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yasesancak.bsky.social
Yasemin Sancak
@yasesancak.bsky.social
300 followers 650 following 3 posts
Faculty at UW Seattle, interested in mitochondria, calcium signaling, organelles, cancer metabolism.
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Reposted by Yasemin Sancak
mihaylova.bsky.social
Maria Mihaylova @mihaylova.bsky.social · 16d
Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.
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Reposted by Yasemin Sancak
shechnerlab.bsky.social
Dave Shechner @shechnerlab.bsky.social · Jun 30
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!

tinyurl.com/ydn6e3ac
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yasesancak.bsky.social
Yasemin Sancak @yasesancak.bsky.social · May 31
We show that the liver cancer fibrolamellar carcinoma is characterized by increased mitochondrial calcium levels, which leads to inhibition of BCAA catabolism. Congratulations to all the authors, and many thanks to collaborators @lucasbsullivan.bsky.social @shaoenong.bsky.social
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yasesancak.bsky.social
Yasemin Sancak @yasesancak.bsky.social · May 31
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma
Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.
www.science.org
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yasesancak.bsky.social
Yasemin Sancak @yasesancak.bsky.social · May 31
ATTENTION MITO-CALCIUM ENTHUSIASTS: there's a new game in town! This piece highlights a new paper by the Elrod Lab interrogating TMEM65’s role in mitochondrial calcium efflux. The De Stefani and Glancy labs have recently reported similar findings. Congratulations on this important discovery!
natmetabolism.nature.com
Nature Metabolism @natmetabolism.nature.com · May 20
NEWS & VIEWS | @yasesancak.bsky.social (U Washington):

A new study shows that the mitochondrial protein TMEM65 has a central role in efflux of calcium ions from the mitochondria.

https://bit.ly/3Sdndzq ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
TMEM65 joins the mitochondrial Ca2+ club - Nature Metabolism
Garbincius et al. show that TMEM65, a mitochondrial transmembrane protein of unknown function, has a central role in efflux of calcium ions from the mitochondria. Mitochondrial calcium efflux is crucial for maintaining mitochondrial calcium levels, which is important for metabolic homeostasis and mitochondrial health.
bit.ly
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Reposted by Yasemin Sancak
shechnerlab.bsky.social
Dave Shechner @shechnerlab.bsky.social · Nov 21
It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
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