Vascular Pharmacology
@vaspharma.bsky.social
Editors of Vascular Pharmacology
This is a journal of Vascular Biology and Medicine
https://www.sciencedirect.com/journal/vascular-pharmacology
This is a journal of Vascular Biology and Medicine
https://www.sciencedirect.com/journal/vascular-pharmacology
Pinned
Vascular Pharmacology is a journal of Vascular Biology and Medicine.
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹
Can routine MRA predict which brain aneurysms will rupture? Our latest article shows how patient-specific CFD tool maps hidden blood-flow forces, revealing shear-stress patterns that distinguish stable from high-risk lesions, advancing noninvasive, personalized care
#Neurosci #CFD #StrokePrevention
#Neurosci #CFD #StrokePrevention
February 11, 2026 at 3:44 AM
Can routine MRA predict which brain aneurysms will rupture? Our latest article shows how patient-specific CFD tool maps hidden blood-flow forces, revealing shear-stress patterns that distinguish stable from high-risk lesions, advancing noninvasive, personalized care
#Neurosci #CFD #StrokePrevention
#Neurosci #CFD #StrokePrevention
Our review examines chamber-specific expression and function of ion channels in the human heart. This comprehensive and integrative analysis could serve as a basis for developing therapeutic strategies for improved patient care.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
February 6, 2026 at 3:05 AM
Our review examines chamber-specific expression and function of ion channels in the human heart. This comprehensive and integrative analysis could serve as a basis for developing therapeutic strategies for improved patient care.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
New article:
This study reveals that EndMT contributes to atherosclerosis by generating osteogenic- and chondrogenic-like cells, linking endothelial dysfunction to vascular calcification in disease
#EndMT #Atherosclerosis #VascularBiology #CardiovascularScience
doi.org/10.1016/j.vp...
This study reveals that EndMT contributes to atherosclerosis by generating osteogenic- and chondrogenic-like cells, linking endothelial dysfunction to vascular calcification in disease
#EndMT #Atherosclerosis #VascularBiology #CardiovascularScience
doi.org/10.1016/j.vp...
February 5, 2026 at 3:06 AM
New article:
This study reveals that EndMT contributes to atherosclerosis by generating osteogenic- and chondrogenic-like cells, linking endothelial dysfunction to vascular calcification in disease
#EndMT #Atherosclerosis #VascularBiology #CardiovascularScience
doi.org/10.1016/j.vp...
This study reveals that EndMT contributes to atherosclerosis by generating osteogenic- and chondrogenic-like cells, linking endothelial dysfunction to vascular calcification in disease
#EndMT #Atherosclerosis #VascularBiology #CardiovascularScience
doi.org/10.1016/j.vp...
A new observational study using INSPECTIO supports the effectiveness of guideline-directed therapy and regular risk assessment to optimize treatment strategies in Pulmonary Arterial Hypertension.
#PAH #ClinicalResearch #INSPECTIO #ObservationalStudy #Macitentan #Selexipag
doi.org/10.1016/j.vp...
#PAH #ClinicalResearch #INSPECTIO #ObservationalStudy #Macitentan #Selexipag
doi.org/10.1016/j.vp...
February 4, 2026 at 2:23 AM
A new observational study using INSPECTIO supports the effectiveness of guideline-directed therapy and regular risk assessment to optimize treatment strategies in Pulmonary Arterial Hypertension.
#PAH #ClinicalResearch #INSPECTIO #ObservationalStudy #Macitentan #Selexipag
doi.org/10.1016/j.vp...
#PAH #ClinicalResearch #INSPECTIO #ObservationalStudy #Macitentan #Selexipag
doi.org/10.1016/j.vp...
Announcement: Vascular Pharmacology announces the 2025 Best Cover Image Award winner: “Cdc42 is crucial for mural cell migration, proliferation and patterning of the retinal vasculature” (Álvarez-Aznar et al.) Congratulations!
www.sciencedirect.com/journal/vasc...
#VascularPharmacology #BestCover
www.sciencedirect.com/journal/vasc...
#VascularPharmacology #BestCover
February 2, 2026 at 7:28 AM
Announcement: Vascular Pharmacology announces the 2025 Best Cover Image Award winner: “Cdc42 is crucial for mural cell migration, proliferation and patterning of the retinal vasculature” (Álvarez-Aznar et al.) Congratulations!
www.sciencedirect.com/journal/vasc...
#VascularPharmacology #BestCover
www.sciencedirect.com/journal/vasc...
