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Reposted by Varun Venkataramani

Matthia Karreman @matthiakarreman.bsky.social · Mar 6

Many great speakers, amongst whom the amazing @ekinreyhan.bsky.social from the @venkataramanilab.bsky.social !

EANO @eanoassociation.bsky.social · Mar 6

📣 Still time to register! Join the 3rd Annual Highlights of EANO/SNO 2024 webinar and hear key insights from #EANO2024 (Glasgow) and #SNO2024 (Boston).

🗓 March 7, 2025 | ⏰ 6:30 PM CET | 12:30 PM ET
🔗 Register now: eano.eu/eanowebinar/

@neuroonc.bsky.social

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 12

Thanks so much for your kind words, Wolfgang!

Reposted by Varun Venkataramani

Wolfgang Wick @wickwolfgang.bsky.social · Dec 12

🎉Es ist ein Riesenprivileg, wenn man mit so leistungsstarken und kreativen Wissenschaftler:innen wie @svenjatetzlaff.bsky.social und @venkataramanilab.bsky.social zusammenarbeiten darf.
Der Schritt pathologische Netzwerke in Hirntumoren als Routen für Therapie zu explorieren,ist hochinnovativ.

Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

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Reposted by Varun Venkataramani

Sam Connell @samuelconnell.3i.social · Dec 10

🧪🧵🔬🔥Amazing microscopy here from the Venkataramani lab!

Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

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Reposted by Varun Venkataramani

Maria Puschhof @mariapuschhof.bsky.social · Dec 8

Great to see the study published! Congrats to all co-authors and thanks very much for having us @juliosaezrod.bsky.social @saezlab.bsky.social on the team. A nice example of how the @aihcluster.bsky.social makes new collaborations possible.

Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 7

Thank you so much!

Reposted by Varun Venkataramani

Ghazaleh Tabatabai @ghtabatabai.bsky.social · Dec 7

Outstanding and fascinating… congratulations 👏

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Reposted by Varun Venkataramani

Matthia Karreman @matthiakarreman.bsky.social · Dec 7

Fantastic work by the amazing @svenjaktetzlaff.bsky.social , @ekinreyhan.bsky.social and the @venkataramanilab.bsky.social !!

Important and beautiful study 🤩 and I am happy and honored to have played a small part in it!

Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

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Reposted by Varun Venkataramani

Winkler Laboratory @winklerlab.bsky.social · Dec 7

Important #cancerneuroscience work from the amazing @venkataramanilab.bsky.social and as shared first @svenjaktetzlaff.bsky.social and @ekinreyhan.bsky.social !

Check it out 👇

Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

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Reposted by Varun Venkataramani

Eddy Pasquier 🧪🇫🇷🇦🇺 @eddpasquier.bsky.social · Dec 7

Beautiful work & insightful BlueSkytorial by @venkataramanilab.bsky.social.

Using modified rabies viruses, they show that glioblastoma tumor cells rapidly make connections with neurons & these interactions represent targetable vulnerabilities that could open therapeutic avenues for brain cancers.

Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

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Reposted by Varun Venkataramani

Emmanuelle Huillard @emmanuellehuillard.bsky.social · Dec 7

🔥 Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing: Beautiful work by @venkataramanilab.bsky.social, congratulations !!

www.cell.com/cell/fulltex...

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.

www.cell.com

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Reposted by Varun Venkataramani

Svenja Tetzlaff @svenjaktetzlaff.bsky.social · Dec 6

So happy this is finally out😊 thank you for the amazing supervision @venkataramanilab.bsky.social, to the best partner-in-crime @ekinreyhan.bsky.social and everyone who contributed, such a team effort!🧠🔬

Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

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Reposted by Varun Venkataramani

Ekin Reyhan @ekinreyhan.bsky.social · Dec 6

Thrilled to share our latest work on how glioblastoma integrates into brain-wide networks using rabies-mediated retrograde tracing!🧠 So grateful to have been part of such a big team effort! @svenjaktetzlaff.bsky.social @venkataramanilab.bsky.social

Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🌟 Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact: [email protected] 15/15

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

We are incredibly grateful for the patients, their families and the funding agencies for enabling this research!

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

Sonja Hänzelmann,
@matthiakarreman.bsky.social, Felix Kurz, Manuel Schröter, Marc Thieeir, Abigail Suwala, Karin Forsberg-Nilsson, Claudio Acuna,
@saezlab.bsky.social , Amir Abdollahi, Felix Sahm, Michael Breckwoldt, Bogdana Suchorska, Franz Ricklefs, Dieter Henrik Heiland

Bluesky

arreman.bsky.social

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

@atefehpourkhalili.bsky.social
@ninadrewa.bsky.social
@afaymonville.bsky.social
ville.bsky.social
@ekeifert.bsky.social
eifert.bsky.social, Julia Wagner,
@stellasoyka.bsky.social @marccschubert.bsky.social
@nirosansivapalan.bsky.social

Andres Villegas (@ville.bsky.social)

Systems are life

ville.bsky.social

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

So proud of the shared first authors
@ekinreyhan.bsky.social sky.social @svenjaktetzlaff.bsky.social etzlaff.bsky.social
and the entire team of amazing collaborators
@layern.bsky.social Peter Bengtson, Alina Heuer,
@julianschroers.bsky.social
@afaymonville.bsky.social

Bluesky

Social media as it should be. Find your community among millions of users, unleash your creativity, and have some fun again.

bsky.social

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🔗 This research showcases the importance of bespoke methods development for Cancer Neuroscience, how it will advance our understanding of (brain) cancer circuits and the development of novel therapeutics for yet incurable tumors. 14/15

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

📊 Beyond just mapping, this work provides new therapeutic targets and a platform for testing treatments against these aggressive brain tumors. 13/15

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🦠 Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

Tumor models of individual patients and distinct cell states showed heterogeneous patterns of neural connectivity. 11/15

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

💊 This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

📡 Radiation therapy revealed something unexpected: It increased neuronal activity and subsequently connections between neurons and tumor cells. 9/15

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Varun Venkataramani @venkataramanilab.bsky.social · Dec 6

🔍 A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15

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