Lightnews — Scholar-powered news

Wen Zhu Lab @wenzhulab.bsky.social · 10d

Our first group retreat at Clearwater, FL.

Wen Zhu Lab @wenzhulab.bsky.social · 23d

Congrats Wen! 🎉🎉➡️FSU chemist earns $2.1 million NIH grant to investigate molecular causes of disease: news.fsu.edu/news/science...

FSU chemist earns $2.1 million NIH grant to investigate molecular causes of disease

A Florida State University researcher has received a multi-million-dollar grant to investigate the role enzymes — which influence nearly every process in

news.fsu.edu

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Wen Zhu Lab @wenzhulab.bsky.social · 29d

Succinate dehydrogenase (SDH) uniquely powers both the TCA cycle & electron transport chain. SDH mutations cause SDH deficiency, disrupting energy metabolism & leading to developmental delays. #RareDiseaseThursday

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Wen Zhu Lab @wenzhulab.bsky.social · Aug 28

KARS1 encodes lysyl-tRNA synthetase. Biallelic KARS mutations cause KARS syndrome, a severe disorder that affects multiple organs, particularly the nervous system. #RareDiseaseThursday

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Wen Zhu Lab @wenzhulab.bsky.social · Jul 22

Congratulations to Julia and Adwaith for completing the 2025 Young Scholar Program and research symposium. It was a joy having you both in lab and we are very proud of you!

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Wen Zhu Lab @wenzhulab.bsky.social · Jul 3

Transaldolase deficiency is a rare metabolic disorder affecting the pentose phosphate pathway, leading to liver dysfunction, growth delays, and skin abnormalities. It’s caused by mutations in the TALDO1 gene. Early diagnosis is key to managing symptoms. #RareDiseaseThursday

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Wen Zhu Lab @wenzhulab.bsky.social · Jun 26

#RareDiseaseThursday Ribose-5-phosphate isomerase (RPI) deficiency is one of the rarest inborn errors of metabolism. Still no cure. It affects the pentose phosphate pathway, leading to impaired RNA synthesis or accumulation of D-ribitol and D-arabitol.

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Reposted by Wen Zhu Lab

Oliver Steinbock @osteinbock.bsky.social · Jun 26

🤔 What if classic probability puzzles could be encoded in chemistry? We mapped the Monty Hall problem into a deterministic chemical reaction network using mass-action kinetics. Curious? ... then check out our latest paper with
@wenzhulab.bsky.social in @pccp.rsc.org doi.org/10.1039/D5CP...

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Wen Zhu Lab @wenzhulab.bsky.social · Jun 23

So excited that our work has already inspired one young girl to fall in love with science!

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Wen Zhu Lab @wenzhulab.bsky.social · Jun 17

Welcome to our #ColorMyMetalloE coloring series. This is an interactive adventure that brings the hidden world of metalloenzymes to life! You can also explore various existing careers as a chemist! Simply download the PDF, grab your favorite coloring tools, and let your creativity flow.

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Wen Zhu Lab @wenzhulab.bsky.social · Jun 13

Wrapped up Zhu Lab’s 2nd Annual Undergraduate Researcher Appreciation Day with a sweet treat! 🍦 Thanks to our amazing young scholars, student mentors and neighboring labs for joining the ice cream social!

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Wen Zhu Lab @wenzhulab.bsky.social · Jun 6

On #RareDiseaseThursday, learn about Ribose-phosphate isomerase deficiency: an ultra-rare autosomal recessive disorder causing leukoencephalopathy, developmental delays, and spinocerebellar atrophy. Fewer than 10 cases known; metabolic testing matters!