#VascularPharmacology #BestCover
Announcement: Vascular Pharmacology is pleased to announce the winners of 2025 Young Scientist Award: Dr. Konrad Stępień (Clinical Research) and Dr. Francesca Vacante (Basic Research). The official announcement is live:
www.sciencedirect.com/journal/vasc... #VascularPharmacology
#YoungScientistAward
www.sciencedirect.com/journal/vasc... #VascularPharmacology
#YoungScientistAward
News - Vascular Pharmacology | ScienceDirect.com by Elsevier
Read the latest articles of Vascular Pharmacology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
www.sciencedirect.com
February 2, 2026 at 7:19 AM
Announcement: Vascular Pharmacology is pleased to announce the winners of 2025 Young Scientist Award: Dr. Konrad Stępień (Clinical Research) and Dr. Francesca Vacante (Basic Research). The official announcement is live:
www.sciencedirect.com/journal/vasc... #VascularPharmacology
#YoungScientistAward
www.sciencedirect.com/journal/vasc... #VascularPharmacology
#YoungScientistAward
A newly published systematic review & meta-analysis reveals that exercise pulmonary hypertension could be a promising endpoint for evaluating pharmacological therapies for chronic thromboembolic pulmonary disease without resting pulmonary hypertension.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
January 22, 2026 at 3:45 AM
A newly published systematic review & meta-analysis reveals that exercise pulmonary hypertension could be a promising endpoint for evaluating pharmacological therapies for chronic thromboembolic pulmonary disease without resting pulmonary hypertension.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
Sotatercept has been found effective in PAH treatment. This review explores Sotatercept's pleiotropic benefits, particularly in erythropoiesis, muscle atrophy, and bone loss, and suggests how it could be transformative for PAH therapy.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
January 15, 2026 at 2:41 AM
Sotatercept has been found effective in PAH treatment. This review explores Sotatercept's pleiotropic benefits, particularly in erythropoiesis, muscle atrophy, and bone loss, and suggests how it could be transformative for PAH therapy.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
Vascular smooth muscle cells are the underrated shapeshifters driving plaque evolution. Our new review unpacks how mechanics, molecular signals, and RNA regulation push vSMCs toward phenotypes that fuel plaque growth and vulnerability.
#Atherosclerosis #VascularBiology #SmoothMuscleCells
#Atherosclerosis #VascularBiology #SmoothMuscleCells
December 16, 2025 at 2:52 AM
Vascular smooth muscle cells are the underrated shapeshifters driving plaque evolution. Our new review unpacks how mechanics, molecular signals, and RNA regulation push vSMCs toward phenotypes that fuel plaque growth and vulnerability.
#Atherosclerosis #VascularBiology #SmoothMuscleCells
#Atherosclerosis #VascularBiology #SmoothMuscleCells
New Italian multicenter registry data reveal how pulmonary arterial hypertension (PAH) is diagnosed and treated in real life, early detection, comprehensive workups, and guideline-driven care. A sharper picture of patient needs.
#PAH #PulmonaryHypertension #RealWorldData #PHResearch #CardioScience'.
#PAH #PulmonaryHypertension #RealWorldData #PHResearch #CardioScience'.
December 16, 2025 at 2:50 AM
New Italian multicenter registry data reveal how pulmonary arterial hypertension (PAH) is diagnosed and treated in real life, early detection, comprehensive workups, and guideline-driven care. A sharper picture of patient needs.
#PAH #PulmonaryHypertension #RealWorldData #PHResearch #CardioScience'.
#PAH #PulmonaryHypertension #RealWorldData #PHResearch #CardioScience'.
New study reveals that microplastics can worsen pulmonary hypertension by promoting EndMT, inflammation, and histone lactylation in endothelial cells. Key genes like TNFRSF11B and SGK1 emerge as potential therapeutic targets to counter PH progression.
#PulmonaryHypertension #EndMT #Microplastics
#PulmonaryHypertension #EndMT #Microplastics
December 9, 2025 at 2:30 AM
New study reveals that microplastics can worsen pulmonary hypertension by promoting EndMT, inflammation, and histone lactylation in endothelial cells. Key genes like TNFRSF11B and SGK1 emerge as potential therapeutic targets to counter PH progression.
#PulmonaryHypertension #EndMT #Microplastics
#PulmonaryHypertension #EndMT #Microplastics
New review explores amylin receptor agonists (AMYRAs) as next generation therapies for obesity, offering benefits that go beyond weight loss. With advances in AMYR biology, dual agonism, and delivery tech, AMYRAs may redefine precision obesity care by 2030.
#ObesityResearch #MetabolicHealth #Amylin
#ObesityResearch #MetabolicHealth #Amylin
December 9, 2025 at 2:28 AM
New review explores amylin receptor agonists (AMYRAs) as next generation therapies for obesity, offering benefits that go beyond weight loss. With advances in AMYR biology, dual agonism, and delivery tech, AMYRAs may redefine precision obesity care by 2030.
#ObesityResearch #MetabolicHealth #Amylin
#ObesityResearch #MetabolicHealth #Amylin
New review highlights how adaptive immunity shapes the development of aortic aneurysm and dissection (AAD) — from antigen activation to aortic damage. Understanding these immune pathways could unlock targeted therapies for this deadly condition.
#AorticDisease #Immunology #CardioResearch #AAD
#AorticDisease #Immunology #CardioResearch #AAD
December 9, 2025 at 2:20 AM
New review highlights how adaptive immunity shapes the development of aortic aneurysm and dissection (AAD) — from antigen activation to aortic damage. Understanding these immune pathways could unlock targeted therapies for this deadly condition.
