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ACR Journals @acr-journals.bsky.social · 7h

Case report describes a 61 y/o woman with IgG4-RD presenting with retroperitoneal fibrosis & autoimmune pancreatitis, followed by sequential development of papillary thyroid carcinoma and diffuse large B cell lymphoma

ACR Open Rheumatology
doi.org/10.1002/acr2...

#Medsky #oncology

Pathologic and imaging features in a patient with IgG4-related disease (IgG4-RD) and subsequent malignancies. (A and B) Retroperitoneal biopsy showing hallmark features of IgG4-RD. (A) H&E staining reveals storiform fibrosis with dense lymphoplasmacytic infiltration. (B) Immunohistochemistry highlights abundant IgG4-positive plasma cells. (C and D) Histopathologic features of papillary thyroid carcinoma. (C) H&E staining shows typical papillary architecture with fibrovascular cores. (D) CK19 immunostaining demonstrates strong and diffuse membranous positivity in tumor cells. (E and F) PET-CT findings during disease progression. (E) Whole-body PET scan reveals metabolically active lymphadenopathy across multiple regions. (F) Coronal PET-CT fusion image shows intense FDG uptake in retroperitoneal and pelvic masses. (G and H) Lymph node biopsy confirming diffuse large B cell lymphoma. (G) H&E staining shows diffuse infiltration of large atypical lymphoid cells with prominent nucleoli. (H) Immunohistochemistry for CD20 shows strong membranous positivity, confirming B cell lineage

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ACR Journals @acr-journals.bsky.social · 15h

Study identified a panel of serum soluble mediators as potential biomarkers for monitoring proliferative lupus nephritis. Early reductions in syndecan-1 and VCAM-1 were predictive of 12-month treatment response in proliferative LN

Arthritis Care & Research
doi.org/10.1002/acr....

#Medsky

Serum soluble mediator profiles distinguish proliferative lupus nephritis (LN). Soluble mediator concentrations were measured at the time of kidney biopsy. Bootstrapped LASSO regression was used to select mediators associated with proliferative LN. (A) Forest plot of associations between these LASSO-selected soluble mediator concentrations and proliferative LN, as determined by univariate or multivariate logistic regression incorporating all selected mediators. (B) Forest plot displaying the area under the curve (AUC) for the performance of LASSO-selected soluble mediator concentrations in predicting proliferative LN. (C) Receiver operating characteristic curves for multivariate logistic regression models predicting proliferative LN: LASSO-selected soluble mediators (Model 1), clinical/demographic factors (race, ethnicity, biopsy history, SLEDAI, C3, C4; Model 2), and combined LASSO-selected soluble mediators and clinical/demographic factors (Model 3).

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ACR Journals @acr-journals.bsky.social · 1d

Longitudinal study in Japanese women found increased serum urate levels several years before menopause, with the largest increase occurring during peri-menopause, particularly in overweight or obese women and those with lower eGFR

Arthritis & Rheumatology
doi.org/10.1002/art....

#Medsky

Longitudinal trends in serum urate and hyperuricemia. Legend: Mean serum urate levels (A) and the proportion of hyperuricemia (B) with a 95% CI were described. The date of menopause was defined as the median date between the two consecutive visits immediately before and after the self-reported menopause occurrence. The time from menopause was calculated for each visit. Participant data were then summarized by years from menopause. eGFR, estimated glomerular filtration rate; CI, confidence intervals

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ACR Journals @acr-journals.bsky.social · 1d

Arthritis Care & Research - October Issue Editor's Pick

👉 Metabolic Consequences of Rheumatoid Arthritis
doi.org/10.1002/acr....

Review examines current understanding of mechanisms underlying disruptions in metabolic pathways in RA, their clinical effects, & how treatment affects these changes

Arthritis Care & Research Editor's Pick banner - October 2025 issue cover

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ACR Journals @acr-journals.bsky.social · 1d

Early IL-1 inhibitor introduction in patients with Still disease may lead to higher rates of clinical inactive disease and GC discontinuation compared with late treatment, supporting a window of opportunity in Still disease management

ACR Open Rheumatology
doi.org/10.1002/acr2...

#Medsky

Early IL‐1 Inhibition in Still's Disease: A Window of Opportunity for Improving Outcomes

Objective Still's disease is a complex, multisystemic disorder requiring prompt diagnosis and treatment. This study provides a general assessment of a Still's disease cohort aiming to evaluate the e...

doi.org

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ACR Journals @acr-journals.bsky.social · 2d

Maturational signal in the sacroiliac joint of skeletally immature youth is often misinterpreted as inflammation. This study defined apparent diffusion coefficient reference ranges by age group along the iliac and sacral SI joint

Arthritis Care & Research
doi.org/10.1002/acr....

