UK MND Research Institute
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ukmndri.bsky.social
UK MND Research Institute
@ukmndri.bsky.social
A national network of MND centres that work together to understand how #MND happens, what treatment works, and test possible treatments in clinical trials.
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🚨We’ve launched a new home for the @MNDRegister!

The MND Register is the first comprehensive source of information about people with #MND/#ALS.

We hope that by counting every person with MND, we can learn more about the disease.

Learn more below🔗
mndregister.ac.uk
MND Register for England, Wales and Northern Ireland
The primary objective of the MND Register is to build a centralised database of patients with MND across England, Wales and Northern Ireland.
mndregister.ac.uk
We've hit 100 sign-ups to our Remote Research Platform!

Thank you to everyone who has signed up; together, we’re building a more inclusive #MND/#ALS research community.

🔗If you haven't joined, sign up below!

ukmndri.org/research/und...
Get involved in MND research from home - UKMNDRI
Get involved You can now take part in MND research without having to travel. In collaboration with researchers at the University of Sheffield, we’ve created a secure online platform that makes it s...
ukmndri.org
November 21, 2025 at 11:06 AM
Drug development is a complex and costly process.

By using medicines approved for other conditions, we can overcome barriers in drug development.

Read our blog explaining why we believe repurposed drugs could help us find new treatments for #MND/#ALS.

ukmndri.org/2025/11/13/r...
Repurposed Drugs: Accelerating MND Treatment Discovery
Discover how repurposed drugs are helping accelerate the search for effective treatments for MND through innovative UK research.
ukmndri.org
November 14, 2025 at 9:34 AM
Yesterday, we attended @mndoddie5.bsky.social's Discovery Network Showcase 2025.

Researchers, clinicians, industry partners, and people affected by #MND/#ALS discussed how the network can drive forward progress in better understanding MND and the development of new treatments.
November 13, 2025 at 1:59 PM
Our Co-Director, Prof. @ammaralchalabi.bsky.social, gave a fantastic talk yesterday, hosted by @mndassoc.bsky.social, on #MND/#ALS genetics, why they matter and how discoveries are shaping new treatments.

Thank you to everyone who joined in person & online!
#MNDresearch #genetics
November 5, 2025 at 8:04 PM
New research finds that #MND/#ALS may slow molecular transport and nerve cell growth before cells begin to die.

These early changes could hold clues to how the disease starts and how to treat it.

ukmndri.org/2025/10/24/e...
Cellular changes in sporadic ALS may reveal new treatment targets
A new study suggests that MND may slow molecular transport and cell growth before nerve cells die. This could help identify new therapeutic targets.
ukmndri.org
October 24, 2025 at 3:56 PM
A new UK-wide study finds that people who experience a traumatic brain injury may face a higher short-term risk of developing MND.

This risk appears temporary, suggesting injury may sometimes be an early consequence of undiagnosed disease.

Read more👇
ukmndri.org/2025/10/21/t...
Traumatic brain injury linked to short-term MND risk
A new study finds traumatic brain injury linked to a short-term rise in MND risk, suggesting this may reflect early disease signs, not cause them.
ukmndri.org
October 21, 2025 at 1:33 PM
We’re deeply sorry to hear that former England rugby captain Lewis Moody has been diagnosed with MND.

His courage in sharing his diagnosis will raise vital awareness.

Our thoughts are with Lewis and his family.

We must find an effective treatment for #ALS/#MND.

www.bbc.co.uk/sport/rugby-...
Lewis Moody: Former England captain reveals motor neurone disease diagnosis
Former England captain Lewis Moody says in an exclusive BBC interview he has
www.bbc.co.uk
October 6, 2025 at 8:47 AM
This is fantastic news and highlights the importance of consistently funding collaborative science in neurodegenerative diseases.

We are committed to doing the same for #MND/#ALS and finding new ways to successfully treat the disease.

www.bbc.co.uk/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.co.uk
September 26, 2025 at 10:27 AM
Sign up now to a special symposium in memory of Euan MacDonald MBE, hosted by the Euan MacDonald Centre for #MND Research.