#AorticDisease #Immunology #CardioResearch #AAD
#AorticDisease #Immunology #CardioResearch #AAD
New review: Nebivolol through NO-mediated vasodilation, shows promise in heart failure. Evidence highlights vascular, metabolic, and clinical benefits, with potential in personalized HF therapy.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
December 5, 2025 at 8:22 AM
New review: Nebivolol through NO-mediated vasodilation, shows promise in heart failure. Evidence highlights vascular, metabolic, and clinical benefits, with potential in personalized HF therapy.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
New study shows 17β-estradiol induces NOS-dependent vasorelaxation in mouse aorta, with subtle sex- differences among ER subtypes. PI3K inhibition enhances relaxation by reducing MLC phosphorylation.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
November 11, 2025 at 2:27 AM
New study shows 17β-estradiol induces NOS-dependent vasorelaxation in mouse aorta, with subtle sex- differences among ER subtypes. PI3K inhibition enhances relaxation by reducing MLC phosphorylation.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
Does vessel size truly dictate soluble guanylate cyclase sensitivity? A new commentary on Lubomirov et al. suggests enhanced cinaciguat responses in smaller arteries may reflect hypoxia–reoxygenation and pathological context, not intrinsic diameter effects. #vascularbiology #NOcGMP #sGC
Redirecting
doi.org
November 3, 2025 at 2:28 AM
Does vessel size truly dictate soluble guanylate cyclase sensitivity? A new commentary on Lubomirov et al. suggests enhanced cinaciguat responses in smaller arteries may reflect hypoxia–reoxygenation and pathological context, not intrinsic diameter effects. #vascularbiology #NOcGMP #sGC
New study: Reduced LMOD1 promotes smooth muscle cell proliferation and vascular lesion growth via CDK6 activation. Targeting CDK6 restores normal proliferation, revealing a reversible pathway in vascular remodeling.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 28, 2025 at 3:40 AM
New study: Reduced LMOD1 promotes smooth muscle cell proliferation and vascular lesion growth via CDK6 activation. Targeting CDK6 restores normal proliferation, revealing a reversible pathway in vascular remodeling.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
October 28, 2025 at 3:38 AM
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
🚨New publication alert: GDF15 alleviates diabetic endothelial dysfunction & oxidative stress through AMPK-dependent pathways. A promising therapeutic target for vascular protection in diabetes
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
October 23, 2025 at 2:49 AM
🚨New publication alert: GDF15 alleviates diabetic endothelial dysfunction & oxidative stress through AMPK-dependent pathways. A promising therapeutic target for vascular protection in diabetes
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
October 23, 2025 at 2:48 AM
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
A systematic meta-analysis evaluates lorundrostat, a novel aldosterone synthase inhibitor, in patients with uncontrolled hypertension. The analysis suggests potential blood pressure–lowering effects, though further large-scale trials are needed to confirm long-term efficacy and safety #Hypertension
October 22, 2025 at 7:49 AM
A systematic meta-analysis evaluates lorundrostat, a novel aldosterone synthase inhibitor, in patients with uncontrolled hypertension. The analysis suggests potential blood pressure–lowering effects, though further large-scale trials are needed to confirm long-term efficacy and safety #Hypertension
Our new review explores how targeting hypothalamic signaling may transform obesity care. GLP-1R agonists & next-gen peptides, such as AMG 133, show enhanced weight loss & metabolic effects.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 22, 2025 at 7:48 AM
Our new review explores how targeting hypothalamic signaling may transform obesity care. GLP-1R agonists & next-gen peptides, such as AMG 133, show enhanced weight loss & metabolic effects.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
New review highlights the Apelin/APJ pathway as a promising target in glioblastoma. By driving tumor angiogenesis, growth, and therapy resistance, Apelin could hold the key to more effective GBM treatments
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
October 22, 2025 at 7:43 AM
New review highlights the Apelin/APJ pathway as a promising target in glioblastoma. By driving tumor angiogenesis, growth, and therapy resistance, Apelin could hold the key to more effective GBM treatments
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
Atherosclerosis isn’t just about LDL, it’s also about leaky arteries. Our latest review explores emerging therapies that target transendothelial permeability, a promising, underexplored frontier in atherosclerosis.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 13, 2025 at 2:52 AM
Atherosclerosis isn’t just about LDL, it’s also about leaky arteries. Our latest review explores emerging therapies that target transendothelial permeability, a promising, underexplored frontier in atherosclerosis.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
🎉Vascular Pharmacology Young Researcher Award 2025! Support emerging scientists—apply or nominate today! #VascularResearch #YoungScientists
More detials: www.sciencedirect.com/journal/vasc...
More detials: www.sciencedirect.com/journal/vasc...
October 12, 2025 at 5:03 AM
🎉Vascular Pharmacology Young Researcher Award 2025! Support emerging scientists—apply or nominate today! #VascularResearch #YoungScientists
More detials: www.sciencedirect.com/journal/vasc...
More detials: www.sciencedirect.com/journal/vasc...