#Medsky #Radsky

Diffusion-Weighted Imaging for the Evaluation of the Sacroiliac Joint in Pediatric Patients. Graphical abstract created using BioRender

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ACR Journals @acr-journals.bsky.social · 2d

Cross-sectional study of patients with GCA compared ultrasound and CT in measuring ascending aorta diameter. Results showed strong correlation and agreement between ultrasound and CT measurements. In this cohort, 18% developed aortic aneurysms over a mean 4.5 years

AC&R
doi.org/10.1002/acr....

Measurements of the diameter of the ascending aorta by ultrasound and CT (mm)

ACR Journals @acr-journals.bsky.social · 4d

Late-onset interstitial lung disease (ILD) in scleroderma may be more common than we think. In our NEWEST episode, we discuss why ILD can develop years after diagnosis and what this means for screening practices
🎙️ LISTEN NOW → https://acr.tw/4mAoxJ6

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ACR Journals @acr-journals.bsky.social · 4d

New in Arthritis Care & Research →

Developing a prediction model to identify risk of difficult-to-treat RA
doi.org/10.1002/acr....

Opioid prescribing trends for adults w/ axSpA
doi.org/10.1002/acr....

Review: Raynaud phenomenon treatment guidelines focused on vasodilation
doi.org/10.1002/acr....

Weekly recap in ACR Journals banner - Arthritis Care & Research cover

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ACR Journals @acr-journals.bsky.social · 4d

Immunology Series: Sjögren disease endotyping and emerging B cell-targeted therapies
doi.org/10.1002/art....

Influence of race, ethnicity, & historical redlining on PsA disease burden
doi.org/10.1002/art....

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell‐Targeted Therapies

Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations af....

doi.org

ACR Journals @acr-journals.bsky.social · 4d

New in Arthritis & Rheumatology →

Anakinra vs canakinumab in VEXAS syndrome
doi.org/10.1002/art....

Emulated target trial: impact of GLP-1RA on cardiovascular and kidney outcomes among patients with SLE and T2D
doi.org/10.1002/art....

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#Medksy

Weekly recap in ACR journals banner - Arthritis & Rheumatology cover

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ACR Journals @acr-journals.bsky.social · 5d

Analysis of PsA patient data in the ACR RISE registry showed Black PsA patients had higher burden of comorbidity & social deprivation, and more time in high disease activity. Results also reveal residual impact of historical redlining on regional health outcomes

A&R
doi.org/10.1002/art....
#Medsky

The Influence of Race, Ethnicity and Historical Redlining on Psoriatic Disease Burden and Clinical Outcomes. Graphical abstract created using BioRender

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ACR Journals @acr-journals.bsky.social · 5d

New installment in the A&R Immunology for the Rheumatologist series explores Sjögren disease endotyping to enhance patient stratification and clinical decision-making, and reviews emerging B cell-targeted therapies grounded in disease immunopathology

doi.org/10.1002/art....

#Medsky #Immunosky

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell-Targeted Therapies. Graphical abstract created using BioRender

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ACR Journals @acr-journals.bsky.social · 6d

Treatment of pain related to Raynaud phenomenon is a challenge due to diagnostic and training limitations and therapeutic access to guideline-based vasodilator medications. Review in AC&R examines current RP treatment guidelines that focus on vasodilation

doi.org/10.1002/acr....

#Medsky

Re-thinking Strategies for a Pharmaceutical Approach to Pain-related to Connective Tissue Related Raynaud's Phenomenon in the United States. Graphical abstract created using BioRender

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ACR Journals @acr-journals.bsky.social · 6d

Emulated target trial evaluated impact of GLP-1RA vs. comparator hypoglycemic agents, DPP4i, on CV and kidney outcomes among patients with SLE and T2D. Results showed GLP-1RAs provided substantial cardioprotective & kidney-protective benefits

Arthritis & Rheumatology
doi.org/10.1002/art....
#Medsky

Glucagon‐Like Peptide‐1 Receptor Agonist Use and the Risk of Adverse Cardiac and Kidney Outcomes Among Patients with Systemic Lupus Erythematosus and Lupus Nephritis

Objective Glucagon-like peptide-1 receptor agonists (GLP-1RA) have cardioprotective and kidney-protective benefits among patients with type 2 diabetes (T2D). We sought to determine whether GLP-1RA u...

doi.org

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ACR Journals @acr-journals.bsky.social · 7d

October Arthritis & Rheumatology In This Issue

•Prophylactic TMP-SMX & risk of infections in AAV
•Biomarkers for NHL in primary Sjögren disease
•Long-term voclosporin for lupus nephritis
🔎3-yr outcome analysis of the CARRA polyarticular JIA consensus treatment plan study

acr.tw/3Iz3itx

#Medsky

Arthritis & Rheumatology In This Issue banner - October 2025 Issue Cover

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ACR Journals @acr-journals.bsky.social · 7d

October Arthritis & Rheumatology Clinical Connections

❇️ Tapering TNFi to Withdrawal Compared With Continued TNFi Among Patients With Rheumatoid Arthritis

❇️ Longitudinal Associations Between Sarcopenia and Knee Osteoarthritis Progression

acrjournals.onlinelibrary.wiley.com/doi/epdf/10....