📍 Edinburgh
📅 8–9 October
🔬 Cutting-edge MND/ALS research
🌍 Public sessions on SpeakUnique & Euan’s Guide
euanmacdonaldcentre.org/euan-macdonald-tribute-symposium-2025
A tribute to Euan MacDonald: celebrating the Euan MacDonald Centre and Euan's legacy
A 1.5-day symposium showcasing current MND research, and a celebration of Euan's legacy, including Euan's Guide and SpeakUnique.
euanmacdonaldcentre.org
September 8, 2025 at 11:16 AM
Fatigue affects nearly all people with #MND/#ALS, yet it's often overlooked. A new UK-wide study reveals how fatigue evolves, its severity, and its link to other symptoms. This can inform future research and care.

🔗Read more👇
ukmndri.org/2025/09/04/f...
September 4, 2025 at 11:33 AM
One of Raya Therapeutic's compounds has been selected for our EXPERTS-ALS programme. A pioneering initiative designed to fast-track promising treatments for #ALS/#MND.

Read more about the story and why it is so significant below👇

ukmndri.org/2025/09/03/r...
Raya Therapeutics compound selected for EXPERTS-ALS platform
Raya Therapeutic’s ALS/MND compound joins the UK EXPERTS-ALS trial, aiming to accelerate development of a new promising treatment.
ukmndri.org
September 3, 2025 at 12:46 PM
Reposted by UK MND Research Institute
🧠 The @ukmndri.bsky.social is an #MND powerhouse, accelerating progress towards new treatments and, ultimately, a cure.

Read their article about how the #LongitudePrizeOnALS could be a game-changer for drug discovery in neurodegenerative diseases.

🔗 bit.ly/40Tmmsh

@ammaralchalabi.bsky.social
Longitude Prize launched to accelerate AI-driven drug discovery
A new international challenge prize has been launched to transform drug discovery for ALS, the most common form of MND through AI.
ukmndri.org
August 5, 2025 at 9:16 AM
A new study has identified a blood-based biomarker panel that can detect #ALS up to a decade before symptoms appear.

Using machine learning and protein profiling, researchers found 33 proteins that distinguish ALS from other conditions.

ukmndri.org/2025/08/28/2...
Protein signature could predict ALS a decade early
A new study has identified a blood-based protein signature that may predict ALS up to ten years before symptoms appear.
ukmndri.org
August 28, 2025 at 1:41 PM
A simple finger-prick blood test could transform how #MND/#ALS is monitored.

New research from @ucl.ac.uk shows that NfL levels from capillary samples match those from traditional blood draws, suggesting a more convenient and less invasive way to sample blood.

ukmndri.org/2025/08/20/f...
Finger-prick blood test could offer less invasive monitoring in MND
A simple finger-prick blood test could revolutionise how motor neuron disease and other neurological conditions are monitored.
ukmndri.org
August 20, 2025 at 11:45 AM
The first treatment for a form of #MND/#ALS has been approved in the UK.

#Tofersen is authorised for SOD1 MND, demonstrating the potential of gene-targeted therapies.

UKMNDRI RI partners @sheffielduni.bsky.social & @kingsioppn.bsky.social contributed to the trials.

ukmndri.org/2025/07/31/f...
First treatment approved in the UK for rare genetic form of MND - UKMNDRI
The MHRA has approved the use of tofersen, the first licensed treatment in the UK for MND caused by a variation in the SOD1 gene.
ukmndri.org
July 31, 2025 at 2:17 PM
We're thrilled to see the first research nurse recruited to the @mndassoc.bsky.social’s new #MND Research Nurse Network.

The network will be essential in providing the support and expertise needed to create equitable access to trials for all🔎

Read more 🔗 www.mndassociation.org/media/latest...
First nurse recruited into MND Association’s Research Nurse Network
The ambitious £7.2 million Research Nurse Network will give more people diagnosed with motor neurone disease (MND) the opportunity to take part in vital research
www.mndassociation.org
July 28, 2025 at 10:58 AM
New research has examined how disrupted sleep patterns may signal the early stages of #MND / #ALS or FTD, providing clues to earlier detection.

Read more ⬇️
🔗 ukmndri.org/2025/07/16/r...

