@trollkarin.bsky.social
Instructor in the Scadden lab thinking about how to make the thymus and people younger
Thanks Nick! It's so nice to see it in print!
November 3, 2025 at 3:11 PM
Thanks Nick! It's so nice to see it in print!
When we replace these cells or the factors they make, T cell production recovers.The thymus turns out to be more than just its epithelial cells.
October 31, 2025 at 2:19 PM
When we replace these cells or the factors they make, T cell production recovers.The thymus turns out to be more than just its epithelial cells.
Thymic mesenchymal cells produce key factors that attract and organize T cell progenitors. Lose the mesenchyme — through aging or damage — and T cell output drops.
October 31, 2025 at 2:19 PM
Thymic mesenchymal cells produce key factors that attract and organize T cell progenitors. Lose the mesenchyme — through aging or damage — and T cell output drops.
Everyone talks about thymic epithelial cells when it comes to T cell development. They play a major role — just not the only one. Our new paper in @natbiotech.nature.com shows the mesenchyme has been quietly pulling strings: rdcu.be/eNF24
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity
Nature Biotechnology - T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.
rdcu.be
October 31, 2025 at 2:19 PM
Everyone talks about thymic epithelial cells when it comes to T cell development. They play a major role — just not the only one. Our new paper in @natbiotech.nature.com shows the mesenchyme has been quietly pulling strings: rdcu.be/eNF24