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David Collister @turbodc.bsky.social · 19d

Dr. Moorthy reviewing the WHO global action plan for clinical trial ecosystem strengthening at the 4th Annual ACT meeting in Cape Breton, NS. We are making progress in Canada but lots of work to do!
@cvcualberta.bsky.social @csnscn.bsky.social @ualberta.bsky.social

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David Collister @turbodc.bsky.social · Sep 3

The percentage in the placebo arm reflects that potassium fluctuations in HD are common related to missed dialysis, diet and other factors. Other takeaway is that hyperkalemia is manageable and typically harm patients.

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David Collister @turbodc.bsky.social · Sep 3

I think we are all excited to see how to anti-inflammatory hypothesis pans out over the next couple of years as well

David Collister @turbodc.bsky.social · Sep 3

And stayed tuned for some secondary papers in addition to the ones already published on run-in adherence assessment (study within a trial) and heart failure event definitions in dialysis RCTs (meta-epidemiological)

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David Collister @turbodc.bsky.social · Sep 3

Late to the party but important takeaways: large publically funded international trials are feasible in dialysis, run-ins are great, low dose spironolactone is safe and consider it’s use in HFrEF in dialysis or PD for low K+ or for volume, we don’t believe the sex subgroup analysis #NephJC

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David Collister @turbodc.bsky.social · Aug 16

Some really interesting stories in this one!

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David Collister @turbodc.bsky.social · Jul 30

We need a Canadian registry!

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David Collister @turbodc.bsky.social · Jul 30

Local approach in the couple of places I’ve practiced in Canada is to intensify with daily HD because of the morbidity and mortality of calciphylaxis. Does this mean you would keep on PD if adequate MBD parameters? Could this be a domain in BEAT-Calci? I doubt given lack of equipoise.

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David Collister @turbodc.bsky.social · Jul 23

When I order eGFR cys it’s because I think eGFR Cr is falsely high or low and I have a clinical reason for this which I already know affects prognosis (e.g. cirrhosis, malignancy, neuromuscular disease, athlete). How was this accounted for?

David Collister @turbodc.bsky.social · Jul 8

Would you accept 0.3mg po every other day over prednisone for “idiopathic” pericarditis?

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David Collister @turbodc.bsky.social · Jul 8

What’s your treatment for idiopathic pericarditis in PD?
NSAIDs will cause loss of RRF and risk of UGIB. Colchicine at even low doses=diarrhea (and myopathy/cytopenias). Prednisone or try colchicine 0.3-0.6mg po daily to see if tolerated? Defer to cardiology? @askrenal.bsky.social #askrenal

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David Collister @turbodc.bsky.social · Jun 27

Great paper! Would like to see this work also done in Alberta where I suspect MRP, remuneration model, work up and evaluation process, access to weight loss programs and navigators all play a role.

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Reposted by David Collister

CJKHD @cjkhd.bsky.social · Jun 26

In patients receiving #maintenancedialysis, there is substantial variability across the 4 steps required to receive a #kidneytransplant with the rate of referral varying almost 8-fold across Ontario’s Regional Renal Programs
@lhsccanada.bsky.social @csnscn.bsky.social

doi.org/10.1177/2054...

Figure 5 demonstrates the average number of steps completed toward receiving a kidney transplant which varied from 11.7 (95% CI: 9.3, 14.8) to 44.0 (95% CI: 38.6, 50.1) steps per 100 patient-years across RRPs.

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Reposted by David Collister

CJKHD @cjkhd.bsky.social · Jun 20

Design of the international #ACHIEVE trial comparing spironolactone to placebo in over 2500 people receiving #dialysis for #kidneyfailure.
@csnscn.bsky.social @cjkhd.bsky.social

doi.org/10.1177/2054...

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David Collister @turbodc.bsky.social · May 1

It was a pleasure to work with Dr. Adeera Levin on this JCI editorial re: the impact of gender affirming hormone therapy on blood/urine biomarkers and renal plasma flow/iohexol plasma GFR. Provides new insights to sex based differences in kidney function.

pubmed.ncbi.nlm.nih.gov/40309772/

The differential effects of sex hormone therapy on kidney function: insights into biological sex differences - PubMed

There are known sex (i.e., biological) and gender (i.e., social) differences in the epidemiology and outcomes of chronic kidney disease. In this issue of the JCI, van Eeghen et al. provide a prospecti...

pubmed.ncbi.nlm.nih.gov

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David Collister @turbodc.bsky.social · May 1

Really enjoyed writing this editorial on the PK of Sativex in healthy controls and CKD from Denmark with Brendan Smyth from Sydney:

pubmed.ncbi.nlm.nih.gov/40303213/

Stay tuned for our PK study of oral THC/CBD (MPL-001) in CKD/dialysis @lastwalsh.bsky.social @csnscn.bsky.social @cntn

Searching for Fire Amid the Smoke: Will Cannabinoids Prove Useful and Safe for Those With CKD? - PubMed

Searching for Fire Amid the Smoke: Will Cannabinoids Prove Useful and Safe for Those With CKD?

pubmed.ncbi.nlm.nih.gov

David Collister @turbodc.bsky.social · Mar 27

So weird

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David Collister @turbodc.bsky.social · Mar 17

I used this to find my current position. Definitely worth checking out, we have some fantastic institutions in Canada.

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David Collister @turbodc.bsky.social · Feb 24

I think the only place that does bone biopsy in Canada is in Quebec! Wish we had it availability locally.

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David Collister @turbodc.bsky.social · Feb 24

What’s the eGFR? 31 is probably different than 59 for the risk of adverse events. I don’t think I would have any concerns re: bisphosphonate but would monitor PTH more closely than usual and if it drops or there is an AE consider an alternative.

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David Collister @turbodc.bsky.social · Feb 17

Agree with getting what you can on board ASAP

David Collister @turbodc.bsky.social · Feb 9

Congrats @kidneydoc101.bsky.social

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David Collister @turbodc.bsky.social · Feb 8

Here are our thoughts!

www.kireports.org/article/S246...

www.kireports.org

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David Collister @turbodc.bsky.social · Jan 30

Sus

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David Collister @turbodc.bsky.social · Jan 28

Usually will start with LMWH then transition to 5mg po bid or 2.5mg po bid depending on weight/age with F/U anticoagulation clinic. I have never specifically loaded in dialysis.

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