This post is part of our Research Snapshot series, powered by Readable Research at @sheffielduni.bsky.social
Could sleep changes signal the early stages of MND or FTD?
Research has found that disrupted sleep may offer some clues to possible early warning signs of the ALS or FTD.
ukmndri.org
July 16, 2025 at 1:23 PM
Today is #MNDAwarenessDay, a moment to highlight the hidden realities of living with #MND.

Our translational research projects aim to find treatments for MND through a national, coordinated approach.

👉 Discover more: ukmndri.org/2025/06/20/f...
How our translational research will find new treatments for MND
On MND Awareness Day, we’re spotlighting the projects accelerating real progress and explaining why translational research is key.
ukmndri.org
June 21, 2025 at 11:57 AM
Read about our latest findings from the @MNDRegister showcased at the @ENCALS Meeting 2025.🌍

Findings ranged from a new #MND/#ALS incidence and prevalence analysis to clinical characteristics and outcomes.

Read more here⬇️

ukmndri.org/2025/06/04/m...
Our latest findings from the MND Register at ENCALS 2025 - UKMNDRI
Read about some of our latest findings from the MND Register that were showcased at the ENCALS Meeting 2025 in Turin, Italy.
ukmndri.org
June 5, 2025 at 9:35 AM
We are pleased to announce that the @ucl Queen Square Motor Neuron Disease Centre Sixth Hybrid #ALS/#MND International Symposium in Partnership will be held on Friday 5/9/25.

The theme is Translating Targets to Therapies.

To register, click below⬇️

www.eventbrite.co.uk/e/ucl-queen-...
UCL Queen Square MND Centre Sixth ALS/MND International Symposium
International Conference, in partnership with the UK MND Research Institute, on ALS / MND - TRANSLATING TARGETS TO THERAPIES
www.eventbrite.co.uk
May 29, 2025 at 9:05 AM
This week, we launched our brand new and redesigned website for the @MNDRegister.🗺️

But why is it so important?

Find out how this vital resource is helping researchers understand who is affected by #MND/#ALS and why.

📖Read more below. ukmndri.org/2025/05/28/m...
Why our MND Register is a vital resource for MND research - UKMNDRI
The new MND Register website helps track MND across the UK and support research into who is affected, how, and why. Visit to learn more.
ukmndri.org
May 28, 2025 at 11:58 AM
🚨We’ve launched a new home for the @MNDRegister!

The MND Register is the first comprehensive source of information about people with #MND/#ALS.

We hope that by counting every person with MND, we can learn more about the disease.

Learn more below🔗
mndregister.ac.uk
MND Register for England, Wales and Northern Ireland
The primary objective of the MND Register is to build a centralised database of patients with MND across England, Wales and Northern Ireland.
mndregister.ac.uk
May 27, 2025 at 7:57 AM
🔬RESEARCH SNAPSHOT📢

A recent study has uncovered that a breakdown in communication between structures in nerve cells can disrupt their ability to produce energy.

This could potentially lead to new treatment targets for #MND/#ALS

🔎Read more👇

ukmndri.org/2025/05/20/r...
Research reveals how disrupted energy production in cells damages neurons
A new study highlights how disrupted energy production in nerve cells is caused by disrupted cell communication, offering a potential new treatment target.
ukmndri.org
May 20, 2025 at 10:44 AM
📄The UK MND Clinical Studies Group has released an official statement in response to the MIROCALS study results.

Find out what it means for future research into #MND / #ALS

🔗 ukmndri.org/2025/05/15/uk-mnd-clinical-studies-group-issues-statement-on-mirocals-trial-findings/
UK MND Clinical Studies Group statement on MIROCALS trial
The UK MND Clinical Studies Group has released a statement regarding the MIROCALS clinical trial results, recently published in The Lancet.
ukmndri.org
May 15, 2025 at 9:13 AM
We’re working to shape the UK’s research environment for MND to accelerate the search for a cure.🔬

Our goals:
✅ Accelerate drug discovery
✅ Better understand MND
✅ Support research participation
✅ Coordinate a national strategy

Learn more 👉 ukmndri.org/ourstory
About the UK Motor Neuron Disease Research Institute
Researchers across the country are carrying out world-leading MND research in a coordinated way to accelerate the search for a cure.
ukmndri.org
April 17, 2025 at 2:42 PM