Physics has a reputation for being dominated by men, especially a century ago, as quantum physics was just being invented – but there have been so many women who helped shaped the field since its inception

Landmark study in Bangladesh confirms that reducing arsenic exposure lowers chronic disease deaths

Chemists decipher dual degradation pathways for a once popular pigment

Existing drugs combined in new ways, as well as new molecules, deliver in late-stage trials

Humor has helped this professor connect with students and colleagues—and remain resilient during hard times

Multiple lines of evidence suggest that pigeons sense magnetic fields by detecting electric currents in their inner ears.

When this scientist’s father fell ill far away, he had to reconsider how best to honor his family’s sacrifice

Scientists capture a unique—and gruesome—example of matricide in the animal kingdom

Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students

Science historian Nathaniel Comfort reflects on the “most famous scientist of the 20th century, and the most infamous of the 21st”

New research supports counterintuitive explanation, but debate is far from settled

“I have learned to keep pushing forward, at a more relaxed pace,” this retired scientist writes

A thoroughly researched account of the history and relationships that shaped the scientist who co-discovered the structure of DNA.

While other places in the US are increasingly censuring how they tell their multicultural histories to travellers, one community is highlighting them.

Pentalene-based system can reversibly switch between aromatic and antiaromatic states without undergoing skeletal or conformational changes

Although the chemistry of autumn colours is well understood, there is an ongoing debate among scientists about why trees evolved their vivid autumn colours in the first place.

The prebiotic potential of ocean worlds such as Europa and Enceladus, while not well constrained, is vital in the search for potential life elsewhere. To better understand this potential, laboratory studies provide experimental insight into the chemical environment(s) of ocean worlds and any constraints to hold prebiotically relevant systems. However, simulated ocean world solutions present a technical challenge for analytical techniques such as mass spectrometry (MS), as the high saline content required for simulating ocean world environments results in ion suppression and reduced sensitivity. Here, we compare three sample preparation techniques, C4 ZipTips, C18 ZipTips, and on-plate washing, for matrix-assisted laser desorption/ionization – time-of-flight (MALDI-TOF) MS of saline solutions similar to environments expected in ocean worlds. We determined that using C18 ZipTips was optimal when paired with 2,5-dihydroxybenzoic acid (DHB) matrix, whereas on-plate desalting was optimal when paired with α-cyano-4-hydroxycinnamic acid (CHCA) matrix. The methodology described here presents simple, low-volume sample preparation strategies for MALDI-TOF MS of model prebiotic reactions in saline solutions.

Drugs targeting the kidneys for diabetes treatment stem from almost two centuries of research that began with an uprooted apple orchard.