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Reposted by Tomáš Heger

Institute for Protein Innovation @ipiproteins.bsky.social · 19d

Frequent user of epitope tags? Try ours!

IPI epitope tag antibodies & plasmids are now available through our partner @addgene.bsky.social!

buff.ly/YEuZDIp

Epitope tag antibody collection

Epitope tags are short amino acid sequences fused to a protein’s N- or C-terminus. When paired with an antibody that specifically recognizes this sequence, epit

buff.ly

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Reposted by Tomáš Heger

Sigurbjörn Markússon @sigurbjornm.bsky.social · Aug 21

Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

www.nature.com

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Reposted by Tomáš Heger

henrietteautzen.bsky.social @henrietteautzen.bsky.social · Jul 28

I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.

We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.

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Tomáš Heger @tomasheger.bsky.social · Jul 12

Check out this fascinating study on a fungal multipass translocon! What's really neat is how they did it: cryo-EM structure from the endogenously tagged and purified SND3 complex. It will be exciting to see if there is any potential for SBDD against fungi, Trypanosoma, and Leishmania (?).

Melanie McDowell @melaniemcdowell.bsky.social · Jul 12

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

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Reposted by Tomáš Heger

Azadeh Shahsavar @azadeh-shahsavar.bsky.social · Mar 29

We are excited to present the first #cryoEM structures of human GABA transporter 3 – GAT3 – bound to an in-house selective inhibitor, SR-THAP, to substrate GABA, and in the substrate-free state!
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

Structural basis for selective inhibition of human GABA transporter GAT3

The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy f...

www.biorxiv.org

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Tomáš Heger @tomasheger.bsky.social · Mar 9

Yes, please. I go with Nemesis drones and like their motto "to see means to win":
www.dronynemesis.cz/en.

Tomáš Heger @tomasheger.bsky.social · Jan 19

I am very grateful that you were my opponent and joined us in Aarhus, also giving such an interesting lecture on the SND pathway! I really enjoyed it a lot.

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Tomáš Heger @tomasheger.bsky.social · Jan 18

Oh yeah, P-types ❤️💙💛 and the copper one, ATP7B!

It was a great day full of science. Thank you so much everyone for being involved!

Charlott Stock @charlottstock.bsky.social · Jan 18

Huge congrats to @tomasheger.bsky.social who succesfully defended his PhD yesterday.
Such a joy to supervise with @tdieudonne.bsky.social and @poulnissen.bsky.social.
Big thank you to @melaniemcdowell.bsky.social, @henrietteautzen.bsky.social and Daan van Aalten for a great discussion.
P-type ❤️💙💛

Tomáš Heger @tomasheger.bsky.social · Jan 18

Thank you very much, Charlott, for these kind words and for being such a great supervisor!

Tomáš Heger @tomasheger.bsky.social · Jan 18

Thank you so much, Thibaud. It was so great that I could start this journey with you, I am very grateful for that.

Tomáš Heger @tomasheger.bsky.social · Jan 18

Thank you so much for guiding me on this amazing journey, @poulnissen.bsky.social, @charlottstock.bsky.social, and @tdieudonne.bsky.social. So great and thorough discussion with @melaniemcdowell.bsky.social, @henrietteautzen.bsky.social and Daan van Aalten. I highly appreciate your involvement.

Thibaud Dieudonné @tdieudonne.bsky.social · Jan 18

🎉Congrats @tomasheger.bsky.social for this excellent PhD defense. You were the expert in the room. Very very proud supervisors with @charlottstock.bsky.social and @poulnissen.bsky.social ! Many thanks to the jury members Daan van Aalten, @henrietteautzen.bsky.social and @melaniemcdowell.bsky.social

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