This Viewpoint discusses the use of glucagon-like peptide-1 receptor agonist treatments for weight management in youth.

Scientific Reports - Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques

Acute myocardial infarction (MI) is a leading cause of death worldwide, accounting for >1 million deaths/year in the United States alone. Although parental obesity is a risk factor for offspring cardi...

Nature Communications - The relationship between pancreatic β-cell dysfunction and autoinflammation in T2DM is unclear. Here, the authors show the key role of a UCP2/mtDNA/STING axis in the...

Nature Metabolism, Published online: 11 July 2025; doi:10.1038/s42255-025-01343-5Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.

Nature Reviews Endocrinology, Published online: 16 July 2025; doi:10.1038/s41574-025-01154-4Adult-onset type 1 diabetes mellitus differs from the early onset form in terms of residual endogenous insulin secretion, comorbidities and baseline cardiorenal risk. Adjunct therapy with glucagon-like peptide 1 receptor agonists could offer benefits in this population of patients by preserving β-cell mass and function while also contributing to cardiorenal risk mitigation.