#Medsky

Tapering TNFi to Withdrawal Compared With Continued TNFi Among Patients With Rheumatoid Arthritis

Longitudinal Associations Between Sarcopenia and Knee Osteoarthritis Progression

ACR Journals @acr-journals.bsky.social · 7d

Arthritis & Rheumatology October Issue Editor's Pick:

Comparative Analysis of Circulating and Synovial Immune Cells in Early Untreated Rheumatoid Arthritis and Their Relationship With Molecular Pathology and Disease Outcomes

doi.org/10.1002/art....

Arthritis & Rheumatology Editor's Pick banner - October 2025 Issue cover

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ACR Journals @acr-journals.bsky.social · 8d

Ongoing reliance on opioids represents a public health concern. Data from IMRD & MarketScan for adults with axSpA showed, despite increased TNFi use over past 2 decades, opioid prescribing trends have remained stable in the UK & only modestly declined in the US

AC&R
doi.org/10.1002/acr....
#Medsky

Trends in Opioid Prescriptions in Individuals with Axial Spondyloarthritis in the US and UK in the Last Two Decades: Analysis of Electronic Health Records and Insurance Claims Data. Graphical abstract created using BioRender

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ACR Journals @acr-journals.bsky.social · 8d

Among 20 young adults with prior history of juvenile dermatomyositis, ultrasound brachial artery reactivity testing revealed evidence of persistent endothelial dysfunction, suggesting potentially increased CVD risk

ACR Open Rheumatology
doi.org/10.1002/acr2...

#Medsky

Impaired Brachial Artery Reactivity in Young Adults With Clinically Quiescent Juvenile Dermatomyositis

Objective This study characterized brachial artery reactivity, an ultrasound indicator of endothelial function, in young adults who had clinically quiescent juvenile dermatomyositis (JDM) compared w...

doi.org

ACR Journals @acr-journals.bsky.social · 8d

Multicenter retrospective study compared anakinra and canakinumab in VEXAS syndrome. Canakinumab showed better efficacy vs anakinra, as reflected by a higher clinical response and longer drug survival, as well as a superior safety profile

Arthritis & Rheumatology
doi.org/10.1002/art....

#Medsky

Comparative efficacy and safety of anakinra and canakinumab in patients with VEXAS syndrome – an international multicenter study. A graphical abstract

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ACR Journals @acr-journals.bsky.social · 9d

Data from 2 large obs cohorts of pts with RA were used to develop & validate a prediction model to identify pts at risk of difficult-to-treat RA. The resulting model's moderate discrimination & calibration underscore need for research into add'tl biomarkers

AC&R
doi.org/10.1002/acr....

#Medsky

Development and External Validation of a Multivariable Predictive Model for Progression to Difficult-to-Treat Rheumatoid Arthritis in Biologic-Experienced Patients. Graphical abstract created using BioRender

ACR Journals @acr-journals.bsky.social · 9d

The PROGRESS OA study combined data from 4 RCTs to conduct external validation of prognostic MRI biomarkers for OA. Results showed similar assoc. as the phase 1 study analyses, with regression formula yielding AUC of 0.67 (vs 0.72 in phase 1 data)

ACROR
doi.org/10.1002/acr2...

#Medsky

Univariable associations between the primary set of baseline magnetic resonance imagin biomarkers and joint space width loss ≥0.7 mm in PROGRESS OA. The results from unadjusted univariable logistic regression are shown for each biomarker. Individual biomarkers are shown along the y-axis and unadjusted odds ratios with 95% confidence intervals are shown along the x-axis. The x-axis is on the log scale. P values and AUCs for each biomarker are shown in the columns on the right. AUC, area under the curve; ccMF.ThCtAB, central weight-bearing medial femoral condyle; ecMF.ThCtAB, central medial femoral condyle (external); LFTJ, lateral tibiofemoral joint; MFTC.ThCtAB, total medial femorotibial compartment; MFTJ, medial tibiofemoral joint; PFJ, patellofemoral joint; Q, quantitative; SQ, semiquantitative; SR, subregion

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ACR Journals @acr-journals.bsky.social · 10d

Attending #ACR25? This study will also be presented as part of the A&R and ARD joint journal club with the editors session

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ACR Journals @acr-journals.bsky.social · 10d

Arthritis & Rheumatology
doi.org/10.1002/art....