Research could offer hope for ME patients – but some experts urge caution and say more studies needed

npj Urban Sustainability - Assessing the exposure of buildings to long-term sea level rise across the Global South

Novel theories have emerged in the past decade pertaining to how the brain processes internal body sensations and how such processes underpin not only perception but also how we act in the world. These neuroscientific advances offer new perspectives for research and practice allied to medicine, sport and exercise science. The construct of perceived fatigue has been understudied until recent recognition of its prevalence and influence on perceptions and behaviours in health, diseases and performance. The aim of the present perspective piece is to propose a theoretical and conceptual framework for understanding perceived fatigue and its emergence during exercise. We encourage the use of the definition proposed by Micklewright et al. (2017), that is “a feeling of diminishing capacity to cope with physical or mental stressors, either imagined or real”, from a critique of contemporary taxonomies and a distinction made with other key percepts in the field of medicine, sport and exercise. We also offer some methodological considerations for its measure. We then succinctly describe a neurobiologically plausible mechanistic underpinning of exercise-induced perceived fatigue based on the theory of predictive processing applied to homeostatic regulation through allostatic control and metacognition. Finally, we position the model of perceived fatigue through Metacognitive Inference of Dyshomeostasis (MID) within the wider corpus of knowledge. We first contrast the MID model with the most dominant biology-grounded models of perceived fatigue proposed in the literature to then provide preliminary evidence in support of the MID model and suggest some testable predictions for future research.

A self-floating photocatalytic film enables rapid bacterial inactivation under weak natural sunlight.

Stimulus-reactive neuronal populations are groups of neurons that become activated by environmental stimuli. These sparsely activated neuronal assembl…

In 2025, the Brilliant Poetry competition invited people from around the world to explore the beauty and mystery of quantum science through verse. The response was extraordinary. In only three months,...

Electromagnetic Energy Extraction from Kerr Black Holes: Ab Initio Calculations, Meringolo, Claudio, Camilloni, Filippo, Rezzolla, Luciano

Researchers in Australia find 16 genetic variants linked to depression in women but only eight in men

Medical specialists, wary of the guidance provided by Trump’s team, offer up their own advice independently of the government.

Climate change is disrupting the reliability of photoperiod as a cue signalling seasonal changes in temperature. We show that gray treefrogs under a late-season photoperiod accumulated large reserves...

The unprecedented June 2023 marine heatwave in north-western Europe had a 10% annual likelihood, with climate change accelerating the risk of similar events, according to ensemble climate model simulations.

Forest coverage loss from wildfires and deforestation increases flood risk for large-scale river catchments by reducing interception, according to analysis of data from twenty-one watersheds in Australia.

The global context has shifted dramatically since publication of the first EAT–Lancet Commission in 2019, with increased geopolitical instability, soaring food prices, and the COVID-19 pandemic exacer...

Tandem electro-biocatalytic systems present a versatile platform for producing a variety of synthetic products using CO2 as a starting material. Here direct ocean carbon capture is incorporated into an electrolysis scheme to produce formic acid from CO2 dissolved in seawater that is subsequently converted to succinate in a bioreactor.

This cross-sectional study estimates greenhouse gas emissions from all inhalers approved for asthma or chronic obstructive pulmonary disease (COPD) using aggregated dispensing data across the US outpa...

This blog was kindly authored by Sam Illingworth, Professor of Creative Pedagogies at Edinburgh Napier University.  Debates about Artificial Intelligence (AI) in higher education tend to fall into two...

Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

Scientific Reports - Exploring the role of green space in mitigating childhood opportunity across the U.S

Little is known about the early history of lizards, snakes and their kin. New fossil discoveries reveal a complex evolutionary journey.

Background: The long-term impacts of traumatic brain injury (TBI) in older adults are not well known. Our objective was to describe the association between late-life TBI, incident dementia, and health...

At Edinburgh Napier University, we nurture talent and create knowledge that shapes communities all around the world.

A decade of BGC-Argo and plankton records shows North Pacific heatwaves reshape food webs and trap small particles in midwater, slowing deep-ocean carbon export. Impacts vary by event, underscoring the need for sustained ocean monitoring.

AI is not neutral. It mirrors bias in data and design. Learn a simple practice to ask who is left out, and why diverse voices matter for real solutions.

Entomology; Food microbiology

Stronger association seen for patients with both hearing loss and allergic rhinitis than for those with either one alone.

Population-weighted exposure to tropical storms and hurricanes increased in the USA between 1992 and 2017. The attractions of high-risk areas currently outweigh incentives to reduce exposure to future storms through migration.

Humanities and Social Sciences Communications - Inspiration booster or creative fixation? The dual mechanisms of LLMs in shaping individual creativity in tasks of different complexity