Single-color 3D MINFLUX of periodic paralemmin-1 along the axon of a mature neuron. YFP-Palm1 was detected with a nanobody against YFP with DNA-PAINT. Image courtesy: @vmacarron.bsky.social, MPI MR, Heidelberg, Germany
More in the paper www.science.org/doi/full/10....

#fluorescencefriday

Are you interested in muscle research? 💪 🏋
We are excited to invite you to our Muscle Mini-Symposium: “Exploring skeletal muscle communication: From tissues down to molecules”

🗣️ Speakers: Fanny Sage, Ana Banito, Xuejun Yuan, Joerg Heineke

Many Thanks and Kudos to all authors, colleagues and collaborators from Heidelberg and Göttingen. Looking forward to what comes next!

How does it work? The expression level of Paralemmin-1 controls the degree of periodicity of the MPS.
⬇️Low levels: poorly organized MPS
⬆️High levels: tightly organized MPS
Paralemmin-1 binds ßII-spectrin and is located in close proximity to actin and adducin
#STED #MINFLUX #Y2H

🔬🧠We are pleased to announce that our work on Paralemmin-1 as a powerful regulator of the neuronal submembrane cytoskeleton has been published in Science Advances @science.org! Read the full study here: www.science.org/doi/10.1126/...
#Neuroscience

Time for changes! New week, new month, new platform. Hi scientific community!