Yicheng Long
@yichenglong.bsky.social
Assistant Professor of Biochemistry, Weill Cornell Medicine. www.longlab.org. Studying epigenetics, nucleic acids, stem cells and heart. Cech lab alumnus
Reposted by Yicheng Long
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Our department at Weill Cornell is hiring a junior faculty member in the broad field of fundamental biomedical science. Please spread the word. Job ad here: www.nature.com/naturecareer...
Assistant Professor-Basic Science - New York City, New York (US) job with Weill Cornell Medicine | 12845084
WCM invites applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics.
www.nature.com
September 22, 2025 at 7:55 PM
Our department at Weill Cornell is hiring a junior faculty member in the broad field of fundamental biomedical science. Please spread the word. Job ad here: www.nature.com/naturecareer...
Reposted by Yicheng Long
Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells
www.cell.com/developmenta...
www.cell.com/developmenta...
Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm
Correct patterning of emerging tissues in the developing embryo is essential for the
formation of functional organ systems. Using genetic tools for controlled protein
depletion, Ee et al. identify the...
www.cell.com
August 19, 2025 at 6:14 PM
Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted by Yicheng Long
Online Now: Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation Online now:
Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation
Much et al. reveal that the PRC2 subcomplexes PRC2.1 and PRC2.2 play distinct roles in the epigenetic repression of developmental genes in human stem cells. Interactions between the PRC2 core and its accessory proteins, DNA, and H3K36me3 dictate PRC2 activity and, ultimately, modulate cardiac differentiation and function.
dlvr.it
August 12, 2025 at 10:57 PM
Online Now: Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation Online now:
Excited to share our work on the specificity of PRC2 subcomplexes in stem cell and differentiation. We show that PRC2.1 and PRC2.2 exhibit distinct H3K27 methylation specificity in human pluripotent stem cells and opposing role in differentiation. Now online at Mol Cell: www.cell.com/molecular-ce...
Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation
Much et al. reveal that the PRC2 subcomplexes PRC2.1 and PRC2.2 play distinct roles
in the epigenetic repression of developmental genes in human stem cells. Interactions
between the PRC2 core and its ...
www.cell.com
August 12, 2025 at 3:38 PM
Excited to share our work on the specificity of PRC2 subcomplexes in stem cell and differentiation. We show that PRC2.1 and PRC2.2 exhibit distinct H3K27 methylation specificity in human pluripotent stem cells and opposing role in differentiation. Now online at Mol Cell: www.cell.com/molecular-ce...
Reposted by Yicheng Long
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 23, 2025 at 11:38 PM
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share a preprint from my lab on distinct specificity and functions of PRC2 subcomplexes: www.biorxiv.org/content/10.1...
Macromolecular interactions dictate Polycomb-mediated epigenetic repression
The dynamic regulation of epigenetic states relies on complex macromolecular interactions. PRC2, the methyltransferase complex responsible for depositing H3K27me3, interacts with distinct accessory pr...
www.biorxiv.org
May 16, 2025 at 5:33 PM
Excited to share a preprint from my lab on distinct specificity and functions of PRC2 subcomplexes: www.biorxiv.org/content/10.1...