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Thomaz Pinotti

@tpinotti.bsky.social

110 followers 160 following 3 posts

Evolutionary biologist at the University of Copenhagen and Universidade Federal de Minas Gerais. Likes: Ancient DNA, Indigenous peoples. Dislikes: Mercator projection.

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Reposted by Thomaz Pinotti

Evan Irving-Pease @evanirvingpease.bsky.social · May 8

Delighted to see our paper on the evolutionary history of the CCR5Δ32 deletion published this week in @cellpress.bsky.social. Work led by @ravnkirstine.bsky.social, Leonardo Cobuccio and Rasa Muktupavela, and co-supervised by me and @simorasmu.bsky.social. See 🧵 for main findings...

Graphical abstract: The chemokine receptor variant CCR5delta32 is linked to HIV-1 resistance and other conditions. Its evolutionary history and allele frequency (10%–16%) in European populations have been extensively debated. We provide a detailed perspective of the evolutionary history of the deletion through time and space. We discovered that the CCR5delta32 allele arose on a pre-existing haplotype consisting of 84 variants. Using this information, we developed a haplotype-aware probabilistic model to screen 934 low-coverage ancient genomes and traced the origin of the CCR5delta32 deletion to at least 6,700 years before the present (BP) in the Western Eurasian Steppe region. Furthermore, we present strong evidence for positive selection acting upon the CCR5delta32 haplotype between 8,000 and 2,000 years BP in Western Eurasia and show that the presence of the haplotype in Latin America can be explained by post-Columbian genetic exchanges. Finally, we point to complex CCR5delta32 genotype-haplotype-phenotype relationships, which demand consideration when targeting the CCR5 receptor for therapeutic strategies.

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Reposted by Thomaz Pinotti

Nature Portfolio @natureportfolio.nature.com · Apr 30

A collaborative study initiated by the sovereign nation of Picuris Pueblo in New Mexico addresses gaps in traditional knowledge and furthers understanding of their population history and ancestry, according to a paper in Nature. go.nature.com/3YLNzfF 🏺 🧬 🧪

Victor Moreno Mayar, Clifford Tsosie, Eske Willerslev and Thomaz Pinotti
Credit: Mike Adler

Researchers look at a Round House
Credit: Thomaz Pinotti

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Reposted by Thomaz Pinotti

Nature @nature.com · May 1

Ancient and present-day genomes from members of the Indigenous American tribe Picuris Pueblo in the US Southwest show genetic continuity with Ancestral Pueblo individuals from the Chaco Canyon, New Mexico.

https://go.nature.com/4cWV2Os

Indigenous American tribe’s ancestral history confirmed by genomes

Study reveals genetic continuity between Ancestral Puebloans from Chaco Canyon, New Mexico, and present-day Picuris people.

go.nature.com

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Thomaz Pinotti @tpinotti.bsky.social · May 5

We hope this work contributes to greater respect for oral history and traditional knowledge. Research shaped unilaterally by researchers – its questions, narratives, and data control – has often brought little benefit to Indigenous ppl. We hope our collaboration encourages more equitable approaches.

Thomaz Pinotti @tpinotti.bsky.social · May 5

Excited to share our study on and with Picuris Pueblo! It’s a true honor to have worked alongside the community. Combining oral history and genomics, we show a long-standing continuity in the US Southwest and challenge ideas of pre-Columbian population collapse.

www.nature.com/articles/s41...

Picuris Pueblo oral history and genomics reveal continuity in US Southwest - Nature

A collaborative study initiated by the sovereign nation of Picuris Pueblo in the Northern Rio Grande region of New Mexico addresses gaps in traditional knowledge and furthers understanding of their po...

www.nature.com

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Thomaz Pinotti @tpinotti.bsky.social · May 5

Grazie mille, Marco!