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Wen Zhu Lab @wenzhulab.bsky.social · May 29

Fructose-1,6-bisphosphatase deficiency is a rare metabolic disorder characterized by impaired gluconeogenesis. Without this enzyme, the body can't maintain blood sugar, leading to hypoglycemia, lactic acidosis, and coma. #RareDiseaseThursday

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Wen Zhu Lab @wenzhulab.bsky.social · May 15

#RareDiseaseThursday Mutations in glucose-6-phosphatase (G6Pase), an enzyme critical for glucose release, can lead to Von Gierke's Disease Type I. Dysfunctional G6Pase results in glycogen buildup in the liver and kidneys, leading to low blood sugar and organ damage

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Wen Zhu Lab @wenzhulab.bsky.social · Apr 17

Today is a heartbreaking day. Our thoughts and deepest sympathies are with the victims and their families. It's time to put an end to gun violence on campuses!

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Wen Zhu Lab @wenzhulab.bsky.social · Apr 13

We had several great presentations lately! Lucciano passed his second-year milestone talk. Jack presented at the FSU Undergraduate Research Symposium. Congrats!

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Wen Zhu Lab @wenzhulab.bsky.social · Apr 8

Congratulations to Caitlin Padgett on receiving the Honorable Mention in the NSF Graduate Research Fellowship Program! We're incredibly proud of your hard work and achievements! 🥳🥳🥳

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Wen Zhu Lab @wenzhulab.bsky.social · Apr 4

Our latest review on #TBCK and #TBCKSyndrome is out now in Frontiers in Biophysics!! We look into the multi-domain architecture of the protein and its cellular function, shedding light on how mutations can lead to neurological disorders. #Raredisease www.frontiersin.org/journals/bio...

Frontiers | Decoding TBCK: from bioinformatic insights of domain architecture to disease implications

www.frontiersin.org

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Wen Zhu Lab @wenzhulab.bsky.social · Mar 27

🖋️Hexosaminidase A deficiency leads to the devastating effects of Tay-Sachs disease, an autosomal recessive lysosomal storage disorder. Understanding this enzyme is key to advancing diagnosis and treatment options.🧠 #TaySachsDisease #RareDiseaseThursday

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Reposted by Wen Zhu Lab

Canadian History Ehx @cdnhistoryehx.bsky.social · Mar 20

On this day in 1879, Maud Menten was born in Port Lambton, Ontario.
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!

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A black-and-white photo shows a woman in a patterned dress with a lace collar and pearl necklace, sitting in a chair. The background features shelves with bottles and a wire basket, suggesting an early 20th-century setting, possibly a pharmacy or study.

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Wen Zhu Lab @wenzhulab.bsky.social · Mar 20

🧬 Meet SOD1, a crucial Cu/Zn metalloenzyme that protects cells from oxidative stress. Mutations in SOD1 are linked to a rare form of Amyotrophic Lateral Sclerosis, leading to motor neuron degeneration & paralysis. 🧠⚡ #RareDiseaseThursday #SOD1

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Wen Zhu Lab @wenzhulab.bsky.social · Mar 14

We are excited to welcome Dr. Maurya joining our lab as a postdoctoral scholar! Her expertise in protein biochemistry will be a great addition to our translational enzymology team!

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Wen Zhu Lab @wenzhulab.bsky.social · Mar 13

🧬Meet TBCK, a key regulator in cell growth & metabolism. Mutations in TBCK cause TBCK Syndrome, a rare neurodevelopmental disorder linked to motor delays, hypotonia, & intellectual disability. Understanding TBCK helps uncover new therapeutic paths!🧠✨ #RareDiseaseThursday #TBCK

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Wen Zhu Lab @wenzhulab.bsky.social · Mar 6

🚨 Meet ASNS (Asparagine Synthetase) – a crucial enzyme that makes asparagine, an amino acid vital for brain development. Mutations in ASNS cause Asparagine Synthetase Deficiency (ASD), a rare disease leading to severe neurodevelopmental impairments. 🧠⚠️ #RareDisease #ASNS #Neurobiology

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Wen Zhu Lab @wenzhulab.bsky.social · Mar 6

Our lab studies proteins and enzymes linked to rare diseases. Our mission is to create a brighter future for affected individuals and their families. To raise awareness, we’re launching #RareDiseaseThursday. #RareDisease

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