The educational cleavage is restructuring electoral competition in many democracies, yet there has been insufficient attention on how variation in educational content affects this. In order to addr...

Psilocybin therapy may reduce suicidal thoughts in people with mental health diagnoses, according to a new review in Therapeutic Advances in Psychopharmacology. The analysis combined results from clin...

The advent of genetically edited porcine-to-human xenotransplantation has predominantly focused on cardiac and renal applications, with no reported cases of porcine-to-human liver xenotransplantation....

The effects of green tea on metabolic diseases such as obesity and diabetes have been extensively studied. Obesity often leads to insulin resistance, particularly in peripheral tissues such as skelet...

Amid the declining clinical severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and diminishing public uptake of annual coronavirus disease 2019 (Covid-19) vaccines, ...

The newfound ensemble of neurons could lead to therapies to treat persistent pain, which affects roughly one of five people globally.

Only the third interstellar comet ever to be seen contains material from other star systems that can be observed close up

Humanities and Social Sciences Communications - Exploring subjective understandings among vaccine-hesitant individuals: findings from a Q methodology study

Ketamine is a highly effective treatment for difficult-to-treat or treatment-resistant depression (TRD). The commercially developed intranasal spray c…

If recent discoveries that dark energy is evolving hold any water, our Universe will collapse under its own gravity on a finite timeline, new calculations suggest.

The transport of Rapa Nui's (Easter Island) monumental moai statues has been debated for over a century. Based on a systematic analysis of 962 moai, w…

Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by natur...

Extensive measurements of the emissions of methane, nitrous oxide and ammonia from wastewater treatment facilities in the USA present higher values than are currently stated in national inventories. The results of this analysis show that greenhouse gas and nitrogenous emissions from the wastewater sector are often overlooked and that their impact on climate should be reassessed.

Forgetting is a vital, active process that clears irrelevant memories and supports new learning. Using the model organism Caenorhabditis elegans, we investigated how dopamine, a key neurotransmitter,....

The Patagonian ice sheet not only responded to climate change but also actively influenced it regionally, highlighting the role of topographic forcing in shaping atmospheric circulation during glacial-interglacial cycles, according to a modeling study.

Research could offer hope for ME patients – but some experts urge caution and say more studies needed

npj Urban Sustainability - Assessing the exposure of buildings to long-term sea level rise across the Global South

Novel theories have emerged in the past decade pertaining to how the brain processes internal body sensations and how such processes underpin not only perception but also how we act in the world. These neuroscientific advances offer new perspectives for research and practice allied to medicine, sport and exercise science. The construct of perceived fatigue has been understudied until recent recognition of its prevalence and influence on perceptions and behaviours in health, diseases and performance. The aim of the present perspective piece is to propose a theoretical and conceptual framework for understanding perceived fatigue and its emergence during exercise. We encourage the use of the definition proposed by Micklewright et al. (2017), that is “a feeling of diminishing capacity to cope with physical or mental stressors, either imagined or real”, from a critique of contemporary taxonomies and a distinction made with other key percepts in the field of medicine, sport and exercise. We also offer some methodological considerations for its measure. We then succinctly describe a neurobiologically plausible mechanistic underpinning of exercise-induced perceived fatigue based on the theory of predictive processing applied to homeostatic regulation through allostatic control and metacognition. Finally, we position the model of perceived fatigue through Metacognitive Inference of Dyshomeostasis (MID) within the wider corpus of knowledge. We first contrast the MID model with the most dominant biology-grounded models of perceived fatigue proposed in the literature to then provide preliminary evidence in support of the MID model and suggest some testable predictions for future research.

A self-floating photocatalytic film enables rapid bacterial inactivation under weak natural sunlight.

Stimulus-reactive neuronal populations are groups of neurons that become activated by environmental stimuli. These sparsely activated neuronal assembl…

In 2025, the Brilliant Poetry competition invited people from around the world to explore the beauty and mystery of quantum science through verse. The response was extraordinary. In only three months,...

Electromagnetic Energy Extraction from Kerr Black Holes: Ab Initio Calculations, Meringolo, Claudio, Camilloni, Filippo, Rezzolla, Luciano

Researchers in Australia find 16 genetic variants linked to depression in women but only eight in men

Medical specialists, wary of the guidance provided by Trump’s team, offer up their own advice independently of the government.

Climate change is disrupting the reliability of photoperiod as a cue signalling seasonal changes in temperature. We show that gray treefrogs under a late-season photoperiod accumulated large reserves...

The unprecedented June 2023 marine heatwave in north-western Europe had a 10% annual likelihood, with climate change accelerating the risk of similar events, according to ensemble climate model simulations.

Forest coverage loss from wildfires and deforestation increases flood risk for large-scale river catchments by reducing interception, according to analysis of data from twenty-one watersheds in Australia.

The global context has shifted dramatically since publication of the first EAT–Lancet Commission in 2019, with increased geopolitical instability, soaring food prices, and the COVID-19 pandemic exacer...