Lencz

A.S.H. @alexanderhatoum.bsky.social · Aug 6

We lay out three consensuses from the field of psychiatric genetics that should be considered before approving genetic tests for psychiatric disorders. The letter was signed by 140 experts in psychiatric genetics and published in Lancet Psychiatry. Now on Pubmed: pmc.ncbi.nlm.nih.gov/articles/PMC...

Concerns About Genetic Risk Testing for Opioid Use Disorder

pmc.ncbi.nlm.nih.gov

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Todd Lencz @toddlencz.bsky.social · Jul 24

Congratulations, Sunny—All the more impressive given the current environment. Your work is truly at the cutting edge!

Todd Lencz @toddlencz.bsky.social · Jul 24

This looks fascinating - I can’t wait to read it in detail.

I am wondering if your approach resembles something we tried on a much smaller scale a few years ago: pubmed.ncbi.nlm.nih.gov/32956347/

Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts - PubMed

Evidence from both GWAS and clinical observation has suggested that certain psychiatric, metabolic, and autoimmune diseases are heterogeneous, comprising multiple subtypes with distinct genomic etiolo...

pubmed.ncbi.nlm.nih.gov

Todd Lencz @toddlencz.bsky.social · Jun 14

Need to double-check but I think it could be design / MAF cut-offs for each type of study

Todd Lencz @toddlencz.bsky.social · May 14

More details at the link:
t.co/ThiWw7QdkU

https://www.biologicalpsychiatryjournal.com/article/S0006-3223(25)00989-8/fulltext

t.co

Todd Lencz @toddlencz.bsky.social · May 14

Concordant SNPs (low cognition / increased SZ risk) were associated with early neurodevelopmental (prenatal) forebrain abnormalities. Discordant SNPs (high cognition / increased SZ risk) associated with adult synaptic function and hindbrain (cerebellar) development. (2/3)

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Todd Lencz @toddlencz.bsky.social · May 14

New publication!
We expand on our prior work demonstrating that pleiotropic effects of cognitive GWAS can provide biological insights into schizophrenia GWAS results. We differentiated "concordant" from "discordant" subsets of schizophrenia risk SNPs (1/3)

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Todd Lencz @toddlencz.bsky.social · May 8

💯 always take the reader by the hand and walk them through slowly paragraph by paragraph

Todd Lencz @toddlencz.bsky.social · Apr 1

A very thoughtful and comprehensive piece on polygenic embryo screening in today's NY Times:
www.nytimes.com/interactive/...

Opinion | I.V.F., Gene Selection and Embryo Screening: Is This the Future of Making Babies? (Gift Article)

Advances in genetic testing and artificial intelligence are changing what’s possible for those undergoing I.V.F. Are we ready for the future of fertility?

www.nytimes.com

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Todd Lencz @toddlencz.bsky.social · Mar 13

Re-upping for the early crowd - link in reply

Todd Lencz @toddlencz.bsky.social · Mar 12

New Paper!
Online now in JAMA Psychiatry, we have performed a large-scale Mendelian Randomization study of circulating proteins in schizophrenia, bipolar disorder, major depression, and cognitive task performance.

Todd Lencz @toddlencz.bsky.social · Mar 12

We identified 113 Bonferroni-corrected putatively causal associations (46 novel) involving 91 proteins, providing support for repurposing of anti-inflammatory agents for SCZ, amantadine for BD, retinoic acid for MDD, and duloxetine for CTP.
jamanetwork.com/journals/jam...

Circulating Blood-Based Proteins in Psychopathology and Cognition

This mendelian randomization study identifies circulating proteins associated with risk for schizophrenia, bipolar disorder, major depressive disorder, and cognitive task performance.

jamanetwork.com

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Todd Lencz @toddlencz.bsky.social · Mar 12

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Todd Lencz @toddlencz.bsky.social · Mar 10

But then you run right into DISC1

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Todd Lencz @toddlencz.bsky.social · Mar 9

We have a position open in my lab. Please see my pinned post!

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Todd Lencz @toddlencz.bsky.social · Feb 15

I'm hiring a postdoc and/or bioinformatician in
psychiatric genomics and related fields

acnp.org/wp-content/u...

acnp.org

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Reposted by Todd Lencz

International Society of Psychiatric Genetics @ispg.bsky.social · Jan 24

Unsure how recent changes in U.S. policy regarding the NIH will impact the psychiatric genetics world? You're not alone. Join ISPG for a Member’s Meetup for community discussion and support:

📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...

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Todd Lencz @toddlencz.bsky.social · Dec 22

For me, the simplicity and ease of both upload and download are the best parts or bioRxiv and medRxiv. (Bravo, Richard!)

If anything, I notice that the site sometimes hangs despite the simplicity of the interface, suggesting that the network is already loaded to capacity.

Todd Lencz @toddlencz.bsky.social · Dec 9

I’m recruiting for a postdoc position in psychiatric genetics

Come talk to me at poster M160!

acnp.org/wp-content/u...

acnp.org

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Todd Lencz @toddlencz.bsky.social · Dec 7

On my way to #ACNP2024 🌵

Now recruiting for a #postdoc position in psychiatric genetics: t.co/Stst3V9agM

If you are interested in the genetics of psychotic disorders and their endophenotypes, check out my poster M160 on Monday!

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Reposted by Todd Lencz

Leah Mayo @mayoonthebrain.bsky.social · Dec 2

Guess who's joining the party over here?? 🎉🦋

@npp-journal.bsky.social
@dpn-journal.bsky.social &
@acnporg.bsky.social

Be sure to follow☝️ahead of #ACNP2024

a man in a sweater is standing in front of a door with christmas wreaths on it .

ALT: a man in a sweater is standing in front of a door with christmas wreaths on it .

media.tenor.com

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Todd Lencz @toddlencz.bsky.social · Nov 26

very cool! cc: @kgjonas.bsky.social

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Todd Lencz @toddlencz.bsky.social · Nov 25

combined with similar results recently published in the context of polygenic embryo screening, this suggests the need for clear reporting standards for PRS implementation
www.nature.com/articles/s41...

Inconsistent embryo selection across polygenic score methods - Nature Human Behaviour

Private enterprises offer preimplantation genetic testing with polygenic scores to select embryos with ‘desirable’ potential. In silico simulations using biobank resources show that the selected embry...

www.nature.com

Todd Lencz @toddlencz.bsky.social · Nov 25

I think this JAMA article from last week received insufficient attention - different computations of PRS for the same disease, despite nearly identical population performance, resulted in very different classifications at the individual level #polygenicriskscores
jamanetwork.com/journals/jam...

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores

This study aims to characterize the individual-level agreement of polygenic risk scores for coronary heart disease that perform similarly at the population level.

jamanetwork.com

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